INTEDE - Interactome of Drug-Metabolizing Enzyme Database Title - Tissue-distribution and function data of DMEs Version 1.8.1 (2020.08.15) Provided by IDRB Lab of Innovative Drug Reasearch and Bioinformatics College of Pharmaceutical Sciences Zhejiang University https://idrblab.org/ Any question about data provided here, please contact with: Dr. Yin (yinjiayi@zju.edu.cn) and Dr. Li (lifengcheng@zju.edu.cn) -------------------------------------------------------------------------------------------------------- Abbreviations: DME___ID INTEDE Drug-Metabolizing Enzyme (DME) ID DME_NAME DME Name TISSUDIS DME Tissue Distribution FUNCTION DME Function -------------------------------------------------------------------------------------------------------- DME0001 DME___ID DME0001 DME0001 DME_NAME Cytochrome P450 3A4 (CYP3A4) DME0001 SPESNAME Homo sapiens DME0001 TISSUDIS Primarily distributed in intestine and liverNot Available DME0001 FUNCTION This enzyme is involved in the metabolism of sterols, steroid hormones, retinoids and fatty acidsNot Available It exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta- estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position and plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosteroneNot Available It also metabolizes testosterone to less biologically active 2beta- and 6beta- hydroxytestosteronesNot Available It catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) and the epoxidation of double bonds of PUFA with a preference for the last double bondNot Available It metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15- epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs) and plays a role in the metabolism of retinoidsNot AvailableIn addition, it displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate- limiting step for the biosynthesis of all-trans-retinoic acid (atRA) and further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearanceNot Available It is also responsible for oxidative metabolism of xenobioticsNot Available It metabolizes the majority of the administered drugs; catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole and hydroxylates antimalarial drug quinineNot Available DME0013 DME___ID DME0013 DME0013 DME_NAME Cytochrome P450 2E1 (CYP2E1) DME0013 SPESNAME Homo sapiens DME0013 TISSUDIS Primarily distributed in liverNot Available DME0013 FUNCTION This enzyme is involved in the metabolism of fatty acidsNot Available It catalyzes the hydroxylation of carbon-hydrogen bonds and hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acidsNot AvailableIn addition, it may be involved in the oxidative metabolism of xenobioticsNot Available DME0009 DME___ID DME0009 DME0009 DME_NAME Cytochrome P450 2D6 (CYP2D6) DME0009 SPESNAME Homo sapiens DME0009 TISSUDIS Primarily distributed in liverNot Available DME0009 FUNCTION This enzyme is involved in the metabolism of fatty acids, steroids and retinoidsNot Available It catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA)Not Available It also metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs)Not Available In addition, it catalyzes the hydroxylation of carbon-hydrogen bonds and metabolizes cholesterol toward 25- hydroxycholesterolNot Available It catalyzes the oxidative transformations of all-trans retinol to all-trans retina and also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressantsNot Available DME0019 DME___ID DME0019 DME0019 DME_NAME Cytochrome P450 2C9 (CYP2C9) DME0019 SPESNAME Homo sapiens DME0019 TISSUDIS Primarily distributed in liverNot Available DME0019 FUNCTION This enzyme is involved in the metabolism of various endogenous substrates, including fatty acids and steroidsNot Available It catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) and hydroxylation of carbon-hydrogen bondsNot AvailableIt metabolizes cholesterol toward 25-hydroxycholesterol and catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA)Not Available It also metabolizes plant monoterpenes such as limonene; oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol and metabolizes drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartanNot Available DME0006 DME___ID DME0006 DME0006 DME_NAME Cytochrome P450 1A1 (CYP1A1) DME0006 SPESNAME Homo sapiens DME0006 TISSUDIS Primarily distributed in liver, lung and urinary bladderNot Available DME0006 FUNCTION This enzyme is involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitaminsNot Available It catalyzes the hydroxylation of carbon-hydrogen bonds and exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16- alpha positionsNot Available It also displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation and Catalyzes the epoxidation of double bonds of certain PUFANot Available DME0004 DME___ID DME0004 DME0004 DME_NAME UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004 SPESNAME Homo sapiens DME0004 TISSUDIS Primarily distributed in intestine and liverNot Available DME0004 FUNCTION This enzyme catalyzes the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferoneNot Available DME0011 DME___ID DME0011 DME0011 DME_NAME Glutathione S-transferase alpha-1 (GSTA1) DME0011 SPESNAME Homo sapiens DME0011 TISSUDIS Primarily distributed in adrenal gland, intestine, kidney, liver and testisNot Available DME0011 FUNCTION This enzyme catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene- 3,17-dioneNot Available Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)- hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE, it is also involved in the metabolism of oxidized linoleic acidNot Available DME0021 DME___ID DME0021 DME0021 DME_NAME Mephenytoin 4-hydroxylase (CYP2C19) DME0021 SPESNAME Homo sapiens DME0021 TISSUDIS Primarily distributed in intestine and liverNot Available DME0021 FUNCTION This enzyme is involved in the metabolism of polyunsaturated fatty acids (PUFA)Not Available It catalyzes the hydroxylation of carbon-hydrogen bonds and hydroxylates PUFA specifically at the omega-1 positionNot Available Besides, it also catalyzes the epoxidation of double bonds of PUFA and metabolizes plant monoterpenes such as limoneneNot Available It is also responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramineNot Available DME0005 DME___ID DME0005 DME0005 DME_NAME Cytochrome P450 2A6 (CYP2A6) DME0005 SPESNAME Homo sapiens DME0005 TISSUDIS Primarily distributed in liverNot Available DME0005 FUNCTION This enzyme exhibits a high coumarin 7-hydroxylase activityNot Available It can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamideNot Available It is also competent in the metabolic activation of aflatoxin B1Not Available DME0003 DME___ID DME0003 DME0003 DME_NAME Cytochrome P450 1A2 (CYP1A2) DME0003 SPESNAME Homo sapiens DME0003 TISSUDIS Primarily distributed in liverNot Available DME0003 FUNCTION This enzyme is involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitaminsNot Available It catalyzes the hydroxylation of carbon-hydrogen bonds and exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta- estradiol (E2), namely 2-hydroxy E1 and E2Not Available It metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasisNot Available It also plays a role in the oxidative metabolism of xenobiotics and catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetinNot Available Specificlly, it metabolizes caffeine via N3-demethylationNot Available DME0012 DME___ID DME0012 DME0012 DME_NAME Cytochrome P450 3A5 (CYP3A5) DME0012 SPESNAME Homo sapiens DME0012 TISSUDIS Primarily distributed in intestine, liver and stomachNot Available DME0012 FUNCTION This enzyme is involved in the metabolism of steroid hormones and vitaminsNot Available It catalyzes the hydroxylation of carbon-hydrogen bonds and exhibits high catalytic activity for the formation of catechol estrogens from 17beta- estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2Not Available It also catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione and the oxidative conversion of all-trans- retinol to all-trans-retinalNot Available It further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearanceNot Available It is also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporineNot Available DME0023 DME___ID DME0023 DME0023 DME_NAME Cytochrome P450 1B1 (CYP1B1) DME0023 SPESNAME Homo sapiens DME0023 TISSUDIS Primarily distributed in blood and lungNot Available DME0023 FUNCTION This enzyme is involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitaminsNot Available It exhibits catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2- and 4-hydroxy E1 and E2 and displays a predominant hydroxylase activity toward E2 at the C-4 positionNot Available It metabolizes testosterone and progesterone to B or D ring hydroxylated metabolitesNot Available It catalyzes the epoxidation of double bonds of certain PUFA; converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrENot Available Additionally, it displays dehydratase activity toward oxygenated eicosanoids hydroperoxyeicosatetraenoates (HpETEs)Not Available Also it is involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging productsNot Available DME0114 DME___ID DME0114 DME0114 DME_NAME Prostaglandin G/H synthase 2 (COX-2) DME0114 SPESNAME Homo sapiens DME0114 TISSUDIS Primarily distributed in ductus deferens and seminal vesicleNot Available DME0114 FUNCTION This enzyme converts arachidonate to prostaglandin H2 (PGH2)Not Available DME0002 DME___ID DME0002 DME0002 DME_NAME Aromatase (CYP19A1) DME0002 SPESNAME Homo sapiens DME0002 TISSUDIS Primarily distributed in placentaNot Available DME0002 FUNCTION This enzyme catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectivelyNot Available It catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acidNot Available Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acidNot Available Additionally, it converts dihydrotestosterone to delta1,10-dehydro 19- nordihydrotestosterone and also displays 2-hydroxylase activity toward estroneNot Available DME0097 DME___ID DME0097 DME0097 DME_NAME Quinone reductase 1 (NQO1) DME0097 SPESNAME Homo sapiens DME0097 TISSUDIS Primarily distributed in stomachNot Available DME0097 FUNCTION This enzyme serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathwaysNot Available DME0020 DME___ID DME0020 DME0020 DME_NAME Cytochrome P450 2B6 (CYP2B6) DME0020 SPESNAME Homo sapiens DME0020 TISSUDIS Primarily distributed in liver, lung and heart right ventricleNot Available DME0020 FUNCTION This enzyme is involved in the metabolism of endocannabinoids and steroidsNot Available It catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15- epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs)Not Available It hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 and plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugsNot Available DME0154 DME___ID DME0154 DME0154 DME_NAME Asparagine synthetase (ASNS) DME0154 SPESNAME Homo sapiens DME0154 TISSUDIS Primarily distributed in pancreasNot Available DME0154 FUNCTION This enzyme is a chiefly cytoplasmic enzyme that generates asparagine from aspartateNot Available DME0018 DME___ID DME0018 DME0018 DME_NAME Cytochrome P450 2C8 (CYP2C8) DME0018 SPESNAME Homo sapiens DME0018 TISSUDIS Primarily distributed in liverNot Available DME0018 FUNCTION This enzyme is involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitaminsNot Available It primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond and catalyzes the hydroxylation of carbon-hydrogen bondsNot Available It also metabolizes all trans-retinoic acid toward its 4-hydroxylated form and displays 16-alpha hydroxylase activity toward estrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1)Not Available In addition, it plays a role in the oxidative metabolism of xenobioticsNot Available It is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel (taxol)Not Available DME0099 DME___ID DME0099 DME0099 DME_NAME Cholesterol desmolase (CYP11A1) DME0099 SPESNAME Homo sapiens DME0099 TISSUDIS Primarily distributed in adrenal gland and placentaNot Available DME0099 FUNCTION This enzyme catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormonesNot Available It catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanalNot Available DME0222 DME___ID DME0222 DME0222 DME_NAME Beta-HSD adrenal and gonadal type (HSD3B2) DME0222 SPESNAME Homo sapiens DME0222 TISSUDIS Primarily distributed in adrenal gland, testis and ovaryNot Available DME0222 FUNCTION This enzyme catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroidsNot Available DME0015 DME___ID DME0015 DME0015 DME_NAME Cytochrome P450 3A7 (CYP3A7) DME0015 SPESNAME Homo sapiens DME0015 TISSUDIS Primarily distributed in liverNot Available DME0015 FUNCTION This enzyme is involved in the metabolism of steroid hormones and vitamins during embryogenesisNot Available It catalyzes the hydroxylation of carbon-hydrogen bonds and metabolizes 3beta- hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA) and exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D- ring hydroxylated estrone at the C16-alpha positionNot Available It mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal developmentNot Available And it is also involved in the oxidative metabolism of xenobiotics including anticonvulsantsNot Available DME0040 DME___ID DME0040 DME0040 DME_NAME UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040 SPESNAME Homo sapiens DME0040 TISSUDIS Primarily distributed in kidney and liverNot Available DME0040 FUNCTION This enzyme is uniquely specific for 3,4-catechol estrogens and estriol which suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolitesNot Available And it is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro)Not Available DME0091 DME___ID DME0091 DME0091 DME_NAME Prostaglandin G/H synthase 1 (COX-1) DME0091 SPESNAME Homo sapiens DME0091 TISSUDIS Primarily distributed in smooth muscle and urinary bladderNot Available DME0091 FUNCTION This enzyme converts arachidonate to prostaglandin H2 (PGH2)Not Available DME0124 DME___ID DME0124 DME0124 DME_NAME Nitric oxide synthase inducible (NOS2) DME0124 SPESNAME Homo sapiens DME0124 TISSUDIS Primarily distributed in liver, retina, intestine and lymphoid tissueNot Available DME0124 FUNCTION This enzyme has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2Not Available DME0042 DME___ID DME0042 DME0042 DME_NAME UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042 SPESNAME Homo sapiens DME0042 TISSUDIS Primarily distributed in liver and kidneyNot Available DME0042 FUNCTION This enzyme has specificity for phenolsNot Available DME0123 DME___ID DME0123 DME0123 DME_NAME Nitric oxide synthase endothelial (NOS3) DME0123 SPESNAME Homo sapiens DME0123 TISSUDIS Primarily distributed in lymphoid, placenta, liver and kidneyNot Available DME0123 FUNCTION This enzyme is one of three isoforms that synthesize nitric oxide (NO)Not Available It is a dimer containing two identical monomers of 134 kD constituted by a reductase domain, which displays binding sites for nicotinamide adenine dinucleotide phosphate (NADPH), flavin mononucleotide (FMN), and flavin adenine dinucleotide (FAD), and an oxidase domain, which displays binding sites for heme group, zinc, the cofactor tetrahydrobiopterin (BH4), and the substrate L-arginineNot Available NO is synthesized by eNOS from L-arginine and molecular oxygen, which binds to the heme group of eNOS, is reduced and finally incorporated into L-arginine to form NO and L-citrullineNot Available DME0054 DME___ID DME0054 DME0054 DME_NAME Carboxylesterase 1 (CES1) DME0054 SPESNAME Homo sapiens DME0054 TISSUDIS Primarily distributed in liver with lower levels in heart and lungNot Available DME0054 FUNCTION This enzyme is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugsNot Available It hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA esterNot Available It also hydrolyzes the methyl ester group of cocaine to form benzoylecgonine and catalyzes the transesterification of cocaine to form cocaethyleneNot Available DME0074 DME___ID DME0074 DME0074 DME_NAME Sulfotransferase 2A1 (SULT2A1) DME0074 SPESNAME Homo sapiens DME0074 TISSUDIS Primarily distributed in liver and adrenalNot Available Also expressed at lower level in kidneyNot Available DME0074 FUNCTION This enzyme utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glandsNot Available DME0076 DME___ID DME0076 DME0076 DME_NAME NADPH-cytochrome P450 reductase (CPR) DME0076 SPESNAME Homo sapiens DME0076 TISSUDIS Primarily distributed in liverNot Available DME0076 FUNCTION This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes and can also provide electron transfer to heme oxygenase and cytochrome B5Not Available DME0008 DME___ID DME0008 DME0008 DME_NAME Sulfotransferase 1A1 (SULT1A1) DME0008 SPESNAME Homo sapiens DME0008 TISSUDIS Primarily distributed in liverNot Available Also expressed in lung, adrenal, brain, platelets and skinNot Available DME0008 FUNCTION This enzyme utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmittersNot Available It also has estrogen sulfotransferase activity and is responsible for the sulfonation and activation of minoxidilNot Available It mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding productsNot Available DME0044 DME___ID DME0044 DME0044 DME_NAME Monoamine oxidase type A (MAO-A) DME0044 SPESNAME Homo sapiens DME0044 TISSUDIS Primarily distributed in heart, liver, duodenum, blood vessels and kidneyNot Available DME0044 FUNCTION This enzyme catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissuesNot Available MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrineNot Available DME0052 DME___ID DME0052 DME0052 DME_NAME Aldehyde oxidase (AOX1) DME0052 SPESNAME Homo sapiens DME0052 TISSUDIS Primarily distributed in liverNot Available Also expressed in adipose tissue and at lower levels in lung, skeletal muscle and pancreasNot Available DME0052 FUNCTION This enzyme has broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillinNot Available It plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituentsNot Available It also participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agentNot Available DME0026 DME___ID DME0026 DME0026 DME_NAME Vitamin D(3) 25-hydroxylase (CYP27A1) DME0026 SPESNAME Homo sapiens DME0026 TISSUDIS Primarily distributed in liverNot Available DME0026 FUNCTION This enzyme catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivativesNot Available It hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acidNot Available It plays a role in cholestanol metabolism in the cerebellumNot Available It also hydroxylates retinal 7- ketocholesterol, a noxious oxysterol with pro-inflammatory and pro- apoptotic effects, and may play a role in its elimination from the retinal pigment epitheliumNot Available It catalyzes 25-hydroxylation of vitamin D3 that is required for its conversion to a functionally active formNot Available DME0075 DME___ID DME0075 DME0075 DME_NAME UDP-glucuronosyltransferase 1A10 (UGT1A10) DME0075 SPESNAME Homo sapiens DME0075 TISSUDIS Primarily distributed in liver, colon, esophagus, gallbladder, intestine and stomachNot Available DME0075 FUNCTION This enzyme is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compoundsNot Available DME0137 DME___ID DME0137 DME0137 DME_NAME Thymidylate synthase (TYMS) DME0137 SPESNAME Homo sapiens DME0137 TISSUDIS Primarily distributed in bone marrow and lymphoid tissueNot Available DME0137 FUNCTION This enzyme contributes to the de novo mitochondrial thymidylate biosynthesis pathwayNot Available DME0080 DME___ID DME0080 DME0080 DME_NAME Cytidine aminohydrolase (CDA) DME0080 SPESNAME Homo sapiens DME0080 TISSUDIS Primarily distributed in blood and bone marrowNot Available DME0080 FUNCTION This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesisNot Available DME0419 DME___ID DME0419 DME0419 DME_NAME Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME0419 SPESNAME Homo sapiens DME0419 TISSUDIS Primarily distributed in intestine, kidney and salivary glandNot Available DME0419 FUNCTION This enzyme catalyzes the conversion of cortisol to the inactive metabolite cortisoneNot Available DME0072 DME___ID DME0072 DME0072 DME_NAME UDP-glucuronosyltransferase 1A6 (UGT1A6) DME0072 SPESNAME Homo sapiens DME0072 TISSUDIS Primarily distributed in kidney, liver and urinary bladderNot Available DME0072 FUNCTION This enzyme has specificity for phenolsNot Available DME0017 DME___ID DME0017 DME0017 DME_NAME Cytochrome P450 2C18 (CYP2C18) DME0017 SPESNAME Homo sapiens DME0017 TISSUDIS Primarily distributed in intestine and liverNot Available DME0017 FUNCTION This enzyme is involved in an NADPH-dependent electron transport pathwayNot Available It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobioticsNot Available DME0166 DME___ID DME0166 DME0166 DME_NAME Transglutaminase K (TGM1) DME0166 SPESNAME Homo sapiens DME0166 TISSUDIS Primarily distributed in esophagus, lymphoid tissue and tongueNot Available DME0166 FUNCTION This enzyme catalyzes the cross-linking of proteins and the conjugation of polyamines to proteinsNot Available DME0088 DME___ID DME0088 DME0088 DME_NAME Glutathione S-transferase pi (GSTP1) DME0088 SPESNAME Homo sapiens DME0088 TISSUDIS Low tissue/organ specificityNot Available DME0088 FUNCTION This enzyme conjugates reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophilesNot Available DME0141 DME___ID DME0141 DME0141 DME_NAME Dihydrofolate reductase (DHFR) DME0141 SPESNAME Homo sapiens DME0141 TISSUDIS Low tissue/organ specificityNot Available DME0141 FUNCTION This enzyme converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of pyrimidines, thymidylic acid, and certain amino acidsNot Available DME0118 DME___ID DME0118 DME0118 DME_NAME Aldo-keto reductase 1C3 (AKR1C3) DME0118 SPESNAME Homo sapiens DME0118 TISSUDIS Primarily distributed in blood and intestineNot Available DME0118 FUNCTION This enzyme catalyzes the conversion of aldehydes and ketones to alcoholsNot Available It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2 and functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSDNot Available Besides, it can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites and preferentially transforms androstenedione (4-dione) to testosteroneNot Available DME0218 DME___ID DME0218 DME0218 DME_NAME Steroid 5-alpha-reductase 2 (SRD5A2) DME0218 SPESNAME Homo sapiens DME0218 TISSUDIS Primarily distributed in epididymis, liver and prostateNot Available DME0218 FUNCTION This enzyme converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroidsNot Available DME0041 DME___ID DME0041 DME0041 DME_NAME UDP-glucuronosyltransferase 1A3 (UGT1A3) DME0041 SPESNAME Homo sapiens DME0041 TISSUDIS Primarily distributed in liverNot Available Also expressed in kidney, colon and small intestineNot Available DME0041 FUNCTION This enzyme is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compoundsNot Available DME0125 DME___ID DME0125 DME0125 DME_NAME DOPA decarboxylase (DDC) DME0125 SPESNAME Homo sapiens DME0125 TISSUDIS Primarily distributed in intestine and kidneyNot Available DME0125 FUNCTION This enzyme catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamineNot Available DME0057 DME___ID DME0057 DME0057 DME_NAME Carboxylesterase 2 (CES2) DME0057 SPESNAME Homo sapiens DME0057 TISSUDIS Primarily distributed in esophagus, intestine and liverNot Available DME0057 FUNCTION This enzyme is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugsNot Available It shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphineNot Available It also hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerolNot Available DME0159 DME___ID DME0159 DME0159 DME_NAME Glutamine amidotransferase (GMPS) DME0159 SPESNAME Homo sapiens DME0159 TISSUDIS Low tissue/organ specificityNot Available DME0159 FUNCTION This enzyme is involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell divisionNot Available DME0165 DME___ID DME0165 DME0165 DME_NAME Transglutaminase E (TGM3) DME0165 SPESNAME Homo sapiens DME0165 TISSUDIS Primarily distributed in esophagus, lymphoid tissue and tongueNot Available DME0165 FUNCTION This enzyme catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteinsNot Available It is involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytesNot Available And it catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffoldNot Available DME0122 DME___ID DME0122 DME0122 DME_NAME Nitric oxide synthase brain (NOS1) DME0122 SPESNAME Homo sapiens DME0122 TISSUDIS Primarily distributed in brain and skeletal muscleNot Available DME0122 FUNCTION This enzyme has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRRNot Available DME0172 DME___ID DME0172 DME0172 DME_NAME Tryptophan oxygenase (TRPO) DME0172 SPESNAME Homo sapiens DME0172 TISSUDIS Primarily distributed in liverNot Available DME0172 FUNCTION This enzyme catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenineNot Available It catalyzes the oxidative cleavage of the indole moietyNot Available DME0049 DME___ID DME0049 DME0049 DME_NAME UDP-glucuronosyltransferase 2B15 (UGT2B15) DME0049 SPESNAME Homo sapiens DME0049 TISSUDIS Primarily distributed in gallbladder, intestine and liverNot Available DME0049 FUNCTION This enzyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7- hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolitesNot Available And it also catalyzes the glucuronidation of endogenous estrogens and androgensNot Available DME0083 DME___ID DME0083 DME0083 DME_NAME Methylenetetrahydrofolate reductase (MTHFR) DME0083 SPESNAME Homo sapiens DME0083 TISSUDIS Low tissue/organ specificityNot Available DME0083 FUNCTION This enzyme catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionineNot Available DME0156 DME___ID DME0156 DME0156 DME_NAME Hexosephosphate aminotransferase 2 (GFPT2) DME0156 SPESNAME Homo sapiens DME0156 TISSUDIS Primarily distributed in heart, placenta and spinal cordNot Available DME0156 FUNCTION This enzyme is most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteinsNot Available DME0043 DME___ID DME0043 DME0043 DME_NAME Catechol O-methyltransferase (COMT) DME0043 SPESNAME Homo sapiens DME0043 TISSUDIS Primarily distributed in liverNot Available Also expressed in brain, placenta, lymphocytes and erythrocytesNot Available DME0043 FUNCTION This enzyme catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormonesNot Available It also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenolNot Available DME0067 DME___ID DME0067 DME0067 DME_NAME NADPH-dependent carbonyl reductase 1 (CBR1) DME0067 SPESNAME Homo sapiens DME0067 TISSUDIS Primarily distributed in intestineNot Available DME0067 FUNCTION This enzyme has broad substrate specificityNot Available It catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobioticsNot Available It can also catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinolNot Available Besides, it can convert prostaglandin E2 to prostaglandin F2- alpha and catalyzes the reduction of S-nitrosoglutathioneNot Available DME0010 DME___ID DME0010 DME0010 DME_NAME Cytochrome P450 4B1 (CYP4B1) DME0010 SPESNAME Homo sapiens DME0010 TISSUDIS Primarily distributed in liver and lungNot Available DME0010 FUNCTION This enzyme is involved in an NADPH-dependent electron transport pathwayNot Available It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobioticsNot Available DME0071 DME___ID DME0071 DME0071 DME_NAME Cathepsin A (CTSA) DME0071 SPESNAME Homo sapiens DME0071 TISSUDIS Primarily distributed in adrenalNot Available DME0071 FUNCTION This enzyme is a carboxypeptidase and can deamidate tachykininsNot Available DME0098 DME___ID DME0098 DME0098 DME_NAME Aldo-keto reductase 1A1 (AKR1A1) DME0098 SPESNAME Homo sapiens DME0098 TISSUDIS Primarily distributed in kidney, salivary gland and liverNot Available DME0098 FUNCTION This enzyme catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcoholsNot Available It displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehydeNot Available It functions as a detoxifiying enzyme by reducing a range of toxic aldehydesNot Available It can reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxicNot Available It is also involved in the detoxification of lipid-derived aldehydes like acroleinNot Available It plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN)Not Available DME0050 DME___ID DME0050 DME0050 DME_NAME N-acetyltransferase 1 (NAT1) DME0050 SPESNAME Homo sapiens DME0050 TISSUDIS Primarily distributed in intestineNot Available DME0050 FUNCTION This enzyme participates in the detoxification of a plethora of hydrazine and arylamine drugsNot Available It catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogensNot Available DME0380 DME___ID DME0380 DME0380 DME_NAME Sulfotransferase 1B1 (SULT1B1) DME0380 SPESNAME Homo sapiens DME0380 TISSUDIS Primarily distributed in liver, peripheral blood leukocytes, colon, small intestine and spleenNot Available DME0380 FUNCTION This enzyme utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compoundsNot Available It can also result in bioactivation to form active metabolitesNot Available It sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxineNot Available DME0039 DME___ID DME0039 DME0039 DME_NAME Dimethylaniline oxidase 3 (FMO3) DME0039 SPESNAME Homo sapiens DME0039 TISSUDIS Primarily distributed in liverNot Available DME0039 FUNCTION This enzyme catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compoundsNot Available It plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metaboliteNot Available DME0164 DME___ID DME0164 DME0164 DME_NAME Transglutaminase Y (TGM6) DME0164 SPESNAME Homo sapiens DME0164 TISSUDIS Primarily distributed in lymphoid tissue, skin and tongueNot Available DME0164 FUNCTION This enzyme catalyzes the cross-linking of proteins and the conjugation of polyamines to proteinsNot Available DME0105 DME___ID DME0105 DME0105 DME_NAME Arylsulfatase B (ARSB) DME0105 SPESNAME Homo sapiens DME0105 TISSUDIS Low tissue/organ specificityNot Available DME0105 FUNCTION This enzyme removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradationNot Available DME0171 DME___ID DME0171 DME0171 DME_NAME Indoleamine 2,3-dioxygenase 1 (IDO1) DME0171 SPESNAME Homo sapiens DME0171 TISSUDIS Primarily distributed in blood and placentaNot Available DME0171 FUNCTION This enzyme catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathwayNot Available DME0030 DME___ID DME0030 DME0030 DME_NAME Cytochrome P450 2A13 (CYP2A13) DME0030 SPESNAME Homo sapiens DME0030 TISSUDIS Primarily distributed in liverNot Available Also expressed in a number of extrahepatictissues, including nasal mucosa, lung, trachea, brain, mammary gland,prostate, testis and uterusNot Available DME0030 FUNCTION This enzyme exhibits a coumarin 7-hydroxylase activity and is active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco- specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanoneNot Available It possesses phenacetin O-deethylation activityNot Available DME0108 DME___ID DME0108 DME0108 DME_NAME Iduronate 2-sulfatase (IDS) DME0108 SPESNAME Homo sapiens DME0108 TISSUDIS Primarily distributed in liver, kidney, lung, and placentaNot Available DME0108 FUNCTION This enzyme is involved in the degradation pathway of dermatan sulfate and heparan sulfateNot Available DME0056 DME___ID DME0056 DME0056 DME_NAME Carboxylesterase 3 (CES3) DME0056 SPESNAME Homo sapiens DME0056 TISSUDIS Primarily distributed in intestine and liverNot Available DME0056 FUNCTION This enzyme is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugsNot Available It shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]- carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeuticsNot Available DME0092 DME___ID DME0092 DME0092 DME_NAME Thymidine phosphorylase (TYMP) DME0092 SPESNAME Homo sapiens DME0092 TISSUDIS Primarily distributed in lymphoidNot Available DME0092 FUNCTION This enzyme catalyzes the reversible phosphorolysis of thymidineNot Available DME0022 DME___ID DME0022 DME0022 DME_NAME Cytochrome P450 3A43 (CYP3A43) DME0022 SPESNAME Homo sapiens DME0022 TISSUDIS Primarily distributed in prostate, liver, kidney, pancreas, fetal liver and fetal skeletalmuscleNot Available DME0022 FUNCTION This enzyme exhibits low testosterone 6-beta-hydroxylase activityNot Available DME0028 DME___ID DME0028 DME0028 DME_NAME Cholesterol 24-hydroxylase (CYP46A1) DME0028 SPESNAME Homo sapiens DME0028 TISSUDIS Primarily distributed in brainNot Available DME0028 FUNCTION This enzyme catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradationNot Available It further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side chain of these molecules, converting them into active oxysterols involved in lipid signaling and biosynthesisNot Available It acts as an epoxidase converting cholesta-5,24-dien-3beta-ol/desmosterol into (24S),25-epoxycholesterol, Besides, it may also catalyze the oxidative metabolism of xenobiotics, such as clotrimazoleNot Available DME0094 DME___ID DME0094 DME0094 DME_NAME Metallothionein-1A (MT1A) DME0094 SPESNAME Homo sapiens DME0094 TISSUDIS Primarily distributed in adipose tissue, liver and skeletal muscleNot Available DME0094 FUNCTION This enzyme acts as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metalsNot Available DME0244 DME___ID DME0244 DME0244 DME_NAME Eosinophil peroxidase (EPX) DME0244 SPESNAME Homo sapiens DME0244 TISSUDIS Primarily distributed in bone marrow and lymphoid tissueNot Available DME0244 FUNCTION This enzyme mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils and shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysisNot Available DME0176 DME___ID DME0176 DME0176 DME_NAME Tryptophanyl-tRNA synthetase mitochondrial (WARS2) DME0176 SPESNAME Homo sapiens DME0176 TISSUDIS Low tissue/organ specificityNot Available DME0176 FUNCTION This enzyme activates and transfers the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesisNot Available DME0173 DME___ID DME0173 DME0173 DME_NAME Tryptophan 5-hydroxylase 1 (TPH1) DME0173 SPESNAME Homo sapiens DME0173 TISSUDIS Primarily distributed in brain, intestine, pituitary gland and stomachNot Available DME0173 FUNCTION This enzyme catalyzes the formation of 5-hydroxytryptophan, a precursor to the neurotransmitter serotoninNot Available DME0062 DME___ID DME0062 DME0062 DME_NAME Sulfotransferase 1A2 (SULT1A2) DME0062 SPESNAME Homo sapiens DME0062 TISSUDIS Primarily distributed in intestine, liver and seminal vesicleNot Available DME0062 FUNCTION This enzyme utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmittersNot Available It is also responsible for the sulfonation and activation of minoxidilNot Available And it mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding productsNot Available DME0230 DME___ID DME0230 DME0230 DME_NAME Tartrate-resistant acid ATPase (ACP5) DME0230 SPESNAME Homo sapiens DME0230 TISSUDIS Primarily distributed in adipose tissue and lungNot Available DME0230 FUNCTION This enzyme is involved in osteopontin/bone sialoprotein dephosphorylationNot Available DME0197 DME___ID DME0197 DME0197 DME_NAME Aldo-keto reductase 1C1 (AKR1C1) DME0197 SPESNAME Homo sapiens DME0197 TISSUDIS Primarily distributed in liver, mammary gland and brainNot Available DME0197 FUNCTION This enzyme converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP)Not Available DME0111 DME___ID DME0111 DME0111 DME_NAME Ecto-5'-nucleotidase (NT5E) DME0111 SPESNAME Homo sapiens DME0111 TISSUDIS Low tissue/organ specificityNot Available DME0111 FUNCTION This enzyme hydrolyzes extracellular nucleotides into membrane permeable nucleosides and exhibits AMP-, NAD-, and NMN-nucleosidase activitiesNot Available DME0096 DME___ID DME0096 DME0096 DME_NAME Myeloperoxidase (MPO) DME0096 SPESNAME Homo sapiens DME0096 TISSUDIS Primarily distributed in boneNot Available DME0096 FUNCTION This enzyme oxidizes tyrosine to tyrosyl radical using hydrogen peroxide as an oxidizing agentNot Available DME0095 DME___ID DME0095 DME0095 DME_NAME Metallothionein-2A (MT2A) DME0095 SPESNAME Homo sapiens DME0095 TISSUDIS Primarily distributed in liverNot Available DME0095 FUNCTION This enzyme acts as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metalsNot Available DME0113 DME___ID DME0113 DME0113 DME_NAME Heparanase (HPSE) DME0113 SPESNAME Homo sapiens DME0113 TISSUDIS Primarily distributed in placenta and spleenNot Available Also expressed in lymph node, thymus, peripheral blood leukocytes, bonemarrow, endothelial cells and fetal liverNot Available DME0113 FUNCTION This enzyme cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycansNot Available It selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo groupNot Available It can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moietyNot Available DME0045 DME___ID DME0045 DME0045 DME_NAME Monoamine oxidase type B (MAO-B) DME0045 SPESNAME Homo sapiens DME0045 TISSUDIS Primarily distributed in liverNot Available DME0045 FUNCTION This enzyme catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissuesNot Available MAOB preferentially degrades benzylamine and phenylethylamineNot Available DME0201 DME___ID DME0201 DME0201 DME_NAME Arachidonate 5-lipoxygenase (ALOX5) DME0201 SPESNAME Homo sapiens DME0201 TISSUDIS Primarily distributed in blood, bone marrow and lymphoid tissueNot Available DME0201 FUNCTION This enzyme catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processesNot Available DME0064 DME___ID DME0064 DME0064 DME_NAME UDP-glucuronosyltransferase 1A8 (UGT1A8) DME0064 SPESNAME Homo sapiens DME0064 TISSUDIS Primarily distributed in colon, liver, kidney and small intestineNot Available DME0064 FUNCTION This enzyme is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compoundsNot Available DME0037 DME___ID DME0037 DME0037 DME_NAME Steroid 21-hydroxylase (CYP21A2) DME0037 SPESNAME Homo sapiens DME0037 TISSUDIS Primarily distributed in adrenalNot Available DME0037 FUNCTION This enzyme specifically catalyzes the 21-hydroxylation of steroidsNot Available DME0031 DME___ID DME0031 DME0031 DME_NAME Cytochrome P450 2J2 (CYP2J2) DME0031 SPESNAME Homo sapiens DME0031 TISSUDIS Primarily distributed in heart muscle, intestine and liverNot Available DME0031 FUNCTION This enzyme is involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular systemNot Available It catalyzes the epoxidation of double bonds of PUFA and converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE)Not Available In endothelial cells, it participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolitesNot Available In combination with 15- lipoxygenase , it metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs)Not Available It can also catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone; catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole; and catalyzes the sulfoxidation of fenbedazolNot Available DME0187 DME___ID DME0187 DME0187 DME_NAME Methionine-tRNA ligase mitochondrial (MARS2) DME0187 SPESNAME Homo sapiens DME0187 TISSUDIS Low tissue/organ specificityNot Available DME0187 FUNCTION This enzyme participates in 3 metabolic pathways: methionine metabolism, selenoamino acid metabolism, and aminoacyl-trna biosynthesisNot Available DME0188 DME___ID DME0188 DME0188 DME_NAME Peptide methionine sulfoxide reductase (MSRA) DME0188 SPESNAME Homo sapiens DME0188 TISSUDIS Primarily distributed in kidney, cerebellum, liver, heart ventricles, bone marrow and hippocampusNot Available DME0188 FUNCTION This enzyme catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionineNot Available DME0308 DME___ID DME0308 DME0308 DME_NAME Glutathione S-transferase mu-1 (GSTM1) DME0308 SPESNAME Homo sapiens DME0308 TISSUDIS Primarily distributed in liver and seminal vesicleNot Available DME0308 FUNCTION This enzyme conjugates reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophilesNot Available DME0190 DME___ID DME0190 DME0190 DME_NAME S-adenosylmethionine synthase 2 (MAT2A) DME0190 SPESNAME Homo sapiens DME0190 TISSUDIS Primarily distributed in pancreas and kidneyNot Available DME0190 FUNCTION This enzyme catalyzes the formation of S-adenosylmethionine from methionine and ATPNot Available The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphateNot Available DME0127 DME___ID DME0127 DME0127 DME_NAME Alcohol dehydrogenase class-I alpha (ADH1A) DME0127 SPESNAME Homo sapiens DME0127 TISSUDIS Primarily distributed in liverNot Available DME0127 FUNCTION This enzyme metabolizes a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation productsNot Available DME0283 DME___ID DME0283 DME0283 DME_NAME Dimethylaniline oxidase 2 (FMO2) DME0283 SPESNAME Homo sapiens DME0283 TISSUDIS Primarily distributed in adipose tissue, esophagus and lungNot Available DME0283 FUNCTION This enzyme catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediateNot Available And it can catalyze the S-oxidation of methimazoleNot Available DME0073 DME___ID DME0073 DME0073 DME_NAME Alcohol dehydrogenase class-V (ADH6) DME0073 SPESNAME Homo sapiens DME0073 TISSUDIS Primarily distributed in liver and stomachNot Available DME0073 FUNCTION This enzyme metabolizes a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation productsNot Available DME0065 DME___ID DME0065 DME0065 DME_NAME UDP-glucuronosyltransferase 1A7 (UGT1A7) DME0065 SPESNAME Homo sapiens DME0065 TISSUDIS Primarily distributed in liver, gastric tissue, esophagus, lymphoid tissue and tongueNot Available DME0065 FUNCTION This enzyme is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compoundsNot Available DME0314 DME___ID DME0314 DME0314 DME_NAME Glutathione S-transferase omega-2 (GSTO2) DME0314 SPESNAME Homo sapiens DME0314 TISSUDIS Primarily distributed in testisNot Available Also expressed in liver, kidney, skeletal muscle and prostateNot Available DME0314 FUNCTION This enzyme exhibits glutathione-dependent thiol transferase activityNot Available It has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acidNot Available It participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA)Not Available DME0255 DME___ID DME0255 DME0255 DME_NAME Acyl-CoA thioesterase 2 (ACOT2) DME0255 SPESNAME Homo sapiens DME0255 TISSUDIS Primarily distributed in heart, liver, muscle andkidneyNot Available DME0255 FUNCTION This enzyme catalyzes the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASHNot Available It displays higher activity toward long chain acyl CoAs (C14-C20)Not Available And it is involved in enhancing the hepatic fatty acid oxidation in mitochondriaNot Available DME0183 DME___ID DME0183 DME0183 DME_NAME Methionine adenosyltransferase II beta (MAT2B) DME0183 SPESNAME Homo sapiens DME0183 TISSUDIS Low tissue/organ specificityNot Available DME0183 FUNCTION This enzyme is a regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATPNot Available DME0189 DME___ID DME0189 DME0189 DME_NAME S-adenosylmethionine synthase 1 (MAT1A) DME0189 SPESNAME Homo sapiens DME0189 TISSUDIS Primarily distributed in liverNot Available DME0189 FUNCTION This enzyme catalyzes the formation of S-adenosylmethionine from methionine and ATPNot Available The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphateNot Available DME0131 DME___ID DME0131 DME0131 DME_NAME Gastric alcohol dehydrogenase (ADH7) DME0131 SPESNAME Homo sapiens DME0131 TISSUDIS Primarily distributed in stomach, esophagus, lymphoid tissue and tongueNot Available DME0131 FUNCTION This enzyme catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivativesNot Available It oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis- retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acidNot Available In vitro it can also catalyzes the NADH-dependent reduction of all-trans- retinal and aldehydes and their derivativesNot Available It reduces preferentially all trans- retinal, all-trans-4-oxoretinal and hexanalNot Available DME0191 DME___ID DME0191 DME0191 DME_NAME Folylpolyglutamate synthase (FPGS) DME0191 SPESNAME Homo sapiens DME0191 TISSUDIS Low tissue/organ specificityNot Available DME0191 FUNCTION This enzyme catalyzes conversion of folates to polyglutamate derivatives and it can metabolizes methotrexate (MTX) to polyglutamatesNot Available DME0117 DME___ID DME0117 DME0117 DME_NAME Dehydropeptidase-I (DPEP1) DME0117 SPESNAME Homo sapiens DME0117 TISSUDIS Primarily distributed in intestine, kidney and pancreasNot Available DME0117 FUNCTION This enzyme hydrolyzes a wide range of dipeptidesNot Available It implicated in the renal metabolism of glutathione and its conjugatesNot Available DME0024 DME___ID DME0024 DME0024 DME_NAME Steroid 17-alpha-monooxygenase (CYP17A1) DME0024 SPESNAME Homo sapiens DME0024 TISSUDIS Primarily distributed in adrenalNot Available DME0024 FUNCTION This enzyme is involved in corticoid and androgen biosynthesisNot Available It catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathwaysNot Available A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavageNot Available The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisolNot Available Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedioneNot Available It has 16-alpha hydroxylase activityNot Available It catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA and also 16-alpha hydroxylates androgens, relevant for estriol synthesisNot Available DME0147 DME___ID DME0147 DME0147 DME_NAME Cellular glutathione peroxidase (GPX1) DME0147 SPESNAME Homo sapiens DME0147 TISSUDIS Primarily distributed in adipose, bone and testicleNot Available DME0147 FUNCTION This enzyme protects the hemoglobin in erythrocytes from oxidative breakdownNot Available DME0027 DME___ID DME0027 DME0027 DME_NAME Steroid 11-beta-hydroxylase (CYP11B1) DME0027 SPESNAME Homo sapiens DME0027 TISSUDIS Primarily distributed in adrenalNot Available DME0027 FUNCTION This enzyme is involved in the biosynthesis of adrenal corticoidsNot Available It catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectivelyNot Available DME0216 DME___ID DME0216 DME0216 DME_NAME Putrescine acetyltransferase (SSAT1) DME0216 SPESNAME Homo sapiens DME0216 TISSUDIS Low tissue/organ specificityNot Available DME0216 FUNCTION This enzyme catalyzes the acetylation of polyaminesNot Available Substrate specificity: norspermidine = spermidine >> spermine > N(1)- acetylspermine > putrescineNot Available This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyaminesNot Available DME0224 DME___ID DME0224 DME0224 DME_NAME HMG-CoA reductase (HMGCR) DME0224 SPESNAME Homo sapiens DME0224 TISSUDIS Low tissue/organ specificityNot Available DME0224 FUNCTION This enzyme is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteinsNot Available DME0223 DME___ID DME0223 DME0223 DME_NAME Hypoxanthine phosphoribosyltransferase (HPRT1) DME0223 SPESNAME Homo sapiens DME0223 TISSUDIS Low tissue/organ specificityNot Available DME0223 FUNCTION This enzyme converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphateNot Available It transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purineNot Available DME0038 DME___ID DME0038 DME0038 DME_NAME Vitamin D(3) 24-hydroxylase (CYP24A1) DME0038 SPESNAME Homo sapiens DME0038 TISSUDIS Primarily distributed in kidney, lymphoid tissue and urinary bladderNot Available DME0038 FUNCTION This enzyme plays a key role in vitamin D catabolism and calcium homeostasisNot Available Via C24- and C23-oxidation pathways, it catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3))Not Available With initial hydroxylation at C-24 (via C24-oxidation pathway), it performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acidNot Available With initial hydroxylation at C-23 (via C23-oxidation pathway), it catalyzes sequential oxidation of calcidiol leading to the formation of 25(OH)D3-26,23-lactone as end productNot Available It preferentially hydroxylates at C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S- hydroxycholecalciferol and 20S,23-dihydroxycholecalciferolNot Available DME0233 DME___ID DME0233 DME0233 DME_NAME Aldo-keto reductase 1C2 (AKR1C2) DME0233 SPESNAME Homo sapiens DME0233 TISSUDIS Primarily distributed in breast, liver and tongueNot Available DME0233 FUNCTION This enzyme works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids, and it catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha- androstane-3-alpha,17-beta-diol (3-alpha-diol)Not Available DME0286 DME___ID DME0286 DME0286 DME_NAME Aldehyde dehydrogenase 1 (ALDH1) DME0286 SPESNAME Homo sapiens DME0286 TISSUDIS Primarily distributed in liverNot Available DME0286 FUNCTION This enzyme can convert/oxidize retinaldehyde to retinoic acid and it may have a broader specificity and oxidize other aldehydes in vivoNot Available DME0194 DME___ID DME0194 DME0194 DME_NAME Choline phosphatase 1 (PLD1) DME0194 SPESNAME Homo sapiens DME0194 TISSUDIS Primarily distributed in gallbladder, pancreas and heartNot Available Also expressed in brain, placenta, spleen, uterus and small intestineNot Available DME0194 FUNCTION This enzyme catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and cholineNot Available DME0398 DME___ID DME0398 DME0398 DME_NAME Small intestine reductase (AKR1B10) DME0398 SPESNAME Homo sapiens DME0398 TISSUDIS Primarily distributed in small intestine, colon, adrenal gland, esophagus and stomachNot Available DME0398 FUNCTION This enzyme catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcoholsNot Available It displays strong enzymatic activity toward all-trans- retinal, 9-cis-retinal, and 13-cis-retinalNot Available It plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4- hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls)Not Available DME0422 DME___ID DME0422 DME0422 DME_NAME Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DME0422 SPESNAME Homo sapiens DME0422 TISSUDIS Primarily distributed in intestine, liver and placentaNot Available DME0422 FUNCTION This enzyme is capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estroneNot Available It also has 20-alpha- HSD activityNot Available DME0169 DME___ID DME0169 DME0169 DME_NAME Serum paraoxonase/arylesterase 1 (PON1) DME0169 SPESNAME Homo sapiens DME0169 TISSUDIS Primarily distributed in liverNot Available DME0169 FUNCTION This enzyme hydrolyzes the toxic metabolites of a variety of organophosphorus insecticidesNot Available It is capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid estersNot Available DME0227 DME___ID DME0227 DME0227 DME_NAME Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME0227 SPESNAME Homo sapiens DME0227 TISSUDIS Primarily distributed in liver and retinaNot Available DME0227 FUNCTION This enzyme is involved in the metabolism of all-trans retinoic acid (atRA)Not Available It catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 and C-18Not Available It has no activity toward 9-cis and 13-cis retinoic acid stereoisomers and may play a role in the oxidative metabolism of xenobiotics such as tazarotenic acidNot Available DME0195 DME___ID DME0195 DME0195 DME_NAME Phosphodiesterase 5A (PDE5A) DME0195 SPESNAME Homo sapiens DME0195 TISSUDIS Primarily distributed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreasNot Available Also expressed in brain, liver and lungNot Available DME0195 FUNCTION This enzyme catalyzes the specific hydrolysis of cGMP to 5'-GMPNot Available DME0077 DME___ID DME0077 DME0077 DME_NAME Aldehyde dehydrogenase 2 (ALDH2) DME0077 SPESNAME Homo sapiens DME0077 TISSUDIS Primarily distributed in liverNot Available DME0077 FUNCTION This enzyme belongs to the aldehyde dehydrogenase family of enzymes that catalyze the chemical transformation from acetaldehyde to acetic acidNot Available AND it is the second enzyme of the major oxidative pathway of alcohol metabolismNot Available DME0090 DME___ID DME0090 DME0090 DME_NAME Catalase (CAT) DME0090 SPESNAME Homo sapiens DME0090 TISSUDIS Primarily distributed in blood and liverNot Available DME0090 FUNCTION This enzyme catalyzes the decomposition of hydrogen peroxide to water and oxygenNot Available DME0046 DME___ID DME0046 DME0046 DME_NAME Calcidiol 1-monooxygenase (CYP27B1) DME0046 SPESNAME Homo sapiens DME0046 TISSUDIS Primarily distributed in kidneyNot Available DME0046 FUNCTION This enzyme is involved in vitamin D metabolismNot Available It catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1alpha- position to form the hormonally active form of vitamin D3, 1alpha,25- dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR)Not Available It has 1alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway and converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3 and also active on 25-hydroxyvitamin D2Not Available DME0058 DME___ID DME0058 DME0058 DME_NAME Acetylcholinesterase (ACHE) DME0058 SPESNAME Homo sapiens DME0058 TISSUDIS Primarily distributed in brain and skeletal muscleNot Available DME0058 FUNCTION This enzyme hydrolyzes of the acetylcholine released into the synaptic cleft to terminate signal transduction at the neuromuscular junctionNot Available DME0206 DME___ID DME0206 DME0206 DME_NAME Sodium/potassium-transporting ATPase gamma (FXYD2) DME0206 SPESNAME Homo sapiens DME0206 TISSUDIS Primarily distributed in kidney, pancreas and salivary glandNot Available DME0206 FUNCTION This enzyme is involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPaseNot Available DME0158 DME___ID DME0158 DME0158 DME_NAME Glutamyl-tRNA(Gln) amidotransferase B (GATB) DME0158 SPESNAME Homo sapiens DME0158 TISSUDIS Primarily distributed in muscle and heartNot Available DME0158 FUNCTION This enzyme allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondriaNot Available DME0126 DME___ID DME0126 DME0126 DME_NAME L-glutamine amidohydrolase (GLS) DME0126 SPESNAME Homo sapiens DME0126 TISSUDIS Primarily distributed in kidneyNot Available DME0126 FUNCTION This enzyme catalyzes the first reaction in the primary pathway for the renal catabolism of glutamineNot Available DME0198 DME___ID DME0198 DME0198 DME_NAME Aldo-keto reductase 1C4 (AKR1C4) DME0198 SPESNAME Homo sapiens DME0198 TISSUDIS Primarily distributed in liverNot Available DME0198 FUNCTION This enzyme catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan- 3-alpha,17-beta-diol (3-alpha-diol)Not Available It also has some 20-alpha- hydroxysteroid dehydrogenase activityNot Available The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory routeNot Available DME0420 DME___ID DME0420 DME0420 DME_NAME Estradiol 17-beta-dehydrogenase 1 (HSD17B1) DME0420 SPESNAME Homo sapiens DME0420 TISSUDIS Primarily distributed in placentaNot Available DME0420 FUNCTION This enzyme favors the reduction of estrogens and androgensNot Available It also has 20- alpha-HSD activityNot Available DME0410 DME___ID DME0410 DME0410 DME_NAME Serine sulfhydrase (CBS) DME0410 SPESNAME Homo sapiens DME0410 TISSUDIS Primarily distributed in liver and pancreasNot Available DME0410 FUNCTION This enzyme catalyzes the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteineNot Available This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteineNot Available DME0089 DME___ID DME0089 DME0089 DME_NAME Microsomal glutathione S-transferase 2 (MGST2) DME0089 SPESNAME Homo sapiens DME0089 TISSUDIS Primarily distributed in liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver and fetal spleenNot Available DME0089 FUNCTION This enzyme can catalyze the production of LTC4 from LTA4 and reduced glutathione, and it can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathioneNot Available DME0162 DME___ID DME0162 DME0162 DME_NAME Transglutaminase H (TGM2) DME0162 SPESNAME Homo sapiens DME0162 TISSUDIS Primarily distributed in liver and placentaNot Available DME0162 FUNCTION This enzyme catalyzes the cross-linking of proteins, such as WDR54, and the conjugation of polyamines to proteinsNot Available DME0079 DME___ID DME0079 DME0079 DME_NAME Alkaline phosphatase (ALPL) DME0079 SPESNAME Homo sapiens DME0079 TISSUDIS Primarily distributed in blood, liver and lungNot Available DME0079 FUNCTION This enzyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi)Not Available DME0414 DME___ID DME0414 DME0414 DME_NAME Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME0414 SPESNAME Homo sapiens DME0414 TISSUDIS Primarily distributed in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cordNot Available DME0414 FUNCTION This enzyme catalyzes the reduction of all-trans-retinal to all-trans- retinol in the presence of NADPHNot Available DME0048 DME___ID DME0048 DME0048 DME_NAME UDP-glucuronosyltransferase 1A4 (UGT1A4) DME0048 SPESNAME Homo sapiens DME0048 TISSUDIS Primarily distributed in liverNot Available Also expressed in kidney, colon and small intestineNot Available DME0048 FUNCTION This enzyme glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugateNot Available DME0109 DME___ID DME0109 DME0109 DME_NAME Superoxide dismutase 1 (SOD1) DME0109 SPESNAME Homo sapiens DME0109 TISSUDIS Primarily distributed in liverNot Available DME0109 FUNCTION This enzyme destroys radicals which are normally produced within the cells and which are toxic to biological systemsNot Available DME0066 DME___ID DME0066 DME0066 DME_NAME UDP-glucuronosyltransferase 2B17 (UGT2B17) DME0066 SPESNAME Homo sapiens DME0066 TISSUDIS Primarily distributed in intestine and liverNot Available DME0066 FUNCTION This enzyme has a major substrates eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT)Not Available DME0155 DME___ID DME0155 DME0155 DME_NAME Glutamine-dependent NAD(+) synthetase (NADSYN1) DME0155 SPESNAME Homo sapiens DME0155 TISSUDIS Low tissue/organ specificityNot Available DME0155 FUNCTION This enzyme catalyzes the ATP-dependent amidation of deamido-NAD to form NADNot Available DME0069 DME___ID DME0069 DME0069 DME_NAME Butyrylcholine esterase (BCHE) DME0069 SPESNAME Homo sapiens DME0069 TISSUDIS Primarily distributed in liverNot Available DME0069 FUNCTION This enzyme has a broad substrate specificityNot Available It contributes to the inactivation of the neurotransmitter acetylcholine and it can degrade neurotoxic organophosphate estersNot Available DME0161 DME___ID DME0161 DME0161 DME_NAME Phosphoribosylformylglycinamidine synthase (PFAS) DME0161 SPESNAME Homo sapiens DME0161 TISSUDIS Low tissue/organ specificityNot Available DME0161 FUNCTION This enzyme catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamateNot Available DME0160 DME___ID DME0160 DME0160 DME_NAME Kynurenine aminotransferase I (KYAT1) DME0160 SPESNAME Homo sapiens DME0160 TISSUDIS Low tissue/organ specificityNot Available DME0160 FUNCTION This enzyme catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA)Not Available It metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolitesNot Available It also catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bondNot Available DME0078 DME___ID DME0078 DME0078 DME_NAME Adenine phosphoribosyltransferase (APRT) DME0078 SPESNAME Homo sapiens DME0078 TISSUDIS Low tissue/organ specificityNot Available DME0078 FUNCTION This enzyme catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesisNot Available DME0163 DME___ID DME0163 DME0163 DME_NAME Transglutaminase X (TGM5) DME0163 SPESNAME Homo sapiens DME0163 TISSUDIS Primarily distributed in esophagus, lymphoid tissue, skin and tongueNot Available DME0163 FUNCTION This enzyme catalyzes the cross-linking of proteins and the conjugation of polyamines to proteinsNot Available DME0326 DME___ID DME0326 DME0326 DME_NAME UDP-glucuronosyltransferase 2A3 (UGT2A3) DME0326 SPESNAME Homo sapiens DME0326 TISSUDIS Primarily distributed in intestine and kidneyNot Available DME0326 FUNCTION This enzyme catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretionNot Available DME0142 DME___ID DME0142 DME0142 DME_NAME Gamma-Glu-X carboxypeptidase (GGH) DME0142 SPESNAME Homo sapiens DME0142 TISSUDIS Primarily distributed in kidney and liverNot Available DME0142 FUNCTION This enzyme hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates and progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamateNot Available It may play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolatesNot Available DME0177 DME___ID DME0177 DME0177 DME_NAME Cytosolic branched aminotransferase (BCAT1) DME0177 SPESNAME Homo sapiens DME0177 TISSUDIS Primarily distributed in pancreasNot Available DME0177 FUNCTION This enzyme catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valineNot Available DME0200 DME___ID DME0200 DME0200 DME_NAME Bile acid-CoA thioesterase (BAAT) DME0200 SPESNAME Homo sapiens DME0200 TISSUDIS Primarily distributed in liver, gallbladder mucosa and pancreasNot Available DME0200 FUNCTION This enzyme catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycineNot Available Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolismNot Available It may also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acidsNot Available In vitro, it catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAsNot Available DME0413 DME___ID DME0413 DME0413 DME_NAME Delta(24)-sterol reductase (DHCR24) DME0413 SPESNAME Homo sapiens DME0413 TISSUDIS Primarily distributed in adrenal gland and liverNot Available DME0413 FUNCTION This enzyme catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesisNot Available In addition to its cholesterol-synthesizing activity, it can protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress and protects against amyloid-beta peptide-induced apoptosisNot Available DME0402 DME___ID DME0402 DME0402 DME_NAME Arachidonate 12-lipoxygenase (ALOX12B) DME0402 SPESNAME Homo sapiens DME0402 TISSUDIS Primarily distributed in skin and tongueNot Available DME0402 FUNCTION This enzyme catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy speciesNot Available DME0139 DME___ID DME0139 DME0139 DME_NAME Uridine phosphorylase 1 (UPP1) DME0139 SPESNAME Homo sapiens DME0139 TISSUDIS Low tissue/organ specificityNot Available DME0139 FUNCTION This enzyme catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphateNot Available DME0070 DME___ID DME0070 DME0070 DME_NAME Xanthine dehydrogenase/oxidase (XDH) DME0070 SPESNAME Homo sapiens DME0070 TISSUDIS Primarily distributed in intestine and liverNot Available DME0070 FUNCTION This enzyme is a key enzyme in purine degradationNot Available It catalyzes the oxidation of hypoxanthine to xanthine and catalyzes the oxidation of xanthine to uric acidNot Available DME0205 DME___ID DME0205 DME0205 DME_NAME UDP-glucuronosyltransferase 2B10 (UGT2B10) DME0205 SPESNAME Homo sapiens DME0205 TISSUDIS Primarily distributed in liverNot Available DME0205 FUNCTION This enzyme is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compoundsNot Available DME0170 DME___ID DME0170 DME0170 DME_NAME Serum paraoxonase/lactonase 3 (PON3) DME0170 SPESNAME Homo sapiens DME0170 TISSUDIS Primarily distributed in liverNot Available DME0170 FUNCTION This enzyme has low activity towards the organophosphate paraxon and aromatic carboxylic acid estersNot Available It rapidly hydrolyzes lactones such as statin prodrugs (eNot AvailablegNot Available lovastatin) and hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituentsNot Available DME0007 DME___ID DME0007 DME0007 DME_NAME RNA cytidine acetyltransferase (hALP) DME0007 SPESNAME Homo sapiens DME0007 TISSUDIS Low tissue/organ specificityNot Available DME0007 FUNCTION This enzyme catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAsNot Available It catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translationNot Available In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitroNot Available DME0400 DME___ID DME0400 DME0400 DME_NAME Aldo-keto reductase 1D1 (AKR1D1) DME0400 SPESNAME Homo sapiens DME0400 TISSUDIS Primarily distributed in liverNot Available Also expressed in testis and weakly in colonNot Available DME0400 FUNCTION This enzyme catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junctionNot Available This cis-configuration plays important roles in steroid metabolismNot Available It is also capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one)Not Available DME0014 DME___ID DME0014 DME0014 DME_NAME Thiopurine methyltransferase (TPMT) DME0014 SPESNAME Homo sapiens DME0014 TISSUDIS Primarily distributed in thyroidNot Available DME0014 FUNCTION This enzyme catalyzes the S-methylation of thiopurine drugs such as 6- mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S- adenosyl-L-methionine as the methyl donorNot Available TPMT activity modulates the cytotoxic effects of thiopurine prodrugsNot Available A natural substrate for this enzyme has yet to be identifiedNot Available DME0120 DME___ID DME0120 DME0120 DME_NAME NADH-ubiquinone oxidoreductase 30 kDa (NDUFS3) DME0120 SPESNAME Homo sapiens DME0120 TISSUDIS Primarily distributed in skeletalNot Available DME0120 FUNCTION This enzyme is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I)Not AvailableComplex I functions in the transfer of electrons from NADH to the respiratory chainNot Available The immediate electron acceptor for the enzyme is believed to be ubiquinoneNot Available DME0485 DME___ID DME0485 DME0485 DME_NAME Glutamate-cysteine ligase catalytic (GCLC) DME0485 SPESNAME Homo sapiens DME0485 TISSUDIS Primarily distributed in liverNot Available DME0485 FUNCTION This enzyme is the first rate limiting enzyme of glutathione synthesisNot Available The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunitNot Available DME0053 DME___ID DME0053 DME0053 DME_NAME Dihydrothymine dehydrogenase (DPYD) DME0053 SPESNAME Homo sapiens DME0053 TISSUDIS Primarily distributed in liver and peripheral blood mononuclear cellsNot Available DME0053 FUNCTION This enzyme is involved in pyrimidine base degradationNot Available It catalyzes the reduction of uracil and thymine and also involved the degradation of the chemotherapeutic drug 5-fluorouracilNot Available DME0138 DME___ID DME0138 DME0138 DME_NAME Uridine 5'-monophosphate synthase (UMPS) DME0138 SPESNAME Homo sapiens DME0138 TISSUDIS Low tissue/organ specificityNot Available DME0138 FUNCTION This enzyme catalyzes the final two reactions of the de novo biosynthesis of UMP in mammalian cells by the sequential action of orotate phosphoribosyltransferase and orotidine 5'-monophosphate (OMP) decarboxylaseNot Available DME0428 DME___ID DME0428 DME0428 DME_NAME Uracil phosphoribosyltransferase (UPRT) DME0428 SPESNAME Homo sapiens DME0428 TISSUDIS Primarily distributed in leukocytes, liver and spleen andthymusNot Available Also expressed in brain, lung and skeletal muscleNot Available DME0428 FUNCTION This enzyme is an enzyme which creates UMP from uracil and phosphoribosylpyrophosphateNot Available DME0081 DME___ID DME0081 DME0081 DME_NAME Glutathione S-transferase alpha-2 (GSTA2) DME0081 SPESNAME Homo sapiens DME0081 TISSUDIS Primarily distributed in kidney, liver and pancreasNot Available DME0081 FUNCTION This enzyme conjugates reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophilesNot Available DME0061 DME___ID DME0061 DME0061 DME_NAME Sulfotransferase 1E1 (SULT1E1) DME0061 SPESNAME Homo sapiens DME0061 TISSUDIS Primarily distributed in intestine, liver and vaginaNot Available DME0061 FUNCTION This enzyme utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estroneNot Available The sulfation of estrogens leads to their inactivationNot Available It also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficencyNot Available DME0299 DME___ID DME0299 DME0299 DME_NAME Aminomuconic semialdehyde dehydrogenase (ALDH12) DME0299 SPESNAME Homo sapiens DME0299 TISSUDIS Primarily distributed in kidney and liverNot Available DME0299 FUNCTION This enzyme catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradationNot Available DME0047 DME___ID DME0047 DME0047 DME_NAME UDP-glucuronosyltransferase 2B4 (UGT2B4) DME0047 SPESNAME Homo sapiens DME0047 TISSUDIS Primarily distributed in liverNot Available DME0047 FUNCTION This enzyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol)Not Available It is also capable of 6 alpha- hydroxyglucuronidation of hyodeoxycholic acidNot Available DME0208 DME___ID DME0208 DME0208 DME_NAME Oleamide hydrolase 1 (FAAH) DME0208 SPESNAME Homo sapiens DME0208 TISSUDIS Primarily distributed in brain, small intestine, pancreas, skeletal muscle and testisNot Available Also expressed in kidney, liver, lung, placenta and prostateNot Available DME0208 FUNCTION This enzyme degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acidsNot Available It also hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substratesNot Available DME0119 DME___ID DME0119 DME0119 DME_NAME NADH-ubiquinone oxidoreductase 49 kDa (NDUFS2) DME0119 SPESNAME Homo sapiens DME0119 TISSUDIS Primarily distributed in skeletalNot Available DME0119 FUNCTION This enzyme is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I)Not AvailableComplex I functions in the transfer of electrons from NADH to the respiratory chainNot Available The immediate electron acceptor for the enzyme is believed to be ubiquinoneNot Available DME0405 DME___ID DME0405 DME0405 DME_NAME Copper amine oxidase (AOC3) DME0405 SPESNAME Homo sapiens DME0405 TISSUDIS Primarily distributed in peripheral lymph node, hepatic endothelia, appendix, lung and small intestineNot Available DME0405 FUNCTION This enzyme has semicarbazide-sensitive (SSAO) monoamine oxidase activityNot Available DME0383 DME___ID DME0383 DME0383 DME_NAME Sulfotransferase 1C4 (SULT1C4) DME0383 SPESNAME Homo sapiens DME0383 TISSUDIS Primarily distributed in fetal lung and kidneyNot Available Also expressed in fetal heart, adult kidney, ovary and spinal chordNot Available DME0383 FUNCTION This enzyme utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmittersNot Available It is also involved in the activation of carcinogenic hydroxylaminesNot Available It has activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF)Not Available DME0145 DME___ID DME0145 DME0145 DME_NAME Alanyl aminopeptidase (ANPEP) DME0145 SPESNAME Homo sapiens DME0145 TISSUDIS Primarily distributed in intestine, kidney and pancreasNot Available DME0145 FUNCTION This enzyme plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteasesNot Available DME0107 DME___ID DME0107 DME0107 DME_NAME N-acetyl-beta-glucosaminidase beta (HEXB) DME0107 SPESNAME Homo sapiens DME0107 TISSUDIS Primarily distributed in placentaNot Available DME0107 FUNCTION This enzyme is responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissuesNot Available DME0411 DME___ID DME0411 DME0411 DME_NAME Microsomal cytochrome MCB5 (CYB5A) DME0411 SPESNAME Homo sapiens DME0411 TISSUDIS Primarily distributed in liverNot Available DME0411 FUNCTION This enzyme functions as an electron carrier for several membrane-bound oxygenasesNot Available DME0417 DME___ID DME0417 DME0417 DME_NAME Galactose kinase (GALK1) DME0417 SPESNAME Homo sapiens DME0417 TISSUDIS Primarily distributed in bloodNot Available DME0417 FUNCTION This enzyme is important for galactose metabolismNot Available DME0167 DME___ID DME0167 DME0167 DME_NAME Transglutaminase Z (TGM7) DME0167 SPESNAME Homo sapiens DME0167 TISSUDIS Primarily distributed in lymphoid tissue and testisNot Available DME0167 FUNCTION This enzyme catalyzes the cross-linking of proteins and the conjugation of polyamines to proteinsNot Available DME0051 DME___ID DME0051 DME0051 DME_NAME N-acetyltransferase 2 (NAT2) DME0051 SPESNAME Homo sapiens DME0051 TISSUDIS Primarily distributed in intestine and liverNot Available DME0051 FUNCTION This enzyme participates in the detoxification of a plethora of hydrazine and arylamine drugsNot Available It catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogensNot Available DME0431 DME___ID DME0431 DME0431 DME_NAME Methionine synthase reductase (MTRR) DME0431 SPESNAME Homo sapiens DME0431 TISSUDIS Primarily distributed in skeletal muscleNot Available DME0431 FUNCTION This enzyme is involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional stateNot Available It is necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritanceNot Available Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effectsNot Available DME0389 DME___ID DME0389 DME0389 DME_NAME Bifunctional epoxide hydrolase 2 (EPHX2) DME0389 SPESNAME Homo sapiens DME0389 TISSUDIS Primarily distributed in intestine and liverNot Available DME0389 FUNCTION This enzyme has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides and plays a role in xenobiotic metabolism by degrading potentially toxic epoxidesNot Available Besides, it also determines steady- state levels of physiological mediators Additionally, the N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10- phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acidNot Available DME0475 DME___ID DME0475 DME0475 DME_NAME ADP-dependent glucokinase (ADPGK) DME0475 SPESNAME Homo sapiens DME0475 TISSUDIS Low tissue/organ specificityNot Available DME0475 FUNCTION This enzyme catalyzes the phosphorylation of D-glucose to D-glucose 6- phosphate using ADP as the phosphate donorNot Available DME0415 DME___ID DME0415 DME0415 DME_NAME Thymidylate kinase (DTYMK) DME0415 SPESNAME Homo sapiens DME0415 TISSUDIS Low tissue/organ specificityNot Available DME0415 FUNCTION This enzyme catalyzes the conversion of dTMP to dTDPNot Available DME0168 DME___ID DME0168 DME0168 DME_NAME Neprilysin (MME) DME0168 SPESNAME Homo sapiens DME0168 TISSUDIS Primarily distributed in blood, intestine and kidneyNot Available DME0168 FUNCTION This enzyme has thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acidsNot Available It is biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond and able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9Not Available It is also involved in the degradation of atrial natriuretic factorNot Available DME0202 DME___ID DME0202 DME0202 DME_NAME Fatty acid desaturase 1 (FADS1) DME0202 SPESNAME Homo sapiens DME0202 TISSUDIS Primarily distributed in liver, brain, adrenal gland, heart, fetal liver and brainNot Available DME0202 FUNCTION This enzyme acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chainNot Available It is involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursorsNot Available Specifically, it desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectivelyNot Available As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, it controls the metabolism of inflammatory lipids like prostaglandin E2Not Available DME0016 DME___ID DME0016 DME0016 DME_NAME Cytochrome P450 2F1 (CYP2F1) DME0016 SPESNAME Homo sapiens DME0016 TISSUDIS Primarily distributed in lung, lymphoid tissue, pituitary gland and testisNot Available DME0016 FUNCTION This enzyme is involved in the metabolism of various pneumotoxicants including naphthaleneNot Available It is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufinNot Available It bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenineNot Available DME0199 DME___ID DME0199 DME0199 DME_NAME Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME0199 SPESNAME Homo sapiens DME0199 TISSUDIS Primarily distributed in liverNot Available DME0199 FUNCTION This enzyme catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone and the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterolNot Available DME0106 DME___ID DME0106 DME0106 DME_NAME Beta-glucuronidase (GUSB) DME0106 SPESNAME Homo sapiens DME0106 TISSUDIS Low tissue/organ specificityNot Available DME0106 FUNCTION This enzyme Plays an important role in the degradation of dermatan and keratan sulfatesNot Available DME0036 DME___ID DME0036 DME0036 DME_NAME Aldosterone synthase (CYP11B2) DME0036 SPESNAME Homo sapiens DME0036 TISSUDIS Primarily distributed in adrenalNot Available DME0036 FUNCTION This enzyme catalyzes the biosynthesis of adrenal mineralocorticoid aldosteroneNot Available And it catalyzes three sequential oxidative reactions of 11-deoxycorticosterone/21- hydroxyprogesterone, namely 11-beta hydroxylation followed with two successive oxidations at C18 to yield 18-hydroxy and then 18-aldehyde derivatives, resulting in the formation of aldosteroneNot Available DME0133 DME___ID DME0133 DME0133 DME_NAME Dipeptidyl peptidase IV (DPP4) DME0133 SPESNAME Homo sapiens DME0133 TISSUDIS Primarily distributed in intestine and parathyroid glandNot Available DME0133 FUNCTION This enzyme is involved in the pericellular proteolysis of the extracellular matrix (ECM) in association with FAP, the migration and invasion of endothelial cells into the ECMNot Available It also acts as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormonesNot Available It removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is prolineNot Available DME0221 DME___ID DME0221 DME0221 DME_NAME Dihydrotestosterone oxidoreductase (HSD3B1) DME0221 SPESNAME Homo sapiens DME0221 TISSUDIS Primarily distributed in placenta and skinNot Available DME0221 FUNCTION This enzyme is responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo- Delta(4)-steroidsNot Available It specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosteroneNot Available Additionally, it catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active formsNot Available And it specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR and converts androstanedione, a precursor of testosterone and estrone, to epiandrosteroneNot Available DME0225 DME___ID DME0225 DME0225 DME_NAME Cytosolic phospholipase A2 (PLA2G4A) DME0225 SPESNAME Homo sapiens DME0225 TISSUDIS Primarily distributed in ductus deferens, parathyroid gland and seminal vesicleNot Available DME0225 FUNCTION This enzyme selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acidNot Available DME0203 DME___ID DME0203 DME0203 DME_NAME Fatty acid desaturase 2 (FADS2) DME0203 SPESNAME Homo sapiens DME0203 TISSUDIS Primarily distributed in liver, brain, lung, heart and retinaNot Available DME0203 FUNCTION This enzyme acts as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chainNot Available It is involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursorsNot Available It catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectivelyNot Available Subsequently, in the biosynthetic pathway of HUFA n- 3 series, desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system functionNot Available DME0234 DME___ID DME0234 DME0234 DME_NAME Succinic semialdehyde reductase (AKR7A2) DME0234 SPESNAME Homo sapiens DME0234 TISSUDIS Primarily distributed in brain, liver, small intestine and testisNot Available Also expressed in heart, prostate, skeletal muscle and spleenNot Available DME0234 FUNCTION This enzyme catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrateNot Available It may have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB) and has broad substrate specificityNot Available It also has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2- aldehyde (in vitro)Not Available It can reduce 1,2-naphthoquinone and 9,10- phenanthrenequinone (in vitro) and reduce the dialdehyde protein- binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcoholNot Available It may be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogenNot Available DME0438 DME___ID DME0438 DME0438 DME_NAME Phosphodiesterase 7B (PDE7B) DME0438 SPESNAME Homo sapiens DME0438 TISSUDIS Primarily distributed in brainNot Available Also expressed in heart, liver, skeletal muscle and pancreasNot Available DME0438 FUNCTION This enzyme hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processesNot Available DME0468 DME___ID DME0468 DME0468 DME_NAME NADPH:quinone reductase (CRYZ) DME0468 SPESNAME Homo sapiens DME0468 TISSUDIS Primarily distributed in kidney and liverNot Available DME0468 FUNCTION This enzyme acts in the detoxification of xenobioticsNot Available DME0219 DME___ID DME0219 DME0219 DME_NAME Steroid 5-alpha-reductase 3 (SRD5A3) DME0219 SPESNAME Homo sapiens DME0219 TISSUDIS Low tissue/organ specificityNot Available DME0219 FUNCTION This enzyme plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolicholNot Available It acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism and is also able to convert testosterone (T) into 5- alpha-dihydrotestosterone (DHT)Not Available DME0204 DME___ID DME0204 DME0204 DME_NAME Steroid 5-alpha-reductase 1 (SRD5A1) DME0204 SPESNAME Homo sapiens DME0204 TISSUDIS Primarily distributed in liverNot Available DME0204 FUNCTION This enzyme converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroidsNot Available DME0207 DME___ID DME0207 DME0207 DME_NAME Proline dehydrogenase 1 (PRODH) DME0207 SPESNAME Homo sapiens DME0207 TISSUDIS Primarily distributed in lung, skeletal muscle, brain and intestineNot Available DME0207 FUNCTION This enzyme converts proline to delta-1-pyrroline-5-carboxylateNot Available DME0068 DME___ID DME0068 DME0068 DME_NAME NADPH-dependent carbonyl reductase 3 (CBR3) DME0068 SPESNAME Homo sapiens DME0068 TISSUDIS Primarily distributed in tongue, ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte and prostateand testisNot Available DME0068 FUNCTION This enzyme has low NADPH-dependent oxidoreductase activity towards 4- benzoylpyridine and menadione (in vitro)Not Available DME0634 DME___ID DME0634 DME0634 DME_NAME Dimethylaniline oxidase 5 (FMO5) DME0634 SPESNAME Homo sapiens DME0634 TISSUDIS Primarily distributed in intestine, liver and stomachNot Available DME0634 FUNCTION This enzyme is expressed in fetal and adult liverNot Available Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobioticsNot Available DME0403 DME___ID DME0403 DME0403 DME_NAME Arachidonate 15-lipoxygenase (ALOX15) DME0403 SPESNAME Homo sapiens DME0403 TISSUDIS Primarily distributed in adipose tissue, blood and lungNot Available DME0403 FUNCTION This enzyme catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediatorsNot Available It converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETENot Available It also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid and may also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3Not Available DME0215 DME___ID DME0215 DME0215 DME_NAME Adenosine 5'-monophosphoramidase (HINT1) DME0215 SPESNAME Homo sapiens DME0215 TISSUDIS Low tissue/organ specificityNot Available DME0215 FUNCTION This enzyme hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate)Not Available It hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl esterNot Available It can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O- phosphates with concomitant release of hydrogen sulfideNot Available DME0193 DME___ID DME0193 DME0193 DME_NAME Arylsulfatase A (ARSA) DME0193 SPESNAME Homo sapiens DME0193 TISSUDIS Low tissue/organ specificityNot Available DME0193 FUNCTION This enzyme hydrolyzes cerebroside sulfateNot Available DME0153 DME___ID DME0153 DME0153 DME_NAME Vitamin B12 methionine synthase (MTR) DME0153 SPESNAME Homo sapiens DME0153 TISSUDIS Primarily distributed in pancreas, heart, brain, skeletal muscle and placentaNot Available Also expressed at lower levels in lung, liver and kidneyNot Available DME0153 FUNCTION This enzyme catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionineNot Available Subsequently, remethylates the cofactor using methyltetrahydrofolateNot Available DME0287 DME___ID DME0287 DME0287 DME_NAME Retinal dehydrogenase 2 (ALDH1A2) DME0287 SPESNAME Homo sapiens DME0287 TISSUDIS Low tissue/organ specificityNot Available DME0287 FUNCTION This enzyme converts retinaldehyde to retinoic acidNot Available It recognizes as substrates free retinal and cellular retinol-binding protein-bound retinalNot Available It can also metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanalNot Available DME0121 DME___ID DME0121 DME0121 DME_NAME NADH-ubiquinone oxidoreductase 20 kDa (NDUFS7) DME0121 SPESNAME Homo sapiens DME0121 TISSUDIS Primarily distributed in skeletalNot Available DME0121 FUNCTION This enzyme is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I)Not AvailableComplex I functions in the transfer of electrons from NADH to the respiratory chainNot Available The immediate electron acceptor for the enzyme is believed to be ubiquinoneNot Available DME0457 DME___ID DME0457 DME0457 DME_NAME Sucrase-isomaltase intestinal (SI) DME0457 SPESNAME Homo sapiens DME0457 TISSUDIS Primarily distributed in intestineNot Available DME0457 FUNCTION This enzyme plays an important role in the final stage of carbohydrate digestionNot Available It is specific for both alpha-1,4- and alpha-1,6-oligosaccharidesNot Available DME0209 DME___ID DME0209 DME0209 DME_NAME Pyridoxamine-phosphate oxidase (PNPO) DME0209 SPESNAME Homo sapiens DME0209 TISSUDIS Primarily distributed in liverNot Available DME0209 FUNCTION This enzyme catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)Not Available DME0246 DME___ID DME0246 DME0246 DME_NAME Lactoperoxidase (LPO) DME0246 SPESNAME Homo sapiens DME0246 TISSUDIS Primarily distributed in salivaryNot Available DME0246 FUNCTION This enzyme catalyzes the oxidation of a number of inorganic and organic substrates by hydrogen peroxideNot Available These substrates include bromide and iodide and therefore lactoperoxidase can be categorised as a haloperoxidaseNot Available Another important substrate is thiocyanateNot Available DME0336 DME___ID DME0336 DME0336 DME_NAME Cysteinyl-conjugate N-acetyltransferase (NAT8) DME0336 SPESNAME Homo sapiens DME0336 TISSUDIS Primarily distributed in liver and kidneyNot Available DME0336 FUNCTION This enzyme acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acidsNot Available This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugatesNot Available The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bileNot Available Alternatively, it may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteinsNot Available DME0087 DME___ID DME0087 DME0087 DME_NAME Aldo-keto reductase 1B1 (AKR1B1) DME0087 SPESNAME Homo sapiens DME0087 TISSUDIS Primarily distributed in adrenal gland and seminal vesicleNot Available DME0087 FUNCTION This enzyme catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcoholsNot Available It displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substratesNot Available It displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinalNot Available It can also catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2- (5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamidesNot Available Besides, it plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls)Not Available DME0175 DME___ID DME0175 DME0175 DME_NAME Tryptophanyl-tRNA synthetase cytoplasmic (WARS1) DME0175 SPESNAME Homo sapiens DME0175 TISSUDIS Primarily distributed in blood and thyroid glandNot Available DME0175 FUNCTION This enzyme has aminoacylation activity while T2-TrpRS lacks itNot Available DME0174 DME___ID DME0174 DME0174 DME_NAME Tryptophan 5-hydroxylase 2 (TPH2) DME0174 SPESNAME Homo sapiens DME0174 TISSUDIS Primarily distributed in brainNot Available DME0174 FUNCTION This enzyme catalyzes the rate-limiting step in 5-HT synthesisNot Available DME0424 DME___ID DME0424 DME0424 DME_NAME Keto-steroid reductase (HSD17B7) DME0424 SPESNAME Homo sapiens DME0424 TISSUDIS Primarily distributed in adrenal gland, liver, lung and thymusNot Available DME0424 FUNCTION This enzyme is responsible for the reduction of the keto group on the C-3 of sterolsNot Available DME0459 DME___ID DME0459 DME0459 DME_NAME Indoleamine 2,3-dioxygenase 2 (IDO2) DME0459 SPESNAME Homo sapiens DME0459 TISSUDIS Primarily distributed in liver and placentaNot Available DME0459 FUNCTION This enzyme catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathwayNot Available DME0399 DME___ID DME0399 DME0399 DME_NAME Farnesol dehydrogenase (AKR1B15) DME0399 SPESNAME Homo sapiens DME0399 TISSUDIS Primarily distributed in breast, placenta, testis and adipose tissueNot Available DME0399 FUNCTION This enzyme catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compoundsNot Available In addition, it catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta- hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAsNot Available It displays strong enzymatic activity toward all-trans- retinal and 9-cis-retinal and may play a physiological role in retinoid metabolismNot Available DME0104 DME___ID DME0104 DME0104 DME_NAME Alpha-L-iduronidase (IDUA) DME0104 SPESNAME Homo sapiens DME0104 TISSUDIS Low tissue/organ specificityNot Available DME0104 FUNCTION This enzyme catalyses the hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfateNot Available DME0213 DME___ID DME0213 DME0213 DME_NAME Hydroxyacid-oxoacid transhydrogenase (ADHFE1) DME0213 SPESNAME Homo sapiens DME0213 TISSUDIS Primarily distributed in liverNot Available DME0213 FUNCTION This enzyme catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG)Not Available D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activitiesNot Available DME0476 DME___ID DME0476 DME0476 DME_NAME Brain form hexokinase (HK1) DME0476 SPESNAME Homo sapiens DME0476 TISSUDIS Primarily distributed in testisNot Available DME0476 FUNCTION This enzyme catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively) but does not phosphorylate N-acetyl-D-glucosamineNot Available DME0212 DME___ID DME0212 DME0212 DME_NAME Acetyl-CoA synthetase (ACSS2) DME0212 SPESNAME Homo sapiens DME0212 TISSUDIS Primarily distributed in skeletalNot Available DME0212 FUNCTION This enzyme catalyzes the synthesis of acetyl-CoA from short-chain fatty acidsNot Available Acetate is the preferred substrateNot Available And it can also utilize propionate with a much lower affinityNot Available DME0102 DME___ID DME0102 DME0102 DME_NAME Choline O-acetyltransferase (CHAT) DME0102 SPESNAME Homo sapiens DME0102 TISSUDIS Primarily distributed in brain and placentaNot Available DME0102 FUNCTION This enzyme catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapsesNot Available DME0250 DME___ID DME0250 DME0250 DME_NAME Xylosyl phosphatase (PXYLP1) DME0250 SPESNAME Homo sapiens DME0250 TISSUDIS Primarily distributed in spleen and fetal liverNot Available Also expressed in placenta, pancreas, kidney, thymus and colonNot Available DME0250 FUNCTION This enzyme is responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chainsNot Available DME0232 DME___ID DME0232 DME0232 DME_NAME Prostatic acid phosphatase (ACP3) DME0232 SPESNAME Homo sapiens DME0232 TISSUDIS Primarily distributed in prostate, restricted toglandular and ductal epithelial cellsNot Available DME0232 FUNCTION This enzyme dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteinsNot Available It has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasmaNot Available DME0151 DME___ID DME0151 DME0151 DME_NAME Phosphorylcholine transferase A (PCYT1A) DME0151 SPESNAME Homo sapiens DME0151 TISSUDIS Low tissue/organ specificityNot Available DME0151 FUNCTION This enzyme controls phosphatidylcholine synthesisNot Available DME0103 DME___ID DME0103 DME0103 DME_NAME Choline/ethanolaminephosphotransferase 1 (CEPT1) DME0103 SPESNAME Homo sapiens DME0103 TISSUDIS Low tissue/organ specificityNot Available DME0103 FUNCTION This enzyme catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectivelyNot Available It is involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surfaceNot Available It has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activityNot Available DME0231 DME___ID DME0231 DME0231 DME_NAME Acid phosphatase-like protein 1 (ACP6) DME0231 SPESNAME Homo sapiens DME0231 TISSUDIS Primarily distributed in kidney, heart, small intestine,muscle, liver, prostate, testis and ovaryNot Available DME0231 FUNCTION This enzyme hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerolNot Available It has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acidNot Available DME0140 DME___ID DME0140 DME0140 DME_NAME Uridine phosphorylase 2 (UPP2) DME0140 SPESNAME Homo sapiens DME0140 TISSUDIS Primarily distributed in kidney and liverNot Available DME0140 FUNCTION This enzyme catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphateNot Available It shows substrate specificity and accepts uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substratesNot Available DME0416 DME___ID DME0416 DME0416 DME_NAME Friedreich ataxia protein (FXN) DME0416 SPESNAME Homo sapiens DME0416 TISSUDIS Primarily distributed in heart, peripheral blood lymphocytes and dermal fibroblastsNot Available DME0416 FUNCTION This enzyme promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathwaysNot Available It may play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activityNot Available It may be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerizationNot Available DME0086 DME___ID DME0086 DME0086 DME_NAME Bleomycin hydrolase (BLMH) DME0086 SPESNAME Homo sapiens DME0086 TISSUDIS Primarily distributed in skinNot Available DME0086 FUNCTION This enzyme catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicityNot Available DME0132 DME___ID DME0132 DME0132 DME_NAME Alcohol dehydrogenase class-III (ADH5) DME0132 SPESNAME Homo sapiens DME0132 TISSUDIS Low tissue/organ specificityNot Available DME0132 FUNCTION This enzyme catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione, and oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioateNot Available DME0128 DME___ID DME0128 DME0128 DME_NAME Alcohol dehydrogenase class-I beta (ADH1B) DME0128 SPESNAME Homo sapiens DME0128 TISSUDIS Primarily distributed in adipose tissue and liverNot Available DME0128 FUNCTION This enzyme catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolismNot Available In vitro it can also catalyzes the NADH-dependent reduction of all-trans- retinal and its derivatives such as all-trans-4-oxoretinalNot Available DME1121 DME___ID DME1121 DME1121 DME_NAME Glutamate racemase (MurI) DME1121 SPESNAME Escherichia coli DME1121 TISSUDIS Primarily distributed in human gutNot Available DME1121 FUNCTION This enzyme is a pyridoxal-phosphate protein providing the (R)-glutamate required for cell wall biosynthesis and converting L- or D-glutamate to D- or L-glutamate, respectively, but not other amino acids such as alanine, aspartate, and glutamineNot Available DME1304 DME___ID DME1304 DME1304 DME_NAME Glutamate decarboxylase (gadB) DME1304 SPESNAME Escherichia coli DME1304 TISSUDIS Primarily distributed in human gutNot Available DME1304 FUNCTION This enzyme converts glutamate to gamma-aminobutyrate (GABA)Not Available The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartateNot Available DME1041 DME___ID DME1041 DME1041 DME_NAME NADH dehydrogenase (nuoE) DME1041 SPESNAME Streptomyces griseus DME1041 TISSUDIS Primarily distributed in human gutNot Available DME1041 FUNCTION This enzyme is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivativesNot Available DME1422 DME___ID DME1422 DME1422 DME_NAME Molybdopterin-dependent enzyme (molD) DME1422 SPESNAME Escherichia coli DME1422 TISSUDIS Primarily distributed in human gutNot Available DME1422 FUNCTION This enzyme catalyzes the conversion of doxorubicin to 7-deoxydoxorubicinol and 7-deoxydoxorubicinolone via a reductive deglycosylation mechanismNot Available DME1953 DME___ID DME1953 DME1953 DME_NAME Glutamate racemase (MurI) DME1953 SPESNAME Streptococcus mutans DME1953 TISSUDIS Primarily distributed in human oral cavityNot Available DME1953 FUNCTION This enzyme is a pyridoxal-phosphate protein providing the (R)-glutamate required for cell wall biosynthesis and converting L- or D-glutamate to D- or L-glutamate, respectively, but not other amino acids such as alanine, aspartate, and glutamineNot Available DME0184 DME___ID DME0184 DME0184 DME_NAME Methionine-R-sulfoxide reductase B1 (MSRB1) DME0184 SPESNAME Homo sapiens DME0184 TISSUDIS Primarily distributed in blood, liver and pancreasNot Available DME0184 FUNCTION This enzyme specifically reduces methionine (R)-sulfoxide back to methionineNot Available DME1242 DME___ID DME1242 DME1242 DME_NAME NADPH-dependent oxidoreductase (nfrA) DME1242 SPESNAME Staphylococcus aureus DME1242 TISSUDIS Primarily distributed in human gutNot Available DME1242 FUNCTION This enzyme reduces FMN, organic nitro compounds and disulfide DTNBNot Available And it is involved in maintenance of the cellular redox state and the disulfide stress responseNot Available DME0407 DME___ID DME0407 DME0407 DME_NAME Aquaporin adipose (AQP7) DME0407 SPESNAME Homo sapiens DME0407 TISSUDIS Primarily distributed in adipose tissue, breast and heart muscleNot Available DME0407 FUNCTION This enzyme functions as important facilitator of glycerol transport across the cell membrane and modulators in controlling the metabolism of glycerol, contributing to the pathophysiology of obesity and diabetesNot Available DME1048 DME___ID DME1048 DME1048 DME_NAME Oxygen-insensitive NADPH nitroreductase B (nfsB) DME1048 SPESNAME Escherichia coli DME1048 TISSUDIS Primarily distributed in human gutNot Available DME1048 FUNCTION This enzyme can reduce a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferredNot Available And it can reduce nitrofurazone, quinones and the anti-tumor agent CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)Not Available DME1788 DME___ID DME1788 DME1788 DME_NAME Beta-glucuronidase (uidA) DME1788 SPESNAME Escherichia coli DME1788 TISSUDIS Primarily distributed in human gutNot Available DME1788 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available DME1077 DME___ID DME1077 DME1077 DME_NAME NADPH-dependent curcumin reductase (curA) DME1077 SPESNAME Escherichia coli DME1077 TISSUDIS Primarily distributed in human gutNot Available DME1077 FUNCTION This enzyme catalyzes the metal-independent reduction of curcumin to dihydrocurcumin (DHC) as an intermediate product, followed by further reduction to tetrahydrocurcumin (THC) as an end productNot Available And the enzyme also acts on 3-octene-2-one, 3-hepten-2-one, resveratrol, and trans-2-octenalNot Available DME0313 DME___ID DME0313 DME0313 DME_NAME Glutathione S-transferase omega-1 (GSTO1) DME0313 SPESNAME Homo sapiens DME0313 TISSUDIS Primarily distributed in pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heartNot Available DME0313 FUNCTION This enzyme exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activitiesNot Available It has both S-(phenacyl)glutathione reductase and glutathione S-transferase activityNot Available It participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acidNot Available DME1110 DME___ID DME1110 DME1110 DME_NAME Arylamine N-acetyltransferase (NAT) DME1110 SPESNAME Pseudomonas aeruginosa DME1110 TISSUDIS Primarily distributed in human gutNot Available DME1110 FUNCTION This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoANot Available DME1098 DME___ID DME1098 DME1098 DME_NAME Oxygen-insensitive NADPH nitroreductase A (nfsA) DME1098 SPESNAME Escherichia coli DME1098 TISSUDIS Primarily distributed in human gutNot Available DME1098 FUNCTION This enzyme is major oxygen-insensitive nitroreductase in ENot AvailablecoliNot Available And it catalyzes the reduction of nitroaromatic compounds using NADPH, and has a broad electron acceptor specificityNot Available Moreover, it reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer productNot Available DME1087 DME___ID DME1087 DME1087 DME_NAME Hydroxybenzoate 3-monooxygenase (pobA) DME1087 SPESNAME Pseudomonas aeruginosa DME1087 TISSUDIS Primarily distributed in human gutNot Available DME1087 FUNCTION This enzyme is a flavoprotein (FAD) and can catalyzes the incorporation of an atom of dioxygen into p-hydroxybenzoate (p-OHB) to form 3,4-dihydroxybenzoate (3,4DOHB)Not Available DME0100 DME___ID DME0100 DME0100 DME_NAME Vitamin D 25-hydroxylase (CYP2R1) DME0100 SPESNAME Homo sapiens DME0100 TISSUDIS Low tissue/organ specificityNot Available DME0100 FUNCTION This enzyme has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3)Not Available DME0130 DME___ID DME0130 DME0130 DME_NAME Alcohol dehydrogenase class-II (ADH4) DME0130 SPESNAME Homo sapiens DME0130 TISSUDIS Primarily distributed in liverNot Available DME0130 FUNCTION This enzyme catalyzes the NAD-dependent oxidation of either all-trans- retinol or 9-cis-retinolNot AvailableIt also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioateNot Available Besides, it can also catalyzes the reduction of benzoquinonesNot Available DME0185 DME___ID DME0185 DME0185 DME_NAME Methionine-R-sulfoxide reductase B2 (MSRB2) DME0185 SPESNAME Homo sapiens DME0185 TISSUDIS Primarily distributed in heartNot Available DME0185 FUNCTION This enzyme specifically reduces methionine (R)-sulfoxide back to methionineNot Available DME0093 DME___ID DME0093 DME0093 DME_NAME Glutathione S-transferase theta-1 (GSTT1) DME0093 SPESNAME Homo sapiens DME0093 TISSUDIS Primarily distributed in liver and lungNot Available DME0093 FUNCTION This enzyme conjugates reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophilesNot Available It acts on 1,2-epoxy- 3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide and displays glutathione peroxidase activity with cumene hydroperoxideNot Available DME1022 DME___ID DME1022 DME1022 DME_NAME Tyramine oxidase (tynA) DME1022 SPESNAME Escherichia coli DME1022 TISSUDIS Primarily distributed in human gutNot Available DME1022 FUNCTION This enzyme can oxidize primary monoamines but have little or no activity towards diamines, such as histamine, or towards secondary and tertiary aminesNot Available DME1097 DME___ID DME1097 DME1097 DME_NAME N-ethylmaleimide reductase (nemA) DME1097 SPESNAME Escherichia coli DME1097 TISSUDIS Primarily distributed in human gutNot Available DME1097 FUNCTION This enzyme is involved in the degradation of toxic compoundsNot Available And it can use a variety of substrates, including the nitrate ester explosives glycerol trinitrate (GTN) and pentaerythritol tetranitrate (PETN), chromate and various electrophiles such as quinonesNot Available Moreover, it also can catalyze the reduction of N-ethylmaleimide (NEM) to N-ethylsuccinimideNot Available Together with NfsA and NfsB, can use the nitroaromatic explosive 2,4,6-trinitrotoluene (TNT)Not Available DME1028 DME___ID DME1028 DME1028 DME_NAME Chloramphenicolase (chlR) DME1028 SPESNAME Escherichia coli DME1028 TISSUDIS Primarily distributed in human gutNot Available DME1028 FUNCTION This enzyme catalyzes the hydrolysis of the amide bond in chloramphenicolNot Available DME1096 DME___ID DME1096 DME1096 DME_NAME Azoreductase (azoR) DME1096 SPESNAME Escherichia coli DME1096 TISSUDIS Primarily distributed in human gutNot Available DME1096 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available And it requires NADH, but not NADPH, as an electron donor for its activityNot Available And it can reduce ethyl red and methyl red, but is not able to convert sulfonated azo dyesNot Available DME0504 DME___ID DME0504 DME0504 DME_NAME NADP-dependent malic enzyme (ME1) DME0504 SPESNAME Homo sapiens DME0504 TISSUDIS Primarily distributed in liver, placenta and white adipose tissueNot Available DME0504 FUNCTION This enzyme is reversible oxidative decarboxylation of malate to pyruvate, links the glycolytic and citric acid cyclesNot Available DME0579 DME___ID DME0579 DME0579 DME_NAME Glutamate carboxypeptidase II (FOLH1) DME0579 SPESNAME Homo sapiens DME0579 TISSUDIS Primarily distributed in brain, intestine and prostateNot Available DME0579 FUNCTION This enzyme has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activityNot Available It has a preference for tri- alpha-glutamate peptidesNot Available It also exhibits a dipeptidyl-peptidase IV type activityNot Available In vitro, it cleaves Gly-Pro-AMCNot Available DME0116 DME___ID DME0116 DME0116 DME_NAME Alpha-methylacyl-CoA racemase (AMACR) DME0116 SPESNAME Homo sapiens DME0116 TISSUDIS Primarily distributed in kidney and liverNot Available DME0116 FUNCTION This enzyme catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA estersNot Available DME0614 DME___ID DME0614 DME0614 DME_NAME Sulfotransferase 1C2 (SULT1C2) DME0614 SPESNAME Homo sapiens DME0614 TISSUDIS Primarily distributed in gallbladder, kidney and stomachNot Available DME0614 FUNCTION This enzyme utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmittersNot Available DME0489 DME___ID DME0489 DME0489 DME_NAME Liver-type arginase (ARG1) DME0489 SPESNAME Homo sapiens DME0489 TISSUDIS Primarily distributed in liverNot Available DME0489 FUNCTION This enzyme is a key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamidesNot Available DME0494 DME___ID DME0494 DME0494 DME_NAME Insulin-degrading enzyme (IDE) DME0494 SPESNAME Homo sapiens DME0494 TISSUDIS Low tissue/organ specificityNot Available DME0494 FUNCTION This enzyme plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, glucagon, bradykinin, kallidin and other peptidesNot Available Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulinNot Available It plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microgliaNot Available DME0613 DME___ID DME0613 DME0613 DME_NAME Glutathione S-transferase mu-4 (GSTM4) DME0613 SPESNAME Homo sapiens DME0613 TISSUDIS Primarily distributed in intestineNot Available DME0613 FUNCTION This enzyme actives on 1-chloro-2,4-dinitrobenzene and it conjugates of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophilesNot Available DME0610 DME___ID DME0610 DME0610 DME_NAME Glutathione peroxidase 6 (GPX6) DME0610 SPESNAME Homo sapiens DME0610 TISSUDIS Primarily distributed in epididymisNot Available DME0610 FUNCTION This enzyme has glutathione peroxidase activity and peroxidase activityNot Available DME0616 DME___ID DME0616 DME0616 DME_NAME Docosahexaenoic acid omega-hydroxylase (CYP4F11) DME0616 SPESNAME Homo sapiens DME0616 TISSUDIS Primarily distributed in liverNot Available Also expressed in kidney, heart and skeletal muscleNot Available DME0616 FUNCTION This enzyme involves in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivativesNot Available DME0129 DME___ID DME0129 DME0129 DME_NAME Alcohol dehydrogenase class-I gamma (ADH1C) DME0129 SPESNAME Homo sapiens DME0129 TISSUDIS Primarily distributed in intestine, liver and stomachNot Available DME0129 FUNCTION This enzyme metabolizes a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation productsNot Available DME0432 DME___ID DME0432 DME0432 DME_NAME Gamma-glutamyltranspeptidase 5 (GGT5) DME0432 SPESNAME Homo sapiens DME0432 TISSUDIS Low tissue/organ specificityNot Available DME0432 FUNCTION This enzyme cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itselfNot Available It converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4)Not Available DME0112 DME___ID DME0112 DME0112 DME_NAME Deoxycytidylate deaminase (DCTD) DME0112 SPESNAME Homo sapiens DME0112 TISSUDIS Low tissue/organ specificityNot Available DME0112 FUNCTION This enzyme supplies the nucleotide substrate for thymidylate synthetaseNot Available DME1124 DME___ID DME1124 DME1124 DME_NAME Glutamate racemase (MurI) DME1124 SPESNAME Bacillus subtilis DME1124 TISSUDIS Primarily distributed in human gutNot Available DME1124 FUNCTION This enzyme is a pyridoxal-phosphate protein providing the (R)-glutamate required for cell wall biosynthesis and converting L- or D-glutamate to D- or L-glutamate, respectively, but not other amino acids such as alanine, aspartate, and glutamineNot Available DME1125 DME___ID DME1125 DME1125 DME_NAME Glutamate racemase (MurI) DME1125 SPESNAME Bacillus pumilus DME1125 TISSUDIS Primarily distributed in human gutNot Available DME1125 FUNCTION This enzyme is a pyridoxal-phosphate protein providing the (R)-glutamate required for cell wall biosynthesis and converting L- or D-glutamate to D- or L-glutamate, respectively, but not other amino acids such as alanine, aspartate, and glutamineNot Available DME1243 DME___ID DME1243 DME1243 DME_NAME NADPH-dependent nitroreductase (nfrA1) DME1243 SPESNAME Bacillus subtilis DME1243 TISSUDIS Primarily distributed in human gutNot Available DME1243 FUNCTION This enzyme can reduce FMNH(2) to FMN, with NADPH as reductant, and also can reduce nitroaromatic compounds, quinones and azo dyesNot Available DME1104 DME___ID DME1104 DME1104 DME_NAME Arylamine N-acetyltransferase (NAT) DME1104 SPESNAME Serratia marcescens DME1104 TISSUDIS Primarily distributed in human gutNot Available DME1104 FUNCTION This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoANot Available DME1302 DME___ID DME1302 DME1302 DME_NAME General stress protein 14 (ywrO) DME1302 SPESNAME Bacillus subtilis DME1302 TISSUDIS Primarily distributed in human gutNot Available DME1302 FUNCTION This enzyme has electron transfer activity, FMN binding, and NAD(P)H dehydrogenase (quinone) activityNot Available DME1039 DME___ID DME1039 DME1039 DME_NAME Molybdopterin-dependent enzyme (molD) DME1039 SPESNAME Klebsiella pneumoniae DME1039 TISSUDIS Primarily distributed in human gutNot Available DME1039 FUNCTION This enzyme catalyzes the conversion of doxorubicin to 7-deoxydoxorubicinol and 7-deoxydoxorubicinolone via a reductive deglycosylation mechanismNot Available DME2014 DME___ID DME2014 DME2014 DME_NAME Insulin-degrading enzyme (ide) DME2014 SPESNAME Vibrio vulnificus DME2014 TISSUDIS Primarily distributed in human gutNot Available DME2014 FUNCTION This enzyme catalyzes the hydrolysis of insulinNot Available DME1090 DME___ID DME1090 DME1090 DME_NAME Aminoglycoside phosphotransferase (aph-Ib) DME1090 SPESNAME Campylobacter jejuni DME1090 TISSUDIS Primarily distributed in human gutNot Available DME1090 FUNCTION This enzyme is the most clinically important aminoglycoside-modifying enzyme in Gram-positive bacteria, responsible for high-level resistance in both Enterococci and StaphylococciNot Available And this bacterial enzyme phosphorylates many 4,6-disubstituted aminoglycoside antibiotics that have a hydroxyl group at position 2'', including kanamycin A, kanamycin B, tobramycin, dibekacin, arbekacin, amikacin, gentamicin C, sisomicin and netilmicinNot Available DME1968 DME___ID DME1968 DME1968 DME_NAME Nitroreductase (NTR) DME1968 SPESNAME Salmonella typhimurium DME1968 TISSUDIS Primarily distributed in human gutNot Available DME1968 FUNCTION This enzyme catalyzes the reduction of a variety of nitroaromatic compoundsNot Available DME1063 DME___ID DME1063 DME1063 DME_NAME Nitroreductase (NTR) DME1063 SPESNAME Salmonella enterica DME1063 TISSUDIS Primarily distributed in human gutNot Available DME1063 FUNCTION This enzyme can reduce other azo dyes, such as Methyl Red, Rocceline, Solar Orange and Sumifix Black BNot Available DME1461 DME___ID DME1461 DME1461 DME_NAME Homoserine-O-transsuccinylase (metAA) DME1461 SPESNAME Salmonella enterica DME1461 TISSUDIS Primarily distributed in human gutNot Available DME1461 FUNCTION This enzyme catalyzes the conversion of L-homoserine to O-succinyl-L-homoserine and takes part in methionine metabolism and sulfur metabolismNot Available DME1023 DME___ID DME1023 DME1023 DME_NAME Beta-lactamase (blaB) DME1023 SPESNAME Klebsiella pneumoniae DME1023 TISSUDIS Primarily distributed in human lungNot Available DME1023 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1024 DME___ID DME1024 DME1024 DME_NAME Beta-lactamase (blaB) DME1024 SPESNAME Klebsiella variicola DME1024 TISSUDIS Primarily distributed in human lungNot Available DME1024 FUNCTION This enzyme hydrolyzes cefotaxime, ceftazidime and other broad spectrum cephalosporinsNot Available DME1055 DME___ID DME1055 DME1055 DME_NAME Cytidine deaminase (cdd) DME1055 SPESNAME Escherichia coli DME1055 TISSUDIS Primarily distributed in human gutNot Available DME1055 FUNCTION This enzyme catalyzes the deamination of cytidine and 2'-deoxycytidine with similar efficienciesNot Available It is involved in salvage of both exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesisNot Available DME1056 DME___ID DME1056 DME1056 DME_NAME Cytidine deaminase (cdd) DME1056 SPESNAME Klebsiella pneumoniae DME1056 TISSUDIS Primarily distributed in human gutNot Available DME1056 FUNCTION This enzyme catalyzes the deamination of cytidine and 2'-deoxycytidine with similar efficienciesNot Available It is involved in salvage of both exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesisNot Available DME1106 DME___ID DME1106 DME1106 DME_NAME Arylamine N-acetyltransferase (NAT) DME1106 SPESNAME Klebsiella pneumoniae DME1106 TISSUDIS Primarily distributed in human gutNot Available DME1106 FUNCTION This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoANot Available DME1115 DME___ID DME1115 DME1115 DME_NAME S-adenosylhomocysteine nucleosidase (mtnN) DME1115 SPESNAME Klebsiella pneumoniae DME1115 TISSUDIS Primarily distributed in human gutNot Available DME1115 FUNCTION This enzyme acts on S-methyl-5'-thioadenosine to give adenine and S-methyl-5-thioriboseNot Available DME1971 DME___ID DME1971 DME1971 DME_NAME Oxygen-insensitive NADPH nitroreductase A (nfsA) DME1971 SPESNAME Salmonella enterica DME1971 TISSUDIS Primarily distributed in human gutNot Available DME1971 FUNCTION This enzyme catalyzes the reduction of nitroaromatic compounds using NADPH, and has a broad electron acceptor specificityNot Available Moreover, it reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer productNot Available DME1881 DME___ID DME1881 DME1881 DME_NAME Metallo-beta-lactamase (blaM) DME1881 SPESNAME Klebsiella pneumoniae DME1881 TISSUDIS Primarily distributed in human gutNot Available DME1881 FUNCTION This enzyme confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring but does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacinNot Available DME1303 DME___ID DME1303 DME1303 DME_NAME Glutamate decarboxylase (gadB) DME1303 SPESNAME Listeria monocytogenes DME1303 TISSUDIS Primarily distributed in human gutNot Available DME1303 FUNCTION This enzyme converts internalized glutamate to GABANot Available The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartateNot Available DME1880 DME___ID DME1880 DME1880 DME_NAME Beta-lactamase (blaB) DME1880 SPESNAME Klebsiella aerogenes DME1880 TISSUDIS Primarily distributed in human gutNot Available DME1880 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1111 DME___ID DME1111 DME1111 DME_NAME Arylamine N-acetyltransferase (NAT) DME1111 SPESNAME Salmonella enterica DME1111 TISSUDIS Primarily distributed in human gutNot Available DME1111 FUNCTION This enzyme catalyzes both the acetyl-CoA-dependent N-acetylation of aromatic amines and the O-acetylation of N-hydroxyarylaminesNot Available And in vitro, it catalyzes the O-acetylation of N-hydroxy-Glu-P-1, and the N-acetylation of isoniazid and 2-aminofluoreneNot Available DME1076 DME___ID DME1076 DME1076 DME_NAME Nicotinamidase (pncA) DME1076 SPESNAME Acinetobacter baumannii DME1076 TISSUDIS Primarily distributed in human lungNot Available DME1076 FUNCTION This enzyme acts on carbon-nitrogen bonds and takes part in nicotinate and nicotinamide metabolismNot Available DME1732 DME___ID DME1732 DME1732 DME_NAME New delhi metallo-beta-lactamase NDM-1 (blaNDM) DME1732 SPESNAME Salmonella enterica DME1732 TISSUDIS Primarily distributed in human gutNot Available DME1732 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1088 DME___ID DME1088 DME1088 DME_NAME Hydroxybenzoate 3-monooxygenase (pobA) DME1088 SPESNAME Pseudomonas fluorescens DME1088 TISSUDIS Primarily distributed in human gutNot Available DME1088 FUNCTION This enzyme is a flavoprotein (FAD) and can catalyzes the incorporation of an atom of dioxygen into p-hydroxybenzoate (p-OHB) to form 3,4-dihydroxybenzoate (3,4DOHB)Not Available DME1068 DME___ID DME1068 DME1068 DME_NAME Aminoglycoside O-phosphotransferase (aphA6) DME1068 SPESNAME Acinetobacter baumannii DME1068 TISSUDIS Primarily distributed in human lungNot Available DME1068 FUNCTION This enzyme acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin ANot Available DME1172 DME___ID DME1172 DME1172 DME_NAME Aminoglycoside N-acetyltransferase (aacC2) DME1172 SPESNAME Acinetobacter baumannii DME1172 TISSUDIS Primarily distributed in human lungNot Available DME1172 FUNCTION This enzyme catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, kanamycin, tobramycin and netilmicinNot Available DME1075 DME___ID DME1075 DME1075 DME_NAME Cytochrome P450 102A1 (cyp102) DME1075 SPESNAME Bacillus megaterium DME1075 TISSUDIS Primarily distributed in human gutNot Available DME1075 FUNCTION This enzyme is P-450 heme-thiolate protein, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groupsNot Available DME1061 DME___ID DME1061 DME1061 DME_NAME Tyrosine decarboxylase (tdc) DME1061 SPESNAME Enterococcus faecalis DME1061 TISSUDIS Primarily distributed in human gutNot Available DME1061 FUNCTION This enzyme catalyzes the decarboxylation of L-tyrosine to produce tyramineNot Available DME1069 DME___ID DME1069 DME1069 DME_NAME Nicotinate dehydrogenase (nicA) DME1069 SPESNAME Pseudomonas putida DME1069 TISSUDIS Primarily distributed in human gutNot Available DME1069 FUNCTION This enzyme is subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathwayNot Available And it mediates conversion of nicotinate into 6-hydroxynicotinate (6HNA)Not Available DME1239 DME___ID DME1239 DME1239 DME_NAME Folylpolyglutamate synthetase (fpgS) DME1239 SPESNAME Lactobacillus casei DME1239 TISSUDIS Primarily distributed in human gutNot Available DME1239 FUNCTION This enzyme is involved in the conversion of folates to polyglutamate derivatives, and likely functions in the retention of cellular folate poolsNot Available It catalyzes successive MgATP-dependent additions of glutamate to a pteroylmonoglutamate substrate, with a high preference for 5,10-methylenetetrahydrofolate (mTHF)Not Available Thus, it metabolizes mTHF to the tetraglutamate derivative, but longer glutamate chain length products are not observedNot Available DME1072 DME___ID DME1072 DME1072 DME_NAME Cytochrome P450 MEG (cyp106) DME1072 SPESNAME Bacillus megaterium DME1072 TISSUDIS Primarily distributed in human gutNot Available DME1072 FUNCTION This enzyme has the capacity to hydroxylate certain steroids in the 15-beta position, and it also hydroxylates progesterone in the 11-alpha and 9-beta positionNot Available DME1085 DME___ID DME1085 DME1085 DME_NAME VanA ligase (vanA) DME1085 SPESNAME Enterococcus faecalis DME1085 TISSUDIS Primarily distributed in human gutNot Available DME1085 FUNCTION This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6Not Available3Not Available2Not Available7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6Not Available3Not Available2Not Available13), UDP-N-acetylmuramate---L-alanine ligase (EC 6Not Available3Not Available2Not Available8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6Not Available3Not Available2Not Available9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6Not Available3Not Available2Not Available10) in the synthesis of a cell-wall peptideNot Available DME1123 DME___ID DME1123 DME1123 DME_NAME Glutamate racemase (MurI) DME1123 SPESNAME Lactobacillus fermentum DME1123 TISSUDIS Primarily distributed in human gutNot Available DME1123 FUNCTION This enzyme is a pyridoxal-phosphate protein providing the (R)-glutamate required for cell wall biosynthesis and converting L- or D-glutamate to D- or L-glutamate, respectively, but not other amino acids such as alanine, aspartate, and glutamineNot Available DME1126 DME___ID DME1126 DME1126 DME_NAME Glutamate racemase (MurI) DME1126 SPESNAME Bacillus anthracis DME1126 TISSUDIS Primarily distributed in human gutNot Available DME1126 FUNCTION This enzyme is a pyridoxal-phosphate protein providing the (R)-glutamate required for cell wall biosynthesis and converting L- or D-glutamate to D- or L-glutamate, respectively, but not other amino acids such as alanine, aspartate, and glutamineNot Available DME1118 DME___ID DME1118 DME1118 DME_NAME Glutamate decarboxylase (gadB) DME1118 SPESNAME Lactobacillus johnsonii DME1118 TISSUDIS Primarily distributed in human gutNot Available DME1118 FUNCTION This enzyme acts on L-cysteate, 3-sulfino-L-alanine and L-aspartateNot Available DME1305 DME___ID DME1305 DME1305 DME_NAME Glutamate decarboxylase (gadB) DME1305 SPESNAME Shigella flexneri DME1305 TISSUDIS Primarily distributed in human gutNot Available DME1305 FUNCTION This enzyme converts glutamate to gamma-aminobutyrate (GABA)Not Available The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartateNot Available DME1306 DME___ID DME1306 DME1306 DME_NAME Glutamate decarboxylase (gadB) DME1306 SPESNAME Lactococcus lactis DME1306 TISSUDIS Primarily distributed in human gutNot Available DME1306 FUNCTION This enzyme converts internalized glutamate to GABANot Available The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartateNot Available DME1339 DME___ID DME1339 DME1339 DME_NAME Glutamate decarboxylase (gadB) DME1339 SPESNAME Lactobacillus plantarum DME1339 TISSUDIS Primarily distributed in human gutNot Available DME1339 FUNCTION This enzyme acts on L-cysteate, 3-sulfino-L-alanine and L-aspartateNot Available DME1344 DME___ID DME1344 DME1344 DME_NAME Glutamate decarboxylase (gadB) DME1344 SPESNAME Bifidobacterium adolescentis DME1344 TISSUDIS Primarily distributed in human gutNot Available DME1344 FUNCTION This enzyme acts on L-cysteate, 3-sulfino-L-alanine and L-aspartateNot Available DME1550 DME___ID DME1550 DME1550 DME_NAME Cytochrome P450 142A2 (cyp142) DME1550 SPESNAME Mycolicibacterium smegmatis DME1550 TISSUDIS Primarily distributed in human lungNot Available DME1550 FUNCTION This enzyme is a P-450 heme-thiolate protein, and it is involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chainNot Available Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oateNot Available Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-oneNot Available DME1549 DME___ID DME1549 DME1549 DME_NAME Cytochrome P450 125A3 (cyp125) DME1549 SPESNAME Mycolicibacterium smegmatis DME1549 TISSUDIS Primarily distributed in human lungNot Available DME1549 FUNCTION This enzyme is a P-450 heme-thiolate protein found in several bacterial pathogens, and it is involved in degradation of the host's cholesterolNot Available The enzyme catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol Not Available The products are exclusively in the (25S) configurationNot Available And it also accepts cholesterol as a substrateNot Available DME2100 DME___ID DME2100 DME2100 DME_NAME Beta-lactamase (blaB) DME2100 SPESNAME Burkholderia multivorans DME2100 TISSUDIS Primarily distributed in human lungNot Available DME2100 FUNCTION This enzyme hydrolyzes beta-lactam with a substrate specificity for penicillinNot Available DME1315 DME___ID DME1315 DME1315 DME_NAME Azoreductase (azoR) DME1315 SPESNAME Enterococcus faecalis DME1315 TISSUDIS Primarily distributed in human gutNot Available DME1315 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available And it requires NADH, but not NADPH, as an electron donor for its activityNot Available And it can also reduce a wide range of sulfonated azo dyesNot Available The substrate preference order is methyl Red > Orange II > Ponceau BS > Ponceau S > Orange G > AmaranthNot Available DME1472 DME___ID DME1472 DME1472 DME_NAME Cytochrome P450 21A2 (cyp21) DME1472 SPESNAME Bacillus megaterium DME1472 TISSUDIS Primarily distributed in human gutNot Available DME1472 FUNCTION This enzyme is a P-450 heme-thiolate protein and it responsible for the conversion of progesterone and 17alpha-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisolNot Available Involved in the biosynthesis of the hormones aldosterone and cortisolNot Available The electron donor is NADPH---hemoprotein reductaseNot Available DME1328 DME___ID DME1328 DME1328 DME_NAME Nitroreductase (NTR) DME1328 SPESNAME Enterococcus gallinarum DME1328 TISSUDIS Primarily distributed in human gutNot Available DME1328 FUNCTION This enzyme contains FMN and can utilize NADH and NADPH with similar reaction ratesNot Available It also reduces riboflavin and FAD, but more slowlyNot Available DME1442 DME___ID DME1442 DME1442 DME_NAME Cytochrome P450 130A1 (cyp130) DME1442 SPESNAME Mycobacterium tuberculosis DME1442 TISSUDIS Primarily distributed in human gutNot Available DME1442 FUNCTION This enzyme catalyzes the N-demethylation of dextromethorphan yielding 3-methoxymorphinanNot Available DME1245 DME___ID DME1245 DME1245 DME_NAME Nitroreductase (NTR) DME1245 SPESNAME Clostridium perfringens DME1245 TISSUDIS Primarily distributed in human gutNot Available DME1245 FUNCTION This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compoundsNot Available DME1049 DME___ID DME1049 DME1049 DME_NAME Dihydrofolate reductase (folA) DME1049 SPESNAME Escherichia coli DME1049 TISSUDIS Primarily distributed in human gutNot Available DME1049 FUNCTION This enzyme is key enzyme in folate metabolism and can catalyze an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesisNot Available And it also slowly reduces folate to 5,6,7,8-tetrahydrofolateNot Available DME1050 DME___ID DME1050 DME1050 DME_NAME Dihydrofolate reductase (folA) DME1050 SPESNAME Lactobacillus casei DME1050 TISSUDIS Primarily distributed in human gutNot Available DME1050 FUNCTION This enzyme is key enzyme in folate metabolism and can catalyze an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesisNot Available And it also slowly reduces folate to 5,6,7,8-tetrahydrofolateNot Available DME1042 DME___ID DME1042 DME1042 DME_NAME Beta-glucuronidase (uidA) DME1042 SPESNAME Lactobacillus sakei DME1042 TISSUDIS Primarily distributed in human gutNot Available DME1042 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1247 DME___ID DME1247 DME1247 DME_NAME Nitroreductase (NTR) DME1247 SPESNAME Enterobacter cloacae DME1247 TISSUDIS Primarily distributed in human gutNot Available DME1247 FUNCTION This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compoundsNot Available DME1089 DME___ID DME1089 DME1089 DME_NAME Hydroxybenzoate 3-monooxygenase (pobA) DME1089 SPESNAME Pseudomonas putida DME1089 TISSUDIS Primarily distributed in human gutNot Available DME1089 FUNCTION This enzyme is a flavoprotein (FAD) and can catalyzes the incorporation of an atom of dioxygen into p-hydroxybenzoate (p-OHB) to form 3,4-dihydroxybenzoate (3,4DOHB)Not Available DME1094 DME___ID DME1094 DME1094 DME_NAME Beta-lactamase (blaB) DME1094 SPESNAME Citrobacter freundii DME1094 TISSUDIS Primarily distributed in human gutNot Available DME1094 FUNCTION This enzyme hydrolyzes beta-lactam with a substrate specificity for cephalosporinsNot Available DME1102 DME___ID DME1102 DME1102 DME_NAME Arylamine N-acetyltransferase (NAT) DME1102 SPESNAME Morganella morganii DME1102 TISSUDIS Primarily distributed in human gutNot Available DME1102 FUNCTION This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoANot Available DME1103 DME___ID DME1103 DME1103 DME_NAME Arylamine N-acetyltransferase (NAT) DME1103 SPESNAME Citrobacter freundii DME1103 TISSUDIS Primarily distributed in human gutNot Available DME1103 FUNCTION This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoANot Available DME1086 DME___ID DME1086 DME1086 DME_NAME VanA ligase (vanA) DME1086 SPESNAME Enterococcus faecium DME1086 TISSUDIS Primarily distributed in human gutNot Available DME1086 FUNCTION This enzyme is required for high-level resistance to glycopeptide antibioticsNot Available D-Ala--D-Ala ligase of altered specificity catalyzes ester bond formation between D-Ala and various D-hydroxy acids and produces a peptidoglycan which does not terminate in D-alanine but in D-lactate, thus preventing vancomycin or teicoplanin bindingNot Available DME1296 DME___ID DME1296 DME1296 DME_NAME Metallo-beta-lactamase (blaM) DME1296 SPESNAME Achromobacter xylosoxidans DME1296 TISSUDIS Primarily distributed in human stomachNot Available DME1296 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1353 DME___ID DME1353 DME1353 DME_NAME Gamma-glutamylcyclotransferase (GGCT) DME1353 SPESNAME Ralstonia solanacearum DME1353 TISSUDIS Primarily distributed in human vaginaNot Available DME1353 FUNCTION This enzyme acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine and acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-prolineNot Available DME1234 DME___ID DME1234 DME1234 DME_NAME Cytochrome P450 124 (cyp124) DME1234 SPESNAME Mycobacterium tuberculosis DME1234 TISSUDIS Primarily distributed in human gutNot Available DME1234 FUNCTION This enzyme is a P-450 heme-thiolate protein, and it primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphateNot Available And it also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oateNot Available DME1057 DME___ID DME1057 DME1057 DME_NAME Catechol-2,3-dioxygenase (caD) DME1057 SPESNAME Bacillus pumilus DME1057 TISSUDIS Primarily distributed in human gutNot Available DME1057 FUNCTION This enzyme initiates the meta-cleavage pathway of catechol degradation and requires FeIINot Available DME1033 DME___ID DME1033 DME1033 DME_NAME Beta-lactamase (blaB) DME1033 SPESNAME Edwardsiella tarda DME1033 TISSUDIS Primarily distributed in human gutNot Available DME1033 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1345 DME___ID DME1345 DME1345 DME_NAME Azoreductase (azoR) DME1345 SPESNAME Enterococcus faecium DME1345 TISSUDIS Primarily distributed in human gutNot Available DME1345 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available And it requires NADH, but not NADPH, as an electron donor for its activityNot Available DME1092 DME___ID DME1092 DME1092 DME_NAME Aldehyde oxidase (AOX) DME1092 SPESNAME Clostridium sporogenes DME1092 TISSUDIS Primarily distributed in human gutNot Available DME1092 FUNCTION This enzyme acts on a variety of purines and aldehydes, including hypoxanthineNot Available DME1552 DME___ID DME1552 DME1552 DME_NAME Cytochrome P450 142A1 (cyp142) DME1552 SPESNAME Mycobacterium tuberculosis DME1552 TISSUDIS Primarily distributed in human gutNot Available DME1552 FUNCTION This enzyme is a P-450 heme-thiolate protein, and it is involved in degradation of the host cholesterolNot Available The enzyme catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterolNot Available The products are exclusively in the (25R) conformationNot Available And it also accepts cholesterol as a substrateNot Available DME1551 DME___ID DME1551 DME1551 DME_NAME Cytochrome P450 125A1 (cyp125) DME1551 SPESNAME Mycobacterium tuberculosis DME1551 TISSUDIS Primarily distributed in human gutNot Available DME1551 FUNCTION This enzyme is a P-450 heme-thiolate protein found in several bacterial pathogens, and it is involved in degradation of the host's cholesterolNot Available The enzyme catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol Not Available The products are exclusively in the (25S) configurationNot Available And it also accepts cholesterol as a substrateNot Available DME1553 DME___ID DME1553 DME1553 DME_NAME Tyrosine decarboxylase (tdc) DME1553 SPESNAME Lactobacillus brevis DME1553 TISSUDIS Primarily distributed in human gutNot Available DME1553 FUNCTION This enzyme catalyzes the decarboxylation of L-tyrosine to produce tyramineNot Available DME1052 DME___ID DME1052 DME1052 DME_NAME Glyceraldehyde-3-phosphate dehydrogenase (gap) DME1052 SPESNAME Lactobacillus acidophilus DME1052 TISSUDIS Primarily distributed in human gutNot Available DME1052 FUNCTION This enzyme takes part in glucose metabolic processNot Available DME1865 DME___ID DME1865 DME1865 DME_NAME Flavin adenine dinucleotide dehydrogenase (fadd) DME1865 SPESNAME Clostridium perfringens DME1865 TISSUDIS Primarily distributed in human gutNot Available DME1865 FUNCTION This enzyme can reduce either FAD or flavin mononucleotide (FMN) but prefers FADNot Available But it can not reduce riboflavin and does not use NADPH as acceptorNot Available DME1053 DME___ID DME1053 DME1053 DME_NAME L-arabinose isomerase (araA) DME1053 SPESNAME Lactobacillus sakei DME1053 TISSUDIS Primarily distributed in human gutNot Available DME1053 FUNCTION This enzyme catalyzes the conversion of L-arabinose to L-ribuloseNot Available It requires a divalent metal ion and binds the closed form of the sugar and catalyses ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene-diol mechanismNot Available It can also convert D-galactose to D-tagatose with lower efficiencyNot Available DME1002 DME___ID DME1002 DME1002 DME_NAME Dipeptidase (pepV) DME1002 SPESNAME Lactococcus lactis DME1002 TISSUDIS Primarily distributed in human gutNot Available DME1002 FUNCTION This enzyme catalyzes the conversion of dipeptides into amino acidsNot Available DME1140 DME___ID DME1140 DME1140 DME_NAME Beta-galactosidase (bgaB) DME1140 SPESNAME Bifidobacterium adolescentis DME1140 TISSUDIS Primarily distributed in human gutNot Available DME1140 FUNCTION This enzyme is involved in the hydrolysis of transgalactooligosaccharidesNot Available DME1100 DME___ID DME1100 DME1100 DME_NAME Arylamine N-acetyltransferase (NAT) DME1100 SPESNAME Shigella flexneri DME1100 TISSUDIS Primarily distributed in human gutNot Available DME1100 FUNCTION This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoANot Available DME1108 DME___ID DME1108 DME1108 DME_NAME Arylamine N-acetyltransferase (NAT) DME1108 SPESNAME Klebsiella oxytoca DME1108 TISSUDIS Primarily distributed in human gutNot Available DME1108 FUNCTION This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoANot Available DME1317 DME___ID DME1317 DME1317 DME_NAME Alcohol dehydrogenase (ADH) DME1317 SPESNAME Lactobacillus reuteri DME1317 TISSUDIS Primarily distributed in human gutNot Available DME1317 FUNCTION This enzyme uses NAD+ to oxidize ethanol and 1,3-propanediolNot Available DME1630 DME___ID DME1630 DME1630 DME_NAME VanA ligase (vanA) DME1630 SPESNAME Enterococcus gallinarum DME1630 TISSUDIS Primarily distributed in human gutNot Available DME1630 FUNCTION This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6Not Available3Not Available2Not Available7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6Not Available3Not Available2Not Available13), UDP-N-acetylmuramate---L-alanine ligase (EC 6Not Available3Not Available2Not Available8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6Not Available3Not Available2Not Available9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6Not Available3Not Available2Not Available10) in the synthesis of a cell-wall peptideNot Available DME1113 DME___ID DME1113 DME1113 DME_NAME Thymidylate synthase (thyA) DME1113 SPESNAME Lactobacillus casei DME1113 TISSUDIS Primarily distributed in human gutNot Available DME1113 FUNCTION This enzyme catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-productNot Available DME1058 DME___ID DME1058 DME1058 DME_NAME Propanediol dehydrogenase (dhaT) DME1058 SPESNAME Lactobacillus brevis DME1058 TISSUDIS Primarily distributed in human gutNot Available DME1058 FUNCTION This enzyme uses NAD+ to oxidize 1,3-propanediol, glycerol, ethanol and 1,2-propanediolNot Available This enzyme required Mn2+ and are probably octamers with a molecular mass of 350 kDaNot Available DME1331 DME___ID DME1331 DME1331 DME_NAME Nitroreductase (NTR) DME1331 SPESNAME Clostridium sporogenes DME1331 TISSUDIS Primarily distributed in human gutNot Available DME1331 FUNCTION This enzyme contains FMN and can utilize NADH and NADPH with similar reaction ratesNot Available It also reduces riboflavin and FAD, but more slowlyNot Available DME1957 DME___ID DME1957 DME1957 DME_NAME Methylenetetrahydrofolate reductase (metF) DME1957 SPESNAME Streptococcus sanguinis DME1957 TISSUDIS Primarily distributed in human oral cavityNot Available DME1957 FUNCTION This enzyme is a flavoprotein (FAD)Not Available And Menadione can also serve as an electron acceptorNot Available DME1137 DME___ID DME1137 DME1137 DME_NAME Maltose phosphorylase (malP) DME1137 SPESNAME Lactobacillus acidophilus DME1137 TISSUDIS Primarily distributed in human gutNot Available DME1137 FUNCTION This enzyme catalyzes the conversion of maltose to D-glucose and beta-D-glucose 1-phosphateNot Available DME1029 DME___ID DME1029 DME1029 DME_NAME Glycerol-3-phosphate dehydrogenase (gpsA) DME1029 SPESNAME Erysipelothrix rhusiopathiae DME1029 TISSUDIS Primarily distributed in human gutNot Available DME1029 FUNCTION This enzyme shows specificity for the B side of NADPHNot Available DME1030 DME___ID DME1030 DME1030 DME_NAME Chloramphenicolase (chlR) DME1030 SPESNAME Bacillus pumilus DME1030 TISSUDIS Primarily distributed in human gutNot Available DME1030 FUNCTION This enzyme catalyzes the hydrolysis of the amide bond in chloramphenicolNot Available DME1031 DME___ID DME1031 DME1031 DME_NAME Chloramphenicolase (chlR) DME1031 SPESNAME Proteus penneri DME1031 TISSUDIS Primarily distributed in human gutNot Available DME1031 FUNCTION This enzyme catalyzes the hydrolysis of the amide bond in chloramphenicolNot Available DME1134 DME___ID DME1134 DME1134 DME_NAME Cellobiose 2-epimerase (CE) DME1134 SPESNAME Ruminococcus albus DME1134 TISSUDIS Primarily distributed in human gutNot Available DME1134 FUNCTION This enzyme catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man)Not Available It can also epimerizes cellotriose to Glc-Glc-Man, cellotetraose to Glc-Glc-Glc-Man, and lactose to epilactoseNot Available DME1004 DME___ID DME1004 DME1004 DME_NAME Beta-lactamase (blaB) DME1004 SPESNAME Enterobacter cloacae DME1004 TISSUDIS Primarily distributed in human gutNot Available DME1004 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1016 DME___ID DME1016 DME1016 DME_NAME Beta-lactamase (blaB) DME1016 SPESNAME Prevotella melaninogenica DME1016 TISSUDIS Primarily distributed in human gutNot Available DME1016 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1298 DME___ID DME1298 DME1298 DME_NAME Beta-lactamase (blaB) DME1298 SPESNAME Shigella sonnei DME1298 TISSUDIS Primarily distributed in human gutNot Available DME1298 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1047 DME___ID DME1047 DME1047 DME_NAME Beta-glucosidase (bglA) DME1047 SPESNAME Trichophyton rubrum DME1047 TISSUDIS Primarily distributed in human skinNot Available DME1047 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1080 DME___ID DME1080 DME1080 DME_NAME Azoreductase (azoR) DME1080 SPESNAME Streptococcus salivarius DME1080 TISSUDIS Primarily distributed in human gutNot Available DME1080 FUNCTION This enzyme can reduce other azo dyes, such as Methyl Red, Rocceline, Solar Orange and Sumifix Black BNot Available DME1081 DME___ID DME1081 DME1081 DME_NAME Azoreductase (azoR) DME1081 SPESNAME Enterococcus casseliflavus DME1081 TISSUDIS Primarily distributed in human gutNot Available DME1081 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available And it requires NADH, but not NADPH, as an electron donor for its activityNot Available DME1316 DME___ID DME1316 DME1316 DME_NAME Azoreductase (azoR) DME1316 SPESNAME Clostridium perfringens DME1316 TISSUDIS Primarily distributed in human gutNot Available DME1316 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available And it requires NADH, but not NADPH, as an electron donor for its activityNot Available DME1475 DME___ID DME1475 DME1475 DME_NAME Azoreductase (azoR) DME1475 SPESNAME Lactobacillus acidophilus DME1475 TISSUDIS Primarily distributed in human gutNot Available DME1475 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available DME0210 DME___ID DME0210 DME0210 DME_NAME Thioredoxin reductase TR1 (TXNRD1) DME0210 SPESNAME Homo sapiens DME0210 TISSUDIS Primarily distributed in ovary, spleen, heart, liver, kidney and pancreasNot Available DME0210 FUNCTION This enzyme possesses glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusionsNot Available DME0110 DME___ID DME0110 DME0110 DME_NAME Glutathione reductase (GSR) DME0110 SPESNAME Homo sapiens DME0110 TISSUDIS Low tissue/organ specificityNot Available DME0110 FUNCTION This enzyme catalyzes the reduction of glutathione disulfide (GSSG) to the sulfhydryl form glutathione (GSH), which is a critical molecule in resisting oxidative stress and maintaining the reducing environment of the cellNot Available DME0572 DME___ID DME0572 DME0572 DME_NAME Lipocalin-type prostaglandin-D synthase (PTGDS) DME0572 SPESNAME Homo sapiens DME0572 TISSUDIS Primarily distributed in brain, CNS, heart muscle and retinaNot Available DME0572 FUNCTION This enzyme catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregationNot Available It binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic moleculesNot Available DME0409 DME___ID DME0409 DME0409 DME_NAME Carbonic anhydrase II (CA2) DME0409 SPESNAME Homo sapiens DME0409 TISSUDIS Primarily distributed in intestine and stomachNot Available DME0409 FUNCTION This enzyme can hydrate cyanamide to ureaNot Available DME0496 DME___ID DME0496 DME0496 DME_NAME Phosphoenolpyruvate carboxykinase (PCK1) DME0496 SPESNAME Homo sapiens DME0496 TISSUDIS Primarily distributed in liver kidney and adipocytesNot Available DME0496 FUNCTION This enzyme catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle and it also catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetateNot Available DME0538 DME___ID DME0538 DME0538 DME_NAME Cyclic ADP-ribose hydrolase 1 (CD38) DME0538 SPESNAME Homo sapiens DME0538 TISSUDIS Primarily distributed in lymphoid tissue and seminal vesicleNot Available DME0538 FUNCTION This enzyme has cADPr hydrolase activityNot Available DME0573 DME___ID DME0573 DME0573 DME_NAME Cathepsin K (CTSK) DME0573 SPESNAME Homo sapiens DME0573 TISSUDIS Primarily distributed in adipose and osteoclastsNot Available DME0573 FUNCTION This enzyme displays potent endoprotease activity against fibrinogen at acid pH and may play an important role in extracellular matrix degradationNot Available DME0561 DME___ID DME0561 DME0561 DME_NAME Matrix metalloproteinase-2 (MMP-2) DME0561 SPESNAME Homo sapiens DME0561 TISSUDIS Low tissue/organ specificityNot Available DME0561 FUNCTION This enzyme is involved in diverse functions including degrading extracellular matrix proteinsNot Available It cleaves GSK3beta in vitroNot Available Isoform 2 mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial- nuclear stress signaling with activation of the pro-inflammatory NF- kappaB, NFAT and IRF transcriptional pathwaysNot Available DME0446 DME___ID DME0446 DME0446 DME_NAME Angiotensin-converting enzyme 2 (ACE2) DME0446 SPESNAME Homo sapiens DME0446 TISSUDIS Primarily distributed in intestineNot Available DME0446 FUNCTION This enzyme converts angiotensin I to angiotensin 1-9 and angiotensin II to angiotensin 1-7Not Available It can also able to hydrolyze apelin-13 and dynorphin-13 with high efficiencyNot Available DME0512 DME___ID DME0512 DME0512 DME_NAME Dinucleosidetriphosphatase (FHIT) DME0512 SPESNAME Homo sapiens DME0512 TISSUDIS Low tissue/organ specificityNot Available DME0512 FUNCTION This enzyme cleaves P1-P3-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADPNot Available It can also hydrolyze P1-P4-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATPNot Available DME0461 DME___ID DME0461 DME0461 DME_NAME Prolyl 4-hydroxylase alpha-1 (P4HA1) DME0461 SPESNAME Homo sapiens DME0461 TISSUDIS Primarily distributed in vaginaNot Available DME0461 FUNCTION This enzyme catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteinsNot Available DME0425 DME___ID DME0425 DME0425 DME_NAME Methylsterol monooxygenase 1 (MSMO1) DME0425 SPESNAME Homo sapiens DME0425 TISSUDIS Primarily distributed in liverNot Available DME0425 FUNCTION This enzyme catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterolNot Available DME0487 DME___ID DME0487 DME0487 DME_NAME Delta-aminolevulinate synthase 2 (ALAS2) DME0487 SPESNAME Homo sapiens DME0487 TISSUDIS Primarily distributed in bone marrow and placentaNot Available DME0487 FUNCTION This enzyme is an aminolevulinic acid synthase, and it catalyzes the first step in the heme biosynthetic pathwayNot Available DME0566 DME___ID DME0566 DME0566 DME_NAME Prostaglandin dehydrogenase 1 (HPGD) DME0566 SPESNAME Homo sapiens DME0566 TISSUDIS Primarily distributed in colon epithelium and placentaNot Available DME0566 FUNCTION This enzyme catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4Not Available DME0451 DME___ID DME0451 DME0451 DME_NAME Thyroid peroxidase (TPO) DME0451 SPESNAME Homo sapiens DME0451 TISSUDIS Primarily distributed in thyroidNot Available DME0451 FUNCTION This enzyme iodinates and couples hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4)Not Available DME0484 DME___ID DME0484 DME0484 DME_NAME Sphingosine kinase 1 (SPHK1) DME0484 SPESNAME Homo sapiens DME0484 TISSUDIS Low tissue/organ specificityNot Available DME0484 FUNCTION This enzyme catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functionsNot Available It also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo- dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositolNot Available DME0429 DME___ID DME0429 DME0429 DME_NAME Prostaglandin reductase 1 (PTGR1) DME0429 SPESNAME Homo sapiens DME0429 TISSUDIS Primarily distributed in kidney, liver and intestineNot Available DME0429 FUNCTION This enzyme functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alphaNot Available It catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo- leukotriene B4, which is an initial and key step of metabolic inactivation of leukotriene B4Not Available DME0401 DME___ID DME0401 DME0401 DME_NAME Porphobilinogen synthase (ALAD) DME0401 SPESNAME Homo sapiens DME0401 TISSUDIS Primarily distributed in liverNot Available DME0401 FUNCTION This enzyme catalyzes an early step in the biosynthesis of tetrapyrrolesNot Available It binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogenNot Available DME0152 DME___ID DME0152 DME0152 DME_NAME Phosphorylethanolamine transferase (PCYT2) DME0152 SPESNAME Homo sapiens DME0152 TISSUDIS Primarily distributed in testis, liver, heart and skeletalmuscleNot Available DME0152 FUNCTION This enzyme plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamineNot Available It catalyzes the formation of CDP- ethanolamineNot Available DME0534 DME___ID DME0534 DME0534 DME_NAME N-acetylglutamate synthase (NAGS) DME0534 SPESNAME Homo sapiens DME0534 TISSUDIS Primarily distributed in liver, kidney and small intestineNot Available DME0534 FUNCTION This enzyme catalyzes the production of N-acetylglutamate (NAG) from glutamate and acetyl-CoANot Available DME0427 DME___ID DME0427 DME0427 DME_NAME Mevalonate pyrophosphate decarboxylase (MPD) DME0427 SPESNAME Homo sapiens DME0427 TISSUDIS Primarily distributed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placentaNot Available DME0427 FUNCTION This enzyme converts mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP) through ATP dependent decarboxylationNot Available DME0157 DME___ID DME0157 DME0157 DME_NAME Glutaminyl-tRNA synthetase (GLNRS) DME0157 SPESNAME Homo sapiens DME0157 TISSUDIS Primarily distributed in fetal cerebral cortex, particularly in the ventricular zone, inner subventricular zone, outersubventricular zone, and cortical plateNot Available DME0157 FUNCTION This enzyme catalyzes the conversion of L-glutamine and tRNAGln to L-glutaminyl-tRNAGlnNot Available DME0486 DME___ID DME0486 DME0486 DME_NAME Glutamate-cysteine ligase regulatory (GCLM) DME0486 SPESNAME Homo sapiens DME0486 TISSUDIS Primarily distributed in skeletal muscleNot Available DME0486 FUNCTION This enzyme is the first rate limiting enzyme of glutathione synthesisNot Available The enzyme consists of two subunits, a heavy catalytic subuit and a light regulatory subunitNot Available Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemiaNot Available DME0029 DME___ID DME0029 DME0029 DME_NAME Lauric acid omega-hydroxylase (CYP4A11) DME0029 SPESNAME Homo sapiens DME0029 TISSUDIS Primarily distributed in kidney and liverNot Available DME0029 FUNCTION This enzyme is involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins)Not Available It catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acidNot Available It acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver and participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20- hydroxyeicosatetraenoic acid (20-HETE)Not Available It can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiencyNot Available Besides, it may contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shorteningNot Available DME0143 DME___ID DME0143 DME0143 DME_NAME Histamine N-methyltransferase (HNMT) DME0143 SPESNAME Homo sapiens DME0143 TISSUDIS Low tissue/organ specificityNot Available DME0143 FUNCTION This enzyme inactivates histamine by N-methylation and plays an important role in degrading histamineNot Available DME0034 DME___ID DME0034 DME0034 DME_NAME Leukotriene B4 omega-hydroxylase (CYP4F3) DME0034 SPESNAME Homo sapiens DME0034 TISSUDIS Primarily distributed in liverNot Available DME0034 FUNCTION This enzyme is involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins)Not Available Isoform CYP4F3A catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of oxylipins in myeloid cells, displaying higher affinity for arachidonate metabolite leukotriene B4 (LTB4) and inactivates LTB4 via three successive oxidative transformations to 20-hydroxy-LTB4, then to 20-oxo-LTB4 and to 20- carboxy-LTB4Not Available It exhibits omega-hydroxylase activity toward long-chain fatty acid epoxides with preference for 8,9-epoxy- (5Z,11Z,14Z)-eicosatrienoate (EET) and 9,10-epoxyoctadecanoateNot Available It contributes to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shorteningNot Available Isoform CYP4F3B catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of polyunsaturated fatty acids (PUFAs) and participates in the conversion of arachidonic acid to 20- hydroxyeicosatetraenoic acid (20-HETE)Not Available Besides, it exhibits high omega-hydroxylase activity toward other PUFAs, including eicosatrienoic acid (ETA), eicosapentaenoic acid (EPA) and docosahexaenoic acidNot Available It can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of PUFAs with lower efficiencyNot Available It contributes to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid and hexacosanoic acid, by catalyzing successive omega-oxidations and to the corresponding dicarboxylic acids, thereby initiating chain shorteningNot Available DME0060 DME___ID DME0060 DME0060 DME_NAME Adenosine aminohydrolase (ADA) DME0060 SPESNAME Homo sapiens DME0060 TISSUDIS Primarily distributed in blood, intestine and lymphoid tissueNot Available DME0060 FUNCTION This enzyme catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosineNot Available It plays an important role in purine metabolismNot Available DME0542 DME___ID DME0542 DME0542 DME_NAME Oxaloacetate decarboxylase (FAHD1) DME0542 SPESNAME Homo sapiens DME0542 TISSUDIS Low tissue/organ specificityNot Available DME0542 FUNCTION This enzyme hydrolyzes acetylpyruvate and fumarylpyruvate in vitro and also has oxaloacetate decarboxylase activityNot Available DME0294 DME___ID DME0294 DME0294 DME_NAME Aldehyde dehydrogenase 7 (ALDH7) DME0294 SPESNAME Homo sapiens DME0294 TISSUDIS Primarily distributed in kidney and lungNot Available DME0294 FUNCTION This enzyme oxidizes medium and long chain saturated and unsaturated aldehydesNot Available It also metabolizes benzaldehyde and it has low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehydeNot Available DME0214 DME___ID DME0214 DME0214 DME_NAME Succinate-semialdehyde dehydrogenase (ALDH5A1) DME0214 SPESNAME Homo sapiens DME0214 TISSUDIS Primarily distributed in liverNot Available Also expressed in brain, pancreas, heart, skeletal muscle and kidneyNot Available DME0214 FUNCTION This enzyme catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)Not Available DME0583 DME___ID DME0583 DME0583 DME_NAME Retinol dehydrogenase 5 (RDH5) DME0583 SPESNAME Homo sapiens DME0583 TISSUDIS Primarily distributed in adipose tissue and retinaNot Available DME0583 FUNCTION This enzyme catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent mannerNot Available But it has no activity towards all-trans retinalNot Available It plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE)Not Available and also recognizes steroids (androsterone, androstanediol) as its substratesNot Available DME0178 DME___ID DME0178 DME0178 DME_NAME Propionyl-CoA carboxylase beta (PCCB) DME0178 SPESNAME Homo sapiens DME0178 TISSUDIS Primarily distributed in liverNot Available DME0178 FUNCTION This enzyme is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolitesNot Available Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoANot Available Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoANot Available Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rateNot Available Other alternative minor substrates include (2E)- butenoyl-CoA/crotonoyl-CoA (By similarity)Not Available DME0530 DME___ID DME0530 DME0530 DME_NAME Choline glycerophosphodiester phosphodiesterase (ENPP6) DME0530 SPESNAME Homo sapiens DME0530 TISSUDIS Primarily distributed in brain and kidneyNot Available DME0530 FUNCTION This enzyme hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cellsNot Available It has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acidsNot Available In vitro, it hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet- activating factor (PAF) and lysoPAF, but not other lysophospholipidsNot Available DME0575 DME___ID DME0575 DME0575 DME_NAME Ras proteins prenyltransferase alpha (FNTA) DME0575 SPESNAME Homo sapiens DME0575 TISSUDIS Low tissue/organ specificityNot Available DME0575 FUNCTION This enzyme is essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complexNot Available It contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic- aliphatic-XNot Available DME0532 DME___ID DME0532 DME0532 DME_NAME Phosphoserine aminotransferase (PSAT1) DME0532 SPESNAME Homo sapiens DME0532 TISSUDIS Primarily distributed in kidney and liverNot Available DME0532 FUNCTION This enzyme catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonineNot Available DME0531 DME___ID DME0531 DME0531 DME_NAME Alanine aminotransferase 1 (GPT) DME0531 SPESNAME Homo sapiens DME0531 TISSUDIS Primarily distributed in liver, kidney, heart and skeletal musclesNot Available DME0531 FUNCTION This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamateNot Available It participates in cellular nitrogen metabolismNot Available DME0445 DME___ID DME0445 DME0445 DME_NAME Nicotinamide N-methyltransferase (NNMT) DME0445 SPESNAME Homo sapiens DME0445 TISSUDIS Primarily distributed in liverNot Available Also expressed in kidney, lung, skeletal muscle, placenta and heartNot Available DME0445 FUNCTION This enzyme catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ionsNot Available This activity is important for biotransformation of many drugs and xenobiotic compoundsNot Available DME0564 DME___ID DME0564 DME0564 DME_NAME Matrix metalloproteinase-9 (MMP-9) DME0564 SPESNAME Homo sapiens DME0564 TISSUDIS Primarily distributed in adipose tissue, blood, bone marrow and lymphoid tissueNot Available DME0564 FUNCTION This enzyme cleaves KiSS1 at a Gly-|-Leu bond and cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragmentsNot AvailableIt also degrades fibronectin but not laminin or Pz-peptideNot Available DME0146 DME___ID DME0146 DME0146 DME_NAME Phosphoglucomutase 1 (PGM1) DME0146 SPESNAME Homo sapiens DME0146 TISSUDIS Primarily distributed in skeletalNot Available DME0146 FUNCTION This enzyme participates in both the breakdown and synthesis of glucoseNot Available DME0263 DME___ID DME0263 DME0263 DME_NAME Peroxisomal multifunctional enzyme 2 (HSD17B4) DME0263 SPESNAME Homo sapiens DME0263 TISSUDIS Primarily distributed in liver, heart, prostate and testisNot Available DME0263 FUNCTION This enzyme acts on the peroxisomal beta-oxidation pathway for fatty acids and catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acidsNot Available DME0418 DME___ID DME0418 DME0418 DME_NAME Glutamine synthetase (GLUL) DME0418 SPESNAME Homo sapiens DME0418 TISSUDIS Low tissue/organ specificityNot Available DME0418 FUNCTION This enzyme catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamineNot Available Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammoniaNot Available DME0473 DME___ID DME0473 DME0473 DME_NAME Diaphorase-1 (CYB5R3) DME0473 SPESNAME Homo sapiens DME0473 TISSUDIS Low tissue/organ specificityNot Available DME0473 FUNCTION This enzyme is involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reductionNot Available DME0437 DME___ID DME0437 DME0437 DME_NAME Purine nucleoside phosphorylase (PNP) DME0437 SPESNAME Homo sapiens DME0437 TISSUDIS Primarily distributed in epididymisNot Available DME0437 FUNCTION This enzyme catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphateNot Available DME0426 DME___ID DME0426 DME0426 DME_NAME Methylarsonite methyltransferase N6AMT1 (N6AMT1) DME0426 SPESNAME Homo sapiens DME0426 TISSUDIS Primarily distributed in parathyroid and pituitary glandsNot Available DME0426 FUNCTION This enzyme can methylate both proteins and DNA, and to a lower extent, arsenicNot Available Its catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly- Gln-Xaa-Xaa-Xaa-Arg motifNot Available It also methylates ETF1 on 'Gln-185' and acts as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)- methyladenosine)Not Available It may also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acidNot Available It however only plays a limited role in arsenic metabolism compared with AS3MTNot Available DME0149 DME___ID DME0149 DME0149 DME_NAME Vitamin K1 2,3-epoxide reductase 1 (VKOR) DME0149 SPESNAME Homo sapiens DME0149 TISSUDIS Primarily distributed in liverNot Available Also expressed in fetal heart, kidney, lung, adult heart and pancreasNot Available DME0149 FUNCTION This enzyme is involved in vitamin K metabolismNot Available Its catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin KNot Available DME0492 DME___ID DME0492 DME0492 DME_NAME Nicotinate-nucleotide adenylyltransferase 3 (NMNAT3) DME0492 SPESNAME Homo sapiens DME0492 TISSUDIS Primarily distributed in lung and spleenNot Available Also expressed in placenta and kidneyNot Available DME0492 FUNCTION This enzyme catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATPNot Available It can use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency and can use triazofurin monophosphate (TrMP) as substrateNot Available It can also use GTP and ITP as nucleotide donorsNot Available It catalyzes the reverse reaction, iNot AvailableeNot Available the pyrophosphorolytic cleavage of NAD(+)Not Available For the pyrophosphorolytic activity, it can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substratesNot Available DME0576 DME___ID DME0576 DME0576 DME_NAME N-acetyl-D-glucosamine 2-epimerase (AGE) DME0576 SPESNAME Homo sapiens DME0576 TISSUDIS Primarily distributed in kidney and lymphoid tissueNot Available DME0576 FUNCTION This enzyme catalyzes the interconversion of N-acetylglucosamine to N- acetylmannosamineNot Available It is involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathwayNot Available DME0059 DME___ID DME0059 DME0059 DME_NAME Dimethylaniline oxidase 1 (FMO1) DME0059 SPESNAME Homo sapiens DME0059 TISSUDIS Primarily distributed in liver and kidneyNot Available DME0059 FUNCTION This enzyme is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides and form I catalyzes the N-oxygenation of secondary and tertiary aminesNot Available DME0135 DME___ID DME0135 DME0135 DME_NAME Cytochrome P450 4F12 (CYP4F12) DME0135 SPESNAME Homo sapiens DME0135 TISSUDIS Primarily distributed in small intestine, liver, colon and heartNot Available DME0135 FUNCTION This enzyme is involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs)Not Available It catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-2 position and Metabolizes (5Z,8Z,11Z,14Z)- eicosatetraenoic acid (arachidonate) toward 18-hydroxy arachidonateNot Available Besides, it catalyzes the epoxidation of double bonds of PUFAs such as docosapentaenoic and docosahexaenoic acidsNot Available It is also involved in the metabolism of xenobiotics and catalyzes the hydroxylation of the antihistamine drug ebastineNot Available DME0033 DME___ID DME0033 DME0033 DME_NAME Cytochrome P450 2S1 (CYP2S1) DME0033 SPESNAME Homo sapiens DME0033 TISSUDIS Primarily distributed in blood, gallbladder, intestine and stomachNot Available DME0033 FUNCTION This enzyme is involved in the metabolism of retinoids and eicosanoidsNot Available In epidermis, it may contribute to the oxidative metabolism of all-trans- retinoic acidNot Available Additionally, it displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs)Not Available DME0289 DME___ID DME0289 DME0289 DME_NAME Aldehyde dehydrogenase 5 (ALDHX) DME0289 SPESNAME Homo sapiens DME0289 TISSUDIS Primarily distributed in liver, testis and smoothNot Available DME0289 FUNCTION This enzyme plays a major role in the detoxification of alcohol-derived acetaldehyde and is involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidationNot Available DME0384 DME___ID DME0384 DME0384 DME_NAME Sulfotransferase 2B1 (SULT2B1) DME0384 SPESNAME Homo sapiens DME0384 TISSUDIS Primarily distributed in placenta, prostate, trachea, esophagus, lymphoid tissue and tongueNot Available DME0384 FUNCTION This enzyme utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugationNot Available It is also responsible for the sulfation of cholesterolNot Available It can catalyze sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA)Not Available And it preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEANot Available Besides, it plays a role in epidermal cholesterol metabolismNot Available DME0565 DME___ID DME0565 DME0565 DME_NAME D-amino-acid oxidase (DAO) DME0565 SPESNAME Homo sapiens DME0565 TISSUDIS Primarily distributed in brain, kidney and liverNot Available DME0565 FUNCTION This enzyme can act as a detoxifying agent which removes D-amino acids accumulated during aging and acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups and does not act on acidic amino acidsNot Available DME0408 DME___ID DME0408 DME0408 DME_NAME Arsenite methyltransferase (AS3MT) DME0408 SPESNAME Homo sapiens DME0408 TISSUDIS Primarily distributed in adrenal gland and parathyroid glandNot Available DME0408 FUNCTION This enzyme catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicalsNot Available It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2Not Available Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OHNot Available DME0500 DME___ID DME0500 DME0500 DME_NAME Arginine carboxypeptidase (CPN1) DME0500 SPESNAME Homo sapiens DME0500 TISSUDIS Primarily distributed in liverNot Available Synthesized in the liver and secreted in plasmaNot Available DME0500 FUNCTION This enzyme protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulationNot Available DME0535 DME___ID DME0535 DME0535 DME_NAME Thyroxine 5-deiodinase (DIO3) DME0535 SPESNAME Homo sapiens DME0535 TISSUDIS Primarily distributed in cervix, uterine and placentaNot Available DME0535 FUNCTION This enzyme is responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine)Not Available RT3 and T2 are inactive metabolitesNot Available DME0423 DME___ID DME0423 DME0423 DME_NAME Testicular 17-beta-hydroxysteroid dehydrogenase (HSD17B3) DME0423 SPESNAME Homo sapiens DME0423 TISSUDIS Primarily distributed in testisNot Available DME0423 FUNCTION This enzyme favors the reduction of androstenedione to testosteroneNot Available DME0032 DME___ID DME0032 DME0032 DME_NAME Retinoic acid 4-hydroxylase 26B1 (CYP26B1) DME0032 SPESNAME Homo sapiens DME0032 TISSUDIS Primarily distributed in brain, particularly in thecerebellum and ponsNot Available DME0032 FUNCTION This enzyme is involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidationNot Available It is also involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13- cis-RANot Available It generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RANot Available It catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4Not Available It also has a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivoNot Available DME0421 DME___ID DME0421 DME0421 DME_NAME Ketoacyl-CoA reductase (HSD17B12) DME0421 SPESNAME Homo sapiens DME0421 TISSUDIS Primarily distributed in ovary and mammaryNot Available DME0421 FUNCTION This enzyme catalyzes the second of the four reactions of the long-chain fatty acids elongation cycleNot Available This endoplasmic reticulum-bound enzymatic process allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycleNot Available This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongationNot Available It may also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formationNot Available DME0471 DME___ID DME0471 DME0471 DME_NAME Hydroxyacyl-CoA dehydrogenase 2 (HSD17B10) DME0471 SPESNAME Homo sapiens DME0471 TISSUDIS Low tissue/organ specificityNot Available DME0471 FUNCTION This enzyme catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha- hydroxysteroid dehydrogenase activity with androsteroneNot Available It catalyzes the third step in the beta-oxidation of fatty acids and carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acidsNot Available It also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroidsNot Available DME0150 DME___ID DME0150 DME0150 DME_NAME Deoxy-5'-nucleotidase 1 (NT5C) DME0150 SPESNAME Homo sapiens DME0150 TISSUDIS Low tissue/organ specificityNot Available DME0150 FUNCTION This enzyme dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMPNot Available DME0632 DME___ID DME0632 DME0632 DME_NAME Chondroitin 6-sulfotransferase (CHST3) DME0632 SPESNAME Homo sapiens DME0632 TISSUDIS Low tissue/organ specificityNot Available DME0632 FUNCTION This enzyme utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitinNot Available DME0477 DME___ID DME0477 DME0477 DME_NAME Semicarbazide-sensitive amine oxidase (AOC2) DME0477 SPESNAME Homo sapiens DME0477 TISSUDIS Primarily distributed in retinaNot Available DME0477 FUNCTION This enzyme has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamineNot Available DME0491 DME___ID DME0491 DME0491 DME_NAME Phenylalanine--tRNA ligase mitochondrial (FARS2) DME0491 SPESNAME Homo sapiens DME0491 TISSUDIS Low tissue/organ specificityNot Available DME0491 FUNCTION This enzyme is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translationNot Available To a lesser extent, it also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteinsNot Available DME0503 DME___ID DME0503 DME0503 DME_NAME Lactate dehydrogenase C (LDHC) DME0503 SPESNAME Homo sapiens DME0503 TISSUDIS Primarily distributed in testisNot Available DME0503 FUNCTION This enzyme catalyzes the conversion of lactate to pyruvate and back, as it converts NAD+ to NADH and backNot Available DME0136 DME___ID DME0136 DME0136 DME_NAME Amidophosphoribosyltransferase (GPAT) DME0136 SPESNAME Homo sapiens DME0136 TISSUDIS Low tissue/organ specificityNot Available DME0136 FUNCTION This enzyme is responsible for catalyzing the conversion of 5-phosphoribosyl-1-pyrophosphate (PRPP) into 5-phosphoribosyl-1-amine (PRA), using the amine group from a glutamine side-chainNot Available DME0581 DME___ID DME0581 DME0581 DME_NAME Metallo-endopeptidase-like 1 (MMEL1) DME0581 SPESNAME Homo sapiens DME0581 TISSUDIS Primarily distributed in testisNot Available DME0581 FUNCTION This enzyme degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residuesNot Available It shares the same substrate specificity with MME and cleaves peptides at the same amide bondNot Available DME0498 DME___ID DME0498 DME0498 DME_NAME Gamma-glutamyltranspeptidase 1 (GGT1) DME0498 SPESNAME Homo sapiens DME0498 TISSUDIS Primarily distributed in kidney, liver and seminal vesicleNot Available DME0498 FUNCTION This enzyme cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compoundsNot Available The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidasesNot Available In the presence of high concentrations of dipeptides and some amino acids, it can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compoundNot Available DME0482 DME___ID DME0482 DME0482 DME_NAME Cytosolic 5'-nucleotidase II (NT5C2) DME0482 SPESNAME Homo sapiens DME0482 TISSUDIS Low tissue/organ specificityNot Available DME0482 FUNCTION This enzyme preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotidesNot Available DME0490 DME___ID DME0490 DME0490 DME_NAME Chondroitin sulfate glucuronyltransferase (CHPF2) DME0490 SPESNAME Homo sapiens DME0490 TISSUDIS Primarily distributed in placenta, small intestine and pancreasNot Available DME0490 FUNCTION This enzyme transfers glucuronic acid (GlcUA) from UDP-GlcUA to N- acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymerNot Available DME0523 DME___ID DME0523 DME0523 DME_NAME Glucose-6-phosphatase beta (G6PC3) DME0523 SPESNAME Homo sapiens DME0523 TISSUDIS Primarily distributed in skeletal muscleNot Available Also expressed in heart, brain, placenta, kidney, colon, thymus, spleen, pancreas, testis, prostate, ovary, liver, lung, small intestine and peripheral bloodlymphocytesNot Available DME0523 FUNCTION This enzyme hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulumNot Available DME0025 DME___ID DME0025 DME0025 DME_NAME Cytochrome P450 4F2 (CYP4F2) DME0025 SPESNAME Homo sapiens DME0025 TISSUDIS Primarily distributed in intestine and liverNot Available DME0025 FUNCTION This enzyme is involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitaminsNot Available It catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids and displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs)Not Available It participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE) and plays a role in the oxidative inactivation of eicosanoidsNot Available In addition, it catalyzes omega-hydroxylation of 3-hydroxy fatty acids and converts monoepoxides of linoleic acid leukotoxin and isoleukotoxin to omega-hydroxylated metabolitesNot Available It also contributes to the degradation of very long-chain fatty acids (VLCFAs) by catalyzing successive omega-oxidations and chain shorteningNot Available It plays an important role in vitamin metabolism by chain shortening and catalyzes omega- hydroxylation of the phytyl chain of tocopherols (forms of vitamin E), with preference for gamma-tocopherols over alpha-tocopherolsNot Available It also can Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulationNot Available DME0501 DME___ID DME0501 DME0501 DME_NAME Soluble aminopeptidase P (sAmp) DME0501 SPESNAME Homo sapiens DME0501 TISSUDIS Primarily distributed in pancreas, heart, muscle, kidney, liver, lung and brainNot Available DME0501 FUNCTION This enzyme contributes to the degradation of bradykininNot Available It catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-ProNot Available DME0460 DME___ID DME0460 DME0460 DME_NAME Prolyl 4-hydroxylase alpha-2 (P4HA2) DME0460 SPESNAME Homo sapiens DME0460 TISSUDIS Low tissue/organ specificityNot Available DME0460 FUNCTION This enzyme catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteinsNot Available DME0543 DME___ID DME0543 DME0543 DME_NAME Phenylethanolamine N-methyltransferase (PNMT) DME0543 SPESNAME Homo sapiens DME0543 TISSUDIS Primarily distributed in adrenal gland, ductus deferens and seminal vesicleNot Available DME0543 FUNCTION This enzyme converts noradrenaline to adrenalineNot Available DME0544 DME___ID DME0544 DME0544 DME_NAME Maillard deglycase (PARK7) DME0544 SPESNAME Homo sapiens DME0544 TISSUDIS Primarily distributed in pancreas, kidney, skeletalmuscle, liver, testis and heartNot Available DME0544 FUNCTION This enzyme catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxalsNot Available DME0548 DME___ID DME0548 DME0548 DME_NAME Dimethylarginine dimethylaminohydrolase 1 (DDAH1) DME0548 SPESNAME Homo sapiens DME0548 TISSUDIS Primarily distributed in brain, liver, kidney and pancreasNot Available DME0548 FUNCTION This enzyme hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA)Not Available DME0412 DME___ID DME0412 DME0412 DME_NAME Dicarbonyl/L-xylulose reductase (DCXR) DME0412 SPESNAME Homo sapiens DME0412 TISSUDIS Primarily distributed in kidney, liver and epididymisNot Available DME0412 FUNCTION This enzyme catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose and participates in the uronate cycle of glucose metabolismNot Available DME0440 DME___ID DME0440 DME0440 DME_NAME VKORC1-like protein 1 (VKORC1L1) DME0440 SPESNAME Homo sapiens DME0440 TISSUDIS Low tissue/organ specificityNot Available DME0440 FUNCTION This enzyme is involved in vitamin K metabolismNot Available It can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stressNot Available DME0481 DME___ID DME0481 DME0481 DME_NAME Uridine-cytidine kinase 1 (UCK1) DME0481 SPESNAME Homo sapiens DME0481 TISSUDIS Low tissue/organ specificityNot Available DME0481 FUNCTION This enzyme phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate but does not phosphorylate deoxyribonucleosides or purine ribonucleosidesNot Available It can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)- acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidineNot Available DME0456 DME___ID DME0456 DME0456 DME_NAME Uridine/cytidine monophosphate kinase (UMPK) DME0456 SPESNAME Homo sapiens DME0456 TISSUDIS Low tissue/organ specificityNot Available DME0456 FUNCTION This enzyme catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATPNot Available It plays an important role in de novo pyrimidine nucleotide biosynthesis and it has preference for UMP and CMP as phosphate acceptorsNot Available DME0514 DME___ID DME0514 DME0514 DME_NAME UDP-glucose pyrophosphorylase (UGPase) DME0514 SPESNAME Homo sapiens DME0514 TISSUDIS Primarily distributed in liverNot Available DME0514 FUNCTION This enzyme plays a central role as a glucosyl donor in cellular metabolic pathwaysNot Available DME0465 DME___ID DME0465 DME0465 DME_NAME UDP-glucose 6-dehydrogenase (UGDH) DME0465 SPESNAME Homo sapiens DME0465 TISSUDIS Primarily distributed in liverNot Available Also expressed in heart, placenta, pancreas, spleen, thymus, prostate, ovary, small intestine and colonNot Available DME0465 FUNCTION This enzyme catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycansNot Available It is required for the biosynthesis of chondroitin sulfate and heparan sulfateNot Available DME0229 DME___ID DME0229 DME0229 DME_NAME Testicular acid phosphatase (ACP4) DME0229 SPESNAME Homo sapiens DME0229 TISSUDIS Primarily distributed in skin and testisNot Available DME0229 FUNCTION This enzyme dephosphorylates receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavageNot Available And it may play a role in odontogenesisNot Available DME0474 DME___ID DME0474 DME0474 DME_NAME Retinol dehydrogenase 13 (RDH13) DME0474 SPESNAME Homo sapiens DME0474 TISSUDIS Low tissue/organ specificityNot Available DME0474 FUNCTION This enzyme has a clear preference for NADPNot Available It oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiencyNot Available DME0567 DME___ID DME0567 DME0567 DME_NAME Quinone reductase 2 (NQO2) DME0567 SPESNAME Homo sapiens DME0567 TISSUDIS Low tissue/organ specificityNot Available DME0567 FUNCTION This enzyme serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathwaysNot Available DME0507 DME___ID DME0507 DME0507 DME_NAME HIF-prolyl hydroxylase 3 (EGLN3) DME0507 SPESNAME Homo sapiens DME0507 TISSUDIS Primarily distributed in heart muscle and skinNot Available DME0507 FUNCTION This enzyme is able to catalyze the hydroxylation of proteins such as the subunits of hypoxia-inducible factorNot Available DME0513 DME___ID DME0513 DME0513 DME_NAME Galactose mutarotase (GALM) DME0513 SPESNAME Homo sapiens DME0513 TISSUDIS Primarily distributed in adrenalNot Available DME0513 FUNCTION This enzyme converts alpha-aldose to the beta-anomerNot Available It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactoseNot Available DME0624 DME___ID DME0624 DME0624 DME_NAME Cytochrome P450 7A1 (CYP7A1) DME0624 SPESNAME Homo sapiens DME0624 TISSUDIS Primarily distributed in liverNot Available DME0624 FUNCTION This enzyme involves in the metabolism of endogenous cholesterol and its oxygenated derivativesNot Available DME0593 DME___ID DME0593 DME0593 DME_NAME Carboxypeptidase A4 (CPA4) DME0593 SPESNAME Homo sapiens DME0593 TISSUDIS Primarily distributed in esophagus and skinNot Available DME0593 FUNCTION This enzyme can be involved in the histone hyperacetylation pathwayNot Available It releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -ValNot Available DME0404 DME___ID DME0404 DME0404 DME_NAME Amiloride-sensitive amine oxidase (AOC1) DME0404 SPESNAME Homo sapiens DME0404 TISSUDIS Primarily distributed in intestine and placentaNot Available DME0404 FUNCTION This enzyme catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosisNot Available DME0144 DME___ID DME0144 DME0144 DME_NAME Alpha-N-acetylglucosaminidase (NAG) DME0144 SPESNAME Homo sapiens DME0144 TISSUDIS Primarily distributed in liver, ovary, peripheral blood leukocytes, testis, prostate, spleen, colon, lung, placenta and kidneyNot Available DME0144 FUNCTION This enzyme is involved in the degradation of heparan sulfateNot Available DME0063 DME___ID DME0063 DME0063 DME_NAME Sulfotransferase 1A3 (SULT1A3) DME0063 SPESNAME Homo sapiens DME0063 TISSUDIS Primarily distributed in Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyteNot Available DME0063 FUNCTION This enzyme utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugsNot Available DME0591 DME___ID DME0591 DME0591 DME_NAME Sterol Delta(7)-reductase (DHCR7) DME0591 SPESNAME Homo sapiens DME0591 TISSUDIS Primarily distributed in liver, adrenal gland, testis and brainNot Available DME0591 FUNCTION This enzyme reduces C7-C8 double bond of 7-dehydrocholesterol (7-DHC) to produce cholesterolNot Available DME0590 DME___ID DME0590 DME0590 DME_NAME Spermine oxidase (SMOX) DME0590 SPESNAME Homo sapiens DME0590 TISSUDIS Low tissue/organ specificityNot Available DME0590 FUNCTION This enzyme catalyzes the oxidation of spermine to spermidineNot Available It can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditionsNot Available DME0620 DME___ID DME0620 DME0620 DME_NAME Serum paraoxonase/arylesterase 2 (PON2) DME0620 SPESNAME Homo sapiens DME0620 TISSUDIS Primarily distributed in liver, lung, placenta, testis and heartNot Available DME0620 FUNCTION This enzyme can hydrolyze lactones and a number of aromatic carboxylic acid estersNot Available DME0588 DME___ID DME0588 DME0588 DME_NAME Serine racemase (SRR) DME0588 SPESNAME Homo sapiens DME0588 TISSUDIS Primarily distributed in heart, skeletal muscle, kidney and liverNot Available DME0588 FUNCTION This enzyme catalyzes the synthesis of D-serine from L-serineNot Available It has dehydratase activity towards both L-serine and D-serineNot Available DME0570 DME___ID DME0570 DME0570 DME_NAME Sepiapterin reductase (SPR) DME0570 SPESNAME Homo sapiens DME0570 TISSUDIS Primarily distributed in pancreasNot Available DME0570 FUNCTION This enzyme catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterinNot Available DME0211 DME___ID DME0211 DME0211 DME_NAME Selenocysteine lyase (SCLY) DME0211 SPESNAME Homo sapiens DME0211 TISSUDIS Low tissue/organ specificityNot Available DME0211 FUNCTION This enzyme catalyzes the decomposition of L-selenocysteine to L-alanine and elemental seleniumNot Available DME0497 DME___ID DME0497 DME0497 DME_NAME Red cell/liver pyruvate kinase (PKLR) DME0497 SPESNAME Homo sapiens DME0497 TISSUDIS Primarily distributed in intestine, kidney and liverNot Available DME0497 FUNCTION This enzyme plays a key role in glycolysisNot Available DME0589 DME___ID DME0589 DME0589 DME_NAME Prostaglandin E synthase 2 (PTGES2) DME0589 SPESNAME Homo sapiens DME0589 TISSUDIS Primarily distributed in skeletalNot Available DME0589 FUNCTION This enzyme catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2)Not Available DME0582 DME___ID DME0582 DME0582 DME_NAME Polyamine oxidase (PAOX) DME0582 SPESNAME Homo sapiens DME0582 TISSUDIS Primarily distributed in testisNot Available DME0582 FUNCTION This enzyme catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversionNot Available It can also oxidize N(1)- acetylspermidine to putrescineNot Available Substrate specificity: N(1)- acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermineNot Available But it does not oxidize spermidineNot Available DME0539 DME___ID DME0539 DME0539 DME_NAME Nicotinate-nucleotide adenylyltransferase 2 (NMNAT2) DME0539 SPESNAME Homo sapiens DME0539 TISSUDIS Primarily distributed in brain, particularly in incerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamenNot Available DME0539 FUNCTION This enzyme catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATPNot Available It can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency but cannot use triazofurin monophosphate (TrMP) as substrateNot Available It also catalyzes the reverse reaction, iNot AvailableeNot Available the pyrophosphorolytic cleavage of NAD(+)Not Available DME0547 DME___ID DME0547 DME0547 DME_NAME Neutral alpha-glucosidase AB (GANAB) DME0547 SPESNAME Homo sapiens DME0547 TISSUDIS Primarily distributed in kidney and liverNot Available DME0547 FUNCTION This enzyme cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteinsNot Available DME0621 DME___ID DME0621 DME0621 DME_NAME Microsomal glutathione S-transferase 1 (MGST1) DME0621 SPESNAME Homo sapiens DME0621 TISSUDIS Primarily distributed in liverNot Available DME0621 FUNCTION This enzyme has a wide substrate specificity and it conjugates of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophilesNot Available DME0545 DME___ID DME0545 DME0545 DME_NAME Lecithin-cholesterol acyltransferase (LCAT) DME0545 SPESNAME Homo sapiens DME0545 TISSUDIS Primarily distributed in brain and liverNot Available DME0545 FUNCTION This enzyme is central in the extracellular metabolism of plasma lipoproteinsNot Available It converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs)Not Available DME0525 DME___ID DME0525 DME0525 DME_NAME Inositol polyphosphate 4-phosphatase I (INPP4A) DME0525 SPESNAME Homo sapiens DME0525 TISSUDIS Low tissue/organ specificityNot Available DME0525 FUNCTION This enzyme catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2)Not Available It also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphateNot Available DME0462 DME___ID DME0462 DME0462 DME_NAME HIF-prolyl hydroxylase 2 (EGLN1) DME0462 SPESNAME Homo sapiens DME0462 TISSUDIS Primarily distributed in blood and skeletal muscleNot Available DME0462 FUNCTION This enzyme catalyses the hydroxylation of two sites on HIF-Not Available DME0633 DME___ID DME0633 DME0633 DME_NAME Glutathione S-transferase zeta-1 (GSTZ1) DME0633 SPESNAME Homo sapiens DME0633 TISSUDIS Primarily distributed in liverNot Available Also expressed in kidney, skeletal muscle, brain, melanocytes, synovium, placenta, breast, fetal liver and heartNot Available DME0633 FUNCTION This enzyme shows minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity, and it can catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acidNot Available DME0546 DME___ID DME0546 DME0546 DME_NAME Glucosidase II beta (PRKCSH) DME0546 SPESNAME Homo sapiens DME0546 TISSUDIS Low tissue/organ specificityNot Available DME0546 FUNCTION This enzyme is a regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteinsNot Available DME0522 DME___ID DME0522 DME0522 DME_NAME Glucosamine-6-phosphate deaminase 2 (GNPDA2) DME0522 SPESNAME Homo sapiens DME0522 TISSUDIS Low tissue/organ specificityNot Available DME0522 FUNCTION This enzyme catalyzes the deamination of the glucosamine-6-phosphate involved in the hexosamine signaling pathwayNot Available DME0623 DME___ID DME0623 DME0623 DME_NAME Epoxide hydrolase 1 (EPHX1) DME0623 SPESNAME Homo sapiens DME0623 TISSUDIS Primarily distributed in adrenal gland and liverNot Available DME0623 FUNCTION This enzyme catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of waterNot Available DME0442 DME___ID DME0442 DME0442 DME_NAME Dihydropyrimidinase-related protein 1 (DRP1) DME0442 SPESNAME Homo sapiens DME0442 TISSUDIS Primarily distributed in brain and pituitary glandNot Available DME0442 FUNCTION This enzyme has hydrolase activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidesNot Available DME0609 DME___ID DME0609 DME0609 DME_NAME Dehydrogenase/reductase retSDR3 (HSD17B14) DME0609 SPESNAME Homo sapiens DME0609 TISSUDIS Primarily distributed in brain, placenta, liver and kidneyNot Available DME0609 FUNCTION This enzyme has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activityNot Available And it converts oestradiol to oestroneNot Available DME0607 DME___ID DME0607 DME0607 DME_NAME D-aspartate oxidase (DDO) DME0607 SPESNAME Homo sapiens DME0607 TISSUDIS Low tissue/organ specificityNot Available DME0607 FUNCTION This enzyme selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartateNot Available DME0631 DME___ID DME0631 DME0631 DME_NAME Cytochrome P450 8B1 (CYP8B1) DME0631 SPESNAME Homo sapiens DME0631 TISSUDIS Primarily distributed in liverNot Available DME0631 FUNCTION This enzyme involves in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-oneNot Available And it is responsible for the balance between formation of cholic acid and chenodeoxycholic acidNot Available Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroidsNot Available DME0608 DME___ID DME0608 DME0608 DME_NAME Cytochrome P450 7B1 (CYP7B1) DME0608 SPESNAME Homo sapiens DME0608 TISSUDIS Primarily distributed in brain, testis, ovary, prostate, liver, colon, kidney, small intestine, thymus and spleenNot Available DME0608 FUNCTION This enzyme involves in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroidsNot Available DME0466 DME___ID DME0466 DME0466 DME_NAME Choline kinase alpha (CHKA) DME0466 SPESNAME Homo sapiens DME0466 TISSUDIS Low tissue/organ specificityNot Available DME0466 FUNCTION This enzyme has a key role in phospholipid biosynthesisNot Available It catalyzes the first step in phosphatidylcholine biosynthesis and contributes to phosphatidylethanolamine biosynthesisNot Available It also phosphorylates choline and ethanolamineNot Available DME0101 DME___ID DME0101 DME0101 DME_NAME Choline dehydrogenase (CHDH) DME0101 SPESNAME Homo sapiens DME0101 TISSUDIS Primarily distributed in kidney and liverNot Available DME0101 FUNCTION This enzyme participates in glycine, serine and threonine metabolismNot Available DME0584 DME___ID DME0584 DME0584 DME_NAME Carboxymethylenebutenolidase (CMBL) DME0584 SPESNAME Homo sapiens DME0584 TISSUDIS Primarily distributed in liver, kidney, small intestine and colonNot Available DME0584 FUNCTION This enzyme can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestineNot Available It may also activate beta-lactam antibiotics faropenem medoxomil and lenampicillinNot Available DME0084 DME___ID DME0084 DME0084 DME_NAME Beta,beta-carotene 15,15'-dioxygenase (BCO1) DME0084 SPESNAME Homo sapiens DME0084 TISSUDIS Primarily distributed in intestine and retinaNot Available DME0084 FUNCTION This enzyme symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanismNot Available DME0447 DME___ID DME0447 DME0447 DME_NAME Acid cholesteryl ester hydrolase (LIPA) DME0447 SPESNAME Homo sapiens DME0447 TISSUDIS Primarily distributed in adiposeNot Available DME0447 FUNCTION This enzyme is crucial for the intracellular hydrolysis of cholesteryl esters and triglyceridesNot Available It is important in activation of endogenous cellular cholesteryl ester formationNot Available DME0455 DME___ID DME0455 DME0455 DME_NAME Sulfurylase kinase 1 (PAPSS1) DME0455 SPESNAME Homo sapiens DME0455 TISSUDIS Primarily distributed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liverNot Available DME0455 FUNCTION This enzyme is with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathwayNot Available The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase)Not Available DME0148 DME___ID DME0148 DME0148 DME_NAME Pancreatic alpha-amylase (AMY2A) DME0148 SPESNAME Homo sapiens DME0148 TISSUDIS Primarily distributed in pancreasNot Available DME0148 FUNCTION This enzyme hydrolyzes 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogenNot Available DME0182 DME___ID DME0182 DME0182 DME_NAME Hydroxyindole O-methyltransferase (ASMT) DME0182 SPESNAME Homo sapiens DME0182 TISSUDIS Primarily distributed in brain and epididymisNot Available DME0182 FUNCTION This enzyme catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine)Not Available DME1466 DME___ID DME1466 DME1466 DME_NAME Cytochrome P450 154C2 (cyp154) DME1466 SPESNAME Streptomyces avermitilis DME1466 TISSUDIS Primarily distributed in human gutNot Available DME1466 FUNCTION This enzyme is P-450 heme-thiolate protein, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groupsNot Available DME0430 DME___ID DME0430 DME0430 DME_NAME Tyrosine-protein phosphatase STS1/TULA2 (UBASH3B) DME0430 SPESNAME Homo sapiens DME0430 TISSUDIS Primarily distributed in brain and lymphoid tissueNot Available DME0430 FUNCTION This enzyme interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinasesNot Available It exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70Not Available DME1120 DME___ID DME1120 DME1120 DME_NAME Glutamate racemase (MurI) DME1120 SPESNAME Aquifex pyrophilus DME1120 TISSUDIS Primarily distributed in human gutNot Available DME1120 FUNCTION This enzyme is a pyridoxal-phosphate protein providing the (R)-glutamate required for cell wall biosynthesis and converting L- or D-glutamate to D- or L-glutamate, respectively, but not other amino acids such as alanine, aspartate, and glutamineNot Available DME1307 DME___ID DME1307 DME1307 DME_NAME Glutamate decarboxylase (gadB) DME1307 SPESNAME Bifidobacterium dentium DME1307 TISSUDIS Primarily distributed in human gutNot Available DME1307 FUNCTION This enzyme acts on L-cysteate, 3-sulfino-L-alanine and L-aspartateNot Available DME1346 DME___ID DME1346 DME1346 DME_NAME Glutamate decarboxylase (gadB) DME1346 SPESNAME Bifidobacterium angulatum DME1346 TISSUDIS Primarily distributed in human gutNot Available DME1346 FUNCTION This enzyme acts on L-cysteate, 3-sulfino-L-alanine and L-aspartateNot Available DME2101 DME___ID DME2101 DME2101 DME_NAME Glutamate decarboxylase (gadB) DME2101 SPESNAME Lactobacillus brevis DME2101 TISSUDIS Primarily distributed in human gutNot Available DME2101 FUNCTION This enzyme acts on L-cysteate, 3-sulfino-L-alanine and L-aspartateNot Available DME1040 DME___ID DME1040 DME1040 DME_NAME Molybdopterin-dependent enzyme (molD) DME1040 SPESNAME Raoultella planticola DME1040 TISSUDIS Primarily distributed in human gutNot Available DME1040 FUNCTION This enzyme catalyzes the conversion of doxorubicin to 7-deoxydoxorubicinol and 7-deoxydoxorubicinolone via a reductive deglycosylation mechanismNot Available DME1233 DME___ID DME1233 DME1233 DME_NAME Cytochrome P450 105D7 (cyp105) DME1233 SPESNAME Streptomyces avermitilis DME1233 TISSUDIS Primarily distributed in human gutNot Available DME1233 FUNCTION This enzyme is a P-450 heme-thiolate protein, and it catalyzes the conversion of 1-deoxypentalenic acid to pentalenic acid in the biosynthesis of neopentalenolactone antibioticNot Available DME1906 DME___ID DME1906 DME1906 DME_NAME Alcohol dehydrogenase (ADH) DME1906 SPESNAME Neisseria sicca DME1906 TISSUDIS Primarily distributed in human oral cavityNot Available DME1906 FUNCTION This enzyme acts on primary or secondary alcohols or hemi-acetals with very broad specificity and the enzyme oxidizes methanol much more poorly than ethanolNot Available DME1327 DME___ID DME1327 DME1327 DME_NAME Nitroreductase (NTR) DME1327 SPESNAME Enterococcus casseliflavus DME1327 TISSUDIS Primarily distributed in human gutNot Available DME1327 FUNCTION This enzyme contains FMN and can utilize NADH and NADPH with similar reaction ratesNot Available It also reduces riboflavin and FAD, but more slowlyNot Available DME1294 DME___ID DME1294 DME1294 DME_NAME Rifampicin monooxygenase (rox) DME1294 SPESNAME Nocardia farcinica DME1294 TISSUDIS Primarily distributed in human lungNot Available DME1294 FUNCTION This enzyme can modify rifampicin, thereby inactivating its antibiotic activityNot Available And it constitutes a secondary rifampicin resistance factorNot Available DME1037 DME___ID DME1037 DME1037 DME_NAME Dopamine dehydroxylase (dadH) DME1037 SPESNAME Eggerthella lenta DME1037 TISSUDIS Primarily distributed in human gutNot Available DME1037 FUNCTION This enzyme involves in drug metabolism, as part of an interspecies gut bacterial pathway for Levodopa (L-dopa) metabolism, acting on dopamine produced by Enterecoccus L-dopa decarboxylaseNot Available Removes the para hydroxyl group of dopamine to produce m-tyramine (3-tyramine)Not Available DME1051 DME___ID DME1051 DME1051 DME_NAME Dihydrofolate reductase (folA) DME1051 SPESNAME Chlamydia muridarum DME1051 TISSUDIS Primarily distributed in human gut and vaginaNot Available DME1051 FUNCTION This enzyme can slowly reduces folate to 5,6,7,8-tetrahydrofolate in animals and some micro-organismsNot Available DME1066 DME___ID DME1066 DME1066 DME_NAME Nitroreductase (NTR) DME1066 SPESNAME Entamoeba histolytica DME1066 TISSUDIS Primarily distributed in human vaginaNot Available DME1066 FUNCTION This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compoundsNot Available DME1064 DME___ID DME1064 DME1064 DME_NAME Nitroreductase (NTR) DME1064 SPESNAME Giardia intestinalis DME1064 TISSUDIS Primarily distributed in human vaginaNot Available DME1064 FUNCTION This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compoundsNot Available DME1065 DME___ID DME1065 DME1065 DME_NAME Nitroreductase (NTR) DME1065 SPESNAME Trichomonas vaginalis DME1065 TISSUDIS Primarily distributed in human vaginaNot Available DME1065 FUNCTION This enzyme can reduce other azo dyes, such as Methyl Red, Rocceline, Solar Orange and Sumifix Black BNot Available DME1340 DME___ID DME1340 DME1340 DME_NAME Nitroreductase (NTR) DME1340 SPESNAME Bacteroides fragilis DME1340 TISSUDIS Primarily distributed in human gutNot Available DME1340 FUNCTION This enzyme contains FMN and can utilize NADH and NADPH with similar reaction ratesNot Available It also reduces riboflavin and FAD, but more slowlyNot Available DME1241 DME___ID DME1241 DME1241 DME_NAME Hyaluronoglucosaminidase (nagH) DME1241 SPESNAME Treponema vincentii DME1241 TISSUDIS Primarily distributed in human oral cavityNot Available DME1241 FUNCTION This enzyme hydrolyzes 1,4-beta-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatanNot Available DME1240 DME___ID DME1240 DME1240 DME_NAME Hyaluronate lyase (hyaL) DME1240 SPESNAME Streptobacillus moniliformis DME1240 TISSUDIS Primarily distributed in human bloodNot Available DME1240 FUNCTION This enzyme catalyzes the degradation of hyaluronan by a beta-elimination reaction and it also acts on chondroitinNot Available DME1196 DME___ID DME1196 DME1196 DME_NAME Cytidine deaminase (cdd) DME1196 SPESNAME Mycoplasma hyorhinis DME1196 TISSUDIS Primarily distributed in human gutNot Available DME1196 FUNCTION This enzyme catalyzes the deamination of cytidine and 2'-deoxycytidine with similar efficienciesNot Available It is involved in salvage of both exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesisNot Available DME1911 DME___ID DME1911 DME1911 DME_NAME Sulfatase (sulF) DME1911 SPESNAME Parabacteroides johnsonii DME1911 TISSUDIS Primarily distributed in human gutNot Available DME1911 FUNCTION This enzyme catalyzes the hydrolysis of sulfate estersNot Available DME1919 DME___ID DME1919 DME1919 DME_NAME Sulfatase (sulF) DME1919 SPESNAME Prevotella buccae DME1919 TISSUDIS Primarily distributed in human gutNot Available DME1919 FUNCTION This enzyme catalyzes the hydrolysis of sulfate estersNot Available DME1693 DME___ID DME1693 DME1693 DME_NAME D-Lactate dehydrogenase (ldhA) DME1693 SPESNAME Pseudomonas aeruginosa DME1693 TISSUDIS Primarily distributed in human gutNot Available DME1693 FUNCTION This enzyme has D-lactate dehydrogenase activityNot Available DME1156 DME___ID DME1156 DME1156 DME_NAME Ribosomal 23S RNA methyltransferase Erm (erm) DME1156 SPESNAME Corynebacterium amycolatum DME1156 TISSUDIS Primarily distributed in human skinNot Available DME1156 FUNCTION This enzyme introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine1518 and adenine1519 in 16S rRNANot Available And Strains lacking the methylase are resistant to kasugamycinNot Available DME1238 DME___ID DME1238 DME1238 DME_NAME Ribosomal 23S RNA methyltransferase Erm (erm) DME1238 SPESNAME Corynebacterium jeikeium DME1238 TISSUDIS Primarily distributed in human skinNot Available DME1238 FUNCTION This enzyme introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine1518 and adenine1519 in 16S rRNANot Available And Strains lacking the methylase are resistant to kasugamycinNot Available DME1021 DME___ID DME1021 DME1021 DME_NAME N-acylhomoserine lactone acylase (lacA) DME1021 SPESNAME Acidovorax ebreus DME1021 TISSUDIS Primarily distributed in human gutNot Available DME1021 FUNCTION This enzyme catalyzes the conversion of N-acyl-L-homoserine lactone to N-acyl-L-homoserineNot Available DME1864 DME___ID DME1864 DME1864 DME_NAME Flavin adenine dinucleotide dehydrogenase (fadd) DME1864 SPESNAME Clostridium leptum DME1864 TISSUDIS Primarily distributed in human gutNot Available DME1864 FUNCTION This enzyme can reduce either FAD or flavin mononucleotide (FMN) but prefers FADNot Available But it can not reduce riboflavin and does not use NADPH as acceptorNot Available DME1866 DME___ID DME1866 DME1866 DME_NAME Flavin adenine dinucleotide dehydrogenase (fadd) DME1866 SPESNAME Clostridium sporogenes DME1866 TISSUDIS Primarily distributed in human gutNot Available DME1866 FUNCTION This enzyme can reduce either FAD or flavin mononucleotide (FMN) but prefers FADNot Available But it can not reduce riboflavin and does not use NADPH as acceptorNot Available DME1868 DME___ID DME1868 DME1868 DME_NAME Flavin adenine dinucleotide dehydrogenase (fadd) DME1868 SPESNAME Eubacterium oxidoreducens DME1868 TISSUDIS Primarily distributed in human gutNot Available DME1868 FUNCTION This enzyme can reduce either FAD or flavin mononucleotide (FMN) but prefers FADNot Available But it can not reduce riboflavin and does not use NADPH as acceptorNot Available DME1070 DME___ID DME1070 DME1070 DME_NAME Nitroreductase (NTR) DME1070 SPESNAME Clostridium leptum DME1070 TISSUDIS Primarily distributed in human gutNot Available DME1070 FUNCTION This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compoundsNot Available DME1054 DME___ID DME1054 DME1054 DME_NAME L-arabinose isomerase (araA) DME1054 SPESNAME Clostridium hylemonae DME1054 TISSUDIS Primarily distributed in human gutNot Available DME1054 FUNCTION This enzyme catalyzes the conversion of L-arabinose to L-ribuloseNot Available It requires a divalent metal ion and binds the closed form of the sugar and catalyses ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene-diol mechanismNot Available It can also convert D-galactose to D-tagatose with lower efficiencyNot Available DME1488 DME___ID DME1488 DME1488 DME_NAME Heparin lyase (hepB) DME1488 SPESNAME Streptobacillus moniliformis DME1488 TISSUDIS Primarily distributed in human bloodNot Available DME1488 FUNCTION This enzyme catalyzes the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends DME1116 DME___ID DME1116 DME1116 DME_NAME D-Lactate dehydrogenase (ldhA) DME1116 SPESNAME Megasphaera elsdenii DME1116 TISSUDIS Primarily distributed in human gutNot Available DME1116 FUNCTION This enzyme has D-lactate dehydrogenase activityNot Available DME1905 DME___ID DME1905 DME1905 DME_NAME Cytochrome P450 147G1 (cyp147) DME1905 SPESNAME Mycobacterium marinum DME1905 TISSUDIS Primarily distributed in human skinNot Available DME1905 FUNCTION This enzyme catalyzes the selective hydroxylation of linear and -2 methyl branched fatty acids at the -1 positionNot Available Substrates of Cytochrome P450 147G1 include fatty acids ranging from octanoic to hexadecanoic acidNot Available DME1465 DME___ID DME1465 DME1465 DME_NAME Cytochrome P450 102D1 (cyp102) DME1465 SPESNAME Streptomyces avermitilis DME1465 TISSUDIS Primarily distributed in human gutNot Available DME1465 FUNCTION This enzyme is P-450 heme-thiolate protein, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groupsNot Available DME1112 DME___ID DME1112 DME1112 DME_NAME Carboxylic ester hydrolase (CEH) DME1112 SPESNAME Butyrivibrio fibrisolvens DME1112 TISSUDIS Primarily distributed in human gut and stomachNot Available DME1112 FUNCTION This enzyme can hydrolyse vitamin A esters anh has wide specificityNot Available DME1026 DME___ID DME1026 DME1026 DME_NAME Beta-lactamase (blaB) DME1026 SPESNAME Bacteroides uniformis DME1026 TISSUDIS Primarily distributed in human gutNot Available DME1026 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1095 DME___ID DME1095 DME1095 DME_NAME Beta-lactamase (blaB) DME1095 SPESNAME Bacteroides fragilis DME1095 TISSUDIS Primarily distributed in human gutNot Available DME1095 FUNCTION This enzyme confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ringNot Available DME1025 DME___ID DME1025 DME1025 DME_NAME Beta-glucuronidase (uidA) DME1025 SPESNAME Lactobacillus gasseri DME1025 TISSUDIS Primarily distributed in human gutNot Available DME1025 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1139 DME___ID DME1139 DME1139 DME_NAME Beta-galactosidase (bgaB) DME1139 SPESNAME Victivallis vadensis DME1139 TISSUDIS Primarily distributed in human gutNot Available DME1139 FUNCTION This enzyme hydrolyzes alpha-L-arabinoside and beta-D-fucosides and beta-D-glucosidesNot Available DME1099 DME___ID DME1099 DME1099 DME_NAME Arylamine N-acetyltransferase (NAT) DME1099 SPESNAME Vibrio cholerae DME1099 TISSUDIS Primarily distributed in human lungNot Available DME1099 FUNCTION This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoANot Available DME1101 DME___ID DME1101 DME1101 DME_NAME Arylamine N-acetyltransferase (NAT) DME1101 SPESNAME Plesiomonas shigelloides DME1101 TISSUDIS Primarily distributed in human gutNot Available DME1101 FUNCTION This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoANot Available DME1107 DME___ID DME1107 DME1107 DME_NAME Arylamine N-acetyltransferase (NAT) DME1107 SPESNAME Citrobacter farmeri DME1107 TISSUDIS Primarily distributed in human gutNot Available DME1107 FUNCTION This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoANot Available DME1109 DME___ID DME1109 DME1109 DME_NAME Arylamine N-acetyltransferase (NAT) DME1109 SPESNAME Citrobacter amalonaticus DME1109 TISSUDIS Primarily distributed in human gutNot Available DME1109 FUNCTION This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoANot Available DME1299 DME___ID DME1299 DME1299 DME_NAME Alpha-glucosidase (aglA) DME1299 SPESNAME Lactobacillus paracasei DME1299 TISSUDIS Primarily distributed in human gutNot Available DME1299 FUNCTION This enzyme is probably involved in the catabolism of alpha-glycosides accumulated via a phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS)Not Available And it hydrolyzes a wide variety of 6-phospho-alpha-D-glucosides including the five isomeric derivatives of sucrose, iNot AvailableeNot Available trehalulose-6'-phosphate, turanose-6'-phosphate, maltulose-6'-phosphate, leucrose-6'-phosphate, and palatinose-6'-phosphate, but is not active on sucrose-6-phosphateNot Available Moreover, it can also hydrolyze maltose-6'-phosphate and methyl-alpha-glucose-6-phosphate, and poorly, trehalose-6-phosphateNot Available However, it fails to hydrolyze beta-O-linked phosphorylated disaccharides such as cellobiose-6'-phosphate and gentiobiose-6'-phosphateNot Available DME1291 DME___ID DME1291 DME1291 DME_NAME VanA ligase (vanA) DME1291 SPESNAME Enterococcus avium DME1291 TISSUDIS Primarily distributed in human gutNot Available DME1291 FUNCTION This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6Not Available3Not Available2Not Available7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6Not Available3Not Available2Not Available13), UDP-N-acetylmuramate---L-alanine ligase (EC 6Not Available3Not Available2Not Available8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6Not Available3Not Available2Not Available9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6Not Available3Not Available2Not Available10) in the synthesis of a cell-wall peptideNot Available DME1631 DME___ID DME1631 DME1631 DME_NAME VanA ligase (vanA) DME1631 SPESNAME Enterococcus casseliflavus DME1631 TISSUDIS Primarily distributed in human gutNot Available DME1631 FUNCTION This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6Not Available3Not Available2Not Available7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6Not Available3Not Available2Not Available13), UDP-N-acetylmuramate---L-alanine ligase (EC 6Not Available3Not Available2Not Available8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6Not Available3Not Available2Not Available9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6Not Available3Not Available2Not Available10) in the synthesis of a cell-wall peptideNot Available DME1244 DME___ID DME1244 DME1244 DME_NAME Nitroreductase (NTR) DME1244 SPESNAME Clostridium paraputrificum DME1244 TISSUDIS Primarily distributed in human gutNot Available DME1244 FUNCTION This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compoundsNot Available DME1246 DME___ID DME1246 DME1246 DME_NAME Nitroreductase (NTR) DME1246 SPESNAME Clostridium hiranonis DME1246 TISSUDIS Primarily distributed in human gutNot Available DME1246 FUNCTION This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compoundsNot Available DME1958 DME___ID DME1958 DME1958 DME_NAME Nitroreductase (NTR) DME1958 SPESNAME Prevotella copri DME1958 TISSUDIS Primarily distributed in human gutNot Available DME1958 FUNCTION This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compoundsNot Available DME1615 DME___ID DME1615 DME1615 DME_NAME Naphthalene dioxygenase (doxB) DME1615 SPESNAME Pseudomonas furukawaii DME1615 TISSUDIS Primarily distributed in human gutNot Available DME1615 FUNCTION This enzyme is a member of the ring-hydroxylating dioxygenase (RHD) family of bacterial enzymes that play a critical role in the degradation of aromatic compounds, such as polycyclic aromatic hydrocarbons, and it requires Fe2+Not Available DME1333 DME___ID DME1333 DME1333 DME_NAME Methylenetetrahydrofolate dehydrogenase (folD) DME1333 SPESNAME Blautia producta DME1333 TISSUDIS Primarily distributed in human gutNot Available DME1333 FUNCTION This enzyme catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolateNot Available DME1471 DME___ID DME1471 DME1471 DME_NAME L-malate:NADP(+) oxidoreductase (maeB) DME1471 SPESNAME Hungateiclostridium thermocellum DME1471 TISSUDIS Primarily distributed in human gutNot Available DME1471 FUNCTION This enzyme catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP+ and divalent metal ions, and the decarboxylation of oxaloacetateNot Available DME1091 DME___ID DME1091 DME1091 DME_NAME Kanamycin/gentamycin-resistance enzyme (aacA) DME1091 SPESNAME Campylobacter coli DME1091 TISSUDIS Primarily distributed in human gutNot Available DME1091 FUNCTION This enzyme is the most clinically important aminoglycoside-modifying enzyme in Gram-positive bacteria, responsible for high-level resistance in both Enterococci and StaphylococciNot Available And this bacterial enzyme phosphorylates many 4,6-disubstituted aminoglycoside antibiotics that have a hydroxyl group at position 2'', including kanamycin A, kanamycin B, tobramycin, dibekacin, arbekacin, amikacin, gentamicin C, sisomicin and netilmicinNot Available DME1059 DME___ID DME1059 DME1059 DME_NAME Fumarate reductase flavoprotein (frdA) DME1059 SPESNAME Wolinella succinogenes DME1059 TISSUDIS Primarily distributed in human gutNot Available DME1059 FUNCTION This enzyme utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chainNot Available The enzyme is known as complex II of the electron transfer chain, similarly to succinate dehydrogenase (quinone), to which it is closely relatedNot Available DME1136 DME___ID DME1136 DME1136 DME_NAME Fructokinase (scrK) DME1136 SPESNAME Fusobacterium mortiferum DME1136 TISSUDIS Primarily distributed in human gutNot Available DME1136 FUNCTION This enzyme has fructokinase activity, involved metal ion binding, and cellular carbohydrate catabolic processNot Available DME1525 DME___ID DME1525 DME1525 DME_NAME Cytochrome P450 101D2 (cyp101) DME1525 SPESNAME Novosphingobium aromaticivorans DME1525 TISSUDIS Primarily distributed in human gutNot Available DME1525 FUNCTION This enzyme is a P-450 heme-thiolate protein, and it also acts on (-)-camphor and 1,2-campholide, forming 5-exo-hydroxy-1,2-campholideNot Available DME1524 DME___ID DME1524 DME1524 DME_NAME Cytochrome P450 101D1 (cyp101) DME1524 SPESNAME Novosphingobium aromaticivorans DME1524 TISSUDIS Primarily distributed in human gutNot Available DME1524 FUNCTION This enzyme is a P-450 heme-thiolate protein, and it also acts on (-)-camphor and 1,2-campholide, forming 5-exo-hydroxy-1,2-campholideNot Available DME1128 DME___ID DME1128 DME1128 DME_NAME Cellobiose 2-epimerase (CE) DME1128 SPESNAME Faecalibacterium prausnitzii DME1128 TISSUDIS Primarily distributed in human gutNot Available DME1128 FUNCTION This enzyme catalyzes the interconversion between D-glucose and D-mannose residues at the reducing end of beta-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moietyNot Available Besides, it catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man)Not Available DME1129 DME___ID DME1129 DME1129 DME_NAME Cellobiose 2-epimerase (CE) DME1129 SPESNAME Coprococcus eutactus DME1129 TISSUDIS Primarily distributed in human gutNot Available DME1129 FUNCTION This enzyme catalyzes the interconversion between D-glucose and D-mannose residues at the reducing end of beta-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moietyNot Available Besides, it catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man)Not Available DME1130 DME___ID DME1130 DME1130 DME_NAME Cellobiose 2-epimerase (CE) DME1130 SPESNAME Eubacterium siraeum DME1130 TISSUDIS Primarily distributed in human gutNot Available DME1130 FUNCTION This enzyme catalyzes the interconversion between D-glucose and D-mannose residues at the reducing end of beta-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moietyNot Available Besides, it catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man)Not Available DME1132 DME___ID DME1132 DME1132 DME_NAME Cellobiose 2-epimerase (CE) DME1132 SPESNAME Lachnoclostridium phytofermentans DME1132 TISSUDIS Primarily distributed in human gutNot Available DME1132 FUNCTION This enzyme catalyzes the interconversion between D-glucose and D-mannose residues at the reducing end of beta-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moietyNot Available Besides, it catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man)Not Available DME1133 DME___ID DME1133 DME1133 DME_NAME Cellobiose 2-epimerase (CE) DME1133 SPESNAME Eubacterium cellulosolvens DME1133 TISSUDIS Primarily distributed in human gutNot Available DME1133 FUNCTION This enzyme catalyzes the interconversion between D-glucose and D-mannose residues at the reducing end of beta-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moietyNot Available Besides, it catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man) and epimerizes lactose to epilactoseNot Available DME1301 DME___ID DME1301 DME1301 DME_NAME Catalase-peroxidase (katG) DME1301 SPESNAME Synechococcus elongatus DME1301 TISSUDIS Primarily distributed in human lungNot Available DME1301 FUNCTION This enzyme is with both catalase and broad-spectrum peroxidase activityNot Available DME1036 DME___ID DME1036 DME1036 DME_NAME Cardiac glycoside reductase 2 (cgr2) DME1036 SPESNAME Eggerthella lenta DME1036 TISSUDIS Primarily distributed in human gutNot Available DME1036 FUNCTION This enzyme serves as the terminal electron reductase partner to Cardiac glycoside reductase 1 (Cgr1) by forming an complex with Cgr1 and receiving electrons from Cgr1 at the active site FAD redox cofactorNot Available DME1035 DME___ID DME1035 DME1035 DME_NAME Cardiac glycoside reductase 1 (cgr1) DME1035 SPESNAME Eggerthella lenta DME1035 TISSUDIS Primarily distributed in human gutNot Available DME1035 FUNCTION This enzyme anchors as a dimer in the cytoplasmic membrane and shuttles quinone derived electrons to associated periplasmic nitrite reductasesNot Available DME1009 DME___ID DME1009 DME1009 DME_NAME Biphenyl dioxygenase (bphC) DME1009 SPESNAME Pseudomonas furukawaii DME1009 TISSUDIS Primarily distributed in human gutNot Available DME1009 FUNCTION This enzyme participates in the degradation pathway of biphenyl and PCB (poly chlorinated biphenyls) and contains Fe2+ or Mn2+ Not Available DME1012 DME___ID DME1012 DME1012 DME_NAME Beta-lactamase (blaB) DME1012 SPESNAME Bacteroides eggerthii DME1012 TISSUDIS Primarily distributed in human gutNot Available DME1012 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1013 DME___ID DME1013 DME1013 DME_NAME Beta-lactamase (blaB) DME1013 SPESNAME Pseudoflavonifractor capillosus DME1013 TISSUDIS Primarily distributed in human gutNot Available DME1013 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1014 DME___ID DME1014 DME1014 DME_NAME Beta-lactamase (blaB) DME1014 SPESNAME Acidaminococcus intestini DME1014 TISSUDIS Primarily distributed in human gutNot Available DME1014 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1015 DME___ID DME1015 DME1015 DME_NAME Beta-lactamase (blaB) DME1015 SPESNAME Fusobacterium mortiferum DME1015 TISSUDIS Primarily distributed in human gutNot Available DME1015 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1017 DME___ID DME1017 DME1017 DME_NAME Beta-lactamase (blaB) DME1017 SPESNAME Odoribacter splanchnicus DME1017 TISSUDIS Primarily distributed in human gutNot Available DME1017 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1018 DME___ID DME1018 DME1018 DME_NAME Beta-lactamase (blaB) DME1018 SPESNAME Prevotella oralis DME1018 TISSUDIS Primarily distributed in human gutNot Available DME1018 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1019 DME___ID DME1019 DME1019 DME_NAME Beta-lactamase (blaB) DME1019 SPESNAME Prevotella bivia DME1019 TISSUDIS Primarily distributed in human gutNot Available DME1019 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1020 DME___ID DME1020 DME1020 DME_NAME Beta-lactamase (blaB) DME1020 SPESNAME Acidaminococcus fermentans DME1020 TISSUDIS Primarily distributed in human skinNot Available DME1020 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1215 DME___ID DME1215 DME1215 DME_NAME Beta-lactamase (blaB) DME1215 SPESNAME Bacteroides caccae DME1215 TISSUDIS Primarily distributed in human gutNot Available DME1215 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1216 DME___ID DME1216 DME1216 DME_NAME Beta-lactamase (blaB) DME1216 SPESNAME Parabacteroides distasonis DME1216 TISSUDIS Primarily distributed in human gutNot Available DME1216 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1218 DME___ID DME1218 DME1218 DME_NAME Beta-lactamase (blaB) DME1218 SPESNAME Bacteroides ovatus DME1218 TISSUDIS Primarily distributed in human gutNot Available DME1218 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1219 DME___ID DME1219 DME1219 DME_NAME Beta-lactamase (blaB) DME1219 SPESNAME Bacteroides thetaiotaomicron DME1219 TISSUDIS Primarily distributed in human gutNot Available DME1219 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1220 DME___ID DME1220 DME1220 DME_NAME Beta-lactamase (blaB) DME1220 SPESNAME Bacteroides vulgatus DME1220 TISSUDIS Primarily distributed in human gutNot Available DME1220 FUNCTION This enzyme hydrolyze cephalosporins, penicillins and also cefoxitin; but at a slow rateNot Available DME1221 DME___ID DME1221 DME1221 DME_NAME Beta-lactamase (blaB) DME1221 SPESNAME Capnocytophaga haemolytica DME1221 TISSUDIS Primarily distributed in human oral cavityNot Available DME1221 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1225 DME___ID DME1225 DME1225 DME_NAME Beta-lactamase (blaB) DME1225 SPESNAME Fusobacterium varium DME1225 TISSUDIS Primarily distributed in human gutNot Available DME1225 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1227 DME___ID DME1227 DME1227 DME_NAME Beta-lactamase (blaB) DME1227 SPESNAME Neisseria sicca DME1227 TISSUDIS Primarily distributed in human oral cavityNot Available DME1227 FUNCTION This enzyme hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivativesNot Available DME1229 DME___ID DME1229 DME1229 DME_NAME Beta-lactamase (blaB) DME1229 SPESNAME Prevotella intermedia DME1229 TISSUDIS Primarily distributed in human gutNot Available DME1229 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1230 DME___ID DME1230 DME1230 DME_NAME Beta-lactamase (blaB) DME1230 SPESNAME Prevotella nigrescens DME1230 TISSUDIS Primarily distributed in human gutNot Available DME1230 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1295 DME___ID DME1295 DME1295 DME_NAME Beta-lactamase (blaB) DME1295 SPESNAME Prevotella buccae DME1295 TISSUDIS Primarily distributed in human oral cavityNot Available DME1295 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1300 DME___ID DME1300 DME1300 DME_NAME Beta-lactamase (blaB) DME1300 SPESNAME Capnocytophaga ochracea DME1300 TISSUDIS Primarily distributed in human oral cavityNot Available DME1300 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1308 DME___ID DME1308 DME1308 DME_NAME Beta-lactamase (blaB) DME1308 SPESNAME Prevotella veroralis DME1308 TISSUDIS Primarily distributed in human oral cavityNot Available DME1308 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1309 DME___ID DME1309 DME1309 DME_NAME Beta-lactamase (blaB) DME1309 SPESNAME Alloprevotella tannerae DME1309 TISSUDIS Primarily distributed in human oral cavityNot Available DME1309 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1310 DME___ID DME1310 DME1310 DME_NAME Beta-lactamase (blaB) DME1310 SPESNAME Capnocytophaga gingivalis DME1310 TISSUDIS Primarily distributed in human oral cavityNot Available DME1310 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1314 DME___ID DME1314 DME1314 DME_NAME Beta-lactamase (blaB) DME1314 SPESNAME Photorhabdus asymbiotica DME1314 TISSUDIS Primarily distributed in human skinNot Available DME1314 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1318 DME___ID DME1318 DME1318 DME_NAME Beta-lactamase (blaB) DME1318 SPESNAME Bacteroides dorei DME1318 TISSUDIS Primarily distributed in human gutNot Available DME1318 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1319 DME___ID DME1319 DME1319 DME_NAME Beta-lactamase (blaB) DME1319 SPESNAME Bacteroides intestinalis DME1319 TISSUDIS Primarily distributed in human gutNot Available DME1319 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1326 DME___ID DME1326 DME1326 DME_NAME Beta-lactamase (blaB) DME1326 SPESNAME Capnocytophaga granulosa DME1326 TISSUDIS Primarily distributed in human oral cavityNot Available DME1326 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1329 DME___ID DME1329 DME1329 DME_NAME Beta-lactamase (blaB) DME1329 SPESNAME Prevotella denticola DME1329 TISSUDIS Primarily distributed in human oral cavityNot Available DME1329 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1334 DME___ID DME1334 DME1334 DME_NAME Beta-lactamase (blaB) DME1334 SPESNAME Capnocytophaga sputigena DME1334 TISSUDIS Primarily distributed in human oral cavityNot Available DME1334 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1335 DME___ID DME1335 DME1335 DME_NAME Beta-lactamase (blaB) DME1335 SPESNAME Capnocytophaga leadbetteri DME1335 TISSUDIS Primarily distributed in human oral cavityNot Available DME1335 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1347 DME___ID DME1347 DME1347 DME_NAME Beta-lactamase (blaB) DME1347 SPESNAME Bacteroides stercoris DME1347 TISSUDIS Primarily distributed in human gutNot Available DME1347 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1348 DME___ID DME1348 DME1348 DME_NAME Beta-lactamase (blaB) DME1348 SPESNAME Bacteroides cellulosilyticus DME1348 TISSUDIS Primarily distributed in human gutNot Available DME1348 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1354 DME___ID DME1354 DME1354 DME_NAME Beta-lactamase (blaB) DME1354 SPESNAME Prevotella loescheii DME1354 TISSUDIS Primarily distributed in human oral cavityNot Available DME1354 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1485 DME___ID DME1485 DME1485 DME_NAME Beta-lactamase (blaB) DME1485 SPESNAME Peptostreptococcus anaerobius DME1485 TISSUDIS Primarily distributed in human oral cavityNot Available DME1485 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1921 DME___ID DME1921 DME1921 DME_NAME Beta-lactamase (blaB) DME1921 SPESNAME Prevotella copri DME1921 TISSUDIS Primarily distributed in human oral cavityNot Available DME1921 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1043 DME___ID DME1043 DME1043 DME_NAME Beta-glucosidase (bglA) DME1043 SPESNAME Malassezia furfur DME1043 TISSUDIS Primarily distributed in human skinNot Available DME1043 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1044 DME___ID DME1044 DME1044 DME_NAME Beta-glucosidase (bglA) DME1044 SPESNAME Malassezia sympodialis DME1044 TISSUDIS Primarily distributed in human skinNot Available DME1044 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1045 DME___ID DME1045 DME1045 DME_NAME Beta-glucosidase (bglA) DME1045 SPESNAME Trichophyton interdigitale DME1045 TISSUDIS Primarily distributed in human skinNot Available DME1045 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1082 DME___ID DME1082 DME1082 DME_NAME Azoreductase (azoR) DME1082 SPESNAME Bacteroides thetaiotaomicron DME1082 TISSUDIS Primarily distributed in human gutNot Available DME1082 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available DME1083 DME___ID DME1083 DME1083 DME_NAME Azoreductase (azoR) DME1083 SPESNAME Bifidobacterium dentium DME1083 TISSUDIS Primarily distributed in human gutNot Available DME1083 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available DME1322 DME___ID DME1322 DME1322 DME_NAME Azoreductase (azoR) DME1322 SPESNAME Lactobacillus buchneri DME1322 TISSUDIS Primarily distributed in human gutNot Available DME1322 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available And it requires NADH, but not NADPH, as an electron donor for its activityNot Available DME1473 DME___ID DME1473 DME1473 DME_NAME Azoreductase (azoR) DME1473 SPESNAME Bacteroides fragilis DME1473 TISSUDIS Primarily distributed in human gutNot Available DME1473 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available DME1474 DME___ID DME1474 DME1474 DME_NAME Azoreductase (azoR) DME1474 SPESNAME Bifidobacterium animalis DME1474 TISSUDIS Primarily distributed in human gutNot Available DME1474 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available DME1321 DME___ID DME1321 DME1321 DME_NAME Arylamine N-acetyltransferase (NAT) DME1321 SPESNAME Tsukamurella paurometabola DME1321 TISSUDIS Primarily distributed in human lungNot Available DME1321 FUNCTION This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoANot Available DME1949 DME___ID DME1949 DME1949 DME_NAME Arginine dihydrolase (arcA) DME1949 SPESNAME Staphylococcus petrasii DME1949 TISSUDIS Primarily distributed in human bloodNot Available DME1949 FUNCTION This enzyme acts on canavanineNot Available DME1138 DME___ID DME1138 DME1138 DME_NAME Alpha-glucosidase (aglA) DME1138 SPESNAME Blautia obeum DME1138 TISSUDIS Primarily distributed in human gutNot Available DME1138 FUNCTION This enzyme is probably involved in the catabolism of alpha-glycosides accumulated via a phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS)Not Available And it hydrolyzes a wide variety of 6-phospho-alpha-D-glucosides including the five isomeric derivatives of sucrose, iNot AvailableeNot Available trehalulose-6'-phosphate, turanose-6'-phosphate, maltulose-6'-phosphate, leucrose-6'-phosphate, and palatinose-6'-phosphate, but is not active on sucrose-6-phosphateNot Available Moreover, it can also hydrolyze maltose-6'-phosphate and methyl-alpha-glucose-6-phosphate, and poorly, trehalose-6-phosphateNot Available However, it fails to hydrolyze beta-O-linked phosphorylated disaccharides such as cellobiose-6'-phosphate and gentiobiose-6'-phosphateNot Available DME1200 DME___ID DME1200 DME1200 DME_NAME L,D-carboxypeptidase A (ldcA) DME1200 SPESNAME Escherichia coli DME1200 TISSUDIS Primarily distributed in human gutNot Available DME1200 FUNCTION This enzyme hydrolyzes peptide bonds of C-terminal residues with aromatic or aliphatic side-chainsNot Available DME1724 DME___ID DME1724 DME1724 DME_NAME Glycoside hydrolase (cscA) DME1724 SPESNAME Escherichia coli DME1724 TISSUDIS Primarily distributed in human gutNot Available DME1724 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available Substrates include sucroseNot Available DME1690 DME___ID DME1690 DME1690 DME_NAME D-Lactate dehydrogenase (ldhA) DME1690 SPESNAME Escherichia coli DME1690 TISSUDIS Primarily distributed in human gutNot Available DME1690 FUNCTION This enzyme has D-lactate dehydrogenase activityNot Available DME1223 DME___ID DME1223 DME1223 DME_NAME Beta-lactamase (blaB) DME1223 SPESNAME Escherichia coli DME1223 TISSUDIS Primarily distributed in human gutNot Available DME1223 FUNCTION This enzyme is the most prevalent beta-lactamase in enterobacteriaNot Available It hydrolyzes the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporinsNot Available TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidimeNot Available TEM-5 is capable of hydrolyzing ceftazidimeNot Available TEM-6 is capable of hydrolyzing ceftazidime and aztreonamNot Available TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidimeNot Available IRT-4 shows resistance to beta-lactamase inhibitorsNot Available DME0578 DME___ID DME0578 DME0578 DME_NAME Sorbitol dehydrogenase (SORD) DME0578 SPESNAME Homo sapiens DME0578 TISSUDIS Primarily distributed in cervix, uterine, liver and thyroid glandNot Available DME0578 FUNCTION This enzyme catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcoholsNot Available It is mostly active with D- sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D- xylulose, and D-ribulose, respectivelyNot Available It is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolismNot Available It also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediolNot Available And to a lesser extent, it can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitroNot Available DME0464 DME___ID DME0464 DME0464 DME_NAME S-methyl-5'-thioadenosine phosphorylase (MTAP) DME0464 SPESNAME Homo sapiens DME0464 TISSUDIS Low tissue/organ specificityNot Available DME0464 FUNCTION This enzyme catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphateNot Available It is involved in the breakdown of MTA, a major by-product of polyamine biosynthesisNot Available And it is responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionineNot Available Additionally, it has broad substrate specificity with 6-aminopurine nucleosides as preferred substratesNot Available DME0536 DME___ID DME0536 DME0536 DME_NAME Phosphoglucomutase 3 (PGM3) DME0536 SPESNAME Homo sapiens DME0536 TISSUDIS Primarily distributed in pancreas, heart, liver and placentaNot Available DME0536 FUNCTION This enzyme catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylationNot Available DME0186 DME___ID DME0186 DME0186 DME_NAME Methionine-tRNA ligase cytoplasmic (MARS) DME0186 SPESNAME Homo sapiens DME0186 TISSUDIS Low tissue/organ specificityNot Available DME0186 FUNCTION This enzyme catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNANot Available DME0450 DME___ID DME0450 DME0450 DME_NAME Gamma-glutamylcyclotransferase 2 (CHAC2) DME0450 SPESNAME Homo sapiens DME0450 TISSUDIS Low tissue/organ specificityNot Available DME0450 FUNCTION This enzyme catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide and acts specifically on glutathione, but not on other gamma-glutamyl peptidesNot Available DME1231 DME___ID DME1231 DME1231 DME_NAME Beta-lactamase (blaB) DME1231 SPESNAME Serratia marcescens DME1231 TISSUDIS Primarily distributed in human gutNot Available DME1231 FUNCTION This enzyme hydrolyzes beta-lactam with a substrate specificity for cephalosporinsNot Available DME1731 DME___ID DME1731 DME1731 DME_NAME Carbapenemase (cphA) DME1731 SPESNAME Aeromonas hydrophila DME1731 TISSUDIS Primarily distributed in human gutNot Available DME1731 FUNCTION This enzyme confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ringNot Available It is able to hydrolyze penicillin and imipenem, but is much less active against cephalothin, cefotaxime, meropenem and ceftazidimeNot Available DME1916 DME___ID DME1916 DME1916 DME_NAME Methylthioribose kinase (mtnK) DME1916 SPESNAME Klebsiella pneumoniae DME1916 TISSUDIS Primarily distributed in human gutNot Available DME1916 FUNCTION This enzyme catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphateNot Available DME1617 DME___ID DME1617 DME1617 DME_NAME Oxygen-insensitive NADPH nitroreductase B (nfsB) DME1617 SPESNAME Salmonella enterica DME1617 TISSUDIS Primarily distributed in human gutNot Available DME1617 FUNCTION This enzyme can reduce a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferredNot Available And it also can reduce nitrofurazoneNot Available DME1632 DME___ID DME1632 DME1632 DME_NAME Aminoglycoside adenylyltransferase (aadA1a) DME1632 SPESNAME Salmonella enterica DME1632 TISSUDIS Primarily distributed in human gutNot Available DME1632 FUNCTION This enzyme can use ATP, dATP, CTP, ITP and GTP as donors and kanamycin, tobramycin and sisomicin as acceptorsNot Available And it mediates bacterial resistance to the antibiotics streptomycin and spectomycinNot Available DME1342 DME___ID DME1342 DME1342 DME_NAME Beta-lactamase (blaB) DME1342 SPESNAME Acinetobacter baumannii DME1342 TISSUDIS Primarily distributed in human gutNot Available DME1342 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1292 DME___ID DME1292 DME1292 DME_NAME VanB ligase (vanB) DME1292 SPESNAME Enterococcus faecalis DME1292 TISSUDIS Primarily distributed in human gutNot Available DME1292 FUNCTION This enzyme is required for high-level resistance to glycopeptides antibioticsNot Available D-Ala--D-Ala ligase of altered specificity catalyzes ester bond formation between D-Ala and various D-hydroxy acids and produce a peptidoglycan which does not terminate in D-alanine but in D-lactate, thus preventing vancomycin bindingNot Available DME1312 DME___ID DME1312 DME1312 DME_NAME Beta-lactamase (blaB) DME1312 SPESNAME Burkholderia cenocepacia DME1312 TISSUDIS Primarily distributed in human lungNot Available DME1312 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1191 DME___ID DME1191 DME1191 DME_NAME Ampc beta-lactamase (ampC) DME1191 SPESNAME Burkholderia cenocepacia DME1191 TISSUDIS Primarily distributed in human lungNot Available DME1191 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1192 DME___ID DME1192 DME1192 DME_NAME AmpC beta-lactamase (ampC) DME1192 SPESNAME Burkholderia multivorans DME1192 TISSUDIS Primarily distributed in human lungNot Available DME1192 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1476 DME___ID DME1476 DME1476 DME_NAME Azoreductase (azoR) DME1476 SPESNAME Streptococcus pyogenes DME1476 TISSUDIS Primarily distributed in human gutNot Available DME1476 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available DME1562 DME___ID DME1562 DME1562 DME_NAME Beta-lactamase (blaB) DME1562 SPESNAME Corynebacterium acnes DME1562 TISSUDIS Primarily distributed in human oral cavityNot Available DME1562 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1559 DME___ID DME1559 DME1559 DME_NAME PenA beta-lactamase (penA1) DME1559 SPESNAME Burkholderia cepacia DME1559 TISSUDIS Primarily distributed in human lungNot Available DME1559 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1586 DME___ID DME1586 DME1586 DME_NAME Oxygen-insensitive NADPH nitroreductase A (nfsA) DME1586 SPESNAME Pseudomonas putida DME1586 TISSUDIS Primarily distributed in human skinNot Available DME1586 FUNCTION This enzyme can catalyze FMN and also can catalyze FAD and riboflavin with lower activityNot Available DME2062 DME___ID DME2062 DME2062 DME_NAME Glycosyl hydrolase (glyH) DME2062 SPESNAME Pseudomonas putida DME2062 TISSUDIS Primarily distributed in human gutNot Available DME2062 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1332 DME___ID DME1332 DME1332 DME_NAME Beta-lactamase (blaB) DME1332 SPESNAME Burkholderia cepacia DME1332 TISSUDIS Primarily distributed in human lungNot Available DME1332 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME2071 DME___ID DME2071 DME2071 DME_NAME Beta-lactamase (blaB) DME2071 SPESNAME Bacillus pumilus DME2071 TISSUDIS Primarily distributed in human gutNot Available DME2071 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1184 DME___ID DME1184 DME1184 DME_NAME VanB ligase (vanB) DME1184 SPESNAME Enterococcus faecium DME1184 TISSUDIS Primarily distributed in human gutNot Available DME1184 FUNCTION This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6Not Available3Not Available2Not Available7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6Not Available3Not Available2Not Available13), UDP-N-acetylmuramate---L-alanine ligase (EC 6Not Available3Not Available2Not Available8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6Not Available3Not Available2Not Available9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6Not Available3Not Available2Not Available10) in the synthesis of a cell-wall peptideNot Available DME1779 DME___ID DME1779 DME1779 DME_NAME Dipeptidylpeptidase IV (DPP4) DME1779 SPESNAME Streptococcus suis DME1779 TISSUDIS Primarily distributed in human bloodNot Available DME1779 FUNCTION This enzyme cleaves X-proline or X-alanine dipeptides from the N-terminus of polypeptidesNot Available DME1664 DME___ID DME1664 DME1664 DME_NAME Cytochrome P450 monooxygenase 51A (cyp51A) DME1664 SPESNAME Aspergillus fumigatus DME1664 TISSUDIS Primarily distributed in human lungNot Available DME1664 FUNCTION This enzyme is involved in the biosynthesis of ergosterol, and as a cytochrome P-450 (heme-thiolate) protein acts on a range of steroids with a 14alpha-methyl group, such as obtusifoliol and lanosterolNot Available And it catalyses a hydroxylation and a reduction of the 14alpha-methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bondNot Available DME1149 DME___ID DME1149 DME1149 DME_NAME CDP-alcohol phosphatidyltransferase (pgsA) DME1149 SPESNAME Streptococcus mitis DME1149 TISSUDIS Primarily distributed in human oral cavityNot Available DME1149 FUNCTION This enzyme catalyzes the committed step in the biosynthesis of acidic phospholipids known by the common names phophatidylglycerols and cardiolipinsNot Available DME2021 DME___ID DME2021 DME2021 DME_NAME Carbapenemase (cphA) DME2021 SPESNAME Achromobacter xylosoxidans DME2021 TISSUDIS Primarily distributed in human stomachNot Available DME2021 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1699 DME___ID DME1699 DME1699 DME_NAME Beta-lactamase (blaB) DME1699 SPESNAME Morganella morganii DME1699 TISSUDIS Primarily distributed in human gutNot Available DME1699 FUNCTION This enzyme hydrolyzes beta-lactam with a substrate specificity for cephalosporinsNot Available DME2060 DME___ID DME2060 DME2060 DME_NAME Beta-glucosidase (bglA) DME2060 SPESNAME Enterococcus faecium DME2060 TISSUDIS Primarily distributed in human gutNot Available DME2060 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME2059 DME___ID DME2059 DME2059 DME_NAME Beta-galactosidase (bgaB) DME2059 SPESNAME Cronobacter sakazakii DME2059 TISSUDIS Primarily distributed in human gutNot Available DME2059 FUNCTION This enzyme hydrolyzes alpha-L-arabinoside and beta-D-fucosides and beta-D-glucosidesNot Available DME1142 DME___ID DME1142 DME1142 DME_NAME Aminoglycoside O-phosphotransferase (aphA6) DME1142 SPESNAME Providencia stuartii DME1142 TISSUDIS Primarily distributed in human gutNot Available DME1142 FUNCTION This enzyme acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin ANot Available DME1141 DME___ID DME1141 DME1141 DME_NAME Aminoglycoside acetyltransferase (aac) DME1141 SPESNAME Providencia stuartii DME1141 TISSUDIS Primarily distributed in human gutNot Available DME1141 FUNCTION This enzyme catalyzes the coenzyme A-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosidesNot Available DME1164 DME___ID DME1164 DME1164 DME_NAME Xylose isomerase (xylA) DME1164 SPESNAME Bifidobacterium adolescentis DME1164 TISSUDIS Primarily distributed in human gutNot Available DME1164 FUNCTION This enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificityNot Available It binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyses ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sitesNot Available DME1351 DME___ID DME1351 DME1351 DME_NAME VanG ligase (vanG) DME1351 SPESNAME Streptococcus agalactiae DME1351 TISSUDIS Primarily distributed in human gutNot Available DME1351 FUNCTION This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6Not Available3Not Available2Not Available7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6Not Available3Not Available2Not Available13), UDP-N-acetylmuramate---L-alanine ligase (EC 6Not Available3Not Available2Not Available8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6Not Available3Not Available2Not Available9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6Not Available3Not Available2Not Available10) in the synthesis of a cell-wall peptideNot Available DME1185 DME___ID DME1185 DME1185 DME_NAME VanC2 ligase (vanC) DME1185 SPESNAME Enterococcus gallinarum DME1185 TISSUDIS Primarily distributed in human gutNot Available DME1185 FUNCTION This enzyme is required for low-level resistance to the glycopeptide antibiotic vancomycin and it may synthesize a dipeptide or a depsipeptide which is incorporated into peptidoglycan precursors and not recognized by vancomycinNot Available DME1008 DME___ID DME1008 DME1008 DME_NAME Tripeptidase (pepT) DME1008 SPESNAME Lactococcus lactis DME1008 TISSUDIS Primarily distributed in human gutNot Available DME1008 FUNCTION This enzyme catalyzes release of the N-terminal residue from a tripeptideNot Available DME1545 DME___ID DME1545 DME1545 DME_NAME Sucrose phosphorylase (Spase) DME1545 SPESNAME Bifidobacterium longum DME1545 TISSUDIS Primarily distributed in human oral cavityNot Available DME1545 FUNCTION This enzyme catalyzes the conversion of sucrose to D-fructose and alpha-D-glucose-1-phosphateNot Available DME1718 DME___ID DME1718 DME1718 DME_NAME Sucrose phosphorylase (Spase) DME1718 SPESNAME Lactobacillus acidophilus DME1718 TISSUDIS Primarily distributed in human gutNot Available DME1718 FUNCTION This enzyme catalyzes the conversion of sucrose to D-fructose and alpha-D-glucose-1-phosphateNot Available DME1584 DME___ID DME1584 DME1584 DME_NAME Retro-nitroreductase (rNR) DME1584 SPESNAME Enterobacter cloacae DME1584 TISSUDIS Primarily distributed in human gutNot Available DME1584 FUNCTION This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compoundsNot Available DME1691 DME___ID DME1691 DME1691 DME_NAME Pyruvate oxidase (pyrO) DME1691 SPESNAME Lactobacillus casei DME1691 TISSUDIS Primarily distributed in human gutNot Available DME1691 FUNCTION This enzyme is a flavoprotein (FAD) requiring thiamine diphosphateNot Available Two reducing equivalents are transferred from the resonant carbanion/enamine forms of 2-hydroxyethyl-thiamine-diphosphate to the adjacent flavin cofactor, yielding 2-acetyl-thiamine diphosphate (AcThDP) and reduced flavinNot Available DME2103 DME___ID DME2103 DME2103 DME_NAME Phosphotransferase enzyme strB (strB) DME2103 SPESNAME Erwinia amylovora DME2103 TISSUDIS Primarily distributed in human gutNot Available DME2103 FUNCTION This enzyme is enzyme I of the phosphotransferase system, and it acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9Not Available5 kDa) involved in bacterial sugar transportNot Available DME1780 DME___ID DME1780 DME1780 DME_NAME Phosphoenolpyruvate carboxykinase (pckG) DME1780 SPESNAME Ruminococcus flavefaciens DME1780 TISSUDIS Primarily distributed in human gutNot Available DME1780 FUNCTION This enzyme catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycleNot Available DME1720 DME___ID DME1720 DME1720 DME_NAME Phospho-beta-glucosidase (LBA1706) DME1720 SPESNAME Lactobacillus acidophilus DME1720 TISSUDIS Primarily distributed in human gutNot Available DME1720 FUNCTION This enzyme hydrolyzes several other phospho-beta-D-glucosides, but not their non-phosphorylated formsNot Available DME1513 DME___ID DME1513 DME1513 DME_NAME Maltose phosphorylase (malP) DME1513 SPESNAME Lactobacillus brevis DME1513 TISSUDIS Primarily distributed in human gutNot Available DME1513 FUNCTION This enzyme catalyzes the conversion of maltose to D-glucose and beta-D-glucose 1-phosphateNot Available DME1512 DME___ID DME1512 DME1512 DME_NAME L-Lactate dehydrogenase (ldh) DME1512 SPESNAME Lactobacillus casei DME1512 TISSUDIS Primarily distributed in human gutNot Available DME1512 FUNCTION This enzyme catalyzes the conversion of lactate to pyruvate, and it also oxidizes other (S)-2-hydroxymonocarboxylic acidsNot Available DME1688 DME___ID DME1688 DME1688 DME_NAME L-Lactate dehydrogenase (ldh) DME1688 SPESNAME Lactobacillus delbrueckii DME1688 TISSUDIS Primarily distributed in human gutNot Available DME1688 FUNCTION This enzyme catalyzes the conversion of lactate to pyruvate, and it also oxidizes other (S)-2-hydroxymonocarboxylic acidsNot Available DME1338 DME___ID DME1338 DME1338 DME_NAME Linoleate 10-hydratase (10-LAH) DME1338 SPESNAME Lactobacillus plantarum DME1338 TISSUDIS Primarily distributed in human gutNot Available DME1338 FUNCTION This enzyme catalyzes the conversion of linoleic acid to 10-hydroxy-12-octadecenoic acidNot Available DME1005 DME___ID DME1005 DME1005 DME_NAME L-arabinose isomerase (araA) DME1005 SPESNAME Lactobacillus fermentum DME1005 TISSUDIS Primarily distributed in human gutNot Available DME1005 FUNCTION This enzyme catalyzes the conversion of L-arabinose to L-ribuloseNot Available It requires a divalent metal ion and binds the closed form of the sugar and catalyses ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene-diol mechanismNot Available It can also convert D-galactose to D-tagatose with lower efficiencyNot Available DME1198 DME___ID DME1198 DME1198 DME_NAME Lactate racemase (Lsa784) DME1198 SPESNAME Lactobacillus sakei DME1198 TISSUDIS Primarily distributed in human gutNot Available DME1198 FUNCTION This enzyme contains a unique nickel-containing cofactor, pyridinium-3-thioamide-5-thiocarboxylate mononucleotide Ni pincer complexNot Available DME1199 DME___ID DME1199 DME1199 DME_NAME L,D-carboxypeptidase A (ldcA) DME1199 SPESNAME Neisseria gonorrhoeae DME1199 TISSUDIS Primarily distributed in human gutNot Available DME1199 FUNCTION This enzyme hydrolyzes peptide bonds of C-terminal residues with aromatic or aliphatic side-chainsNot Available DME1177 DME___ID DME1177 DME1177 DME_NAME Inositol dehydrogenase (idh) DME1177 SPESNAME Lactobacillus casei DME1177 TISSUDIS Primarily distributed in human gutNot Available DME1177 FUNCTION This enzyme involves in the oxidation of myo-inositol and D-chiro-inositol to 2-keto-myo-inositol and 1-keto-D-chiro-inositol, respectivelyNot Available DME1178 DME___ID DME1178 DME1178 DME_NAME Inositol dehydrogenase (idh) DME1178 SPESNAME Lactobacillus casei DME1178 TISSUDIS Primarily distributed in human gutNot Available DME1178 FUNCTION This enzyme involves in the oxidation of myo-inositol and D-chiro-inositol to 2-keto-myo-inositol and 1-keto-D-chiro-inositol, respectivelyNot Available DME1143 DME___ID DME1143 DME1143 DME_NAME Hyaluronidase (hyl) DME1143 SPESNAME Bacillus megaterium DME1143 TISSUDIS Primarily distributed in human gutNot Available DME1143 FUNCTION This enzyme catalyzes the degradation of hyaluronan by a beta-elimination reaction and it also acts on chondroitinNot Available DME1153 DME___ID DME1153 DME1153 DME_NAME Histidine decarboxylase (hdcA) DME1153 SPESNAME Lactobacillus reuteri DME1153 TISSUDIS Primarily distributed in human gutNot Available DME1153 FUNCTION This enzyme catalyzes the decarboxylation of histidine to form histamineNot Available DME1923 DME___ID DME1923 DME1923 DME_NAME Glycerol/diol dehydratase (dhaB) DME1923 SPESNAME Lactobacillus reuteri DME1923 TISSUDIS Primarily distributed in human gutNot Available DME1923 FUNCTION This enzyme has two formsNot Available One form requires a cobamide coenzyme, while the other is a glycyl radical enzymeNot Available DME1495 DME___ID DME1495 DME1495 DME_NAME Glucansucrase (gtf106B) DME1495 SPESNAME Lactobacillus reuteri DME1495 TISSUDIS Primarily distributed in human gutNot Available DME1495 FUNCTION This enzyme glucosylates the phenolic compounds catechol, pyrogallol, resorcinol, and ethyl gallateNot Available DME1678 DME___ID DME1678 DME1678 DME_NAME GH3 beta-glucosidase (BAD1610) DME1678 SPESNAME Bifidobacterium adolescentis DME1678 TISSUDIS Primarily distributed in human gutNot Available DME1678 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1687 DME___ID DME1687 DME1687 DME_NAME D-Lactate dehydrogenase (ldhA) DME1687 SPESNAME Lactobacillus delbrueckii DME1687 TISSUDIS Primarily distributed in human gutNot Available DME1687 FUNCTION This enzyme has D-lactate dehydrogenase activityNot Available DME1170 DME___ID DME1170 DME1170 DME_NAME Dextransucrase 4 (dsrF4) DME1170 SPESNAME Leuconostoc mesenteroides DME1170 TISSUDIS Primarily distributed in human gutNot Available DME1170 FUNCTION This enzyme involves in the production of dextran, an extracellular glucan polymerNot Available DME1169 DME___ID DME1169 DME1169 DME_NAME Dextransucrase 3 (dsrF3) DME1169 SPESNAME Leuconostoc mesenteroides DME1169 TISSUDIS Primarily distributed in human gutNot Available DME1169 FUNCTION This enzyme involves in the production of dextran, an extracellular glucan polymerNot Available DME1168 DME___ID DME1168 DME1168 DME_NAME Dextransucrase 2 (dsrF2) DME1168 SPESNAME Leuconostoc mesenteroides DME1168 TISSUDIS Primarily distributed in human gutNot Available DME1168 FUNCTION This enzyme involves in the production of dextran, an extracellular glucan polymerNot Available DME1167 DME___ID DME1167 DME1167 DME_NAME Dextransucrase 1 (dsrF1) DME1167 SPESNAME Leuconostoc mesenteroides DME1167 TISSUDIS Primarily distributed in human gutNot Available DME1167 FUNCTION This enzyme involves in the production of dextran, an extracellular glucan polymerNot Available DME1236 DME___ID DME1236 DME1236 DME_NAME Cytochrome P450 BM3 (cypBM3) DME1236 SPESNAME Bacillus megaterium DME1236 TISSUDIS Primarily distributed in human gutNot Available DME1236 FUNCTION This enzyme is P-450 heme-thiolate protein, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groupsNot Available DME1235 DME___ID DME1235 DME1235 DME_NAME Cytochrome P450 51B1 (cyp51) DME1235 SPESNAME Mycobacterium tuberculosis DME1235 TISSUDIS Primarily distributed in human gutNot Available DME1235 FUNCTION This enzyme is cytochrome P-450 (heme-thiolate) protein acting on a range of steroids with a 14alpha-methyl group, such as obtusifoliol and lanosterolNot Available And it catalyses a hydroxylation and a reduction of the 14alpha-methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bondNot Available DME1662 DME___ID DME1662 DME1662 DME_NAME Cytochrome P450 121A1 (cyp121) DME1662 SPESNAME Mycobacterium tuberculosis DME1662 TISSUDIS Primarily distributed in human gutNot Available DME1662 FUNCTION This enzyme is a P-450 heme-thiolate protein, and it catalyzes C-C bond formation between the carbons ortho to the phenolic hydroxyl of cyclo(L-tyr-L-tyr) (cYY) producing mycocyclosinNot Available The enzme also can use cyclo(L-Tyr-L-Phe) (cYF), cyclo(L-Tyr-L-Trp) (cYW) and cyclo(L-Tyr-L-3,4-dihydroxyphenylalanine) (cY-DOPA) as substrateNot Available DME1745 DME___ID DME1745 DME1745 DME_NAME Cytochrome P450 109B1 (cyp109) DME1745 SPESNAME Bacillus anthracis DME1745 TISSUDIS Primarily distributed in human gutNot Available DME1745 FUNCTION This enzyme is P-450 heme-thiolate protein, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groupsNot Available DME1214 DME___ID DME1214 DME1214 DME_NAME Beta-lactamase (blaB) DME1214 SPESNAME Bacillus megaterium DME1214 TISSUDIS Primarily distributed in human gutNot Available DME1214 FUNCTION This enzyme confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ringNot Available DME1226 DME___ID DME1226 DME1226 DME_NAME Beta-lactamase (blaB) DME1226 SPESNAME Klebsiella oxytoca DME1226 TISSUDIS Primarily distributed in human skinNot Available DME1226 FUNCTION This enzyme hydrolyzes broad-spectrum beta-lactam antibiotics and is active against cephalosporinsNot Available DME1311 DME___ID DME1311 DME1311 DME_NAME Beta-lactamase (blaB) DME1311 SPESNAME Salmonella enterica DME1311 TISSUDIS Primarily distributed in human gutNot Available DME1311 FUNCTION This enzyme has cefotaxime-hydrolyzing activityNot Available DME1484 DME___ID DME1484 DME1484 DME_NAME Beta-lactamase (blaB) DME1484 SPESNAME Enterobacter cancerogenus DME1484 TISSUDIS Primarily distributed in human gutNot Available DME1484 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1564 DME___ID DME1564 DME1564 DME_NAME Beta-lactamase (blaB) DME1564 SPESNAME Staphylococcus aureus DME1564 TISSUDIS Primarily distributed in human oral cavityNot Available DME1564 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1643 DME___ID DME1643 DME1643 DME_NAME Beta-lactamase (blaB) DME1643 SPESNAME Chromobacterium violaceum DME1643 TISSUDIS Primarily distributed in human skinNot Available DME1643 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1208 DME___ID DME1208 DME1208 DME_NAME Beta-glucuronidase (uidA) DME1208 SPESNAME Clostridium perfringens DME1208 TISSUDIS Primarily distributed in human gutNot Available DME1208 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1211 DME___ID DME1211 DME1211 DME_NAME Beta-glucuronidase (uidA) DME1211 SPESNAME Lactobacillus rhamnosus DME1211 TISSUDIS Primarily distributed in human gutNot Available DME1211 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1350 DME___ID DME1350 DME1350 DME_NAME Beta-glucuronidase (uidA) DME1350 SPESNAME Streptococcus agalactiae DME1350 TISSUDIS Primarily distributed in human gutNot Available DME1350 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1175 DME___ID DME1175 DME1175 DME_NAME Beta-glucosidase (bglA) DME1175 SPESNAME Bacillus subtilis DME1175 TISSUDIS Primarily distributed in human gutNot Available DME1175 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1207 DME___ID DME1207 DME1207 DME_NAME Beta-glucosidase (bglA) DME1207 SPESNAME Lactobacillus rhamnosus DME1207 TISSUDIS Primarily distributed in human gutNot Available DME1207 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1847 DME___ID DME1847 DME1847 DME_NAME Beta-glucosidase (bglA) DME1847 SPESNAME Bifidobacterium adolescentis DME1847 TISSUDIS Primarily distributed in human gutNot Available DME1847 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1715 DME___ID DME1715 DME1715 DME_NAME Beta-galactosidase (bgaB) DME1715 SPESNAME Lactobacillus acidophilus DME1715 TISSUDIS Primarily distributed in human gutNot Available DME1715 FUNCTION This enzyme hydrolyzes lactose, oNP-galactoside (oNPG), pNP-galactosidase (pNPG), pNP-mannoside, pNP-glucoside, pNP-fucoside, pNP-N-acetylglucosamideNot Available DME1725 DME___ID DME1725 DME1725 DME_NAME Beta-galactosidase (bgaB) DME1725 SPESNAME Enterobacter cloacae DME1725 TISSUDIS Primarily distributed in human gutNot Available DME1725 FUNCTION This enzyme hydrolyzes alpha-L-arabinoside and beta-D-fucosides and beta-D-glucosidesNot Available DME1162 DME___ID DME1162 DME1162 DME_NAME Beta-fructofuranosidase (BFRU) DME1162 SPESNAME Bifidobacterium longum DME1162 TISSUDIS Primarily distributed in human oral cavityNot Available DME1162 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available Substrates include sucroseNot Available DME1713 DME___ID DME1713 DME1713 DME_NAME Beta-fructofuranosidase (BFRU) DME1713 SPESNAME Lactobacillus salivarius DME1713 TISSUDIS Primarily distributed in human gutNot Available DME1713 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available Substrates include sucroseNot Available DME1946 DME___ID DME1946 DME1946 DME_NAME Azoreductase (azoR) DME1946 SPESNAME Shigella dysenteriae DME1946 TISSUDIS Primarily distributed in human gutNot Available DME1946 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available And it requires NADH, but not NADPH, as an electron donor for its activityNot Available DME1154 DME___ID DME1154 DME1154 DME_NAME ATP-dependent 6-phosphofructokinase (pfkA) DME1154 SPESNAME Lactobacillus delbrueckii DME1154 TISSUDIS Primarily distributed in human gutNot Available DME1154 FUNCTION This enzyme catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysisNot Available DME1480 DME___ID DME1480 DME1480 DME_NAME Alpha-L-rhamnosidase (lrA) DME1480 SPESNAME Bacillus subtilis DME1480 TISSUDIS Primarily distributed in human gutNot Available DME1480 FUNCTION This enzyme utilizes an inverting mechanism of hydrolysis, releasing beta-L-rhamnoseNot Available Substrates include naringin, rutin, quercitrin, hesperidin, dioscin, terpenyl glycosides and many other natural glycosides containing terminal alpha-L-rhamnoseNot Available DME1929 DME___ID DME1929 DME1929 DME_NAME Alpha-L-rhamnosidase (lrA) DME1929 SPESNAME Lactobacillus rhamnosus DME1929 TISSUDIS Primarily distributed in human gutNot Available DME1929 FUNCTION This enzyme utilizes an inverting mechanism of hydrolysis, releasing beta-L-rhamnoseNot Available Substrates include naringin, rutin, quercitrin, hesperidin, dioscin, terpenyl glycosides and many other natural glycosides containing terminal alpha-L-rhamnoseNot Available DME1714 DME___ID DME1714 DME1714 DME_NAME Alpha-galactosidase (melA) DME1714 SPESNAME Lactobacillus acidophilus DME1714 TISSUDIS Primarily distributed in human gutNot Available DME1714 FUNCTION This enzyme hydrolyzes alpha-D-fucosides and the short-chain alpha-galactosaccharide raffinoseNot Available DME1719 DME___ID DME1719 DME1719 DME_NAME Alpha-galactosidase (melA) DME1719 SPESNAME Streptococcus thermophilus DME1719 TISSUDIS Primarily distributed in human gutNot Available DME1719 FUNCTION This enzyme hydrolyzes alpha-D-fucosidesNot Available DME2081 DME___ID DME2081 DME2081 DME_NAME Alpha-galactosidase (melA) DME2081 SPESNAME Lactobacillus salivarius DME2081 TISSUDIS Primarily distributed in human gutNot Available DME2081 FUNCTION This enzyme hydrolyzes alpha-D-fucosidesNot Available DME2082 DME___ID DME2082 DME2082 DME_NAME Alpha-galactosidase (melA) DME2082 SPESNAME Lactobacillus brevis DME2082 TISSUDIS Primarily distributed in human gutNot Available DME2082 FUNCTION This enzyme hydrolyzes alpha-D-fucosidesNot Available DME1918 DME___ID DME1918 DME1918 DME_NAME Alcohol dehydrogenase (ADH) DME1918 SPESNAME Lactobacillus brevis DME1918 TISSUDIS Primarily distributed in human gutNot Available DME1918 FUNCTION This enzyme acts on primary or secondary alcohols or hemi-acetals with very broad specificity and the enzyme oxidizes methanol much more poorly than ethanolNot Available DME0526 DME___ID DME0526 DME0526 DME_NAME Xylulose kinase (XYLB) DME0526 SPESNAME Homo sapiens DME0526 TISSUDIS Primarily distributed in liverNot Available DME0526 FUNCTION This enzyme phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesisNot Available DME0551 DME___ID DME0551 DME0551 DME_NAME Xylosylprotein 4-beta-galactosyltransferase (XGalT-1) DME0551 SPESNAME Homo sapiens DME0551 TISSUDIS Primarily distributed in heart, pancreas and liverNot Available Also expressed in placenta and kidneyNot Available DME0551 FUNCTION This enzyme is required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblastsNot Available DME1694 DME___ID DME1694 DME1694 DME_NAME Xylose isomerase (xylA) DME1694 SPESNAME Alistipes indistinctus DME1694 TISSUDIS Primarily distributed in human gutNot Available DME1694 FUNCTION This enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificityNot Available It binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyses ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sitesNot Available DME1186 DME___ID DME1186 DME1186 DME_NAME VanG ligase (vanG) DME1186 SPESNAME Streptococcus anginosus DME1186 TISSUDIS Primarily distributed in human gutNot Available DME1186 FUNCTION This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6Not Available3Not Available2Not Available7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6Not Available3Not Available2Not Available13), UDP-N-acetylmuramate---L-alanine ligase (EC 6Not Available3Not Available2Not Available8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6Not Available3Not Available2Not Available9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6Not Available3Not Available2Not Available10) in the synthesis of a cell-wall peptideNot Available DME1297 DME___ID DME1297 DME1297 DME_NAME VanC2 ligase (vanC) DME1297 SPESNAME Enterococcus casseliflavus DME1297 TISSUDIS Primarily distributed in human gutNot Available DME1297 FUNCTION This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6Not Available3Not Available2Not Available7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6Not Available3Not Available2Not Available13), UDP-N-acetylmuramate---L-alanine ligase (EC 6Not Available3Not Available2Not Available8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6Not Available3Not Available2Not Available9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6Not Available3Not Available2Not Available10) in the synthesis of a cell-wall peptideNot Available DME1489 DME___ID DME1489 DME1489 DME_NAME VanB ligase (vanB) DME1489 SPESNAME Desulfitobacterium chlororespirans DME1489 TISSUDIS Primarily distributed in human gutNot Available DME1489 FUNCTION This enzyme produces the depsipeptide D-alanyl-(R)-lactate, which can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptideNot Available The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteriaNot Available DME1623 DME___ID DME1623 DME1623 DME_NAME VanB ligase (vanB) DME1623 SPESNAME Desulfitobacterium hafniense DME1623 TISSUDIS Primarily distributed in human gutNot Available DME1623 FUNCTION This enzyme produces the depsipeptide D-alanyl-(R)-lactate, which can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptideNot Available The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteriaNot Available DME0179 DME___ID DME0179 DME0179 DME_NAME Valyl-tRNA synthetase (VARS) DME0179 SPESNAME Homo sapiens DME0179 TISSUDIS Low tissue/organ specificityNot Available DME0179 FUNCTION This enzyme catalyzes the aminoacylation of tRNA by their cognate amino acidNot Available DME0480 DME___ID DME0480 DME0480 DME_NAME Uridine-cytidine kinase 2 (UCK2) DME0480 SPESNAME Homo sapiens DME0480 TISSUDIS Primarily distributed in placenta and testisNot Available DME0480 FUNCTION This enzyme phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate but does not phosphorylate deoxyribonucleosides or purine ribonucleosidesNot Available It can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)- acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidineNot Available DME0537 DME___ID DME0537 DME0537 DME_NAME UDP-N-acetylhexosamine pyrophosphorylase (AGX) DME0537 SPESNAME Homo sapiens DME0537 TISSUDIS Primarily distributed in placenta, muscle and liverNot Available DME0537 FUNCTION This enzyme converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAcNot Available Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-PNot Available DME0638 DME___ID DME0638 DME0638 DME_NAME UDP-glucuronosyltransferase 2B28 (UGT2B28) DME0638 SPESNAME Homo sapiens DME0638 TISSUDIS Primarily distributed in breast, salivary gland, liver and kidneyNot Available DME0638 FUNCTION This enzyme is important in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compoundsNot Available This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acidsNot Available DME0640 DME___ID DME0640 DME0640 DME_NAME UDP-glucuronosyltransferase 2B11 (UGT2B11) DME0640 SPESNAME Homo sapiens DME0640 TISSUDIS Primarily distributed in breastNot Available DME0640 FUNCTION This enzyme is important in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compoundsNot Available DME0622 DME___ID DME0622 DME0622 DME_NAME UDP-glucuronosyltransferase 2A1 (UGT2A1) DME0622 SPESNAME Homo sapiens DME0622 TISSUDIS Primarily distributed in kidney, liver and pituitary glandNot Available DME0622 FUNCTION This enzyme catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretionNot Available And it is important in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compoundsNot Available DME0602 DME___ID DME0602 DME0602 DME_NAME UDP-glucuronosyltransferase 1A5 (UGT1A5) DME0602 SPESNAME Homo sapiens DME0602 TISSUDIS Primarily distributed in gallbladder and intestineNot Available DME0602 FUNCTION This enzyme is important in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compoundsNot Available And the isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1Not Available DME0495 DME___ID DME0495 DME0495 DME_NAME Tyrosine-protein phosphatase non-receptor 1 (PTP1B) DME0495 SPESNAME Homo sapiens DME0495 TISSUDIS Low tissue/organ specificityNot Available DME0495 FUNCTION This enzyme mediates dephosphorylation of EIF2AK3/PERK and inactivates the protein kinase activity of EIF2AK3/PERKNot Available DME0470 DME___ID DME0470 DME0470 DME_NAME Triokinase/FMN cyclase (TKFC) DME0470 SPESNAME Homo sapiens DME0470 TISSUDIS Primarily distributed in intestine and liverNot Available DME0470 FUNCTION This enzyme catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrateNot Available DME0550 DME___ID DME0550 DME0550 DME_NAME Trans-L-3-hydroxyproline dehydratase (L3HYPDH) DME0550 SPESNAME Homo sapiens DME0550 TISSUDIS Low tissue/organ specificityNot Available DME0550 FUNCTION This enzyme catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C)Not Available It may be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain itNot Available DME0577 DME___ID DME0577 DME0577 DME_NAME Thimet oligopeptidase (THOP1) DME0577 SPESNAME Homo sapiens DME0577 TISSUDIS Low tissue/organ specificityNot Available DME0577 FUNCTION This enzyme is involved in the metabolism of neuropeptides under 20 amino acid residues long and also involved in cytoplasmic peptide degradationNot Available It is able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragmentsNot Available DME0510 DME___ID DME0510 DME0510 DME_NAME Telethon sulfatase (ARSK) DME0510 SPESNAME Homo sapiens DME0510 TISSUDIS Low tissue/organ specificityNot Available DME0510 FUNCTION This enzyme acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate, whereas iduronate-2-sulfatase (IDS) desulfates synthetic disaccharides containing 2-sulfoiduronate but not 2-sulfoglucuronateNot Available DME1797 DME___ID DME1797 DME1797 DME_NAME Sulfide-quinone reductase (SQR) DME1797 SPESNAME Acidithiobacillus ferrooxidans DME1797 TISSUDIS Primarily distributed in human gutNot Available DME1797 FUNCTION This enzyme contains FAD, and in some organisms it catalyses the formation of sulfur globulesNot Available And it can catalyze the oxidation of hydrogen sulfide, with the help of a quinoneNot Available DME1542 DME___ID DME1542 DME1542 DME_NAME Sucrose-6-phosphate hydrolase scrB (ScrB) DME1542 SPESNAME Anaerostipes caccae DME1542 TISSUDIS Primarily distributed in human oral cavityNot Available DME1542 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available Substrates include sucroseNot Available DME0571 DME___ID DME0571 DME0571 DME_NAME Squalene synthase (FDFT1) DME0571 SPESNAME Homo sapiens DME0571 TISSUDIS Low tissue/organ specificityNot Available DME0571 FUNCTION This enzyme is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squaleneNot Available DME0483 DME___ID DME0483 DME0483 DME_NAME Sphingosine kinase 2 (SPHK2) DME0483 SPESNAME Homo sapiens DME0483 TISSUDIS Primarily distributed in kidney, liver and brainNot Available DME0483 FUNCTION This enzyme catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions and it also acts on D-erythro-dihydrosphingosine, D- erythro-sphingosine and L-threo-dihydrosphingosineNot Available DME0628 DME___ID DME0628 DME0628 DME_NAME Short-chain dehydrogenase/reductase SDR19C1 (DHRS1) DME0628 SPESNAME Homo sapiens DME0628 TISSUDIS Primarily distributed in liver and heartNot Available DME0628 FUNCTION This enzyme can catalyse the in vitro reductive conversion of some steroids (estrone, androstene-3,17-dione and cortisone), as well as other endogenous substances and xenobioticsNot Available DME0586 DME___ID DME0586 DME0586 DME_NAME Short-chain dehydrogenase/reductase retSDR8 (DHRS9) DME0586 SPESNAME Homo sapiens DME0586 TISSUDIS Primarily distributed in adipose tissue, blood, heart muscle and intestineNot Available DME0586 FUNCTION This enzyme converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesteroneNot Available DME0601 DME___ID DME0601 DME0601 DME_NAME Short-chain dehydrogenase/reductase retSDR4 (DHRS7) DME0601 SPESNAME Homo sapiens DME0601 TISSUDIS Primarily distributed in skeletalNot Available DME0601 FUNCTION This enzyme exhibits dual substrate specificity recognizing not only steroids but also retinoids as potential substratesNot Available DME1249 DME___ID DME1249 DME1249 DME_NAME S-(hydroxymethyl)glutathione dehydrogenase (adh) DME1249 SPESNAME Vibrio cholerae DME1249 TISSUDIS Primarily distributed in human gutNot Available DME1249 FUNCTION This enzyme specifically reduces S-(hydroxymethyl)glutathioneNot Available DME0472 DME___ID DME0472 DME0472 DME_NAME Retinol dehydrogenase 14 (RDH14) DME0472 SPESNAME Homo sapiens DME0472 TISSUDIS Low tissue/organ specificityNot Available DME0472 FUNCTION This enzyme has a clear preference for NADPNot Available It displays high activity towards 9-cis, 11-cis and all-trans-retinol, a very weak activity towards 13-cis-retinol but no activity towards steroidNot Available DME0549 DME___ID DME0549 DME0549 DME_NAME Pyrrolidone-carboxylate peptidase (PGPI) DME0549 SPESNAME Homo sapiens DME0549 TISSUDIS Low tissue/organ specificityNot Available DME0549 FUNCTION This enzyme removes 5-oxoproline from various penultimate amino acid residues except L-prolineNot Available DME0560 DME___ID DME0560 DME0560 DME_NAME Pyroglutamase (OPLAH) DME0560 SPESNAME Homo sapiens DME0560 TISSUDIS Primarily distributed in testisNot Available DME0560 FUNCTION This enzyme catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphateNot Available DME0585 DME___ID DME0585 DME0585 DME_NAME Pyridoxal phosphate phosphatase (PDXP) DME0585 SPESNAME Homo sapiens DME0585 TISSUDIS Primarily distributed in brain and liverNot Available DME0585 FUNCTION This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bondsNot Available It participates in vitamin B6 metabolismNot Available DME0574 DME___ID DME0574 DME0574 DME_NAME Prolyl endopeptidase (PREP) DME0574 SPESNAME Homo sapiens DME0574 TISSUDIS Low tissue/organ specificityNot Available DME0574 FUNCTION This enzyme cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids longNot Available DME0463 DME___ID DME0463 DME0463 DME_NAME Prolyl 4-hydroxylase alpha-3 (P4HA3) DME0463 SPESNAME Homo sapiens DME0463 TISSUDIS Primarily distributed in epididymis, placenta, liver and fetal skinNot Available DME0463 FUNCTION This enzyme catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteinsNot Available DME0509 DME___ID DME0509 DME0509 DME_NAME Prolyl 3-hydroxylase 2 (P3H2) DME0509 SPESNAME Homo sapiens DME0509 TISSUDIS Primarily distributed in kidneyNot Available DME0509 FUNCTION This enzyme catalyzes the post-translational formation of 3-hydroxyproline on collagensNot Available It contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsuleNot Available It has high activity with the type IV collagen COL4A1, and lower activity with COL1A1Not Available It catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyprolineNot Available It has no activity on substrates that lack 4- hydroxyproline in the third positionNot Available DME0508 DME___ID DME0508 DME0508 DME_NAME Prolyl 3-hydroxylase 1 (P3H1) DME0508 SPESNAME Homo sapiens DME0508 TISSUDIS Low tissue/organ specificityNot Available DME0508 FUNCTION This enzyme has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagensNot Available DME0594 DME___ID DME0594 DME0594 DME_NAME Poly [ADP-ribose] polymerase 3 (PARP3) DME0594 SPESNAME Homo sapiens DME0594 TISSUDIS Primarily distributed in kidney, skeletal muscle, liver, heart and spleenNot Available DME0594 FUNCTION This enzyme mediates mono-ADP- ribosylation of target proteins and plays a key role in the response to DNA damageNot Available It mediates mono-ADP- ribosylation of glutamate, aspartate or lysine residues on target proteinsNot Available In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylationNot Available DME2102 DME___ID DME2102 DME2102 DME_NAME Phosphotransferase enzyme strA (strA) DME2102 SPESNAME Erwinia amylovora DME2102 TISSUDIS Primarily distributed in human gutNot Available DME2102 FUNCTION This enzyme is enzyme I of the phosphotransferase system, and it acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9Not Available5 kDa) involved in bacterial sugar transportNot Available DME0452 DME___ID DME0452 DME0452 DME_NAME Phosphomannomutase 2 (PMM2) DME0452 SPESNAME Homo sapiens DME0452 TISSUDIS Low tissue/organ specificityNot Available DME0452 FUNCTION This enzyme is involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactionsNot Available DME0453 DME___ID DME0453 DME0453 DME_NAME Phosphomannomutase 1 (PMM1) DME0453 SPESNAME Homo sapiens DME0453 TISSUDIS Primarily distributed in liver, heart, brain and pancreasNot Available DME0453 FUNCTION This enzyme is responsible for the degradation of glucose-1,6-bisphosphate in ischemic brainNot Available DME0444 DME___ID DME0444 DME0444 DME_NAME Phospholipid phosphatase 1 (PLPP1) DME0444 SPESNAME Homo sapiens DME0444 TISSUDIS Primarily distributed in kidney, lung, placenta and liverNot Available DME0444 FUNCTION This enzyme dephosphorylates exogenous bioactive glycerolipids and sphingolipidsNot Available It catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol(DG)Not Available The relative catalytic efficiency is LPA > PA > S-1-P > C-1-PNot Available DME1778 DME___ID DME1778 DME1778 DME_NAME Phospholipase C (plc) DME1778 SPESNAME Clostridium novyi DME1778 TISSUDIS Primarily distributed in human gutNot Available DME1778 FUNCTION This enzyme is a bacterial zinc protein, and it acts on sphingomyelin and phosphatidylinositolNot Available DME1165 DME___ID DME1165 DME1165 DME_NAME Phloroglucinol reductase (PHGR) DME1165 SPESNAME Eubacterium oxidoreducens DME1165 TISSUDIS Primarily distributed in human gutNot Available DME1165 FUNCTION This enzyme is involved in the gallate anaerobic degradation pathway in bacteriaNot Available DME0515 DME___ID DME0515 DME0515 DME_NAME PFK/FBPase 3 (PFKFB3) DME0515 SPESNAME Homo sapiens DME0515 TISSUDIS Primarily distributed in adipose tissue and skeletal muscleNot Available DME0515 FUNCTION This enzyme degrades fructose 2,6-bisphosphateNot Available DME1003 DME___ID DME1003 DME1003 DME_NAME Peroxidase (katG) DME1003 SPESNAME Desulfofarcimen acetoxidans DME1003 TISSUDIS Primarily distributed in human gutNot Available DME1003 FUNCTION This enzyme is with both catalase and broad-spectrum peroxidase activityNot Available DME0502 DME___ID DME0502 DME0502 DME_NAME Pantothenate kinase 3 (PANK3) DME0502 SPESNAME Homo sapiens DME0502 TISSUDIS Primarily distributed in liver and intestineNot Available DME0502 FUNCTION This enzyme plays a role in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cellsNot Available It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoANot Available DME0580 DME___ID DME0580 DME0580 DME_NAME PABA peptide hydrolase (MEP1B) DME0580 SPESNAME Homo sapiens DME0580 TISSUDIS Primarily distributed in intestine and kidneyNot Available DME0580 FUNCTION This enzyme exhibits a strong preference for acidic amino acids at the P1' position and known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-CNot Available DME0619 DME___ID DME0619 DME0619 DME_NAME Oxysterol 7-alpha-hydroxylase (CYP39A1) DME0619 SPESNAME Homo sapiens DME0619 TISSUDIS Primarily distributed in liverNot Available DME0619 FUNCTION This enzyme involves in neural cholesterol clearance through bile acid synthesisNot Available And it catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liverNot Available DME1500 DME___ID DME1500 DME1500 DME_NAME Oligosaccharyltransferase (pglB) DME1500 SPESNAME Helicobacter canadensis DME1500 TISSUDIS Primarily distributed in human gutNot Available DME1500 FUNCTION This enzyme requires Mn2+ or Mg2+ and forms a glycoprotein by the transfer of a glucosyl-N-acetylgalactosaminyl-N,N'-diacetylbacillosamine (GalNAc2(Glc)GalNAc3diNAcBac) polysaccharide and related oligosaccharides to the side-chain of an L-asparagine residue in the sequence -Asp/Glu-Xaa-Asn-Xaa'-Ser/Thr- (Xaa and Xaa' not Pro) in nascent polypeptide chainsNot Available DME1501 DME___ID DME1501 DME1501 DME_NAME Oligosaccharyltransferase (pglB) DME1501 SPESNAME Helicobacter pullorum DME1501 TISSUDIS Primarily distributed in human gutNot Available DME1501 FUNCTION This enzyme requires Mn2+ or Mg2+ and forms a glycoprotein by the transfer of a glucosyl-N-acetylgalactosaminyl-N,N'-diacetylbacillosamine (GalNAc2(Glc)GalNAc3diNAcBac) polysaccharide and related oligosaccharides to the side-chain of an L-asparagine residue in the sequence -Asp/Glu-Xaa-Asn-Xaa'-Ser/Thr- (Xaa and Xaa' not Pro) in nascent polypeptide chainsNot Available DME1502 DME___ID DME1502 DME1502 DME_NAME Oligosaccharyltransferase (pglB) DME1502 SPESNAME Helicobacter winghamensis DME1502 TISSUDIS Primarily distributed in human gutNot Available DME1502 FUNCTION This enzyme requires Mn2+ or Mg2+ and forms a glycoprotein by the transfer of a glucosyl-N-acetylgalactosaminyl-N,N'-diacetylbacillosamine (GalNAc2(Glc)GalNAc3diNAcBac) polysaccharide and related oligosaccharides to the side-chain of an L-asparagine residue in the sequence -Asp/Glu-Xaa-Asn-Xaa'-Ser/Thr- (Xaa and Xaa' not Pro) in nascent polypeptide chainsNot Available DME0493 DME___ID DME0493 DME0493 DME_NAME Nicotinate-nucleotide adenylyltransferase 1 (NMNAT1) DME0493 SPESNAME Homo sapiens DME0493 TISSUDIS Primarily distributed in skeletalmuscle, heart, kidney, liver, pancreas, placenta and brainNot Available DME0493 FUNCTION This enzyme catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATPNot Available It can also use the deamidated form; nicotinic acid mononucleotide (NaMN) and can use triazofurin monophosphate (TrMP) as substrateNot Available It also catalyzes the reverse reaction, iNot AvailableeNot Available the pyrophosphorolytic cleavage of NAD(+)Not Available For the pyrophosphorolytic activity, it prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectivelyNot Available DME0478 DME___ID DME0478 DME0478 DME_NAME Nicotinamide riboside kinase 2 (NRK2) DME0478 SPESNAME Homo sapiens DME0478 TISSUDIS Primarily distributed in heart muscle and skeletal muscleNot Available DME0478 FUNCTION This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)Not Available DME0479 DME___ID DME0479 DME0479 DME_NAME Nicotinamide riboside kinase 1 (NRK1) DME0479 SPESNAME Homo sapiens DME0479 TISSUDIS Low tissue/organ specificityNot Available DME0479 FUNCTION This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)Not Available The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosineNot Available DME1161 DME___ID DME1161 DME1161 DME_NAME N-acetylneuraminate lyase (nanA) DME1161 SPESNAME Fusobacterium nucleatum DME1161 TISSUDIS Primarily distributed in human gutNot Available DME1161 FUNCTION This enzyme catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediateNot Available It also acts on N-glycoloylneuraminate, and on O-acetylated sialic acids, other than 4-O-acetylated derivativesNot Available DME0541 DME___ID DME0541 DME0541 DME_NAME MOSC domain-containing protein 2 (MARC2) DME0541 SPESNAME Homo sapiens DME0541 TISSUDIS Primarily distributed in liver and parathyroid glandNot Available DME0541 FUNCTION This enzyme catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cyclesNot Available As a component of prodrug-converting system, it reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailabilityNot Available DME0540 DME___ID DME0540 DME0540 DME_NAME MOSC domain-containing protein 1 (MARC1) DME0540 SPESNAME Homo sapiens DME0540 TISSUDIS Primarily distributed in adipose tissue and breastNot Available DME0540 FUNCTION This enzyme catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cyclesNot Available As a component of prodrug-converting system, it reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailabilityNot Available DME0454 DME___ID DME0454 DME0454 DME_NAME Mevalonate kinase (MVK) DME0454 SPESNAME Homo sapiens DME0454 TISSUDIS Low tissue/organ specificityNot Available DME0454 FUNCTION This enzyme catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesisNot Available DME1566 DME___ID DME1566 DME1566 DME_NAME Mercaptosuccinate dioxygenase (efe) DME1566 SPESNAME Variovorax paradoxus DME1566 TISSUDIS Primarily distributed in human oral cavityNot Available DME1566 FUNCTION This enzyme catalyzes the conversion of mercaptosuccinate to sulfinosuccinate by the introduction of two molecules of oxygenNot Available DME0511 DME___ID DME0511 DME0511 DME_NAME Lysosomal beta A mannosidase (MANBA) DME0511 SPESNAME Homo sapiens DME0511 TISSUDIS Low tissue/organ specificityNot Available DME0511 FUNCTION This enzyme cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharidesNot Available DME1861 DME___ID DME1861 DME1861 DME_NAME Linoleic acid reductase (cla-r) DME1861 SPESNAME Butyrivibrio fibrisolvens DME1861 TISSUDIS Primarily distributed in human stomachNot Available DME1861 FUNCTION This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compoundsNot Available DME1179 DME___ID DME1179 DME1179 DME_NAME Linoleate isomerase (lai) DME1179 SPESNAME Butyrivibrio fibrisolvens DME1179 TISSUDIS Primarily distributed in human gut and stomachNot Available DME1179 FUNCTION This enzyme takes part in linoleic acid metabolism and catalyzes the conversion of 9-cis,12-cis-octadecadienoate to 9-cis,11-trans-octadecadienoateNot Available DME1636 DME___ID DME1636 DME1636 DME_NAME L-fucose isomerase (fucI) DME1636 SPESNAME Raoultella planticola DME1636 TISSUDIS Primarily distributed in human gutNot Available DME1636 FUNCTION This enzyme converts the aldose L-fucose into the corresponding ketose L-fuculoseNot Available It requires a divalent metal ion and binds the closed form of the sugar and catalyses ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene-diol mechanismNot Available DME0499 DME___ID DME0499 DME0499 DME_NAME Leucyl-tRNA synthetase (LARS2) DME0499 SPESNAME Homo sapiens DME0499 TISSUDIS Primarily distributed in skeletal muscle, heart, and kidneyNot Available DME0499 FUNCTION This enzyme attaches leucine to its cognate tRNANot Available DME0524 DME___ID DME0524 DME0524 DME_NAME Inositol tetrakisphosphate 3-phosphatase (MIPP) DME0524 SPESNAME Homo sapiens DME0524 TISSUDIS Primarily distributed in kidney, liver and placentaNot Available DME0524 FUNCTION This enzyme acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6)Not Available It also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerateNot Available DME0505 DME___ID DME0505 DME0505 DME_NAME Inositol polyphosphate multikinase (IPMK) DME0505 SPESNAME Homo sapiens DME0505 TISSUDIS Primarily distributed in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colonNot Available DME0505 FUNCTION This enzyme has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates and plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activityNot Available DME0603 DME___ID DME0603 DME0603 DME_NAME Hydroxyacylglutathione hydrolase (HAGH) DME0603 SPESNAME Homo sapiens DME0603 TISSUDIS Primarily distributed in liver and kidneyNot Available DME0603 FUNCTION This enzyme catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acidNot Available DME1520 DME___ID DME1520 DME1520 DME_NAME Homogentisate 1,2-dioxygenase (hmgA) DME1520 SPESNAME Variovorax paradoxus DME1520 TISSUDIS Primarily distributed in human oral cavityNot Available DME1520 FUNCTION This enzyme requires Fe2+ to display activityNot Available DME0552 DME___ID DME0552 DME0552 DME_NAME Histo-blood group ABO system transferase (NAGAT) DME0552 SPESNAME Homo sapiens DME0552 TISSUDIS Primarily distributed in bone marrow and bladderNot Available DME0552 FUNCTION This enzyme is the basis of the ABO blood group systemNot Available The histo-blood group ABO involves three carbohydrate antigens: A, B, and HNot Available A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activityNot Available DME1775 DME___ID DME1775 DME1775 DME_NAME Glycosyltransferase (Gtf) DME1775 SPESNAME Actinomyces howellii DME1775 TISSUDIS Primarily distributed in human oral cavityNot Available DME1775 FUNCTION This enzyme requires Mg2+ and it catalyses the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides, and thus enables the synthesis of tri- and tetra-antennary complexesNot Available DME1721 DME___ID DME1721 DME1721 DME_NAME Glycosyl hydrolase (glyH) DME1721 SPESNAME Clostridium butyricum DME1721 TISSUDIS Primarily distributed in human gutNot Available DME1721 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1723 DME___ID DME1723 DME1723 DME_NAME Glycosyl hydrolase (glyH) DME1723 SPESNAME Bacteroides fragilis DME1723 TISSUDIS Primarily distributed in human gutNot Available DME1723 FUNCTION This enzyme does not act on 4-O-acetylated sialic acids and it has no alpha-N-acetylgalactosaminidase activityNot Available DME1726 DME___ID DME1726 DME1726 DME_NAME Glycosyl hydrolase (glyH) DME1726 SPESNAME Marvinbryantia formatexigens DME1726 TISSUDIS Primarily distributed in human gutNot Available DME1726 FUNCTION This enzyme does not act on 4-O-acetylated sialic acids and it has no alpha-N-acetylgalactosaminidase activityNot Available DME1816 DME___ID DME1816 DME1816 DME_NAME Glycerol/diol dehydratase (dhaB) DME1816 SPESNAME Blautia obeum DME1816 TISSUDIS Primarily distributed in human gutNot Available DME1816 FUNCTION This enzyme has two formsNot Available One form requires a cobamide coenzyme, while the other is a glycyl radical enzymeNot Available DME1869 DME___ID DME1869 DME1869 DME_NAME Glycerol/diol dehydratase (dhaB) DME1869 SPESNAME Flavonifractor plautii DME1869 TISSUDIS Primarily distributed in human gutNot Available DME1869 FUNCTION This enzyme has two formsNot Available One form requires a cobamide coenzyme, while the other is a glycyl radical enzymeNot Available DME1904 DME___ID DME1904 DME1904 DME_NAME Glycerol/diol dehydratase (dhaB) DME1904 SPESNAME Anaerobutyricum hallii DME1904 TISSUDIS Primarily distributed in human gutNot Available DME1904 FUNCTION This enzyme has two formsNot Available One form requires a cobamide coenzyme, while the other is a glycyl radical enzymeNot Available DME0606 DME___ID DME0606 DME0606 DME_NAME Glutathione S-transferase alpha-4 (GSTA4) DME0606 SPESNAME Homo sapiens DME0606 TISSUDIS Primarily distributed in adrenal, brain, placenta and skeletal muscleNot Available DME0606 FUNCTION This enzyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal, and it conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophilesNot Available DME0521 DME___ID DME0521 DME0521 DME_NAME Glucosamine-6-phosphate deaminase 1 (GNPDA1) DME0521 SPESNAME Homo sapiens DME0521 TISSUDIS Low tissue/organ specificityNot Available DME0521 FUNCTION This enzyme is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammoniumNot Available DME0529 DME___ID DME0529 DME0529 DME_NAME GDP-mannose 4,6-dehydratase (GMDS) DME0529 SPESNAME Homo sapiens DME0529 TISSUDIS Low tissue/organ specificityNot Available DME0529 FUNCTION This enzyme catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannoseNot Available DME0469 DME___ID DME0469 DME0469 DME_NAME GDP-D-glucose phosphorylase 1 (GDPGP1) DME0469 SPESNAME Homo sapiens DME0469 TISSUDIS Low tissue/organ specificityNot Available DME0469 FUNCTION This enzyme has specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cellsNot Available DME0527 DME___ID DME0527 DME0527 DME_NAME Fucosyltransferase XI (FUT11) DME0527 SPESNAME Homo sapiens DME0527 TISSUDIS Low tissue/organ specificityNot Available DME0527 FUNCTION This enzyme is a probable fucosyltransferaseNot Available DME0528 DME___ID DME0528 DME0528 DME_NAME Fucosyltransferase X (FUT10) DME0528 SPESNAME Homo sapiens DME0528 TISSUDIS Low tissue/organ specificityNot Available DME0528 FUNCTION This enzyme is a probable fucosyltransferaseNot Available DME2104 DME___ID DME2104 DME2104 DME_NAME FMN-dependent NADH-azoreductase (azoR1) DME2104 SPESNAME Pseudomonas aeruginosa DME2104 TISSUDIS Primarily distributed in human gutNot Available DME2104 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available And it requires NADH, but not NADPH, as an electron donor for its activityNot Available DME0506 DME___ID DME0506 DME0506 DME_NAME Factor inhibiting HIF-1 (HIF1AN) DME0506 SPESNAME Homo sapiens DME0506 TISSUDIS Low tissue/organ specificityNot Available DME0506 FUNCTION This enzyme hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD)Not Available DME1641 DME___ID DME1641 DME1641 DME_NAME Endoglucanase Y (EGY) DME1641 SPESNAME Lactobacillus gasseri DME1641 TISSUDIS Primarily distributed in human gutNot Available DME1641 FUNCTION This enzyme hydrolyzes 1,4-linkages in beta-D-glucans also containing 1,3-linkagesNot Available DME1642 DME___ID DME1642 DME1642 DME_NAME Endoglucanase Y (EGY) DME1642 SPESNAME Lactobacillus johnsonii DME1642 TISSUDIS Primarily distributed in human gutNot Available DME1642 FUNCTION This enzyme hydrolyzes 1,4-linkages in beta-D-glucans also containing 1,3-linkagesNot Available DME1182 DME___ID DME1182 DME1182 DME_NAME Endoglucanase A (EGA) DME1182 SPESNAME Lactobacillus gasseri DME1182 TISSUDIS Primarily distributed in human gutNot Available DME1182 FUNCTION This enzyme hydrolyzes 1,4-linkages in beta-D-glucans also containing 1,3-linkagesNot Available DME1183 DME___ID DME1183 DME1183 DME_NAME Endoglucanase A (EGA) DME1183 SPESNAME Lactobacillus johnsonii DME1183 TISSUDIS Primarily distributed in human gutNot Available DME1183 FUNCTION This enzyme hydrolyzes 1,4-linkages in beta-D-glucans also containing 1,3-linkagesNot Available DME1171 DME___ID DME1171 DME1171 DME_NAME D-psicose 3-epimerase (DPEase) DME1171 SPESNAME Ruminiclostridium cellulolyticum DME1171 TISSUDIS Primarily distributed in human gutNot Available DME1171 FUNCTION This enzyme catalyzes the reversible epimerization of D-fructose at the C3 position to yield D-psicose and it is highly specific for D-psicose and shows very low activity with D-tagatoseNot Available DME1686 DME___ID DME1686 DME1686 DME_NAME D-Lactate dehydrogenase (ldhA) DME1686 SPESNAME Fusobacterium nucleatum DME1686 TISSUDIS Primarily distributed in human gutNot Available DME1686 FUNCTION This enzyme has D-lactate dehydrogenase activityNot Available DME0592 DME___ID DME0592 DME0592 DME_NAME Dipeptidyl peptidase II (DPP7) DME0592 SPESNAME Homo sapiens DME0592 TISSUDIS Low tissue/organ specificityNot Available DME0592 FUNCTION This enzyme plays an important role in the degradation of some oligopeptidesNot Available DME1515 DME___ID DME1515 DME1515 DME_NAME Diol dehydratase (pddA) DME1515 SPESNAME Roseburia inulinivorans DME1515 TISSUDIS Primarily distributed in human gutNot Available DME1515 FUNCTION This enzyme has two formsNot Available One form requires a cobamide coenzyme which can dehydrate ethylene glycol to acetaldehyde, while the other is a glycyl radical enzymeNot Available DME0637 DME___ID DME0637 DME0637 DME_NAME Dimethylaniline oxidase 4 (FMO4) DME0637 SPESNAME Homo sapiens DME0637 TISSUDIS Primarily distributed in kidney and liverNot Available DME0637 FUNCTION This enzyme is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticidesNot Available DME1829 DME___ID DME1829 DME1829 DME_NAME Dihydroorotase (pyrC) DME1829 SPESNAME Faecalicatena orotica DME1829 TISSUDIS Primarily distributed in human gutNot Available DME1829 FUNCTION This enzyme catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotateNot Available DME0443 DME___ID DME0443 DME0443 DME_NAME Deoxycytidine kinase (DCK) DME0443 SPESNAME Homo sapiens DME0443 TISSUDIS Primarily distributed in lymphoidNot Available DME0443 FUNCTION This enzyme is required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA)Not Available It has broad substrate specificity, and does not display selectivity based on the chirality of the substrateNot Available It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agentsNot Available DME0611 DME___ID DME0611 DME0611 DME_NAME Dehydrogenase/reductase retSDR2 (HSD17B11) DME0611 SPESNAME Homo sapiens DME0611 TISSUDIS Primarily distributed in blood and intestineNot Available DME0611 FUNCTION This enzyme can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesisNot Available And it may act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit itNot Available DME1337 DME___ID DME1337 DME1337 DME_NAME D-alanylalanine synthetase (ddl) DME1337 SPESNAME Roseburia intestinalis DME1337 TISSUDIS Primarily distributed in human gutNot Available DME1337 FUNCTION This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6Not Available3Not Available2Not Available7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6Not Available3Not Available2Not Available13), UDP-N-acetylmuramate---L-alanine ligase (EC 6Not Available3Not Available2Not Available8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6Not Available3Not Available2Not Available9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6Not Available3Not Available2Not Available10) in the synthesis of a cell-wall peptideNot Available DME0569 DME___ID DME0569 DME0569 DME_NAME Cytosol aminopeptidase (LAP3) DME0569 SPESNAME Homo sapiens DME0569 TISSUDIS Low tissue/organ specificityNot Available DME0569 FUNCTION This enzyme catalyzes the removal of unsubstituted N- terminal amino acids from various peptidesNot Available DME1777 DME___ID DME1777 DME1777 DME_NAME Cytochrome P450 RauA (rauA) DME1777 SPESNAME Rhodococcus erythropolis DME1777 TISSUDIS Primarily distributed in human eyeNot Available DME1777 FUNCTION This enzyme catalyzes the hydroxylation of a nitrogen atom in the quinolone ring of aurachinNot Available DME0600 DME___ID DME0600 DME0600 DME_NAME Cytochrome P450 26C1 (CYP26C1) DME0600 SPESNAME Homo sapiens DME0600 TISSUDIS Primarily distributed in adrenal gland, lymphoid tissue and testisNot Available DME0600 FUNCTION This enzyme plays a role in retinoic acid metabolismNot Available And it acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RANot Available DME1567 DME___ID DME1567 DME1567 DME_NAME Cytochrome P450 111A2 (cyp111) DME1567 SPESNAME Novosphingobium aromaticivorans DME1567 TISSUDIS Primarily distributed in human gutNot Available DME1567 FUNCTION This enzyme is a cytochrome P-450 (heme-thiolate) proteinNot Available DME2085 DME___ID DME2085 DME2085 DME_NAME Cytochrome P450 107W1 (cyp107) DME2085 SPESNAME Streptomyces avermitilis DME2085 TISSUDIS Primarily distributed in human gutNot Available DME2085 FUNCTION This enzyme regioselectively hydroxylates C12 of oligomycin C to produce oligomycin ANot Available DME2063 DME___ID DME2063 DME2063 DME_NAME Cytochrome P450 107L2 (cyp107) DME2063 SPESNAME Streptomyces avermitilis DME2063 TISSUDIS Primarily distributed in human gutNot Available DME2063 FUNCTION This enzyme is a P-450 heme-thiolate protein, and it is involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unitNot Available DME1747 DME___ID DME1747 DME1747 DME_NAME Cytochrome P450 101C1 (cyp101) DME1747 SPESNAME Novosphingobium aromaticivorans DME1747 TISSUDIS Primarily distributed in human gutNot Available DME1747 FUNCTION This enzyme is a P-450 heme-thiolate protein, and it also acts on (-)-camphor and 1,2-campholide, forming 5-exo-hydroxy-1,2-campholideNot Available DME1746 DME___ID DME1746 DME1746 DME_NAME Cytochrome P450 101B1 (cyp101) DME1746 SPESNAME Novosphingobium aromaticivorans DME1746 TISSUDIS Primarily distributed in human gutNot Available DME1746 FUNCTION This enzyme is a P-450 heme-thiolate protein, and it also acts on (-)-camphor and 1,2-campholide, forming 5-exo-hydroxy-1,2-campholideNot Available DME0559 DME___ID DME0559 DME0559 DME_NAME Collagen galactosyltransferase (COLGALT2) DME0559 SPESNAME Homo sapiens DME0559 TISSUDIS Primarily distributed in brain and skeletal muscleNot Available DME0559 FUNCTION This enzyme transfers beta-galactose to hydroxylysine residues of collagenNot Available DME0467 DME___ID DME0467 DME0467 DME_NAME Choline/ethanolamine kinase (CHKB) DME0467 SPESNAME Homo sapiens DME0467 TISSUDIS Low tissue/organ specificityNot Available DME0467 FUNCTION This enzyme has a key role in phospholipid metabolism and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesisNot Available DME0517 DME___ID DME0517 DME0517 DME_NAME CDP-choline phosphohydrolase (ADPRM) DME0517 SPESNAME Homo sapiens DME0517 TISSUDIS Low tissue/organ specificityNot Available DME0517 FUNCTION This enzyme hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucoseNot Available DME1150 DME___ID DME1150 DME1150 DME_NAME CDP-alcohol phosphatidyltransferase (pgsA) DME1150 SPESNAME Streptococcus oralis DME1150 TISSUDIS Primarily distributed in human oral cavityNot Available DME1150 FUNCTION This enzyme catalyzes the committed step in the biosynthesis of acidic phospholipids known by the common names phophatidylglycerols and cardiolipinsNot Available DME0562 DME___ID DME0562 DME0562 DME_NAME Cathepsin H (CTSH) DME0562 SPESNAME Homo sapiens DME0562 TISSUDIS Primarily distributed in lungNot Available DME0562 FUNCTION This enzyme is important for the overall degradation of proteins in lysosomesNot Available DME0488 DME___ID DME0488 DME0488 DME_NAME Carnosine N-methyltransferase (CARNMT1) DME0488 SPESNAME Homo sapiens DME0488 TISSUDIS Primarily distributed in kidneyNot Available Also expressed at lower level in brain and skeletal muscleNot Available DME0488 FUNCTION This enzyme catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosineNot Available Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine)Not Available It also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His)Not Available DME0533 DME___ID DME0533 DME0533 DME_NAME Carnitine O-acetyltransferase (CRAT) DME0533 SPESNAME Homo sapiens DME0533 TISSUDIS Primarily distributed in skeletal muscle and testisNot Available DME0533 FUNCTION This enzyme catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratioNot Available It may be specific for short chain fatty acidsNot Available DME0563 DME___ID DME0563 DME0563 DME_NAME Carboxypeptidase M (CPM) DME0563 SPESNAME Homo sapiens DME0563 TISSUDIS Primarily distributed in adiposeNot Available DME0563 FUNCTION This enzyme specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteinsNot Available It plays important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteinsNot Available DME0568 DME___ID DME0568 DME0568 DME_NAME Carboxyl ester lipase (CEL) DME0568 SPESNAME Homo sapiens DME0568 TISSUDIS Primarily distributed in mammary gland and pancreasNot Available DME0568 FUNCTION This enzyme catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs)Not Available It preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate and unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAsNot Available DME2025 DME___ID DME2025 DME2025 DME_NAME Carbapenemase (cphA) DME2025 SPESNAME Citrobacter youngae DME2025 TISSUDIS Primarily distributed in human gutNot Available DME2025 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME2028 DME___ID DME2028 DME2028 DME_NAME Carbapenemase (cphA) DME2028 SPESNAME Pseudocitrobacter faecalis DME2028 TISSUDIS Primarily distributed in human gutNot Available DME2028 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1808 DME___ID DME1808 DME1808 DME_NAME Beta-porphyranase A (GH86A) DME1808 SPESNAME Bacteroides plebeius DME1808 TISSUDIS Primarily distributed in human gutNot Available DME1808 FUNCTION This enzyme cleaves the sulfated polysaccharide porphyran at the (1->4) linkages between beta-D-galactopyranose and alpha-L-galactopyranose-6-sulfate, forming mostly the disaccharide alpha-L-galactopyranose-6-sulfate-(1->3)-beta-D-galactoseNot Available Some longer oligosaccharides of even number of residues are also observedNot Available And the enzyme is inactive on the non-sulfated agarose portion of the porphyran backboneNot Available DME1195 DME___ID DME1195 DME1195 DME_NAME Beta-mannosidase (manB) DME1195 SPESNAME Bacteroides salyersiae DME1195 TISSUDIS Primarily distributed in human gutNot Available DME1195 FUNCTION This enzyme catalyzes the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosidesNot Available DME1217 DME___ID DME1217 DME1217 DME_NAME Beta-lactamase (blaB) DME1217 SPESNAME Parabacteroides merdae DME1217 TISSUDIS Primarily distributed in human gutNot Available DME1217 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1222 DME___ID DME1222 DME1222 DME_NAME Beta-lactamase (blaB) DME1222 SPESNAME Empedobacter brevis DME1222 TISSUDIS Primarily distributed in human gutNot Available DME1222 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1224 DME___ID DME1224 DME1224 DME_NAME Beta-lactamase (blaB) DME1224 SPESNAME Fusobacterium nucleatum DME1224 TISSUDIS Primarily distributed in human oral cavityNot Available DME1224 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1228 DME___ID DME1228 DME1228 DME_NAME Beta-lactamase (blaB) DME1228 SPESNAME Plesiomonas shigelloides DME1228 TISSUDIS Primarily distributed in human gutNot Available DME1228 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1313 DME___ID DME1313 DME1313 DME_NAME Beta-lactamase (blaB) DME1313 SPESNAME Holdemanella biformis DME1313 TISSUDIS Primarily distributed in human gutNot Available DME1313 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1320 DME___ID DME1320 DME1320 DME_NAME Beta-lactamase (blaB) DME1320 SPESNAME Citrobacter amalonaticus DME1320 TISSUDIS Primarily distributed in human gutNot Available DME1320 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1323 DME___ID DME1323 DME1323 DME_NAME Beta-lactamase (blaB) DME1323 SPESNAME Bacteroides xylanisolvens DME1323 TISSUDIS Primarily distributed in human gutNot Available DME1323 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1336 DME___ID DME1336 DME1336 DME_NAME Beta-lactamase (blaB) DME1336 SPESNAME Clostridium hiranonis DME1336 TISSUDIS Primarily distributed in human gutNot Available DME1336 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1349 DME___ID DME1349 DME1349 DME_NAME Beta-lactamase (blaB) DME1349 SPESNAME Bifidobacterium breve DME1349 TISSUDIS Primarily distributed in human gutNot Available DME1349 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1539 DME___ID DME1539 DME1539 DME_NAME Beta-lactamase (blaB) DME1539 SPESNAME Prevotella pallens DME1539 TISSUDIS Primarily distributed in human gutNot Available DME1539 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1561 DME___ID DME1561 DME1561 DME_NAME Beta-lactamase (blaB) DME1561 SPESNAME Burkholderia pseudomallei DME1561 TISSUDIS Primarily distributed in human oral cavityNot Available DME1561 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1563 DME___ID DME1563 DME1563 DME_NAME Beta-lactamase (blaB) DME1563 SPESNAME Ralstonia pickettii DME1563 TISSUDIS Primarily distributed in human oral cavityNot Available DME1563 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1733 DME___ID DME1733 DME1733 DME_NAME Beta-lactamase (blaB) DME1733 SPESNAME Citrobacter koseri DME1733 TISSUDIS Primarily distributed in human gutNot Available DME1733 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME2023 DME___ID DME2023 DME2023 DME_NAME Beta-lactamase (blaB) DME2023 SPESNAME Chryseobacterium oranimense DME2023 TISSUDIS Primarily distributed in human gutNot Available DME2023 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME2024 DME___ID DME2024 DME2024 DME_NAME Beta-lactamase (blaB) DME2024 SPESNAME Citrobacter braakii DME2024 TISSUDIS Primarily distributed in human gutNot Available DME2024 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME2026 DME___ID DME2026 DME2026 DME_NAME Beta-lactamase (blaB) DME2026 SPESNAME Citrobacter farmeri DME2026 TISSUDIS Primarily distributed in human gutNot Available DME2026 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME2027 DME___ID DME2027 DME2027 DME_NAME Beta-lactamase (blaB) DME2027 SPESNAME Providencia stuartii DME2027 TISSUDIS Primarily distributed in human bloodNot Available DME2027 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME2029 DME___ID DME2029 DME2029 DME_NAME Beta-lactamase (blaB) DME2029 SPESNAME Shigella boydii DME2029 TISSUDIS Primarily distributed in human gutNot Available DME2029 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME2031 DME___ID DME2031 DME2031 DME_NAME Beta-lactamase (blaB) DME2031 SPESNAME Vibrio vulnificus DME2031 TISSUDIS Primarily distributed in human gutNot Available DME2031 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME2046 DME___ID DME2046 DME2046 DME_NAME Beta-lactamase (blaB) DME2046 SPESNAME Chryseobacterium gleum DME2046 TISSUDIS Primarily distributed in human gutNot Available DME2046 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME2070 DME___ID DME2070 DME2070 DME_NAME Beta-lactamase (blaB) DME2070 SPESNAME Azospirillum brasilense DME2070 TISSUDIS Primarily distributed in human skinNot Available DME2070 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME2072 DME___ID DME2072 DME2072 DME_NAME Beta-lactamase (blaB) DME2072 SPESNAME Roseomonas gilardii DME2072 TISSUDIS Primarily distributed in human skinNot Available DME2072 FUNCTION This enzyme hydrolyzes beta-lactamNot Available DME1189 DME___ID DME1189 DME1189 DME_NAME Beta-hydroxysteroid dehydrogenase (hdhB) DME1189 SPESNAME Collinsella aerofaciens DME1189 TISSUDIS Primarily distributed in human gutNot Available DME1189 FUNCTION This enzyme catalyzes the oxidation of the 7beta-hydroxy group of bile acids such as ursodeoxycholateNot Available DME1677 DME___ID DME1677 DME1677 DME_NAME Beta-glycosidase (glyB) DME1677 SPESNAME Parabacteroides distasonis DME1677 TISSUDIS Primarily distributed in human gutNot Available DME1677 FUNCTION This enzyme catalyzes the hydrolysis of substrates containing beta-glycosideNot Available DME1193 DME___ID DME1193 DME1193 DME_NAME Beta-glucuronidase (uidA) DME1193 SPESNAME Bacteroides uniformis DME1193 TISSUDIS Primarily distributed in human gutNot Available DME1193 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1194 DME___ID DME1194 DME1194 DME_NAME Beta-glucuronidase (uidA) DME1194 SPESNAME Bacteroides thetaiotaomicron DME1194 TISSUDIS Primarily distributed in human gutNot Available DME1194 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1210 DME___ID DME1210 DME1210 DME_NAME Beta-glucuronidase (uidA) DME1210 SPESNAME Faecalibacterium prausnitzii DME1210 TISSUDIS Primarily distributed in human gutNot Available DME1210 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1352 DME___ID DME1352 DME1352 DME_NAME Beta-glucuronidase (uidA) DME1352 SPESNAME Bacteroides dorei DME1352 TISSUDIS Primarily distributed in human gutNot Available DME1352 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1798 DME___ID DME1798 DME1798 DME_NAME Beta-glucuronidase (uidA) DME1798 SPESNAME Acidobacterium capsulatum DME1798 TISSUDIS Primarily distributed in human gutNot Available DME1798 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1830 DME___ID DME1830 DME1830 DME_NAME Beta-glucuronidase (uidA) DME1830 SPESNAME Erysipelatoclostridium ramosum DME1830 TISSUDIS Primarily distributed in human gutNot Available DME1830 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1846 DME___ID DME1846 DME1846 DME_NAME Beta-glucuronidase (uidA) DME1846 SPESNAME Bacteroides vulgatus DME1846 TISSUDIS Primarily distributed in human gutNot Available DME1846 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1910 DME___ID DME1910 DME1910 DME_NAME Beta-glucuronidase (uidA) DME1910 SPESNAME Parabacteroides merdae DME1910 TISSUDIS Primarily distributed in human gutNot Available DME1910 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1935 DME___ID DME1935 DME1935 DME_NAME Beta-glucuronidase (uidA) DME1935 SPESNAME Roseburia hominis DME1935 TISSUDIS Primarily distributed in human gutNot Available DME1935 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1937 DME___ID DME1937 DME1937 DME_NAME Beta-glucuronidase (uidA) DME1937 SPESNAME Roseburia intestinalis DME1937 TISSUDIS Primarily distributed in human gutNot Available DME1937 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1940 DME___ID DME1940 DME1940 DME_NAME Beta-glucuronidase (uidA) DME1940 SPESNAME Ruminococcus gnavus DME1940 TISSUDIS Primarily distributed in human gutNot Available DME1940 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available It catalyzes the hydrolysis of beta-glucuronide containing substratesNot Available DME1145 DME___ID DME1145 DME1145 DME_NAME Beta-glucosidase (bglA) DME1145 SPESNAME Streptococcus mutans DME1145 TISSUDIS Primarily distributed in human gutNot Available DME1145 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1146 DME___ID DME1146 DME1146 DME_NAME Beta-glucosidase (bglA) DME1146 SPESNAME Bifidobacterium dentium DME1146 TISSUDIS Primarily distributed in human gutNot Available DME1146 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1147 DME___ID DME1147 DME1147 DME_NAME Beta-glucosidase (bglA) DME1147 SPESNAME Eubacterium cellulosolvens DME1147 TISSUDIS Primarily distributed in human gutNot Available DME1147 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1204 DME___ID DME1204 DME1204 DME_NAME Beta-glucosidase (bglA) DME1204 SPESNAME Actinosynnema mirum DME1204 TISSUDIS Primarily distributed in human gutNot Available DME1204 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1205 DME___ID DME1205 DME1205 DME_NAME Beta-glucosidase (bglA) DME1205 SPESNAME Bifidobacterium animalis DME1205 TISSUDIS Primarily distributed in human gutNot Available DME1205 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1206 DME___ID DME1206 DME1206 DME_NAME Beta-glucosidase (bglA) DME1206 SPESNAME Fusobacterium mortiferum DME1206 TISSUDIS Primarily distributed in human gutNot Available DME1206 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1477 DME___ID DME1477 DME1477 DME_NAME Beta-glucosidase (bglA) DME1477 SPESNAME Bacteroides dorei DME1477 TISSUDIS Primarily distributed in human gutNot Available DME1477 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1479 DME___ID DME1479 DME1479 DME_NAME Beta-glucosidase (bglA) DME1479 SPESNAME Veillonella parvula DME1479 TISSUDIS Primarily distributed in human gutNot Available DME1479 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1815 DME___ID DME1815 DME1815 DME_NAME Beta-glucosidase (bglA) DME1815 SPESNAME Bifidobacterium pseudocatenulatum DME1815 TISSUDIS Primarily distributed in human gutNot Available DME1815 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1835 DME___ID DME1835 DME1835 DME_NAME Beta-glucosidase (bglA) DME1835 SPESNAME Coprococcus comes DME1835 TISSUDIS Primarily distributed in human gutNot Available DME1835 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1842 DME___ID DME1842 DME1842 DME_NAME Beta-glucosidase (bglA) DME1842 SPESNAME Bacteroides thetaiotaomicron DME1842 TISSUDIS Primarily distributed in human gutNot Available DME1842 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1843 DME___ID DME1843 DME1843 DME_NAME Beta-glucosidase (bglA) DME1843 SPESNAME Enhydrobacter aerosaccus DME1843 TISSUDIS Primarily distributed in human gutNot Available DME1843 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1851 DME___ID DME1851 DME1851 DME_NAME Beta-glucosidase (bglA) DME1851 SPESNAME Bifidobacterium angulatum DME1851 TISSUDIS Primarily distributed in human gutNot Available DME1851 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1852 DME___ID DME1852 DME1852 DME_NAME Beta-glucosidase (bglA) DME1852 SPESNAME Bifidobacterium breve DME1852 TISSUDIS Primarily distributed in human gutNot Available DME1852 FUNCTION This enzyme has bifunctional beta-D-glucosidase/beta-D-fucosidaseNot Available And it's activity towards pNP-beta-D-fucoside is about 80-85% of the activity towards pNP-beta-D-glucosideNot Available Also has slight activity (less than 10%) towards pNP-beta-D-galactoside, and very low activity (less than 1%) towards pNP-beta-D-xylosideNot Available And it also hydrolyzes laminaribiose, sophorose, cellobiose and gentobioseNot Available DME1859 DME___ID DME1859 DME1859 DME_NAME Beta-glucosidase (bglA) DME1859 SPESNAME Butyrivibrio fibrisolvens DME1859 TISSUDIS Primarily distributed in human gutNot Available DME1859 FUNCTION This enzyme hydrolyzes cellobiose to a limited extent, cellotriose to cellobiose and glucose, and cellotetraose and cellopentaose to predominantly glucoseNot Available DME1867 DME___ID DME1867 DME1867 DME_NAME Beta-glucosidase (bglA) DME1867 SPESNAME Eubacterium rectale DME1867 TISSUDIS Primarily distributed in human gutNot Available DME1867 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1887 DME___ID DME1887 DME1887 DME_NAME Beta-glucosidase (bglA) DME1887 SPESNAME Coprococcus eutactus DME1887 TISSUDIS Primarily distributed in human gutNot Available DME1887 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1908 DME___ID DME1908 DME1908 DME_NAME Beta-glucosidase (bglA) DME1908 SPESNAME Eubacterium siraeum DME1908 TISSUDIS Primarily distributed in human gutNot Available DME1908 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1933 DME___ID DME1933 DME1933 DME_NAME Beta-glucosidase (bglA) DME1933 SPESNAME Roseburia faecis DME1933 TISSUDIS Primarily distributed in human gutNot Available DME1933 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1934 DME___ID DME1934 DME1934 DME_NAME Beta-glucosidase (bglA) DME1934 SPESNAME Roseburia hominis DME1934 TISSUDIS Primarily distributed in human gutNot Available DME1934 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1936 DME___ID DME1936 DME1936 DME_NAME Beta-glucosidase (bglA) DME1936 SPESNAME Roseburia intestinalis DME1936 TISSUDIS Primarily distributed in human gutNot Available DME1936 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1938 DME___ID DME1938 DME1938 DME_NAME Beta-glucosidase (bglA) DME1938 SPESNAME Roseburia inulinivorans DME1938 TISSUDIS Primarily distributed in human gutNot Available DME1938 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1967 DME___ID DME1967 DME1967 DME_NAME Beta-glucosidase (bglA) DME1967 SPESNAME Blautia obeum DME1967 TISSUDIS Primarily distributed in human gutNot Available DME1967 FUNCTION This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosidesNot Available DME1155 DME___ID DME1155 DME1155 DME_NAME Beta-galactosidase (bgaB) DME1155 SPESNAME Leptotrichia goodfellowii DME1155 TISSUDIS Primarily distributed in human gutNot Available DME1155 FUNCTION This enzyme hydrolyzes alpha-L-arabinoside and beta-D-fucosides and beta-D-glucosidesNot Available DME1637 DME___ID DME1637 DME1637 DME_NAME Beta-galactosidase (bgaB) DME1637 SPESNAME Leptotrichia buccalis DME1637 TISSUDIS Primarily distributed in human oral cavityNot Available DME1637 FUNCTION This enzyme has 6-phospho-beta-galactosidase activity and galactosidase activity and takes part in lactose catabolic processNot Available DME1728 DME___ID DME1728 DME1728 DME_NAME Beta-galactosidase (bgaB) DME1728 SPESNAME Weissella paramesenteroides DME1728 TISSUDIS Primarily distributed in human gutNot Available DME1728 FUNCTION This enzyme hydrolyzes alpha-L-arabinoside and beta-D-fucosides and beta-D-glucosidesNot Available DME1711 DME___ID DME1711 DME1711 DME_NAME Beta-fructofuranosidase (BFRU) DME1711 SPESNAME Lactobacillus buchneri DME1711 TISSUDIS Primarily distributed in human gutNot Available DME1711 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available Substrates include sucroseNot Available DME1712 DME___ID DME1712 DME1712 DME_NAME Beta-fructofuranosidase (BFRU) DME1712 SPESNAME Lactobacillus fermentum DME1712 TISSUDIS Primarily distributed in human gutNot Available DME1712 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available Substrates include sucroseNot Available DME1939 DME___ID DME1939 DME1939 DME_NAME Beta-fructofuranosidase (BFRU) DME1939 SPESNAME Roseburia inulinivorans DME1939 TISSUDIS Primarily distributed in human gutNot Available DME1939 FUNCTION This enzyme takes part in glucuronoside catabolic processNot Available Substrates include sucroseNot Available DME1837 DME___ID DME1837 DME1837 DME_NAME Azoreductase (azoR) DME1837 SPESNAME Corynebacterium acnes DME1837 TISSUDIS Primarily distributed in human gutNot Available DME1837 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available DME1873 DME___ID DME1873 DME1873 DME_NAME Azoreductase (azoR) DME1873 SPESNAME Fusobacterium nucleatum DME1873 TISSUDIS Primarily distributed in human gutNot Available DME1873 FUNCTION This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding aminesNot Available DME0441 DME___ID DME0441 DME0441 DME_NAME ATP-AMP transphosphorylase 2 (AK2) DME0441 SPESNAME Homo sapiens DME0441 TISSUDIS Primarily distributed in heart, liver and kidneyNot Available Also expressed in brain, skeletal muscle and skinNot Available DME0441 FUNCTION This enzyme catalyzes the reversible transfer of the terminal phosphate group between ATP and AMPNot Available It plays an important role in adenine nucleotide metabolismNot Available DME0518 DME___ID DME0518 DME0518 DME_NAME ASM-like phosphodiesterase 3a (SMPDL3A) DME0518 SPESNAME Homo sapiens DME0518 TISSUDIS Low tissue/organ specificityNot Available DME0518 FUNCTION This enzyme has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATPNot Available And it has in vitro activity with p-nitrophenyl-TMP and CDP-cholineNot Available It has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphatesNot Available DME1674 DME___ID DME1674 DME1674 DME_NAME Arylsulfate sulfotransferase (astA) DME1674 SPESNAME Eubacterium rectale DME1674 TISSUDIS Primarily distributed in human gutNot Available DME1674 FUNCTION This enzyme catalyses the transfer of a sulfate group from a phenol sulfate ester to other phenolic compoundsNot Available It's activity is enhanced by Mg2+ and Mn2+Not Available DME1166 DME___ID DME1166 DME1166 DME_NAME Amylosucrase (AMS) DME1166 SPESNAME Deinococcus geothermalis DME1166 TISSUDIS Primarily distributed in human gutNot Available DME1166 FUNCTION This enzyme catalyzes the glucosylation of flavonoids with sucrose as a sugar donorNot Available DME2057 DME___ID DME2057 DME2057 DME_NAME Aminoglycoside 6'-N-acetyltransferase (aacA) DME2057 SPESNAME Klebsiella pneumoniae DME2057 TISSUDIS Primarily distributed in human lungNot Available DME2057 FUNCTION This enzyme catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, kanamycin, tobramycin and netilmicinNot Available DME1201 DME___ID DME1201 DME1201 DME_NAME Alpha-L-rhamnosidase (lrA) DME1201 SPESNAME Bifidobacterium dentium DME1201 TISSUDIS Primarily distributed in human gutNot Available DME1201 FUNCTION This enzyme utilizes an inverting mechanism of hydrolysis, releasing beta-L-rhamnoseNot Available Substrates include naringin, rutin, quercitrin, hesperidin, dioscin, terpenyl glycosides and many other natural glycosides containing terminal alpha-L-rhamnoseNot Available DME1481 DME___ID DME1481 DME1481 DME_NAME Alpha-L-rhamnosidase (lrA) DME1481 SPESNAME Bacteroides thetaiotaomicron DME1481 TISSUDIS Primarily distributed in human gutNot Available DME1481 FUNCTION This enzyme utilizes an inverting mechanism of hydrolysis, releasing beta-L-rhamnoseNot Available Substrates include naringin, rutin, quercitrin, hesperidin, dioscin, terpenyl glycosides and many other natural glycosides containing terminal alpha-L-rhamnoseNot Available DME1759 DME___ID DME1759 DME1759 DME_NAME Alpha-L-rhamnosidase (lrA) DME1759 SPESNAME Veillonella parvula DME1759 TISSUDIS Primarily distributed in human gutNot Available DME1759 FUNCTION This enzyme utilizes an inverting mechanism of hydrolysis, releasing beta-L-rhamnoseNot Available Substrates include naringin, rutin, quercitrin, hesperidin, dioscin, terpenyl glycosides and many other natural glycosides containing terminal alpha-L-rhamnoseNot Available DME1749 DME___ID DME1749 DME1749 DME_NAME Alpha-hydroxysteroid dehydrogenase (12AH) DME1749 SPESNAME Clostridium hiranonis DME1749 TISSUDIS Primarily distributed in human gutNot Available DME1749 FUNCTION This enzyme catalyzes the oxidation of the 12alpha-hydroxy group of bile acids, both in their free and conjugated formNot Available Abd it also acts on bile alcoholsNot Available DME1750 DME___ID DME1750 DME1750 DME_NAME Alpha-hydroxysteroid dehydrogenase (12AH) DME1750 SPESNAME Clostridium scindens DME1750 TISSUDIS Primarily distributed in human gutNot Available DME1750 FUNCTION This enzyme catalyzes the oxidation of the 12alpha-hydroxy group of bile acids, both in their free and conjugated formNot Available Abd it also acts on bile alcoholsNot Available DME1751 DME___ID DME1751 DME1751 DME_NAME Alpha-hydroxysteroid dehydrogenase (12AH) DME1751 SPESNAME Clostridium hylemonae DME1751 TISSUDIS Primarily distributed in human gutNot Available DME1751 FUNCTION This enzyme catalyzes the oxidation of the 12alpha-hydroxy group of bile acids, both in their free and conjugated formNot Available Abd it also acts on bile alcoholsNot Available DME1752 DME___ID DME1752 DME1752 DME_NAME Alpha-hydroxysteroid dehydrogenase (12AH) DME1752 SPESNAME Clostridium leptum DME1752 TISSUDIS Primarily distributed in human gutNot Available DME1752 FUNCTION This enzyme catalyzes the oxidation of the 12alpha-hydroxy group of bile acids, both in their free and conjugated formNot Available Abd it also acts on bile alcoholsNot Available DME2077 DME___ID DME2077 DME2077 DME_NAME Alpha-galactosidase (melA) DME2077 SPESNAME Lactobacillus buchneri DME2077 TISSUDIS Primarily distributed in human gutNot Available DME2077 FUNCTION This enzyme hydrolyzes alpha-D-fucosidesNot Available DME2080 DME___ID DME2080 DME2080 DME_NAME Alpha-galactosidase (melA) DME2080 SPESNAME Lactobacillus fermentum DME2080 TISSUDIS Primarily distributed in human gutNot Available DME2080 FUNCTION This enzyme hydrolyzes alpha-D-fucosidesNot Available DME1774 DME___ID DME1774 DME1774 DME_NAME Alkaline phosphatase (ALP) DME1774 SPESNAME Capnocytophaga gingivalis DME1774 TISSUDIS Primarily distributed in human oral cavityNot Available DME1774 FUNCTION This enzyme can catalyse transphosphorylations and has wide specificityNot Available DME0587 DME___ID DME0587 DME0587 DME_NAME Agmatine ureohydrolase (AGMAT) DME0587 SPESNAME Homo sapiens DME0587 TISSUDIS Primarily distributed in intestine, kidney and liverNot Available DME0587 FUNCTION This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidinesNot Available And it participates in urea cycle and metabolism of amino groupsNot Available DME0448 DME___ID DME0448 DME0448 DME_NAME Adenosine kinase (ADK) DME0448 SPESNAME Homo sapiens DME0448 TISSUDIS Primarily distributed in liverNot Available DME0448 FUNCTION This enzyme catalyzes the transfer of gamma-phosphate from Adenosine triphosphate (ATP) to adenosine (Ado) leading to formation of Adenosine monophosphate (AMP)Not Available DME0516 DME___ID DME0516 DME0516 DME_NAME Acyl-CoA thioesterase 13 (ACOT13) DME0516 SPESNAME Homo sapiens DME0516 TISSUDIS Primarily distributed in liverNot Available DME0516 FUNCTION This enzyme catalyzes the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASHNot Available It has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substratesNot Available It can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4- dihydroxyphenylacetyl-CoA in vitroNot Available DME2039 DME___ID DME2039 DME2039 DME_NAME Acetone carboxylase (ACX) DME2039 SPESNAME Rhodobacter capsulatus DME2039 TISSUDIS Primarily distributed in human gutNot Available DME2039 FUNCTION This enzyme catalyzes the carboxylation of acetone to form acetoacetate, and it has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxideNot Available And it requires Mg2+ and ATPNot Available DME2040 DME___ID DME2040 DME2040 DME_NAME Acetone carboxylase (ACX) DME2040 SPESNAME Xanthobacter autotrophicus DME2040 TISSUDIS Primarily distributed in human gutNot Available DME2040 FUNCTION This enzyme catalyzes the carboxylation of acetone to form acetoacetate, and it has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxideNot Available And it requires Mg2+ and ATPNot Available DME1265 DME___ID DME1265 DME1265 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1265 SPESNAME Escherichia coli DME1265 TISSUDIS Primarily distributed in human gutNot Available DME1265 FUNCTION Not Available DME1692 DME___ID DME1692 DME1692 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1692 SPESNAME Streptococcus mutans DME1692 TISSUDIS Primarily distributed in human oral cavityNot Available DME1692 FUNCTION Not Available DME1274 DME___ID DME1274 DME1274 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1274 SPESNAME Klebsiella pneumoniae DME1274 TISSUDIS Primarily distributed in human gutNot Available DME1274 FUNCTION Not Available DME1418 DME___ID DME1418 DME1418 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1418 SPESNAME Enterococcus faecalis DME1418 TISSUDIS Primarily distributed in human gutNot Available DME1418 FUNCTION Not Available DME1448 DME___ID DME1448 DME1448 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1448 SPESNAME Porphyromonas gingivalis DME1448 TISSUDIS Primarily distributed in human oral cavityNot Available DME1448 FUNCTION Not Available DME1454 DME___ID DME1454 DME1454 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1454 SPESNAME Providencia stuartii DME1454 TISSUDIS Primarily distributed in human gutNot Available DME1454 FUNCTION Not Available DME1413 DME___ID DME1413 DME1413 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1413 SPESNAME Edwardsiella tarda DME1413 TISSUDIS Primarily distributed in human gutNot Available DME1413 FUNCTION Not Available DME1396 DME___ID DME1396 DME1396 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1396 SPESNAME Citrobacter freundii DME1396 TISSUDIS Primarily distributed in human gutNot Available DME1396 FUNCTION Not Available DME1404 DME___ID DME1404 DME1404 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1404 SPESNAME Clostridium sporogenes DME1404 TISSUDIS Primarily distributed in human gutNot Available DME1404 FUNCTION Not Available DME1398 DME___ID DME1398 DME1398 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1398 SPESNAME Clostridioides difficile DME1398 TISSUDIS Primarily distributed in human gutNot Available DME1398 FUNCTION Not Available DME1257 DME___ID DME1257 DME1257 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1257 SPESNAME Bifidobacterium longum DME1257 TISSUDIS Primarily distributed in human gutNot Available DME1257 FUNCTION Not Available DME1435 DME___ID DME1435 DME1435 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1435 SPESNAME Lactobacillus reuteri DME1435 TISSUDIS Primarily distributed in human gutNot Available DME1435 FUNCTION Not Available DME1386 DME___ID DME1386 DME1386 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1386 SPESNAME Bifidobacterium adolescentis DME1386 TISSUDIS Primarily distributed in human gutNot Available DME1386 FUNCTION Not Available DME1416 DME___ID DME1416 DME1416 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1416 SPESNAME Enterobacter cancerogenus DME1416 TISSUDIS Primarily distributed in human gutNot Available DME1416 FUNCTION Not Available DME1462 DME___ID DME1462 DME1462 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1462 SPESNAME Salmonella enterica DME1462 TISSUDIS Primarily distributed in human gutNot Available DME1462 FUNCTION Not Available DME1453 DME___ID DME1453 DME1453 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1453 SPESNAME Providencia rettgeri DME1453 TISSUDIS Primarily distributed in human gutNot Available DME1453 FUNCTION Not Available DME1277 DME___ID DME1277 DME1277 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1277 SPESNAME Lactobacillus rhamnosus DME1277 TISSUDIS Primarily distributed in human gutNot Available DME1277 FUNCTION Not Available DME1260 DME___ID DME1260 DME1260 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1260 SPESNAME Clostridium perfringens DME1260 TISSUDIS Primarily distributed in human gutNot Available DME1260 FUNCTION Not Available DME1288 DME___ID DME1288 DME1288 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1288 SPESNAME Shewanella oneidensis DME1288 TISSUDIS Primarily distributed in human gutNot Available DME1288 FUNCTION Not Available DME1264 DME___ID DME1264 DME1264 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1264 SPESNAME Enterococcus malodoratus DME1264 TISSUDIS Primarily distributed in human gutNot Available DME1264 FUNCTION Not Available DME1272 DME___ID DME1272 DME1272 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1272 SPESNAME Gardnerella vaginalis DME1272 TISSUDIS Primarily distributed in human gut, vagina and urogenital tractNot Available DME1272 FUNCTION Not Available DME1287 DME___ID DME1287 DME1287 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1287 SPESNAME Ralstonia solanacearum DME1287 TISSUDIS Primarily distributed in human vaginaNot Available DME1287 FUNCTION Not Available DME1430 DME___ID DME1430 DME1430 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1430 SPESNAME Helicobacter pylori DME1430 TISSUDIS Primarily distributed in human gutNot Available DME1430 FUNCTION Not Available DME1438 DME___ID DME1438 DME1438 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1438 SPESNAME Lactococcus lactis DME1438 TISSUDIS Primarily distributed in human gutNot Available DME1438 FUNCTION Not Available DME1457 DME___ID DME1457 DME1457 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1457 SPESNAME Ruminococcus albus DME1457 TISSUDIS Primarily distributed in human gutNot Available DME1457 FUNCTION Not Available DME1943 DME___ID DME1943 DME1943 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1943 SPESNAME Saccharomyces cerevisiae DME1943 TISSUDIS Primarily distributed in human gutNot Available DME1943 FUNCTION Not Available DME1273 DME___ID DME1273 DME1273 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1273 SPESNAME Klebsiella oxytoca DME1273 TISSUDIS Primarily distributed in human gut and skinNot Available DME1273 FUNCTION Not Available DME1670 DME___ID DME1670 DME1670 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1670 SPESNAME Lactobacillus salivarius DME1670 TISSUDIS Primarily distributed in human gutNot Available DME1670 FUNCTION Not Available DME1739 DME___ID DME1739 DME1739 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1739 SPESNAME Bacillus subtilis DME1739 TISSUDIS Primarily distributed in human gutNot Available DME1739 FUNCTION Not Available DME1755 DME___ID DME1755 DME1755 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1755 SPESNAME Lactobacillus acidophilus DME1755 TISSUDIS Primarily distributed in human gutNot Available DME1755 FUNCTION Not Available DME1870 DME___ID DME1870 DME1870 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1870 SPESNAME Fusarium oxysporum DME1870 TISSUDIS Primarily distributed in human skinNot Available DME1870 FUNCTION Not Available DME1872 DME___ID DME1872 DME1872 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1872 SPESNAME Fusarium solani DME1872 TISSUDIS Primarily distributed in human skinNot Available DME1872 FUNCTION Not Available DME1279 DME___ID DME1279 DME1279 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1279 SPESNAME Methanobrevibacter oralis DME1279 TISSUDIS Primarily distributed in human gutNot Available DME1279 FUNCTION Not Available DME1280 DME___ID DME1280 DME1280 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1280 SPESNAME Methanobrevibacter smithii DME1280 TISSUDIS Primarily distributed in human gutNot Available DME1280 FUNCTION Not Available DME1281 DME___ID DME1281 DME1281 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1281 SPESNAME Methanomassiliicoccus luminyensis DME1281 TISSUDIS Primarily distributed in human gutNot Available DME1281 FUNCTION Not Available DME1282 DME___ID DME1282 DME1282 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1282 SPESNAME Methanosphaera stadtmanae DME1282 TISSUDIS Primarily distributed in human gutNot Available DME1282 FUNCTION Not Available DME1251 DME___ID DME1251 DME1251 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1251 SPESNAME Bacteroides fragilis DME1251 TISSUDIS Primarily distributed in human gutNot Available DME1251 FUNCTION Not Available DME1253 DME___ID DME1253 DME1253 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1253 SPESNAME Bacteroides oleiciplenus DME1253 TISSUDIS Primarily distributed in human gutNot Available DME1253 FUNCTION Not Available DME1254 DME___ID DME1254 DME1254 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1254 SPESNAME Bacteroides thetaiotaomicron DME1254 TISSUDIS Primarily distributed in human gutNot Available DME1254 FUNCTION Not Available DME1256 DME___ID DME1256 DME1256 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1256 SPESNAME Bacteroides sartorii DME1256 TISSUDIS Primarily distributed in human gutNot Available DME1256 FUNCTION Not Available DME1259 DME___ID DME1259 DME1259 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1259 SPESNAME Intestinibacter bartlettii DME1259 TISSUDIS Primarily distributed in human gutNot Available DME1259 FUNCTION Not Available DME1262 DME___ID DME1262 DME1262 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1262 SPESNAME Enterorhabdus mucosicola DME1262 TISSUDIS Primarily distributed in human gutNot Available DME1262 FUNCTION Not Available DME1263 DME___ID DME1263 DME1263 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1263 SPESNAME Desulfovibrio piger DME1263 TISSUDIS Primarily distributed in human gutNot Available DME1263 FUNCTION Not Available DME1267 DME___ID DME1267 DME1267 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1267 SPESNAME Anaerobutyricum hallii DME1267 TISSUDIS Primarily distributed in human gutNot Available DME1267 FUNCTION Not Available DME1271 DME___ID DME1271 DME1271 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1271 SPESNAME Faecalibacterium prausnitzii DME1271 TISSUDIS Primarily distributed in human gutNot Available DME1271 FUNCTION Not Available DME1275 DME___ID DME1275 DME1275 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1275 SPESNAME Lactobacillus johnsonii DME1275 TISSUDIS Primarily distributed in human gutNot Available DME1275 FUNCTION Not Available DME1278 DME___ID DME1278 DME1278 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1278 SPESNAME Lactobacillus acetotolerans DME1278 TISSUDIS Primarily distributed in human gutNot Available DME1278 FUNCTION Not Available DME1289 DME___ID DME1289 DME1289 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1289 SPESNAME Tannerella forsythia DME1289 TISSUDIS Primarily distributed in human gutNot Available DME1289 FUNCTION Not Available DME1355 DME___ID DME1355 DME1355 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1355 SPESNAME Akkermansia muciniphila DME1355 TISSUDIS Primarily distributed in human gutNot Available DME1355 FUNCTION Not Available DME1357 DME___ID DME1357 DME1357 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1357 SPESNAME Alistipes indistinctus DME1357 TISSUDIS Primarily distributed in human gutNot Available DME1357 FUNCTION Not Available DME1358 DME___ID DME1358 DME1358 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1358 SPESNAME Anaerococcus hydrogenalis DME1358 TISSUDIS Primarily distributed in human gutNot Available DME1358 FUNCTION Not Available DME1359 DME___ID DME1359 DME1359 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1359 SPESNAME Anaerostipes caccae DME1359 TISSUDIS Primarily distributed in human gutNot Available DME1359 FUNCTION Not Available DME1360 DME___ID DME1360 DME1360 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1360 SPESNAME Anaerostipes hadrus DME1360 TISSUDIS Primarily distributed in human gutNot Available DME1360 FUNCTION Not Available DME1361 DME___ID DME1361 DME1361 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1361 SPESNAME Anaerotruncus colihominis DME1361 TISSUDIS Primarily distributed in human gutNot Available DME1361 FUNCTION Not Available DME1362 DME___ID DME1362 DME1362 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1362 SPESNAME Bacteroides caccae DME1362 TISSUDIS Primarily distributed in human gutNot Available DME1362 FUNCTION Not Available DME1363 DME___ID DME1363 DME1363 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1363 SPESNAME Bacteroides cellulosilyticus DME1363 TISSUDIS Primarily distributed in human gutNot Available DME1363 FUNCTION Not Available DME1364 DME___ID DME1364 DME1364 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1364 SPESNAME Bacteroides coprophilus DME1364 TISSUDIS Primarily distributed in human gutNot Available DME1364 FUNCTION Not Available DME1365 DME___ID DME1365 DME1365 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1365 SPESNAME Bacteroides dorei DME1365 TISSUDIS Primarily distributed in human gutNot Available DME1365 FUNCTION Not Available DME1366 DME___ID DME1366 DME1366 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1366 SPESNAME Bacteroides eggerthii DME1366 TISSUDIS Primarily distributed in human gutNot Available DME1366 FUNCTION Not Available DME1367 DME___ID DME1367 DME1367 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1367 SPESNAME Bacteroides finegoldii DME1367 TISSUDIS Primarily distributed in human gutNot Available DME1367 FUNCTION Not Available DME1375 DME___ID DME1375 DME1375 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1375 SPESNAME Bacteroides intestinalis DME1375 TISSUDIS Primarily distributed in human gutNot Available DME1375 FUNCTION Not Available DME1376 DME___ID DME1376 DME1376 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1376 SPESNAME Bacteroides ovatus DME1376 TISSUDIS Primarily distributed in human gutNot Available DME1376 FUNCTION Not Available DME1377 DME___ID DME1377 DME1377 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1377 SPESNAME Bacteroides pectinophilus DME1377 TISSUDIS Primarily distributed in human gutNot Available DME1377 FUNCTION Not Available DME1378 DME___ID DME1378 DME1378 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1378 SPESNAME Bacteroides uniformis DME1378 TISSUDIS Primarily distributed in human gutNot Available DME1378 FUNCTION Not Available DME1379 DME___ID DME1379 DME1379 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1379 SPESNAME Bacteroides stercoris DME1379 TISSUDIS Primarily distributed in human gutNot Available DME1379 FUNCTION Not Available DME1384 DME___ID DME1384 DME1384 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1384 SPESNAME Bacteroides vulgatus DME1384 TISSUDIS Primarily distributed in human gutNot Available DME1384 FUNCTION Not Available DME1385 DME___ID DME1385 DME1385 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1385 SPESNAME Bacteroides xylanisolvens DME1385 TISSUDIS Primarily distributed in human gutNot Available DME1385 FUNCTION Not Available DME1388 DME___ID DME1388 DME1388 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1388 SPESNAME Bifidobacterium breve DME1388 TISSUDIS Primarily distributed in human gutNot Available DME1388 FUNCTION Not Available DME1391 DME___ID DME1391 DME1391 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1391 SPESNAME Bifidobacterium ruminatum DME1391 TISSUDIS Primarily distributed in human gutNot Available DME1391 FUNCTION Not Available DME1392 DME___ID DME1392 DME1392 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1392 SPESNAME Bifidobacterium angulatum DME1392 TISSUDIS Primarily distributed in human gutNot Available DME1392 FUNCTION Not Available DME1393 DME___ID DME1393 DME1393 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1393 SPESNAME Blautia hansenii DME1393 TISSUDIS Primarily distributed in human gutNot Available DME1393 FUNCTION Not Available DME1394 DME___ID DME1394 DME1394 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1394 SPESNAME Blautia luti DME1394 TISSUDIS Primarily distributed in human gutNot Available DME1394 FUNCTION Not Available DME1399 DME___ID DME1399 DME1399 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1399 SPESNAME Enterocloster asparagiformis DME1399 TISSUDIS Primarily distributed in human gutNot Available DME1399 FUNCTION Not Available DME1400 DME___ID DME1400 DME1400 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1400 SPESNAME Enterocloster bolteae DME1400 TISSUDIS Primarily distributed in human gutNot Available DME1400 FUNCTION Not Available DME1401 DME___ID DME1401 DME1401 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1401 SPESNAME Clostridium scindens DME1401 TISSUDIS Primarily distributed in human gutNot Available DME1401 FUNCTION Not Available DME1402 DME___ID DME1402 DME1402 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1402 SPESNAME Clostridium botulinum DME1402 TISSUDIS Primarily distributed in human gutNot Available DME1402 FUNCTION Not Available DME1403 DME___ID DME1403 DME1403 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1403 SPESNAME Clostridium spiroforme DME1403 TISSUDIS Primarily distributed in human gutNot Available DME1403 FUNCTION Not Available DME1405 DME___ID DME1405 DME1405 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1405 SPESNAME Clostridium symbiosum DME1405 TISSUDIS Primarily distributed in human gutNot Available DME1405 FUNCTION Not Available DME1406 DME___ID DME1406 DME1406 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1406 SPESNAME Collinsella aerofaciens DME1406 TISSUDIS Primarily distributed in human gutNot Available DME1406 FUNCTION Not Available DME1407 DME___ID DME1407 DME1407 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1407 SPESNAME Collinsella intestinalis DME1407 TISSUDIS Primarily distributed in human gutNot Available DME1407 FUNCTION Not Available DME1408 DME___ID DME1408 DME1408 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1408 SPESNAME Coprococcus comes DME1408 TISSUDIS Primarily distributed in human gutNot Available DME1408 FUNCTION Not Available DME1409 DME___ID DME1409 DME1409 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1409 SPESNAME Desulfovibrio alaskensis DME1409 TISSUDIS Primarily distributed in human gutNot Available DME1409 FUNCTION Not Available DME1410 DME___ID DME1410 DME1410 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1410 SPESNAME Desulfovibrio desulfuricans DME1410 TISSUDIS Primarily distributed in human gutNot Available DME1410 FUNCTION Not Available DME1411 DME___ID DME1411 DME1411 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1411 SPESNAME Desulfovibrio vulgaris DME1411 TISSUDIS Primarily distributed in human gutNot Available DME1411 FUNCTION Not Available DME1412 DME___ID DME1412 DME1412 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1412 SPESNAME Dorea formicigenerans DME1412 TISSUDIS Primarily distributed in human gutNot Available DME1412 FUNCTION Not Available DME1415 DME___ID DME1415 DME1415 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1415 SPESNAME Eggerthella lenta DME1415 TISSUDIS Primarily distributed in human gutNot Available DME1415 FUNCTION Not Available DME1420 DME___ID DME1420 DME1420 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1420 SPESNAME Erysipelatoclostridium ramosum DME1420 TISSUDIS Primarily distributed in human gutNot Available DME1420 FUNCTION Not Available DME1424 DME___ID DME1424 DME1424 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1424 SPESNAME Eubacterium limosum DME1424 TISSUDIS Primarily distributed in human gutNot Available DME1424 FUNCTION Not Available DME1425 DME___ID DME1425 DME1425 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1425 SPESNAME Eubacterium rectale DME1425 TISSUDIS Primarily distributed in human gutNot Available DME1425 FUNCTION Not Available DME1426 DME___ID DME1426 DME1426 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1426 SPESNAME Eubacterium cellulosolvens DME1426 TISSUDIS Primarily distributed in human gutNot Available DME1426 FUNCTION Not Available DME1427 DME___ID DME1427 DME1427 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1427 SPESNAME Eubacterium ventriosum DME1427 TISSUDIS Primarily distributed in human gutNot Available DME1427 FUNCTION Not Available DME1428 DME___ID DME1428 DME1428 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1428 SPESNAME Fusobacterium varium DME1428 TISSUDIS Primarily distributed in human gutNot Available DME1428 FUNCTION Not Available DME1429 DME___ID DME1429 DME1429 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1429 SPESNAME Helicobacter apodemus DME1429 TISSUDIS Primarily distributed in human gutNot Available DME1429 FUNCTION Not Available DME1431 DME___ID DME1431 DME1431 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1431 SPESNAME Holdemanella biformis DME1431 TISSUDIS Primarily distributed in human gutNot Available DME1431 FUNCTION Not Available DME1432 DME___ID DME1432 DME1432 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1432 SPESNAME Hungatella hathewayi DME1432 TISSUDIS Primarily distributed in human gutNot Available DME1432 FUNCTION Not Available DME1433 DME___ID DME1433 DME1433 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1433 SPESNAME Jeotgalicoccus psychrophilus DME1433 TISSUDIS Primarily distributed in human gutNot Available DME1433 FUNCTION Not Available DME1434 DME___ID DME1434 DME1434 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1434 SPESNAME Lactobacillus crispatus DME1434 TISSUDIS Primarily distributed in human vaginaNot Available DME1434 FUNCTION Not Available DME1439 DME___ID DME1439 DME1439 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1439 SPESNAME Marvinbryantia formatexigens DME1439 TISSUDIS Primarily distributed in human gutNot Available DME1439 FUNCTION Not Available DME1440 DME___ID DME1440 DME1440 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1440 SPESNAME Mediterraneibacter glycyrrhizinilyticus DME1440 TISSUDIS Primarily distributed in human gutNot Available DME1440 FUNCTION Not Available DME1443 DME___ID DME1443 DME1443 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1443 SPESNAME Odoribacter laneus DME1443 TISSUDIS Primarily distributed in human gutNot Available DME1443 FUNCTION Not Available DME1444 DME___ID DME1444 DME1444 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1444 SPESNAME Odoribacter splanchnicus DME1444 TISSUDIS Primarily distributed in human gutNot Available DME1444 FUNCTION Not Available DME1445 DME___ID DME1445 DME1445 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1445 SPESNAME Parabacteroides distasonis DME1445 TISSUDIS Primarily distributed in human gutNot Available DME1445 FUNCTION Not Available DME1446 DME___ID DME1446 DME1446 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1446 SPESNAME Parabacteroides johnsonii DME1446 TISSUDIS Primarily distributed in human gutNot Available DME1446 FUNCTION Not Available DME1447 DME___ID DME1447 DME1447 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1447 SPESNAME Parabacteroides merdae DME1447 TISSUDIS Primarily distributed in human gutNot Available DME1447 FUNCTION Not Available DME1449 DME___ID DME1449 DME1449 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1449 SPESNAME Prevotella copri DME1449 TISSUDIS Primarily distributed in human gutNot Available DME1449 FUNCTION Not Available DME1450 DME___ID DME1450 DME1450 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1450 SPESNAME Prevotella veroralis DME1450 TISSUDIS Primarily distributed in human oral cavityNot Available DME1450 FUNCTION Not Available DME1451 DME___ID DME1451 DME1451 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1451 SPESNAME Proteus penneri DME1451 TISSUDIS Primarily distributed in human gutNot Available DME1451 FUNCTION Not Available DME1452 DME___ID DME1452 DME1452 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1452 SPESNAME Providencia alcalifaciens DME1452 TISSUDIS Primarily distributed in human gutNot Available DME1452 FUNCTION Not Available DME1455 DME___ID DME1455 DME1455 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1455 SPESNAME Raoultella planticola DME1455 TISSUDIS Primarily distributed in human gutNot Available DME1455 FUNCTION Not Available DME1456 DME___ID DME1456 DME1456 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1456 SPESNAME Roseburia intestinalis DME1456 TISSUDIS Primarily distributed in human gutNot Available DME1456 FUNCTION Not Available DME1458 DME___ID DME1458 DME1458 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1458 SPESNAME Ruminococcus gnavus DME1458 TISSUDIS Primarily distributed in human gutNot Available DME1458 FUNCTION Not Available DME1459 DME___ID DME1459 DME1459 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1459 SPESNAME Ruminococcus lactaris DME1459 TISSUDIS Primarily distributed in human gutNot Available DME1459 FUNCTION Not Available DME1460 DME___ID DME1460 DME1460 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1460 SPESNAME Ruminococcus torques DME1460 TISSUDIS Primarily distributed in human gutNot Available DME1460 FUNCTION Not Available DME1463 DME___ID DME1463 DME1463 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1463 SPESNAME Slackia isoflavoniconvertens DME1463 TISSUDIS Primarily distributed in human gutNot Available DME1463 FUNCTION Not Available DME1464 DME___ID DME1464 DME1464 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1464 SPESNAME Sphingomonas colocasiae DME1464 TISSUDIS Primarily distributed in human gutNot Available DME1464 FUNCTION Not Available DME1467 DME___ID DME1467 DME1467 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1467 SPESNAME Subdoligranulum variabile DME1467 TISSUDIS Primarily distributed in human gutNot Available DME1467 FUNCTION Not Available DME1468 DME___ID DME1468 DME1468 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1468 SPESNAME Synergistetes bacterium DME1468 TISSUDIS Primarily distributed in human oral cavityNot Available DME1468 FUNCTION Not Available DME1469 DME___ID DME1469 DME1469 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1469 SPESNAME Variovorax paradoxus DME1469 TISSUDIS Primarily distributed in human oral cavityNot Available DME1469 FUNCTION Not Available DME1470 DME___ID DME1470 DME1470 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1470 SPESNAME Victivallis vadensis DME1470 TISSUDIS Primarily distributed in human gutNot Available DME1470 FUNCTION Not Available DME1533 DME___ID DME1533 DME1533 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1533 SPESNAME Helicobacter rodentium DME1533 TISSUDIS Primarily distributed in human gutNot Available DME1533 FUNCTION Not Available DME1548 DME___ID DME1548 DME1548 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1548 SPESNAME Eubacterium coprostanoligenes DME1548 TISSUDIS Primarily distributed in human gutNot Available DME1548 FUNCTION Not Available DME1558 DME___ID DME1558 DME1558 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1558 SPESNAME Streptomyces griseus DME1558 TISSUDIS Primarily distributed in human bloodNot Available DME1558 FUNCTION Not Available DME1657 DME___ID DME1657 DME1657 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1657 SPESNAME Blautia obeum DME1657 TISSUDIS Primarily distributed in human gutNot Available DME1657 FUNCTION Not Available DME1665 DME___ID DME1665 DME1665 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1665 SPESNAME Bifidobacterium bifidum DME1665 TISSUDIS Primarily distributed in human gutNot Available DME1665 FUNCTION Not Available DME1666 DME___ID DME1666 DME1666 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1666 SPESNAME Bifidobacterium catenulatum DME1666 TISSUDIS Primarily distributed in human gutNot Available DME1666 FUNCTION Not Available DME1667 DME___ID DME1667 DME1667 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1667 SPESNAME Bifidobacterium pseudocatenulatum DME1667 TISSUDIS Primarily distributed in human gutNot Available DME1667 FUNCTION Not Available DME1669 DME___ID DME1669 DME1669 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1669 SPESNAME Lactobacillus gasseri DME1669 TISSUDIS Primarily distributed in human gutNot Available DME1669 FUNCTION Not Available DME1697 DME___ID DME1697 DME1697 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1697 SPESNAME Prevotella amnii DME1697 TISSUDIS Primarily distributed in human oral cavityNot Available DME1697 FUNCTION Not Available DME1735 DME___ID DME1735 DME1735 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1735 SPESNAME Lacrimispora aerotolerans DME1735 TISSUDIS Primarily distributed in human gutNot Available DME1735 FUNCTION Not Available DME1736 DME___ID DME1736 DME1736 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1736 SPESNAME Lacrimispora xylanolytica DME1736 TISSUDIS Primarily distributed in human gutNot Available DME1736 FUNCTION Not Available DME1737 DME___ID DME1737 DME1737 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1737 SPESNAME Fusobacterium canifelinum DME1737 TISSUDIS Primarily distributed in human gutNot Available DME1737 FUNCTION Not Available DME1738 DME___ID DME1738 DME1738 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1738 SPESNAME Streptococcus danieliae DME1738 TISSUDIS Primarily distributed in human gutNot Available DME1738 FUNCTION Not Available DME1742 DME___ID DME1742 DME1742 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1742 SPESNAME Clostridium algifaecis DME1742 TISSUDIS Primarily distributed in human gutNot Available DME1742 FUNCTION Not Available DME1743 DME___ID DME1743 DME1743 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1743 SPESNAME Veillonella parvula DME1743 TISSUDIS Primarily distributed in human gutNot Available DME1743 FUNCTION Not Available DME1754 DME___ID DME1754 DME1754 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1754 SPESNAME Enterococcus gilvus DME1754 TISSUDIS Primarily distributed in human gutNot Available DME1754 FUNCTION Not Available DME1756 DME___ID DME1756 DME1756 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1756 SPESNAME Streptococcus lutetiensis DME1756 TISSUDIS Primarily distributed in human gutNot Available DME1756 FUNCTION Not Available DME1757 DME___ID DME1757 DME1757 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1757 SPESNAME Weissella confusa DME1757 TISSUDIS Primarily distributed in human gutNot Available DME1757 FUNCTION Not Available DME1758 DME___ID DME1758 DME1758 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1758 SPESNAME Paenibacillus aestuarii DME1758 TISSUDIS Primarily distributed in human gutNot Available DME1758 FUNCTION Not Available DME1762 DME___ID DME1762 DME1762 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1762 SPESNAME Eubacterium siraeum DME1762 TISSUDIS Primarily distributed in human gutNot Available DME1762 FUNCTION Not Available DME1764 DME___ID DME1764 DME1764 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1764 SPESNAME Bacteroides vulgatus DME1764 TISSUDIS Primarily distributed in human gutNot Available DME1764 FUNCTION Not Available DME1769 DME___ID DME1769 DME1769 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1769 SPESNAME Bifidobacterium animalis DME1769 TISSUDIS Primarily distributed in human gutNot Available DME1769 FUNCTION Not Available DME1770 DME___ID DME1770 DME1770 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1770 SPESNAME Sphingomonas leidyi DME1770 TISSUDIS Primarily distributed in human gutNot Available DME1770 FUNCTION Not Available DME1772 DME___ID DME1772 DME1772 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1772 SPESNAME Microbacterium agarici DME1772 TISSUDIS Primarily distributed in human gutNot Available DME1772 FUNCTION Not Available DME1860 DME___ID DME1860 DME1860 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1860 SPESNAME Butyrivibrio fibrisolvens DME1860 TISSUDIS Primarily distributed in human gutNot Available DME1860 FUNCTION Not Available DME1907 DME___ID DME1907 DME1907 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1907 SPESNAME Novosphingobium aromaticivorans DME1907 TISSUDIS Primarily distributed in human gutNot Available DME1907 FUNCTION Not Available DME1944 DME___ID DME1944 DME1944 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1944 SPESNAME Serratia proteamaculans DME1944 TISSUDIS Primarily distributed in human oral cavityNot Available DME1944 FUNCTION Not Available DME2041 DME___ID DME2041 DME2041 DME_NAME Unclear metabolic mechanism (DME-unclear) DME2041 SPESNAME Bifidobacterium dentium DME2041 TISSUDIS Primarily distributed in human gutNot Available DME2041 FUNCTION Not Available DME2042 DME___ID DME2042 DME2042 DME_NAME Unclear metabolic mechanism (DME-unclear) DME2042 SPESNAME Clostridium saccharogumia DME2042 TISSUDIS Primarily distributed in human gutNot Available DME2042 FUNCTION Not Available DME2043 DME___ID DME2043 DME2043 DME_NAME Unclear metabolic mechanism (DME-unclear) DME2043 SPESNAME Dorea longicatena DME2043 TISSUDIS Primarily distributed in human gutNot Available DME2043 FUNCTION Not Available DME2044 DME___ID DME2044 DME2044 DME_NAME Unclear metabolic mechanism (DME-unclear) DME2044 SPESNAME Enterobacter cancerogenous DME2044 TISSUDIS Primarily distributed in human gutNot Available DME2044 FUNCTION Not Available DME2045 DME___ID DME2045 DME2045 DME_NAME Unclear metabolic mechanism (DME-unclear) DME2045 SPESNAME Eubacterium ramulus DME2045 TISSUDIS Primarily distributed in human gutNot Available DME2045 FUNCTION Not Available DME2047 DME___ID DME2047 DME2047 DME_NAME Unclear metabolic mechanism (DME-unclear) DME2047 SPESNAME Enterococcus casseliflavus DME2047 TISSUDIS Primarily distributed in human gutNot Available DME2047 FUNCTION Not Available DME2049 DME___ID DME2049 DME2049 DME_NAME Unclear metabolic mechanism (DME-unclear) DME2049 SPESNAME Lactobacillus agilis DME2049 TISSUDIS Primarily distributed in human gutNot Available DME2049 FUNCTION Not Available DME2056 DME___ID DME2056 DME2056 DME_NAME Unclear metabolic mechanism (DME-unclear) DME2056 SPESNAME Serratia odorifera DME2056 TISSUDIS Primarily distributed in human bloodNot Available DME2056 FUNCTION Not Available DME2058 DME___ID DME2058 DME2058 DME_NAME Unclear metabolic mechanism (DME-unclear) DME2058 SPESNAME Rhodobacter capsulatus DME2058 TISSUDIS Primarily distributed in human gutNot Available DME2058 FUNCTION Not Available DME1634 DME___ID DME1634 DME1634 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1634 SPESNAME Scopulariopsis brevicaulis DME1634 TISSUDIS Primarily distributed in human skinNot Available DME1634 FUNCTION Not Available DME1871 DME___ID DME1871 DME1871 DME_NAME Unclear metabolic mechanism (DME-unclear) DME1871 SPESNAME Fusarium proliferatum DME1871 TISSUDIS Primarily distributed in human skinNot Available DME1871 FUNCTION Not Available >END