Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0011)
DME Name	Glutathione S-transferase alpha-1 (GSTA1), Homo sapiens	DME Info
UniProt ID	GSTA1_HUMAN
EC Number	EC: 2.5.1.18 (Click to Show/Hide the Complete EC Tree) Transferase Alkyl/aryl transferase Alkyl/aryl transferase EC: 2.5.1.18
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification Healthy
ICD-11: Healthy		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Transcription-factor regulation
NFE2-related factor 2 (NFE2L2)		Health		Activation
Uniprot ID	NF2L2_HUMAN
Interaction Name	NFE2L2-GSTA1 interaction				[1]
Studied Cell Lines	HEK 293T cell line
Ensembl ID	ENSG00000116044
Description	NFE2-related factor 2 (NFE2L2) is reported to activate the transcription of GSTA1 gene, which leads to an increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between NFE2L2 and GSTA1 can activate the drug-metabolizing process of Glutathione S-transferase alpha-1.
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 11 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Medulloblastoma		Moderate hypermethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 3.22E-14; delta-beta: 2.20E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the GSTA1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Brain neuroblastoma		Significant hypomethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 6.96E-12; delta-beta: -3.89E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GSTA1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can significantly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Brain neuroepithelial tumour		Moderate hypomethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 6.66E-03; delta-beta: -2.41E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTA1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Oligodendroglial tumour		Significant hypermethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 1.57E-06; delta-beta: 3.24E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the GSTA1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can significantly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Vestibular melanotic schwannoma		Moderate hypomethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 5.03E-05; delta-beta: -2.32E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTA1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Multilayered rosettes embryonal tumour		Significant hypomethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 9.73E-19; delta-beta: -4.94E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GSTA1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can significantly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Myxopapillary ependymoma		Moderate hypomethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 7.97E-05; delta-beta: -2.02E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTA1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		RELA YAP fusion ependymoma		Moderate hypomethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 1.16E-05; delta-beta: -2.12E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTA1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Diffuse midline glioma		Significant hypomethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.50E-35; delta-beta: -3.84E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GSTA1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can significantly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Oligodendroglioma		Significant hypermethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 1.94E-17; delta-beta: 3.30E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the GSTA1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can significantly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Atypical teratoid/rhabdoid tumour		Significant hypermethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 3.59E-11; delta-beta: 3.01E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the GSTA1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can significantly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2A01 Meningeal tumour		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Meningioma		Moderate hypermethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 1.73E-22; delta-beta: 2.61E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the GSTA1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B30 Lymphoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lymphoma		Significant hypermethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 6.27E-27; delta-beta: 4.47E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the GSTA1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can significantly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B90 Colorectal cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Colorectal cancer		Significant hypermethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 4.79E-07; delta-beta: 3.09E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the GSTA1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can significantly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Moderate hypermethylation p-value: 1.02E-02; delta-beta: 2.57E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the GSTA1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
NFE2-related factor 2 (NFE2L2)		Liver cancer		Repression
Uniprot ID	NF2L2_HUMAN
Interaction Name	NFE2L2-GSTA1 interaction				[2]
Studied Cell Lines	HepG2 cell line
Ensembl ID	ENSG00000116044
Description	NFE2-related factor 2 (NFE2L2) is reported to repress the transcription of GSTA1 gene, which leads to a decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between NFE2L2 and GSTA1 can repress the drug-metabolizing process of Glutathione S-transferase alpha-1.
DNA methylation
DNA methyltransferase (DNMT)		Liver cancer		Moderate hypomethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 4.62E-07; delta-beta: -2.38E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTA1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C25 Lung cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lung cancer		Moderate hypomethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 3.34E-07; delta-beta: -2.31E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTA1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
The Methylation Level of Disease Section Compare with the Other Disease Section	Moderate hypomethylation p-value: 5.67E-05; delta-beta: -2.73E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTA1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2D50 Brain cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Esthesioneuroblastoma		Moderate hypomethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 4.89E-04; delta-beta: -2.33E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTA1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2F37 Endocrine gland cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Pituitary adenoma		Moderate hypermethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 2.41E-05; delta-beta: 2.56E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the GSTA1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases
ICD-11: 5A61 Pituitary gland hypofunction		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Chordoma		Moderate hypermethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 2.17E-06; delta-beta: 2.79E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the GSTA1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 11 Circulatory system diseases
ICD-11: BD51 Arterial aneurysm		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Arterial aneurysm		Significant hypermethylation
Interaction Name	DNMT-GSTA1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 2.69E-02; delta-beta: 3.56E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the GSTA1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-1. As a result, the interaction between DNMT and GSTA1 can significantly affect the drug-metabolizing process of Glutathione S-transferase alpha-1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual

References
1	Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2. J Biol Chem. 2006 May 26;281(21):14841-51.
2	Nuclear factor erythroid 2-like 2 (Nrf2) expression in End-Stage liver disease environ. Toxicol Pharmacol. 2012 Jul;34(1):87-95.

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