| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI
|
| Oligomerization |
| Cytochrome b5 (CYB5A) |
Health |
Heterooligomer |
| Uniprot ID |
|
| Interaction Name |
CYB5A, POR and CYP2A6 heterooligomerization |
[1] |
| Studied Cell Lines |
Whole-BTC cell line |
| Activity |
Km = 1.45 microM |
| Description |
Cytochrome b5 (CYB5A) and NADPH-CYP450 reductase (POR) are reported to heterooligomerize with the CYP2A6 gene, which is necessary for sustaining the enzyme activity of Cytochrome P450 2A6. As a result, the interaction among CYB5A, POR and CYP2A6 is necessary for sustaining the drug-metabolizing process of Cytochrome P450 2A6. |
| NADPH-CYP450 reductase (POR) |
Health |
Heterooligomer |
| Uniprot ID |
|
| Interaction Name |
POR, CYB5A and CYP2A6 heterooligomerization |
[1] |
| Studied Cell Lines |
Whole-BTC cell line |
| Activity |
Km = 1.45 microM |
| Description |
NADPH-CYP450 reductase (POR) and Cytochrome b5 (CYB5A) are reported to heterooligomerize with the CYP2A6 gene, which is necessary for sustaining the enzyme activity of Cytochrome P450 2A6. As a result, the interaction among POR, CYB5A and CYP2A6 is necessary for sustaining the drug-metabolizing process of Cytochrome P450 2A6. |
| NADPH-CYP450 reductase (POR) |
Health |
Heterooligomer |
| Uniprot ID |
|
| Interaction Name |
POR, CYP2E1 and CYP2A6 heterooligomerization |
[2] |
| Studied Cell Lines |
Baculovirus expression system |
| Affected Substrate(s): |
Coumarin
N-nitrosodimethylamine
|
| Description |
NADPH-CYP450 reductase (POR) and Cytochrome P450 2E1 (CYP2E1) are reported to heterooligomerize with the CYP2A6 protein, which leads to a decreased activity of the drug-metabolizing enzyme Cytochrome P450 2A6. As a result, the interaction among POR, CYP2E1 and CYP2A6 can decrease the drug-metabolizing process of Cytochrome P450 2A6. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C12 Liver cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Transcription-factor regulation |
| Nuclear TF factor Y alpha (NFYA) |
Liver cancer |
Activation |
| Uniprot ID |
|
| Interaction Name |
NFYA-CYP2A6 interaction |
[3] |
| Studied Cell Lines |
HepG2 cell line |
| Ensembl ID |
|
| Description |
Nuclear TF factor Y alpha (NFYA) is reported to activate the transcription of CYP2A6 gene, which leads to an increased expression of the drug-metabolizing enzyme Cytochrome P450 2A6. As a result, the interaction between NFYA and CYP2A6 can activate the drug-metabolizing process of Cytochrome P450 2A6. |
|
|
|
|
|
|
