General Information of Drug-Metabolizing Enzyme (DME ID: DME0010)
DME Name Cytochrome P450 4B1 (CYP4B1), Homo sapiens DME Info
UniProt ID
CP4B1_HUMAN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A00 Brain cancer Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Multilayered rosettes embryonal tumour Significant hypomethylation
Interaction Name DNMT-CYP4B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 2.05E-25; delta-beta: -6.15E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP4B1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 4B1. As a result, the interaction between DNMT and CYP4B1 can significantly affect the drug-metabolizing process of Cytochrome P450 4B1.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
                            DNA methyltransferase (DNMT) Diffuse midline glioma Moderate hypomethylation
Interaction Name DNMT-CYP4B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 1.58E-20; delta-beta: -2.59E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP4B1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 4B1. As a result, the interaction between DNMT and CYP4B1 can moderatly affect the drug-metabolizing process of Cytochrome P450 4B1.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Liver cancer Moderate hypomethylation
Interaction Name DNMT-CYP4B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 2.16E-02; delta-beta: -2.88E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP4B1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 4B1. As a result, the interaction between DNMT and CYP4B1 can moderatly affect the drug-metabolizing process of Cytochrome P450 4B1.
The Methylation Level of Disease Section Compare with the Adjacent Tissue Moderate hypomethylation
p-value: 6.74E-12; delta-beta: -2.74E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP4B1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 4B1. As a result, the interaction between DNMT and CYP4B1 can moderatly affect the drug-metabolizing process of Cytochrome P450 4B1.
The Methylation Level of Disease Section Compare with the Other Disease Section Moderate hypomethylation
p-value: 1.68E-03; delta-beta: -2.46E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP4B1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 4B1. As a result, the interaction between DNMT and CYP4B1 can moderatly affect the drug-metabolizing process of Cytochrome P450 4B1.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2C30 Melanoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Melanoma Significant hypomethylation
Interaction Name DNMT-CYP4B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 6.92E-06; delta-beta: -5.07E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP4B1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 4B1. As a result, the interaction between DNMT and CYP4B1 can significantly affect the drug-metabolizing process of Cytochrome P450 4B1.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2C82 Prostate cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Prostate cancer Moderate hypermethylation
Interaction Name DNMT-CYP4B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypermethylation
p-value: 3.45E-03; delta-beta: 2.09E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CYP4B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cytochrome P450 4B1. As a result, the interaction between DNMT and CYP4B1 can moderatly affect the drug-metabolizing process of Cytochrome P450 4B1.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram

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