Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0010) | |||||
|---|---|---|---|---|---|
| DME Name | Cytochrome P450 4B1 (CYP4B1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.14.14.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-CYP4B1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.05E-25; delta-beta: -6.15E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP4B1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 4B1. As a result, the interaction between DNMT and CYP4B1 can significantly affect the drug-metabolizing process of Cytochrome P450 4B1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CYP4B1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.58E-20; delta-beta: -2.59E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP4B1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 4B1. As a result, the interaction between DNMT and CYP4B1 can moderatly affect the drug-metabolizing process of Cytochrome P450 4B1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2C12 Liver cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Liver cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-CYP4B1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.16E-02; delta-beta: -2.88E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP4B1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 4B1. As a result, the interaction between DNMT and CYP4B1 can moderatly affect the drug-metabolizing process of Cytochrome P450 4B1. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypomethylation p-value: 6.74E-12; delta-beta: -2.74E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP4B1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 4B1. As a result, the interaction between DNMT and CYP4B1 can moderatly affect the drug-metabolizing process of Cytochrome P450 4B1. | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Moderate hypomethylation p-value: 1.68E-03; delta-beta: -2.46E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP4B1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 4B1. As a result, the interaction between DNMT and CYP4B1 can moderatly affect the drug-metabolizing process of Cytochrome P450 4B1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2C30 Melanoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanoma | Significant hypomethylation | |||
| Interaction Name | DNMT-CYP4B1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 6.92E-06; delta-beta: -5.07E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP4B1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 4B1. As a result, the interaction between DNMT and CYP4B1 can significantly affect the drug-metabolizing process of Cytochrome P450 4B1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-CYP4B1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 3.45E-03; delta-beta: 2.09E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CYP4B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cytochrome P450 4B1. As a result, the interaction between DNMT and CYP4B1 can moderatly affect the drug-metabolizing process of Cytochrome P450 4B1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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