INTEDE - Interactome of Drug-Metabolizing Enzyme Database
Title - Metabolizing enzyme-drug affinity data
Version 1.8.1 (2020.08.15)
Provided by IDRB   Lab of Innovative Drug Reasearch and Bioinformatics
                   College of Pharmaceutical Sciences
                   Zhejiang University
                   https://idrblab.org/
Any question about data provided here, please contact with:
Dr. Yin (yinjiayi@zju.edu.cn) and Dr. Li (lifengcheng@zju.edu.cn)

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Abbreviations:
DME___ID	INTEDE Drug-Metabolizing Enzyme (DME) ID
DME_NAME	INTEDE Drug-Metabolizing Enzyme (DME) Name
GENENAME	DME Gene Name
SPESNAME	DME Species Name
AFFINITY	Drug-DME Affinity Assessed
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DME0004	DME___ID	DME0004
DME0004	DME_NAME	UDP-glucuronosyltransferase 1A1 (UGT1A1)
DME0004	GENENAME	UGT1A1
DME0004	SPESNAME	Homo sapiens
DME0004	AFFINITY	Curcumin	Km = 0.1 microM
DME0004	AFFINITY	Ethanol	Km = 8.03 microM
DME0004	AFFINITY	ICI-79,280	Km = 0.004 microM
DME0004	AFFINITY	ACMC-1AKLT	Km = 0.198 microM
DME0004	AFFINITY	Anthraflavic acid	Km = 0.01 microM
DME0004	AFFINITY	Chrysin	Km = 0.004 microM
DME0004	AFFINITY	Cis-4-hydroxytamoxifen	Km = 0.0074 microM
DME0004	AFFINITY	Eugenol	Km = 0.0084 microM
DME0004	AFFINITY	Phloretin	Km = 0.0068 microM

DME0005	DME___ID	DME0005
DME0005	DME_NAME	Cytochrome P450 2A6 (CYP2A6)
DME0005	GENENAME	CYP2A6
DME0005	SPESNAME	Homo sapiens
DME0005	AFFINITY	Fenthion	Km = 0.0016 microM
DME0005	AFFINITY	Fenthion sulfoxide	Km = 0.018 microM

DME0008	DME___ID	DME0008
DME0008	DME_NAME	Sulfotransferase 1A1 (SULT1A1)
DME0008	GENENAME	SULT1A1
DME0008	SPESNAME	Homo sapiens
DME0008	AFFINITY	Benzyl alcohol	Km = 0.0685 microM
DME0008	AFFINITY	Liothyronine	Km = 0.084 microM
DME0008	AFFINITY	Diiodo-l-thyronine	Km = 0.00051 microM
DME0008	AFFINITY	L-thyroxine	Km = 0.101 microM
DME0008	AFFINITY	Triiodo-l-thyronine	Km = 0.036 microM

DME0014	DME___ID	DME0014
DME0014	DME_NAME	Thiopurine methyltransferase (TPMT)
DME0014	GENENAME	TPMT
DME0014	SPESNAME	Homo sapiens
DME0014	AFFINITY	BW-5071	Km = 0.0152 microM

DME0031	DME___ID	DME0031
DME0031	DME_NAME	Cytochrome P450 2J2 (CYP2J2)
DME0031	GENENAME	CYP2J2
DME0031	SPESNAME	Homo sapiens
DME0031	AFFINITY	Ergocalciferol	Km = 0.002 microM
DME0031	AFFINITY	Vitamin D	Km = 0.0077 microM
DME0031	AFFINITY	Alfacalcidol	Km = 0.0044 microM

DME0040	DME___ID	DME0040
DME0040	DME_NAME	UDP-glucuronosyltransferase 2B7 (UGT2B7)
DME0040	GENENAME	UGT2B7
DME0040	SPESNAME	Homo sapiens
DME0040	AFFINITY	Zidovudine	Km = 0.551 microM
DME0040	AFFINITY	BRN-3224996	Km = 0.00036 microM
DME0040	AFFINITY	Alpha-dihydroaldosterone	Km = 0.00023 microM
DME0040	AFFINITY	Tetrahydroaldosterone	Km = 0.00197 microM

DME0042	DME___ID	DME0042
DME0042	DME_NAME	UDP-glucuronosyltransferase 1A9 (UGT1A9)
DME0042	GENENAME	UGT1A9
DME0042	SPESNAME	Homo sapiens
DME0042	AFFINITY	Propofol	Km = 0.0072 microM
DME0042	AFFINITY	Curcumin	Km = 0.1 microM
DME0042	AFFINITY	LM-94	Km = 0.0029 microM
DME0042	AFFINITY	Anthraflavic acid	Km = 0.01 microM
DME0042	AFFINITY	Chrysin	Km = 0.004 microM
DME0042	AFFINITY	Eugenol	Km = 0.0084 microM
DME0042	AFFINITY	Phloretin	Km = 0.0068 microM

DME0044	DME___ID	DME0044
DME0044	DME_NAME	Monoamine oxidase type A (MAO-A)
DME0044	GENENAME	MAOA
DME0044	SPESNAME	Homo sapiens
DME0044	AFFINITY	Benzylamine	Km = 0.21 microM
DME0044	AFFINITY	Phenylethylamine	Km = 0.35 microM
DME0044	AFFINITY	Serotonin	Km = 0.3 microM

DME0047	DME___ID	DME0047
DME0047	DME_NAME	UDP-glucuronosyltransferase 2B4 (UGT2B4)
DME0047	GENENAME	UGT2B4
DME0047	SPESNAME	Homo sapiens
DME0047	AFFINITY	Labetalol	Km = 0.368 microM

DME0048	DME___ID	DME0048
DME0048	DME_NAME	UDP-glucuronosyltransferase 1A4 (UGT1A4)
DME0048	GENENAME	UGT1A4
DME0048	SPESNAME	Homo sapiens
DME0048	AFFINITY	Calcitriol	Km = 0.0073 microM
DME0048	AFFINITY	LM-94	Km = 0.00012 microM
DME0048	AFFINITY	UDP-glucuronate	Km = 0.00025 microM

DME0049	DME___ID	DME0049
DME0049	DME_NAME	UDP-glucuronosyltransferase 2B15 (UGT2B15)
DME0049	GENENAME	UGT2B15
DME0049	SPESNAME	Homo sapiens
DME0049	AFFINITY	BRN-1980310	Km = 0.0301 microM
DME0049	AFFINITY	Hydroxybenzo(a)pyrene	Km = 0.0097 microM
DME0049	AFFINITY	Hydroxybenzo[a]pyrene	Km = 0.0113 microM

DME0050	DME___ID	DME0050
DME0050	DME_NAME	N-acetyltransferase 1 (NAT1)
DME0050	GENENAME	NAT1
DME0050	SPESNAME	Homo sapiens
DME0050	AFFINITY	Asacolitin	Km = 0.0067 microM

DME0051	DME___ID	DME0051
DME0051	DME_NAME	N-acetyltransferase 2 (NAT2)
DME0051	GENENAME	NAT2
DME0051	SPESNAME	Homo sapiens
DME0051	AFFINITY	Asacolitin	Km = 0.0067 microM

DME0054	DME___ID	DME0054
DME0054	DME_NAME	Carboxylesterase 1 (CES1)
DME0054	GENENAME	CES1
DME0054	SPESNAME	Homo sapiens
DME0054	AFFINITY	Nitrophenyl acetate	Km = 0.0031 microM

DME0062	DME___ID	DME0062
DME0062	DME_NAME	Sulfotransferase 1A2 (SULT1A2)
DME0062	GENENAME	SULT1A2
DME0062	SPESNAME	Homo sapiens
DME0062	AFFINITY	Benzyl alcohol	Km = 0.0685 microM
DME0062	AFFINITY	Mononitrophenol	Km = 0.00775 microM

DME0064	DME___ID	DME0064
DME0064	DME_NAME	UDP-glucuronosyltransferase 1A8 (UGT1A8)
DME0064	GENENAME	UGT1A8
DME0064	SPESNAME	Homo sapiens
DME0064	AFFINITY	Curcumin	Km = 0.1 microM
DME0064	AFFINITY	ICI-79,280	Km = 0.004 microM
DME0064	AFFINITY	Anthraflavic acid	Km = 0.01 microM
DME0064	AFFINITY	Chrysin	Km = 0.004 microM
DME0064	AFFINITY	Cis-4-hydroxytamoxifen	Km = 0.0074 microM
DME0064	AFFINITY	Eugenol	Km = 0.0084 microM
DME0064	AFFINITY	Phloretin	Km = 0.0068 microM

DME0065	DME___ID	DME0065
DME0065	DME_NAME	UDP-glucuronosyltransferase 1A7 (UGT1A7)
DME0065	GENENAME	UGT1A7
DME0065	SPESNAME	Homo sapiens
DME0065	AFFINITY	Curcumin	Km = 0.1 microM
DME0065	AFFINITY	Anthraflavic acid	Km = 0.01 microM
DME0065	AFFINITY	Chrysin	Km = 0.004 microM
DME0065	AFFINITY	Eugenol	Km = 0.0084 microM
DME0065	AFFINITY	Phloretin	Km = 0.0068 microM

DME0066	DME___ID	DME0066
DME0066	DME_NAME	UDP-glucuronosyltransferase 2B17 (UGT2B17)
DME0066	GENENAME	UGT2B17
DME0066	SPESNAME	Homo sapiens
DME0066	AFFINITY	Denopamine	Km = 1.48 microM
DME0066	AFFINITY	BRN-1980310	Km = 0.0301 microM
DME0066	AFFINITY	Hydroxybenzo(a)pyrene	Km = 0.0097 microM
DME0066	AFFINITY	Hydroxybenzo[a]pyrene	Km = 0.0113 microM

DME0067	DME___ID	DME0067
DME0067	DME_NAME	NADPH-dependent carbonyl reductase 1 (CBR1)
DME0067	GENENAME	CBR1
DME0067	SPESNAME	Homo sapiens
DME0067	AFFINITY	Daunorubicin	Km = 0.0852 microM
DME0067	AFFINITY	Phenanthrenequinone	Km = 0.0354 microM

DME0068	DME___ID	DME0068
DME0068	DME_NAME	NADPH-dependent carbonyl reductase 3 (CBR3)
DME0068	GENENAME	CBR3
DME0068	SPESNAME	Homo sapiens
DME0068	AFFINITY	Menadione	Km = 0.043 microM
DME0068	AFFINITY	ACMC-209cv7	Km = 0.3 microM
DME0068	AFFINITY	Isatin	Km = 0.0078 microM
DME0068	AFFINITY	Nitrobenzaldehyde	Km = 0.13 microM
DME0068	AFFINITY	Phenanthrenequinone	Km = 0.0043 microM

DME0072	DME___ID	DME0072
DME0072	DME_NAME	UDP-glucuronosyltransferase 1A6 (UGT1A6)
DME0072	GENENAME	UGT1A6
DME0072	SPESNAME	Homo sapiens
DME0072	AFFINITY	BRN-2217626	Km = 0.0066 microM
DME0072	AFFINITY	LM-94	Km = 0.00012 microM
DME0072	AFFINITY	A-estradiol	Km = 0.024 microM
DME0072	AFFINITY	Bilirubin	Km = 0.024 microM
DME0072	AFFINITY	BRN-1999480	Km = 0.014 microM
DME0072	AFFINITY	Hydroxyestradiol	Km = 0.01 microM
DME0072	AFFINITY	Hydroxyestrone	Km = 0.021 microM
DME0072	AFFINITY	Hydroxytryptophol	Km = 0.135 microM
DME0072	AFFINITY	Hyodeoxycholic acid	Km = 0.011 microM
DME0072	AFFINITY	UDP-glucuronate	Km = 0.00025 microM

DME0074	DME___ID	DME0074
DME0074	DME_NAME	Sulfotransferase 2A1 (SULT2A1)
DME0074	GENENAME	SULT2A1
DME0074	SPESNAME	Homo sapiens
DME0074	AFFINITY	Dehydroepiandrosterone	Km = 0.002 microM
DME0074	AFFINITY	Daidzein	Km = 0.1673 microM
DME0074	AFFINITY	Pregnenolone	Km = 0.0018 microM
DME0074	AFFINITY	BIO-300	Km = 0.041 microM
DME0074	AFFINITY	Biphenol A	Km = 0.0043 microM
DME0074	AFFINITY	N-nonylphenol	Km = 0.0715 microM
DME0074	AFFINITY	Tetramethylbutylphenol	Km = 0.0051 microM

DME0084	DME___ID	DME0084
DME0084	DME_NAME	Beta,beta-carotene 15,15'-dioxygenase (BCO1)
DME0084	GENENAME	BCO1
DME0084	SPESNAME	Homo sapiens
DME0084	AFFINITY	Beta carotene	Km = 0.0172 microM

DME0091	DME___ID	DME0091
DME0091	DME_NAME	Prostaglandin G/H synthase 1 (COX-1)
DME0091	GENENAME	PTGS1
DME0091	SPESNAME	Homo sapiens
DME0091	AFFINITY	Gamma-linolenic acid	Km = 0.0048 microM
DME0091	AFFINITY	SC-411	Km = 0.0011 microM
DME0091	AFFINITY	Alpha-linolenic acid	Km = 0.0031 microM
DME0091	AFFINITY	Arachidonic acid	Km = 0.0017 microM
DME0091	AFFINITY	BML3-C01	Km = 0.0027 microM
DME0091	AFFINITY	Eicosadienoic acid	Km = 0.0052 microM
DME0091	AFFINITY	Icosapentum	Km = 0.0012 microM
DME0091	AFFINITY	Icosatrienoic acid	Km = 0.002 microM

DME0098	DME___ID	DME0098
DME0098	DME_NAME	Aldo-keto reductase 1A1 (AKR1A1)
DME0098	GENENAME	AKR1A1
DME0098	SPESNAME	Homo sapiens
DME0098	AFFINITY	BRN-0471734	Km = 0.038 microM
DME0098	AFFINITY	D-glucuronate	Km = 364 microM
DME0098	AFFINITY	Dl-glyceraldehyde	Km = 1.7 microM
DME0098	AFFINITY	Nitrobenzaldehyde	Km = 0.16 microM

DME0114	DME___ID	DME0114
DME0114	DME_NAME	Prostaglandin G/H synthase 2 (COX-2)
DME0114	GENENAME	PTGS2
DME0114	SPESNAME	Homo sapiens
DME0114	AFFINITY	Gamma-linolenic acid	Km = 0.0048 microM
DME0114	AFFINITY	SC-411	Km = 0.0011 microM
DME0114	AFFINITY	Alpha-linolenic acid	Km = 0.0031 microM
DME0114	AFFINITY	Arachidonic acid	Km = 0.0017 microM
DME0114	AFFINITY	BML3-C01	Km = 0.0027 microM
DME0114	AFFINITY	Eicosadienoic acid	Km = 0.0052 microM
DME0114	AFFINITY	Icosapentum	Km = 0.0012 microM
DME0114	AFFINITY	Icosatrienoic acid	Km = 0.002 microM

DME0118	DME___ID	DME0118
DME0118	DME_NAME	Aldo-keto reductase 1C3 (AKR1C3)
DME0118	GENENAME	AKR1C3
DME0118	SPESNAME	Homo sapiens
DME0118	AFFINITY	BRN-2217626	Km = 0.0035 microM
DME0118	AFFINITY	Acenaphthenol	Km = 0.022 microM
DME0118	AFFINITY	Indan-1-ol	Km = 0.048 microM

DME0126	DME___ID	DME0126
DME0126	DME_NAME	L-glutamine amidohydrolase (GLS)
DME0126	GENENAME	GLS
DME0126	SPESNAME	Homo sapiens
DME0126	AFFINITY	L-glutamine	Km = 0.4 microM

DME0129	DME___ID	DME0129
DME0129	DME_NAME	Alcohol dehydrogenase class-I gamma (ADH1C)
DME0129	GENENAME	ADH1C
DME0129	SPESNAME	Homo sapiens
DME0129	AFFINITY	Ethanol	Km = 0.77 microM
DME0129	AFFINITY	Acetaldehyde	Km = 0.34 microM
DME0129	AFFINITY	BRN-2330710	Km = 0.00048 microM
DME0129	AFFINITY	Heptyl carbinol	Km = 0.39 microM
DME0129	AFFINITY	Hydroxymethylpyrene	Km = 0.00059 microM
DME0129	AFFINITY	Octanal	Km = 9.6 microM
DME0129	AFFINITY	Pyrene-1-aldehyde	Km = 0.0005 microM
DME0129	AFFINITY	Pyrenemethanol	Km = 0.00037 microM

DME0130	DME___ID	DME0130
DME0130	DME_NAME	Alcohol dehydrogenase class-II (ADH4)
DME0130	GENENAME	ADH4
DME0130	SPESNAME	Homo sapiens
DME0130	AFFINITY	Ethanol	Km = 0.77 microM
DME0130	AFFINITY	Acetaldehyde	Km = 0.34 microM
DME0130	AFFINITY	BRN-2330710	Km = 0.00048 microM
DME0130	AFFINITY	Heptyl carbinol	Km = 0.39 microM
DME0130	AFFINITY	Hydroxymethylpyrene	Km = 0.00059 microM
DME0130	AFFINITY	Octanal	Km = 9.6 microM
DME0130	AFFINITY	Pyrene-1-aldehyde	Km = 0.0005 microM
DME0130	AFFINITY	Pyrenemethanol	Km = 0.00037 microM

DME0137	DME___ID	DME0137
DME0137	DME_NAME	Thymidylate synthase (TYMS)
DME0137	GENENAME	TYMS
DME0137	SPESNAME	Homo sapiens
DME0137	AFFINITY	Deoxy-UMP	Km = 0.0007 microM

DME0155	DME___ID	DME0155
DME0155	DME_NAME	Glutamine-dependent NAD(+) synthetase (NADSYN1)
DME0155	GENENAME	NADSYN1
DME0155	SPESNAME	Homo sapiens
DME0155	AFFINITY	L-glutamine	Km = 1.44 microM
DME0155	AFFINITY	Deamido-NAD	Km = 0.049 microM

DME0169	DME___ID	DME0169
DME0169	DME_NAME	Serum paraoxonase/arylesterase 1 (PON1)
DME0169	GENENAME	PON1
DME0169	SPESNAME	Homo sapiens
DME0169	AFFINITY	RTR-003632	Km = 0.27 microM
DME0169	AFFINITY	Coumaranone	Km = 0.013 microM
DME0169	AFFINITY	Dihydrocoumarin	Km = 0.013 microM
DME0169	AFFINITY	Gamma-butyrolactone	Km = 15 microM
DME0169	AFFINITY	Gamma-thiobutyrolactone	Km = 2.8 microM
DME0169	AFFINITY	Homogentisic acid	Km = 0.45 microM
DME0169	AFFINITY	Paraoxon	Km = 0.27 microM

DME0171	DME___ID	DME0171
DME0171	DME_NAME	Indoleamine 2,3-dioxygenase 1 (IDO1)
DME0171	GENENAME	IDO1
DME0171	SPESNAME	Homo sapiens
DME0171	AFFINITY	TRP-01	Km = 0.0141 microM

DME0174	DME___ID	DME0174
DME0174	DME_NAME	Tryptophan 5-hydroxylase 2 (TPH2)
DME0174	GENENAME	TPH2
DME0174	SPESNAME	Homo sapiens
DME0174	AFFINITY	TRP-01	Km = 0.0186 microM
DME0174	AFFINITY	Sapropterin	Km = 0.0684 microM
DME0174	AFFINITY	Tetrahydrobiopterin	Km = 0.0147 microM

DME0176	DME___ID	DME0176
DME0176	DME_NAME	Tryptophanyl-tRNA synthetase mitochondrial (WARS2)
DME0176	GENENAME	WARS2
DME0176	SPESNAME	Homo sapiens
DME0176	AFFINITY	TRP-01	Km = 0.027 microM

DME0183	DME___ID	DME0183
DME0183	DME_NAME	Methionine adenosyltransferase II beta (MAT2B)
DME0183	GENENAME	MAT2B
DME0183	SPESNAME	Homo sapiens
DME0183	AFFINITY	Methionine	Km = 0.022 microM

DME0186	DME___ID	DME0186
DME0186	DME_NAME	Methionine-tRNA ligase cytoplasmic (MARS)
DME0186	GENENAME	MARS1
DME0186	SPESNAME	Homo sapiens
DME0186	AFFINITY	Methionine	Km = 0.018 microM

DME0197	DME___ID	DME0197
DME0197	DME_NAME	Aldo-keto reductase 1C1 (AKR1C1)
DME0197	GENENAME	AKR1C1
DME0197	SPESNAME	Homo sapiens
DME0197	AFFINITY	Androstanolone	Km = 0.00218 microM

DME0199	DME___ID	DME0199
DME0199	DME_NAME	Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)
DME0199	GENENAME	HSD11B1
DME0199	SPESNAME	Homo sapiens
DME0199	AFFINITY	Cortisone acetate	Km = 0.00052 microM
DME0199	AFFINITY	Dehydrocorticosterone	Km = 0.00042 microM

DME0200	DME___ID	DME0200
DME0200	DME_NAME	Bile acid-CoA thioesterase (BAAT)
DME0200	GENENAME	BAAT
DME0200	SPESNAME	Homo sapiens
DME0200	AFFINITY	Glycine	Km = 5 microM
DME0200	AFFINITY	Taurine	Km = 1 microM
DME0200	AFFINITY	NSC-39851	Km = 2 microM
DME0200	AFFINITY	ZX-AP000068	Km = 2 microM

DME0205	DME___ID	DME0205
DME0205	DME_NAME	UDP-glucuronosyltransferase 2B10 (UGT2B10)
DME0205	GENENAME	UGT2B10
DME0205	SPESNAME	Homo sapiens
DME0205	AFFINITY	Cotinine	Km = 0.0278 microM

DME0209	DME___ID	DME0209
DME0209	DME_NAME	Pyridoxamine-phosphate oxidase (PNPO)
DME0209	GENENAME	PNPO
DME0209	SPESNAME	Homo sapiens
DME0209	AFFINITY	Pyridoxine-P	Km = 0.00618 microM

DME0216	DME___ID	DME0216
DME0216	DME_NAME	Putrescine acetyltransferase (SSAT1)
DME0216	GENENAME	SAT1
DME0216	SPESNAME	Homo sapiens
DME0216	AFFINITY	CCG-205124	Km = 0.022 microM
DME0216	AFFINITY	KM-1406	Km = 0.0057 microM
DME0216	AFFINITY	Diethylenetriamine	Km = 0.194 microM
DME0216	AFFINITY	Ethylenediamine	Km = 0.196 microM
DME0216	AFFINITY	Propandiamine	Km = 0.107 microM

DME0221	DME___ID	DME0221
DME0221	DME_NAME	Dihydrotestosterone oxidoreductase (HSD3B1)
DME0221	GENENAME	HSD3B1
DME0221	SPESNAME	Homo sapiens
DME0221	AFFINITY	Dehydroepiandrosterone	Km = 0.00164 microM
DME0221	AFFINITY	Pregnenolone	Km = 0.0028 microM
DME0221	AFFINITY	NSC-63853	Km = 0.0035 microM

DME0222	DME___ID	DME0222
DME0222	DME_NAME	Beta-HSD adrenal and gonadal type (HSD3B2)
DME0222	GENENAME	HSD3B2
DME0222	SPESNAME	Homo sapiens
DME0222	AFFINITY	Dehydroepiandrosterone	Km = 0.00164 microM
DME0222	AFFINITY	Pregnenolone	Km = 0.0028 microM
DME0222	AFFINITY	NSC-63853	Km = 0.0035 microM

DME0286	DME___ID	DME0286
DME0286	DME_NAME	Aldehyde dehydrogenase 1 (ALDH1)
DME0286	GENENAME	ALDH1A1
DME0286	SPESNAME	Homo sapiens
DME0286	AFFINITY	All-trans-retinal	Km = 0.0081 microM
DME0286	AFFINITY	Decanal	Km = 0.01 microM

DME0289	DME___ID	DME0289
DME0289	DME_NAME	Aldehyde dehydrogenase 5 (ALDHX)
DME0289	GENENAME	ALDH1B1
DME0289	SPESNAME	Homo sapiens
DME0289	AFFINITY	SC-47945	Km = 0.0004 microM

DME0294	DME___ID	DME0294
DME0294	DME_NAME	Aldehyde dehydrogenase 7 (ALDH7)
DME0294	GENENAME	ALDH3B1
DME0294	SPESNAME	Homo sapiens
DME0294	AFFINITY	SC-47945	Km = 0.0004 microM

DME0299	DME___ID	DME0299
DME0299	DME_NAME	Aminomuconic semialdehyde dehydrogenase (ALDH12)
DME0299	GENENAME	ALDH8A1
DME0299	SPESNAME	Homo sapiens
DME0299	AFFINITY	SC-47945	Km = 0.0004 microM

DME0313	DME___ID	DME0313
DME0313	DME_NAME	Glutathione S-transferase omega-1 (GSTO1)
DME0313	GENENAME	GSTO1
DME0313	SPESNAME	Homo sapiens
DME0313	AFFINITY	ANW-43980	Km = 4.18 microM
DME0313	AFFINITY	Dehydroascorbate	Km = 0.43 microM

DME0314	DME___ID	DME0314
DME0314	DME_NAME	Glutathione S-transferase omega-2 (GSTO2)
DME0314	GENENAME	GSTO2
DME0314	SPESNAME	Homo sapiens
DME0314	AFFINITY	ANW-43980	Km = 4.18 microM
DME0314	AFFINITY	Dehydroascorbate	Km = 0.43 microM

DME0326	DME___ID	DME0326
DME0326	DME_NAME	UDP-glucuronosyltransferase 2A3 (UGT2A3)
DME0326	GENENAME	UGT2A3
DME0326	SPESNAME	Homo sapiens
DME0326	AFFINITY	Hyodeoxycholic acid	Km = 0.044 microM

DME0336	DME___ID	DME0336
DME0336	DME_NAME	Cysteinyl-conjugate N-acetyltransferase (NAT8)
DME0336	GENENAME	NAT8
DME0336	SPESNAME	Homo sapiens
DME0336	AFFINITY	Acetyl-CoA	Km = 0.023 microM

DME0380	DME___ID	DME0380
DME0380	DME_NAME	Sulfotransferase 1B1 (SULT1B1)
DME0380	GENENAME	SULT1B1
DME0380	SPESNAME	Homo sapiens
DME0380	AFFINITY	Benzyl alcohol	Km = 0.0685 microM
DME0380	AFFINITY	Dopamine hydrochloride	Km = 0.0014 microM
DME0380	AFFINITY	Aminophenol	Km = 0.009 microM
DME0380	AFFINITY	Mononitrophenol	Km = 0.00036 microM

DME0384	DME___ID	DME0384
DME0384	DME_NAME	Sulfotransferase 2B1 (SULT2B1)
DME0384	GENENAME	SULT2B1
DME0384	SPESNAME	Homo sapiens
DME0384	AFFINITY	Pregnenolone	Km = 0.0018 microM

DME0389	DME___ID	DME0389
DME0389	DME_NAME	Bifunctional epoxide hydrolase 2 (EPHX2)
DME0389	GENENAME	EPHX2
DME0389	SPESNAME	Homo sapiens
DME0389	AFFINITY	Myrisglycerol-phosphate	Km = 0.0051 microM

DME0399	DME___ID	DME0399
DME0399	DME_NAME	Farnesol dehydrogenase (AKR1B15)
DME0399	GENENAME	AKR1B15
DME0399	SPESNAME	Homo sapiens
DME0399	AFFINITY	Estrone	Km = 0.0035 microM
DME0399	AFFINITY	Testosterone cypionate	Km = 0.0071 microM
DME0399	AFFINITY	BRN-2217626	Km = 0.0028 microM
DME0399	AFFINITY	E-3A	Km = 0.0091 microM

DME0405	DME___ID	DME0405
DME0405	DME_NAME	Copper amine oxidase (AOC3)
DME0405	GENENAME	AOC3
DME0405	SPESNAME	Homo sapiens
DME0405	AFFINITY	LS-103895	Km = 0.056 microM
DME0405	AFFINITY	Benzylamine	Km = 0.167 microM
DME0405	AFFINITY	Methylamine	Km = 0.67 microM
DME0405	AFFINITY	Phenylethylamine	Km = 0.077 microM

DME0419	DME___ID	DME0419
DME0419	DME_NAME	Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)
DME0419	GENENAME	HSD11B2
DME0419	SPESNAME	Homo sapiens
DME0419	AFFINITY	Cortisone acetate	Km = 0.00052 microM
DME0419	AFFINITY	Dehydrocorticosterone	Km = 0.00042 microM

DME0421	DME___ID	DME0421
DME0421	DME_NAME	Ketoacyl-CoA reductase (HSD17B12)
DME0421	GENENAME	HSD17B12
DME0421	SPESNAME	Homo sapiens
DME0421	AFFINITY	Estrone	Km = 0.0025 microM

DME0427	DME___ID	DME0427
DME0427	DME_NAME	Mevalonate pyrophosphate decarboxylase (MPD)
DME0427	GENENAME	MVD
DME0427	SPESNAME	Homo sapiens
DME0427	AFFINITY	Mevalonate-PP	Km = 0.0289 microM

DME0431	DME___ID	DME0431
DME0431	DME_NAME	Methionine synthase reductase (MTRR)
DME0431	GENENAME	MTRR
DME0431	SPESNAME	Homo sapiens
DME0431	AFFINITY	Doxorubicin	Km = 0.0286 microM
DME0431	AFFINITY	Menadione	Km = 0.0177 microM
DME0431	AFFINITY	Dichloroindophenol	Km = 0.0023 microM
DME0431	AFFINITY	Ferricyanide	Km = 0.663 microM

DME0432	DME___ID	DME0432
DME0432	DME_NAME	Gamma-glutamyltranspeptidase 5 (GGT5)
DME0432	GENENAME	GGT5
DME0432	SPESNAME	Homo sapiens
DME0432	AFFINITY	ANW-43980	Km = 0.0105 microM
DME0432	AFFINITY	Glutathiol	Km = 0.0088 microM
DME0432	AFFINITY	C-46053	Km = 0.0346 microM
DME0432	AFFINITY	Glutathione ester	Km = 0.0182 microM
DME0432	AFFINITY	Leukotriene C4	Km = 0.0102 microM

DME0438	DME___ID	DME0438
DME0438	DME_NAME	Phosphodiesterase 7B (PDE7B)
DME0438	GENENAME	PDE7B
DME0438	SPESNAME	Homo sapiens
DME0438	AFFINITY	Adenosine-c-phosphate	Km = 0.0002 microM

DME0450	DME___ID	DME0450
DME0450	DME_NAME	Gamma-glutamylcyclotransferase 2 (CHAC2)
DME0450	GENENAME	CHAC2
DME0450	SPESNAME	Homo sapiens
DME0450	AFFINITY	ANW-43980	Km = 3.7 microM

DME0451	DME___ID	DME0451
DME0451	DME_NAME	Thyroid peroxidase (TPO)
DME0451	GENENAME	TPO
DME0451	SPESNAME	Homo sapiens
DME0451	AFFINITY	Guaiacol	Km = 5.55 microM

DME0452	DME___ID	DME0452
DME0452	DME_NAME	Phosphomannomutase 2 (PMM2)
DME0452	GENENAME	PMM2
DME0452	SPESNAME	Homo sapiens
DME0452	AFFINITY	D-glucose 1-phosphate	Km = 0.0075 microM
DME0452	AFFINITY	D-mannose-1-phosphate	Km = 0.016 microM

DME0453	DME___ID	DME0453
DME0453	DME_NAME	Phosphomannomutase 1 (PMM1)
DME0453	GENENAME	PMM1
DME0453	SPESNAME	Homo sapiens
DME0453	AFFINITY	D-glucose 1-phosphate	Km = 0.0075 microM
DME0453	AFFINITY	D-mannose-1-phosphate	Km = 0.016 microM

DME0454	DME___ID	DME0454
DME0454	DME_NAME	Mevalonate kinase (MVK)
DME0454	GENENAME	MVK
DME0454	SPESNAME	Homo sapiens
DME0454	AFFINITY	Mevalonate	Km = 0.0324 microM

DME0455	DME___ID	DME0455
DME0455	DME_NAME	Sulfurylase kinase 1 (PAPSS1)
DME0455	GENENAME	PAPSS1
DME0455	SPESNAME	Homo sapiens
DME0455	AFFINITY	Adenylylsulfate	Km = 0.0004 microM
DME0455	AFFINITY	Sulfate	Km = 0.16 microM

DME0456	DME___ID	DME0456
DME0456	DME_NAME	Uridine/cytidine monophosphate kinase (UMPK)
DME0456	GENENAME	CMPK1
DME0456	SPESNAME	Homo sapiens
DME0456	AFFINITY	Gemcitabine	Km = 0.0146 microM

DME0457	DME___ID	DME0457
DME0457	DME_NAME	Sucrase-isomaltase intestinal (SI)
DME0457	GENENAME	SI
DME0457	SPESNAME	Homo sapiens
DME0457	AFFINITY	M-7403	Km = 7.1 microM

DME0459	DME___ID	DME0459
DME0459	DME_NAME	Indoleamine 2,3-dioxygenase 2 (IDO2)
DME0459	GENENAME	IDO2
DME0459	SPESNAME	Homo sapiens
DME0459	AFFINITY	TRP-01	Km = 0.02 microM

DME0460	DME___ID	DME0460
DME0460	DME_NAME	Prolyl 4-hydroxylase alpha-2 (P4HA2)
DME0460	GENENAME	P4HA2
DME0460	SPESNAME	Homo sapiens
DME0460	AFFINITY	Ascorbic acid	Km = 0.33 microM
DME0460	AFFINITY	Oxoglutarate	Km = 0.022 microM

DME0461	DME___ID	DME0461
DME0461	DME_NAME	Prolyl 4-hydroxylase alpha-1 (P4HA1)
DME0461	GENENAME	P4HA1
DME0461	SPESNAME	Homo sapiens
DME0461	AFFINITY	Ascorbic acid	Km = 0.33 microM
DME0461	AFFINITY	Oxoglutarate	Km = 0.022 microM

DME0462	DME___ID	DME0462
DME0462	DME_NAME	HIF-prolyl hydroxylase 2 (EGLN1)
DME0462	GENENAME	EGLN1
DME0462	SPESNAME	Homo sapiens
DME0462	AFFINITY	Ascorbic acid	Km = 0.14 microM
DME0462	AFFINITY	Oxoglutarate	Km = 0.02 microM

DME0463	DME___ID	DME0463
DME0463	DME_NAME	Prolyl 4-hydroxylase alpha-3 (P4HA3)
DME0463	GENENAME	P4HA3
DME0463	SPESNAME	Homo sapiens
DME0463	AFFINITY	Ascorbic acid	Km = 0.18 microM
DME0463	AFFINITY	Oxoglutarate	Km = 0.06 microM

DME0464	DME___ID	DME0464
DME0464	DME_NAME	S-methyl-5'-thioadenosine phosphorylase (MTAP)
DME0464	GENENAME	MTAP
DME0464	SPESNAME	Homo sapiens
DME0464	AFFINITY	Methylthioadenosine	Km = 0.005 microM

DME0465	DME___ID	DME0465
DME0465	DME_NAME	UDP-glucose 6-dehydrogenase (UGDH)
DME0465	GENENAME	UGDH
DME0465	SPESNAME	Homo sapiens
DME0465	AFFINITY	UDP-glucose	Km = 0.011 microM

DME0466	DME___ID	DME0466
DME0466	DME_NAME	Choline kinase alpha (CHKA)
DME0466	GENENAME	CHKA
DME0466	SPESNAME	Homo sapiens
DME0466	AFFINITY	BRN-1736748	Km = 0.021 microM

DME0467	DME___ID	DME0467
DME0467	DME_NAME	Choline/ethanolamine kinase (CHKB)
DME0467	GENENAME	CHKB
DME0467	SPESNAME	Homo sapiens
DME0467	AFFINITY	BRN-1736748	Km = 0.021 microM

DME0468	DME___ID	DME0468
DME0468	DME_NAME	NADPH:quinone reductase (CRYZ)
DME0468	GENENAME	CRYZ
DME0468	SPESNAME	Homo sapiens
DME0468	AFFINITY	Acetyl ethylene	Km = 0.035 microM
DME0468	AFFINITY	Hexylacrolein	Km = 0.48 microM
DME0468	AFFINITY	Hydroxy-2-nonenal	Km = 0.55 microM
DME0468	AFFINITY	J-009747	Km = 0.13 microM

DME0469	DME___ID	DME0469
DME0469	DME_NAME	GDP-D-glucose phosphorylase 1 (GDPGP1)
DME0469	GENENAME	GDPGP1
DME0469	SPESNAME	Homo sapiens
DME0469	AFFINITY	GDP-alpha-D-glucose	Km = 0.002 microM
DME0469	AFFINITY	Phosphate	Km = 2.9 microM

DME0470	DME___ID	DME0470
DME0470	DME_NAME	Triokinase/FMN cyclase (TKFC)
DME0470	GENENAME	TKFC
DME0470	SPESNAME	Homo sapiens
DME0470	AFFINITY	D-glyceraldehyde	Km = 0.0071 microM
DME0470	AFFINITY	Dihydroxyacetone	Km = 0.0099 microM

DME0471	DME___ID	DME0471
DME0471	DME_NAME	Hydroxyacyl-CoA dehydrogenase 2 (HSD17B10)
DME0471	GENENAME	HSD17B10
DME0471	SPESNAME	Homo sapiens
DME0471	AFFINITY	Dihydrocozymase	Km = 0.02 microM

DME0472	DME___ID	DME0472
DME0472	DME_NAME	Retinol dehydrogenase 14 (RDH14)
DME0472	GENENAME	RDH14
DME0472	SPESNAME	Homo sapiens
DME0472	AFFINITY	Dihydrocozymase	Km = 1200 microM

DME0473	DME___ID	DME0473
DME0473	DME_NAME	Diaphorase-1 (CYB5R3)
DME0473	GENENAME	CYB5R3
DME0473	SPESNAME	Homo sapiens
DME0473	AFFINITY	Dihydrocozymase	Km = 0.006 microM
DME0473	AFFINITY	Ferricyanide	Km = 0.006 microM

DME0474	DME___ID	DME0474
DME0474	DME_NAME	Retinol dehydrogenase 13 (RDH13)
DME0474	GENENAME	RDH13
DME0474	SPESNAME	Homo sapiens
DME0474	AFFINITY	Dihydrocozymase	Km = 6 microM

DME0475	DME___ID	DME0475
DME0475	DME_NAME	ADP-dependent glucokinase (ADPGK)
DME0475	GENENAME	ADPGK
DME0475	SPESNAME	Homo sapiens
DME0475	AFFINITY	D-glucose	Km = 0.27 microM

DME0476	DME___ID	DME0476
DME0476	DME_NAME	Brain form hexokinase (HK1)
DME0476	GENENAME	HK1
DME0476	SPESNAME	Homo sapiens
DME0476	AFFINITY	D-glucose	Km = 0.057 microM

DME0477	DME___ID	DME0477
DME0477	DME_NAME	Semicarbazide-sensitive amine oxidase (AOC2)
DME0477	GENENAME	AOC2
DME0477	SPESNAME	Homo sapiens
DME0477	AFFINITY	LS-103895	Km = 0.056 microM
DME0477	AFFINITY	Benzylamine	Km = 0.167 microM
DME0477	AFFINITY	Methylamine	Km = 0.67 microM
DME0477	AFFINITY	Phenylethylamine	Km = 0.077 microM

DME0478	DME___ID	DME0478
DME0478	DME_NAME	Nicotinamide riboside kinase 2 (NRK2)
DME0478	GENENAME	NMRK2
DME0478	SPESNAME	Homo sapiens
DME0478	AFFINITY	Uridine	Km = 1.3 microM
DME0478	AFFINITY	CI-909	Km = 0.11 microM
DME0478	AFFINITY	Cytidine	Km = 15 microM
DME0478	AFFINITY	D-ribosylnicotinate	Km = 0.068 microM

DME0479	DME___ID	DME0479
DME0479	DME_NAME	Nicotinamide riboside kinase 1 (NRK1)
DME0479	GENENAME	NMRK1
DME0479	SPESNAME	Homo sapiens
DME0479	AFFINITY	Uridine	Km = 1.3 microM
DME0479	AFFINITY	CI-909	Km = 0.11 microM
DME0479	AFFINITY	Cytidine	Km = 15 microM
DME0479	AFFINITY	D-ribosylnicotinate	Km = 0.068 microM

DME0480	DME___ID	DME0480
DME0480	DME_NAME	Uridine-cytidine kinase 2 (UCK2)
DME0480	GENENAME	UCK2
DME0480	SPESNAME	Homo sapiens
DME0480	AFFINITY	Uridine	Km = 0.05 microM
DME0480	AFFINITY	Cytidine	Km = 0.086 microM

DME0481	DME___ID	DME0481
DME0481	DME_NAME	Uridine-cytidine kinase 1 (UCK1)
DME0481	GENENAME	UCK1
DME0481	SPESNAME	Homo sapiens
DME0481	AFFINITY	Uridine	Km = 0.05 microM
DME0481	AFFINITY	Cytidine	Km = 0.086 microM

DME0482	DME___ID	DME0482
DME0482	DME_NAME	Cytosolic 5'-nucleotidase II (NT5C2)
DME0482	GENENAME	NT5C2
DME0482	SPESNAME	Homo sapiens
DME0482	AFFINITY	Ribavirin	Km = 0.024 microM
DME0482	AFFINITY	Inosine	Km = 1.8 microM

DME0483	DME___ID	DME0483
DME0483	DME_NAME	Sphingosine kinase 2 (SPHK2)
DME0483	GENENAME	SPHK2
DME0483	SPESNAME	Homo sapiens
DME0483	AFFINITY	YP-005	Km = 0.014 microM

DME0484	DME___ID	DME0484
DME0484	DME_NAME	Sphingosine kinase 1 (SPHK1)
DME0484	GENENAME	SPHK1
DME0484	SPESNAME	Homo sapiens
DME0484	AFFINITY	YP-005	Km = 0.014 microM

DME0485	DME___ID	DME0485
DME0485	DME_NAME	Glutamate-cysteine ligase catalytic (GCLC)
DME0485	GENENAME	GCLC
DME0485	SPESNAME	Homo sapiens
DME0485	AFFINITY	L-glutamine	Km = 1.9 microM
DME0485	AFFINITY	E-920	Km = 0.1 microM

DME0486	DME___ID	DME0486
DME0486	DME_NAME	Glutamate-cysteine ligase regulatory (GCLM)
DME0486	GENENAME	GCLM
DME0486	SPESNAME	Homo sapiens
DME0486	AFFINITY	L-glutamine	Km = 1.9 microM
DME0486	AFFINITY	E-920	Km = 0.1 microM

DME0487	DME___ID	DME0487
DME0487	DME_NAME	Delta-aminolevulinate synthase 2 (ALAS2)
DME0487	GENENAME	ALAS2
DME0487	SPESNAME	Homo sapiens
DME0487	AFFINITY	Glycine	Km = 12 microM

DME0488	DME___ID	DME0488
DME0488	DME_NAME	Carnosine N-methyltransferase (CARNMT1)
DME0488	GENENAME	CARNMT1
DME0488	SPESNAME	Homo sapiens
DME0488	AFFINITY	BRN-0087671	Km = 4.96 microM

DME0489	DME___ID	DME0489
DME0489	DME_NAME	Liver-type arginase (ARG1)
DME0489	GENENAME	ARG1
DME0489	SPESNAME	Homo sapiens
DME0489	AFFINITY	L-arginine	Km = 0.02 microM

DME0490	DME___ID	DME0490
DME0490	DME_NAME	Chondroitin sulfate glucuronyltransferase (CHPF2)
DME0490	GENENAME	CHPF2
DME0490	SPESNAME	Homo sapiens
DME0490	AFFINITY	UDP-glucuronate	Km = 0.0824 microM

DME0491	DME___ID	DME0491
DME0491	DME_NAME	Phenylalanine--tRNA ligase mitochondrial (FARS2)
DME0491	GENENAME	FARS2
DME0491	SPESNAME	Homo sapiens
DME0491	AFFINITY	L-phenylalanine	Km = 0.033 microM

DME0492	DME___ID	DME0492
DME0492	DME_NAME	Nicotinate-nucleotide adenylyltransferase 3 (NMNAT3)
DME0492	GENENAME	NMNAT3
DME0492	SPESNAME	Homo sapiens
DME0492	AFFINITY	Nicotinate-MN	Km = 0.0145 microM
DME0492	AFFINITY	NMN zwitterion	Km = 0.021 microM

DME0493	DME___ID	DME0493
DME0493	DME_NAME	Nicotinate-nucleotide adenylyltransferase 1 (NMNAT1)
DME0493	GENENAME	NMNAT1
DME0493	SPESNAME	Homo sapiens
DME0493	AFFINITY	Nicotinate-MN	Km = 0.0145 microM
DME0493	AFFINITY	NMN zwitterion	Km = 0.032 microM

DME0494	DME___ID	DME0494
DME0494	DME_NAME	Insulin-degrading enzyme (IDE)
DME0494	GENENAME	IDE
DME0494	SPESNAME	Homo sapiens
DME0494	AFFINITY	Insulin	Km = 0.0000657 microM

DME0495	DME___ID	DME0495
DME0495	DME_NAME	Tyrosine-protein phosphatase non-receptor 1 (PTP1B)
DME0495	GENENAME	PTPN1
DME0495	SPESNAME	Homo sapiens
DME0495	AFFINITY	Nitrophenylphosphate	Km = 0.38 microM

DME0496	DME___ID	DME0496
DME0496	DME_NAME	Phosphoenolpyruvate carboxykinase (PCK1)
DME0496	GENENAME	PCK1
DME0496	SPESNAME	Homo sapiens
DME0496	AFFINITY	Oxaloacetate	Km = 0.033 microM
DME0496	AFFINITY	Phosphoenolpyruvate	Km = 0.036 microM

DME0497	DME___ID	DME0497
DME0497	DME_NAME	Red cell/liver pyruvate kinase (PKLR)
DME0497	GENENAME	PKLR
DME0497	SPESNAME	Homo sapiens
DME0497	AFFINITY	Phosphoenolpyruvate	Km = 0.112 microM

DME0498	DME___ID	DME0498
DME0498	DME_NAME	Gamma-glutamyltranspeptidase 1 (GGT1)
DME0498	GENENAME	GGT1
DME0498	SPESNAME	Homo sapiens
DME0498	AFFINITY	Glutathiol	Km = 0.0088 microM
DME0498	AFFINITY	C-46053	Km = 0.0346 microM
DME0498	AFFINITY	Glutathione ester	Km = 0.0099 microM
DME0498	AFFINITY	Leukotriene C4	Km = 0.0102 microM

DME0499	DME___ID	DME0499
DME0499	DME_NAME	Leucyl-tRNA synthetase (LARS2)
DME0499	GENENAME	LARS2
DME0499	SPESNAME	Homo sapiens
DME0499	AFFINITY	GTPL-3312	Km = 0.045 microM

DME0500	DME___ID	DME0500
DME0500	DME_NAME	Arginine carboxypeptidase (CPN1)
DME0500	GENENAME	CPN1
DME0500	SPESNAME	Homo sapiens
DME0500	AFFINITY	BRS-640	Km = 0.0706 microM

DME0501	DME___ID	DME0501
DME0501	DME_NAME	Soluble aminopeptidase P (sAmp)
DME0501	GENENAME	XPNPEP1
DME0501	SPESNAME	Homo sapiens
DME0501	AFFINITY	BRS-640	Km = 0.101 microM

DME0502	DME___ID	DME0502
DME0502	DME_NAME	Pantothenate kinase 3 (PANK3)
DME0502	GENENAME	PANK3
DME0502	SPESNAME	Homo sapiens
DME0502	AFFINITY	Pantothenate	Km = 0.014 microM

DME0503	DME___ID	DME0503
DME0503	DME_NAME	Lactate dehydrogenase C (LDHC)
DME0503	GENENAME	LDHC
DME0503	SPESNAME	Homo sapiens
DME0503	AFFINITY	Lactate	Km = 10.73 microM

DME0504	DME___ID	DME0504
DME0504	DME_NAME	NADP-dependent malic enzyme (ME1)
DME0504	GENENAME	ME1
DME0504	SPESNAME	Homo sapiens
DME0504	AFFINITY	Malate	Km = 0.8 microM

DME0505	DME___ID	DME0505
DME0505	DME_NAME	Inositol polyphosphate multikinase (IPMK)
DME0505	GENENAME	IPMK
DME0505	SPESNAME	Homo sapiens
DME0505	AFFINITY	Inositol-trisphosphate	Km = 0.00028 microM

DME0506	DME___ID	DME0506
DME0506	DME_NAME	Factor inhibiting HIF-1 (HIF1AN)
DME0506	GENENAME	HIF1AN
DME0506	SPESNAME	Homo sapiens
DME0506	AFFINITY	Oxoglutarate	Km = 0.02 microM

DME0507	DME___ID	DME0507
DME0507	DME_NAME	HIF-prolyl hydroxylase 3 (EGLN3)
DME0507	GENENAME	EGLN3
DME0507	SPESNAME	Homo sapiens
DME0507	AFFINITY	Oxoglutarate	Km = 0.055 microM

DME0508	DME___ID	DME0508
DME0508	DME_NAME	Prolyl 3-hydroxylase 1 (P3H1)
DME0508	GENENAME	P3H1
DME0508	SPESNAME	Homo sapiens
DME0508	AFFINITY	Oxoglutarate	Km = 0.08 microM

DME0509	DME___ID	DME0509
DME0509	DME_NAME	Prolyl 3-hydroxylase 2 (P3H2)
DME0509	GENENAME	P3H2
DME0509	SPESNAME	Homo sapiens
DME0509	AFFINITY	Oxoglutarate	Km = 0.08 microM

DME0510	DME___ID	DME0510
DME0510	DME_NAME	Telethon sulfatase (ARSK)
DME0510	GENENAME	ARSK
DME0510	SPESNAME	Homo sapiens
DME0510	AFFINITY	Nitrocatechol sulfate	Km = 10.9 microM

DME0511	DME___ID	DME0511
DME0511	DME_NAME	Lysosomal beta A mannosidase (MANBA)
DME0511	GENENAME	MANBA
DME0511	SPESNAME	Homo sapiens
DME0511	AFFINITY	P-nitrophenyl	Km = 2.5 microM

DME0512	DME___ID	DME0512
DME0512	DME_NAME	Dinucleosidetriphosphatase (FHIT)
DME0512	GENENAME	FHIT
DME0512	SPESNAME	Homo sapiens
DME0512	AFFINITY	Adenylylsulfate	Km = 2.4 microM

DME0513	DME___ID	DME0513
DME0513	DME_NAME	Galactose mutarotase (GALM)
DME0513	GENENAME	GALM
DME0513	SPESNAME	Homo sapiens
DME0513	AFFINITY	Alpha-D-galactose	Km = 37 microM
DME0513	AFFINITY	Alpha-D-glucose	Km = 54 microM

DME0514	DME___ID	DME0514
DME0514	DME_NAME	UDP-glucose pyrophosphorylase (UGPase)
DME0514	GENENAME	UGP2
DME0514	SPESNAME	Homo sapiens
DME0514	AFFINITY	D-glucose 1-phosphate	Km = 0.067 microM

DME0515	DME___ID	DME0515
DME0515	DME_NAME	PFK/FBPase 3 (PFKFB3)
DME0515	GENENAME	PFKFB3
DME0515	SPESNAME	Homo sapiens
DME0515	AFFINITY	Beta-fructose phosphate	Km = 0.0064 microM

DME0516	DME___ID	DME0516
DME0516	DME_NAME	Acyl-CoA thioesterase 13 (ACOT13)
DME0516	GENENAME	ACOT13
DME0516	SPESNAME	Homo sapiens
DME0516	AFFINITY	Hydroxybutyryl-CoA	Km = 0.11 microM

DME0517	DME___ID	DME0517
DME0517	DME_NAME	CDP-choline phosphohydrolase (ADPRM)
DME0517	GENENAME	ADPRM
DME0517	SPESNAME	Homo sapiens
DME0517	AFFINITY	IP-302	Km = 0.35 microM

DME0518	DME___ID	DME0518
DME0518	DME_NAME	ASM-like phosphodiesterase 3a (SMPDL3A)
DME0518	GENENAME	SMPDL3A
DME0518	SPESNAME	Homo sapiens
DME0518	AFFINITY	IP-302	Km = 0.262 microM

DME0521	DME___ID	DME0521
DME0521	DME_NAME	Glucosamine-6-phosphate deaminase 1 (GNPDA1)
DME0521	GENENAME	GNPDA1
DME0521	SPESNAME	Homo sapiens
DME0521	AFFINITY	D-glucosamine-phosphate	Km = 0.27 microM

DME0522	DME___ID	DME0522
DME0522	DME_NAME	Glucosamine-6-phosphate deaminase 2 (GNPDA2)
DME0522	GENENAME	GNPDA2
DME0522	SPESNAME	Homo sapiens
DME0522	AFFINITY	D-glucosamine-phosphate	Km = 0.27 microM

DME0523	DME___ID	DME0523
DME0523	DME_NAME	Glucose-6-phosphatase beta (G6PC3)
DME0523	GENENAME	G6PC3
DME0523	SPESNAME	Homo sapiens
DME0523	AFFINITY	D-glucose 6-phosphate	Km = 1 microM

DME0524	DME___ID	DME0524
DME0524	DME_NAME	Inositol tetrakisphosphate 3-phosphatase (MIPP)
DME0524	GENENAME	MINPP1
DME0524	SPESNAME	Homo sapiens
DME0524	AFFINITY	DMI-tetrakisphosphate	Km = 0.0016 microM

DME0525	DME___ID	DME0525
DME0525	DME_NAME	Inositol polyphosphate 4-phosphatase I (INPP4A)
DME0525	GENENAME	INPP4A
DME0525	SPESNAME	Homo sapiens
DME0525	AFFINITY	DMI-bisphosphate	Km = 0.028 microM
DME0525	AFFINITY	DMI-trisphosphate	Km = 0.046 microM

DME0526	DME___ID	DME0526
DME0526	DME_NAME	Xylulose kinase (XYLB)
DME0526	GENENAME	XYLB
DME0526	SPESNAME	Homo sapiens
DME0526	AFFINITY	D-xylulose	Km = 0.024 microM

DME0527	DME___ID	DME0527
DME0527	DME_NAME	Fucosyltransferase XI (FUT11)
DME0527	GENENAME	FUT11
DME0527	SPESNAME	Homo sapiens
DME0527	AFFINITY	GDP-l-fucose	Km = 0.013 microM

DME0528	DME___ID	DME0528
DME0528	DME_NAME	Fucosyltransferase X (FUT10)
DME0528	GENENAME	FUT10
DME0528	SPESNAME	Homo sapiens
DME0528	AFFINITY	GDP-l-fucose	Km = 0.013 microM

DME0529	DME___ID	DME0529
DME0529	DME_NAME	GDP-mannose 4,6-dehydratase (GMDS)
DME0529	GENENAME	GMDS
DME0529	SPESNAME	Homo sapiens
DME0529	AFFINITY	GDP-mannose	Km = 0.0035 microM

DME0530	DME___ID	DME0530
DME0530	DME_NAME	Choline glycerophosphodiester phosphodiesterase (ENPP6)
DME0530	GENENAME	ENPP6
DME0530	SPESNAME	Homo sapiens
DME0530	AFFINITY	Cholini alfosceras	Km = 0.344 microM

DME0531	DME___ID	DME0531
DME0531	DME_NAME	Alanine aminotransferase 1 (GPT)
DME0531	GENENAME	GPT
DME0531	SPESNAME	Homo sapiens
DME0531	AFFINITY	Glyoxylate	Km = 0.75 microM

DME0532	DME___ID	DME0532
DME0532	DME_NAME	Phosphoserine aminotransferase (PSAT1)
DME0532	GENENAME	PSAT1
DME0532	SPESNAME	Homo sapiens
DME0532	AFFINITY	Glyoxylate	Km = 0.75 microM

DME0533	DME___ID	DME0533
DME0533	DME_NAME	Carnitine O-acetyltransferase (CRAT)
DME0533	GENENAME	CRAT
DME0533	SPESNAME	Homo sapiens
DME0533	AFFINITY	Levocarnitine	Km = 0.11 microM

DME0534	DME___ID	DME0534
DME0534	DME_NAME	N-acetylglutamate synthase (NAGS)
DME0534	GENENAME	NAGS
DME0534	SPESNAME	Homo sapiens
DME0534	AFFINITY	L-glutamine	Km = 2.5 microM

DME0535	DME___ID	DME0535
DME0535	DME_NAME	Thyroxine 5-deiodinase (DIO3)
DME0535	GENENAME	DIO3
DME0535	SPESNAME	Homo sapiens
DME0535	AFFINITY	L-thyroxine	Km = 0.0000035 microM

DME0536	DME___ID	DME0536
DME0536	DME_NAME	Phosphoglucomutase 3 (PGM3)
DME0536	GENENAME	PGM3
DME0536	SPESNAME	Homo sapiens
DME0536	AFFINITY	NA-alpha-D-glucosamine	Km = 0.046 microM

DME0537	DME___ID	DME0537
DME0537	DME_NAME	UDP-N-acetylhexosamine pyrophosphorylase (AGX)
DME0537	GENENAME	UAP1
DME0537	SPESNAME	Homo sapiens
DME0537	AFFINITY	NAG 1-phosphate	Km = 0.0053 microM

DME0538	DME___ID	DME0538
DME0538	DME_NAME	Cyclic ADP-ribose hydrolase 1 (CD38)
DME0538	GENENAME	CD38
DME0538	SPESNAME	Homo sapiens
DME0538	AFFINITY	FT-0654944	Km = 5 microM

DME0539	DME___ID	DME0539
DME0539	DME_NAME	Nicotinate-nucleotide adenylyltransferase 2 (NMNAT2)
DME0539	GENENAME	NMNAT2
DME0539	SPESNAME	Homo sapiens
DME0539	AFFINITY	Nicotinate-MN	Km = 0.0145 microM

DME0540	DME___ID	DME0540
DME0540	DME_NAME	MOSC domain-containing protein 1 (MARC1)
DME0540	GENENAME	MTARC1
DME0540	SPESNAME	Homo sapiens
DME0540	AFFINITY	Nitrite	Km = 9.5 microM

DME0541	DME___ID	DME0541
DME0541	DME_NAME	MOSC domain-containing protein 2 (MARC2)
DME0541	GENENAME	MTARC2
DME0541	SPESNAME	Homo sapiens
DME0541	AFFINITY	Nitrite	Km = 9.5 microM

DME0542	DME___ID	DME0542
DME0542	DME_NAME	Oxaloacetate decarboxylase (FAHD1)
DME0542	GENENAME	FAHD1
DME0542	SPESNAME	Homo sapiens
DME0542	AFFINITY	Oxaloacetate	Km = 0.032 microM

DME0543	DME___ID	DME0543
DME0543	DME_NAME	Phenylethanolamine N-methyltransferase (PNMT)
DME0543	GENENAME	PNMT
DME0543	SPESNAME	Homo sapiens
DME0543	AFFINITY	Phenylethanolamine	Km = 0.1 microM

DME0544	DME___ID	DME0544
DME0544	DME_NAME	Maillard deglycase (PARK7)
DME0544	GENENAME	PARK7
DME0544	SPESNAME	Homo sapiens
DME0544	AFFINITY	Phenylglyoxal	Km = 13 microM

DME0545	DME___ID	DME0545
DME0545	DME_NAME	Lecithin-cholesterol acyltransferase (LCAT)
DME0545	GENENAME	LCAT
DME0545	SPESNAME	Homo sapiens
DME0545	AFFINITY	Phosphatidylcholine	Km = 0.0006 microM

DME0546	DME___ID	DME0546
DME0546	DME_NAME	Glucosidase II beta (PRKCSH)
DME0546	GENENAME	PRKCSH
DME0546	SPESNAME	Homo sapiens
DME0546	AFFINITY	PNA-D-glucopyranoside	Km = 0.5 microM

DME0547	DME___ID	DME0547
DME0547	DME_NAME	Neutral alpha-glucosidase AB (GANAB)
DME0547	GENENAME	GANAB
DME0547	SPESNAME	Homo sapiens
DME0547	AFFINITY	PNA-D-glucopyranoside	Km = 0.5 microM

DME0548	DME___ID	DME0548
DME0548	DME_NAME	Dimethylarginine dimethylaminohydrolase 1 (DDAH1)
DME0548	GENENAME	DDAH1
DME0548	SPESNAME	Homo sapiens
DME0548	AFFINITY	S-MTC	Km = 0.0014 microM

DME0549	DME___ID	DME0549
DME0549	DME_NAME	Pyrrolidone-carboxylate peptidase (PGPI)
DME0549	GENENAME	PGPEP1
DME0549	SPESNAME	Homo sapiens
DME0549	AFFINITY	KPS-0373	Km = 0.046 microM

DME0550	DME___ID	DME0550
DME0550	DME_NAME	Trans-L-3-hydroxyproline dehydratase (L3HYPDH)
DME0550	GENENAME	L3HYPDH
DME0550	SPESNAME	Homo sapiens
DME0550	AFFINITY	AK-41099	Km = 9.34 microM

DME0551	DME___ID	DME0551
DME0551	DME_NAME	Xylosylprotein 4-beta-galactosyltransferase (XGalT-1)
DME0551	GENENAME	B4GALT7
DME0551	SPESNAME	Homo sapiens
DME0551	AFFINITY	UDP-galactose	Km = 0.22 microM

DME0552	DME___ID	DME0552
DME0552	DME_NAME	Histo-blood group ABO system transferase (NAGAT)
DME0552	GENENAME	ABO
DME0552	SPESNAME	Homo sapiens
DME0552	AFFINITY	UDP-galactose	Km = 0.027 microM

DME0559	DME___ID	DME0559
DME0559	DME_NAME	Collagen galactosyltransferase (COLGALT2)
DME0559	GENENAME	COLGALT2
DME0559	SPESNAME	Homo sapiens
DME0559	AFFINITY	UDP-galactose	Km = 0.01877 microM

DME1026	DME___ID	DME1026
DME1026	DME_NAME	Beta-lactamase (blaB)
DME1026	GENENAME	cblA
DME1026	SPESNAME	Bacteroides uniformis
DME1026	AFFINITY	Ampicillin	Km = 4.4 microM
DME1026	AFFINITY	Cephalothin	Km = 113 microM
DME1026	AFFINITY	Penicillin G	Km = 3.5 microM
DME1026	AFFINITY	Piperacillin	Km = 0.58 microM
DME1026	AFFINITY	Cefaloridine	Km = 177 microM

DME1069	DME___ID	DME1069
DME1069	DME_NAME	Nicotinate dehydrogenase (nicA)
DME1069	GENENAME	nicA
DME1069	SPESNAME	Pseudomonas putida
DME1069	AFFINITY	Nicotine	Km = 0.24 microM

DME1120	DME___ID	DME1120
DME1120	DME_NAME	Glutamate racemase (MurI)
DME1120	GENENAME	murI
DME1120	SPESNAME	Aquifex pyrophilus
DME1120	AFFINITY	L-glutamine	Km = 3300 microM

DME1121	DME___ID	DME1121
DME1121	DME_NAME	Glutamate racemase (MurI)
DME1121	GENENAME	murI
DME1121	SPESNAME	Escherichia coli
DME1121	AFFINITY	L-glutamine	Km = 4000 microM

DME1123	DME___ID	DME1123
DME1123	DME_NAME	Glutamate racemase (MurI)
DME1123	GENENAME	murI
DME1123	SPESNAME	Lactobacillus fermentum
DME1123	AFFINITY	L-glutamine	Km = 330 microM

DME1124	DME___ID	DME1124
DME1124	DME_NAME	Glutamate racemase (MurI)
DME1124	GENENAME	racE
DME1124	SPESNAME	Bacillus subtilis
DME1124	AFFINITY	L-glutamine	Km = 50000 microM

DME1125	DME___ID	DME1125
DME1125	DME_NAME	Glutamate racemase (MurI)
DME1125	GENENAME	yrpC
DME1125	SPESNAME	Bacillus pumilus
DME1125	AFFINITY	L-glutamine	Km = 50000 microM

DME1126	DME___ID	DME1126
DME1126	DME_NAME	Glutamate racemase (MurI)
DME1126	GENENAME	racE1
DME1126	SPESNAME	Bacillus anthracis
DME1126	AFFINITY	L-glutamine	Km = 3700 microM

DME1140	DME___ID	DME1140
DME1140	DME_NAME	Beta-galactosidase (bgaB)
DME1140	GENENAME	bgaB
DME1140	SPESNAME	Bifidobacterium adolescentis
DME1140	AFFINITY	PNA-D-glucopyranoside	Km = 60000 microM

DME1143	DME___ID	DME1143
DME1143	DME_NAME	Hyaluronidase (hyl)
DME1143	GENENAME	hyl
DME1143	SPESNAME	Bacillus megaterium
DME1143	AFFINITY	Hyaluronan	Km = 20 microM

DME1164	DME___ID	DME1164
DME1164	DME_NAME	Xylose isomerase (xylA)
DME1164	GENENAME	xylA
DME1164	SPESNAME	Bifidobacterium adolescentis
DME1164	AFFINITY	Xylose	Km = 4000 microM

DME1193	DME___ID	DME1193
DME1193	DME_NAME	Beta-glucuronidase (uidA)
DME1193	GENENAME	uidA_1
DME1193	SPESNAME	Bacteroides uniformis
DME1193	AFFINITY	MUG trihydrate	Km = 25 microM

DME1194	DME___ID	DME1194
DME1194	DME_NAME	Beta-glucuronidase (uidA)
DME1194	GENENAME	uidA_2
DME1194	SPESNAME	Bacteroides thetaiotaomicron
DME1194	AFFINITY	MUG trihydrate	Km = 80 microM

DME1195	DME___ID	DME1195
DME1195	DME_NAME	Beta-mannosidase (manB)
DME1195	GENENAME	manB
DME1195	SPESNAME	Bacteroides salyersiae
DME1195	AFFINITY	Man-b-4MU	Km = 1050 microM
DME1195	AFFINITY	Mannotetraose	Kcat/Km = 0.0045 s-1microM-1
DME1195	AFFINITY	W-201259	Kcat/Km = 0.0022 s-1microM-1

DME1196	DME___ID	DME1196
DME1196	DME_NAME	Cytidine deaminase (cdd)
DME1196	GENENAME	cdd
DME1196	SPESNAME	Mycoplasma hyorhinis
DME1196	AFFINITY	Cytarabine	Km = 6172 microM
DME1196	AFFINITY	Gemcitabine	Km = 2586 microM

DME1201	DME___ID	DME1201
DME1201	DME_NAME	Alpha-L-rhamnosidase (lrA)
DME1201	GENENAME	lrA
DME1201	SPESNAME	Bifidobacterium dentium
DME1201	AFFINITY	BRN-0075455	Km = 2190 microM
DME1201	AFFINITY	Ginsenoside Re	Km = 860 microM
DME1201	AFFINITY	Naringin	Km = 320 microM
DME1201	AFFINITY	PNA-l-rhamnopyranoside	Km = 1060 microM
DME1201	AFFINITY	HY-N2258	Km = 370 microM

DME1204	DME___ID	DME1204
DME1204	DME_NAME	Beta-glucosidase (bglA)
DME1204	GENENAME	bglA
DME1204	SPESNAME	Actinosynnema mirum
DME1204	AFFINITY	SC-46553	Km = 450 microM
DME1204	AFFINITY	Ginsenoside Rb1	Km = 690 microM

DME1233	DME___ID	DME1233
DME1233	DME_NAME	Cytochrome P450 105D7 (cyp105)
DME1233	GENENAME	cyp28
DME1233	SPESNAME	Streptomyces avermitilis
DME1233	AFFINITY	Diclofenac sodium	Kcat/Km = 0.15 s-1microM-1
DME1233	AFFINITY	ML-236B	Km = 39.1 microM

DME1333	DME___ID	DME1333
DME1333	DME_NAME	Methylenetetrahydrofolate dehydrogenase (folD)
DME1333	GENENAME	folD
DME1333	SPESNAME	Blautia producta
DME1333	AFFINITY	ISO-901	Km = 27000 microM

DME1465	DME___ID	DME1465
DME1465	DME_NAME	Cytochrome P450 102D1 (cyp102)
DME1465	GENENAME	cyp102A1
DME1465	SPESNAME	Streptomyces avermitilis
DME1465	AFFINITY	Daidzein	Kcat/Km = 0.28 s-1microM-1

DME1466	DME___ID	DME1466
DME1466	DME_NAME	Cytochrome P450 154C2 (cyp154)
DME1466	GENENAME	cyp154C4-2
DME1466	SPESNAME	Streptomyces avermitilis
DME1466	AFFINITY	Testosterone cypionate	Km = 160 microM

DME1471	DME___ID	DME1471
DME1471	DME_NAME	L-malate:NADP(+) oxidoreductase (maeB)
DME1471	GENENAME	maeB
DME1471	SPESNAME	Hungateiclostridium thermocellum
DME1471	AFFINITY	Malate	Km = 0.3 microM

DME1512	DME___ID	DME1512
DME1512	DME_NAME	L-Lactate dehydrogenase (ldh)
DME1512	GENENAME	ldh
DME1512	SPESNAME	Lactobacillus casei
DME1512	AFFINITY	DB-053072	Km = 1000 microM
DME1512	AFFINITY	Glucose-bisphosphate	Km = 10 microM

DME1553	DME___ID	DME1553
DME1553	DME_NAME	Tyrosine decarboxylase (tdc)
DME1553	GENENAME	tdc
DME1553	SPESNAME	Lactobacillus brevis
DME1553	AFFINITY	L-tyrosine	Km = 590 microM

>END