| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C60 Breast cancer |
Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
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| Non-coding RNA regulation |
| hsa-miR-631 |
Breast cancer |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-631--SULT1A1 regulation |
[2] |
| Studied Cell Lines |
ZR75-1 and MCF7 cell lines |
| Description |
hsa-miR-631 is reported to suppress SULT1A1 mRNA translation by binding to the 3' untranslated region (3'UTR) of SULT1A1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Sulfotransferase 1A1. |
| DNA methylation |
| DNA methyltransferase (DNMT) |
Breast cancer |
Significant hypermethylation |
| Uniprot ID |
|
| Interaction Name |
DNMT-SULT1A1 interaction |
[1] |
| Studied Cell Lines |
Breast tissue |
| Description |
DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the SULT1A1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1A1. As a result, the interaction between DNMT and SULT1A1 can significantly affect the drug-metabolizing process of Sulfotransferase 1A1. |
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