Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0013)
DME Name	Cytochrome P450 2E1 (CYP2E1), Homo sapiens	DME Info
UniProt ID	CP2E1_HUMAN
EC Number	EC: 1.14.14.1 (Click to Show/Hide the Complete EC Tree) Oxidoreductase Oxygen paired donor oxidoreductase Flavin/flavoprotein donor oxidoreductase EC: 1.14.14.1
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification Healthy
ICD-11: Healthy		Click to Show/Hide the Full List of HOSPPI: 7 HOSPPI
Oligomerization
Cytochrome b5 (CYB5A)		Health		Heterooligomer
Uniprot ID	CYB5_HUMAN
Interaction Name	CYB5A-CYP2E1 heterooligomerization				[1], [2]
Studied Cell Lines	Escherichia coli cell line
Affected Substrate(s):	Chlorzoxazone (Metabolic product: Chlorzoxazone 6-hydroxylation)
Activity	Vmax = 9.0 nmol/min/nmol P450
Description	Cytochrome b5 (CYB5A) is reported to heterooligomerize with the CYP2E1 protein, which leads to an increased activity of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between CYB5A and CYP2E1 can facilitate the drug-metabolizing process of Cytochrome P450 2E1.
Cytochrome P450 2A6 (CYP2A6)		Health		Heterooligomer
Uniprot ID	CP2A6_HUMAN
Interaction Name	CYP2E1, POR and CYP2A6 heterooligomerization				[3]
Studied Cell Lines	Baculovirus expression system
Affected Substrate(s):	Coumarin N-nitrosodimethylamine
Description	Cytochrome P450 2A6 (CYP2A6) and NADPH-CYP450 reductase (POR) are reported to heterooligomerize with the CYP2E1 protein, which leads to a decreased activity of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction among CYP2A6, POR and CYP2E1 can decrease the drug-metabolizing process of Cytochrome P450 2E1.
Cytochrome P450 2A6 (CYP2A6)		Health		Heterooligomer
Uniprot ID	CP2A6_HUMAN
Interaction Name	CYP2A6-CYP2E1 heterooligomerization				[4]
Studied Cell Lines	Living cells
Description	Cytochrome P450 2A6 (CYP2A6) is reported to heterooligomerize with the CYP2E1 protein, which leads to a suppressed activity of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between CYP2A6 and CYP2E1 can inhibit the drug-metabolizing process of Cytochrome P450 2E1.
Cytochrome P450 2D6 (CYP2D6)		Health		Heterooligomer
Uniprot ID	CP2D6_HUMAN
Interaction Name	CYP2D6-CYP2E1 heterooligomerization				[5]
Studied Cell Lines	Insect cell microsomes
Affected Substrate(s):	7-Methoxy-4-(trifluoromethyl) coumarin (Metabolic product: 7-MFC O-demethylation)
Description	Cytochrome P450 2D6 (CYP2D6) is reported to heterooligomerize with the CYP2E1 protein, which leads to a decreased activity of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between CYP2D6 and CYP2E1 can decrease the drug-metabolizing process of Cytochrome P450 2E1.
Cytochrome P450 3A4 (CYP3A4)		Health		Heterooligomer
Uniprot ID	CP3A4_HUMAN
Interaction Name	CYP3A4-CYP2E1 heterooligomerization				[6]
Studied Cell Lines	Insect cell microsomes
Affected Substrate(s):	7-Methoxy-4-(trifluoromethyl) coumarin (Metabolic product: 7-MFC O-demethylation)
Description	Cytochrome P450 3A4 (CYP3A4) is reported to heterooligomerize with the CYP2E1 protein, which leads to activation of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between CYP3A4 and CYP2E1 can activate the drug-metabolizing process of Cytochrome P450 2E1.
Cytochrome P450 3A5 (CYP3A5)		Health		Heterooligomer
Uniprot ID	CP3A5_HUMAN
Interaction Name	CYP3A5-CYP2E1 heterooligomerization				[6]
Studied Cell Lines	Insect cell microsomes
Affected Substrate(s):	7-Methoxy-4-(trifluoromethyl) coumarin (Metabolic product: 7-MFC O-demethylation)
Description	Cytochrome P450 3A5 (CYP3A5) is reported to heterooligomerize with the CYP2E1 protein, which leads to activation of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between CYP3A5 and CYP2E1 can activate the drug-metabolizing process of Cytochrome P450 2E1.
NADPH-CYP450 reductase (POR)		Health		Heterodimer
Uniprot ID	NCPR_HUMAN
Interaction Name	POR-CYP2E1 heterodimerization				[3], [7]
Studied Cell Lines	Baculovirus expression system
Affected Substrate(s):	N-nitrosodimethylamine
Description	NADPH-CYP450 reductase (POR) is reported to heterodimerize with the CYP2E1 protein, which leads to an altered activity of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between POR and CYP2E1 can modulate the drug-metabolizing process of Cytochrome P450 2E1.
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 8 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Medulloblastoma		Moderate hypomethylation
Interaction Name	DNMT-CYP2E1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 1.75E-60; delta-beta: -2.61E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP2E1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between DNMT and CYP2E1 can moderatly affect the drug-metabolizing process of Cytochrome P450 2E1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Brain neuroblastoma		Significant hypomethylation
Interaction Name	DNMT-CYP2E1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.50E-07; delta-beta: -3.34E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP2E1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between DNMT and CYP2E1 can significantly affect the drug-metabolizing process of Cytochrome P450 2E1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Central neurocytoma		Moderate hypermethylation
Interaction Name	DNMT-CYP2E1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 2.84E-02; delta-beta: 2.54E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CYP2E1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between DNMT and CYP2E1 can moderatly affect the drug-metabolizing process of Cytochrome P450 2E1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Multilayered rosettes embryonal tumour		Significant hypomethylation
Interaction Name	DNMT-CYP2E1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 8.50E-21; delta-beta: -6.09E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP2E1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between DNMT and CYP2E1 can significantly affect the drug-metabolizing process of Cytochrome P450 2E1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Cerebellar liponeurocytoma		Significant hypomethylation
Interaction Name	DNMT-CYP2E1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 2.33E-04; delta-beta: -5.23E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP2E1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between DNMT and CYP2E1 can significantly affect the drug-metabolizing process of Cytochrome P450 2E1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Diffuse midline glioma		Moderate hypomethylation
Interaction Name	DNMT-CYP2E1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 8.44E-13; delta-beta: -2.18E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP2E1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between DNMT and CYP2E1 can moderatly affect the drug-metabolizing process of Cytochrome P450 2E1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Third ventricle chordoid glioma		Significant hypermethylation
Interaction Name	DNMT-CYP2E1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 6.00E-03; delta-beta: 4.15E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CYP2E1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between DNMT and CYP2E1 can significantly affect the drug-metabolizing process of Cytochrome P450 2E1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Oligodendroglioma		Moderate hypermethylation
Interaction Name	DNMT-CYP2E1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 7.72E-14; delta-beta: 2.12E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CYP2E1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between DNMT and CYP2E1 can moderatly affect the drug-metabolizing process of Cytochrome P450 2E1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B5F Uterine carcinosarcoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Uterine carcinosarcoma		Significant hypomethylation
Interaction Name	DNMT-CYP2E1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 5.11E-04; delta-beta: -3.36E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP2E1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between DNMT and CYP2E1 can significantly affect the drug-metabolizing process of Cytochrome P450 2E1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B60 Squamous cell carcinoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Squamous cell carcinoma		Moderate hypomethylation
Interaction Name	DNMT-CYP2E1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 4.98E-04; delta-beta: -2.65E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP2E1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between DNMT and CYP2E1 can moderatly affect the drug-metabolizing process of Cytochrome P450 2E1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 5 HOSPPI
Oligomerization
Progesterone receptor 1 (PGRMC1)		Liver cancer		Heterooligomer
Uniprot ID	PGRC1_HUMAN
Interaction Name	PGRMC1-CYP2E1 heterooligomerization				[10]
Studied Cell Lines	Human liver cancer cell line (HepG2)
Affected Substrate(s):	Chlorzoxazone (Metabolic product: Chlorzoxazone 6-hydroxylase) 7-ethoxycoumarin (Metabolic product: 7-ethoxycoumarin O-deethylase)
Description	Progesterone receptor 1 (PGRMC1) is reported to heterooligomerize with the CYP2E1 protein, which leads to a slight effect on the enzyme activity of Cytochrome P450 2E1. As a result, the interaction between PGRMC1 and CYP2E1 can slightly affect the drug-metabolizing process of Cytochrome P450 2E1.
Transcription-factor regulation
NF of activated T-cell 1 (NFATC1)		Liver cancer		Activation
Uniprot ID	NFAC1_HUMAN
Interaction Name	NFATC1-CYP2E1 interaction				[9]
Studied Cell Lines	B16A2 cell line
Ensembl ID	ENSG00000131196
Description	NF of activated T-cell 1 (NFATC1) is reported to activate the transcription of CYP2E1 gene, which leads to an increased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between NFATC1 and CYP2E1 can activate the drug-metabolizing process of Cytochrome P450 2E1.
STAT 6 (STAT6)		Liver cancer		Activation
Uniprot ID	STAT6_HUMAN
Interaction Name	STAT6-CYP2E1 interaction				[9]
Studied Cell Lines	B16A2 cell line
Ensembl ID	ENSG00000166888
Description	STAT 6 (STAT6) is reported to activate the transcription of CYP2E1 gene, which leads to an increased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between STAT6 and CYP2E1 can activate the drug-metabolizing process of Cytochrome P450 2E1.
Histone modification
Histone acetyltransferases (HATs)		Liver cancer		Activation
Uniprot ID	HAT1_HUMAN
Interaction Name	HATs-CYP2E1 interaction				[8]
Studied Cell Lines	HepG2 cell line
Description	Histone acetyltransferases (HATs) are reported to acetylate the CYP2E1 gene and thereby activate the transcriptional activity of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between HATs and CYP2E1 can enhance the drug-metabolizing process of Cytochrome P450 2E1.
DNA methylation
DNA methyltransferase (DNMT)		Liver cancer		Moderate hypomethylation
Interaction Name	DNMT-CYP2E1 interaction
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Moderate hypomethylation p-value: 2.85E-07; delta-beta: -2.02E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP2E1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between DNMT and CYP2E1 can moderatly affect the drug-metabolizing process of Cytochrome P450 2E1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C30 Melanoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Melanoma		Significant hypomethylation
Interaction Name	DNMT-CYP2E1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.64E-03; delta-beta: -3.28E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP2E1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between DNMT and CYP2E1 can significantly affect the drug-metabolizing process of Cytochrome P450 2E1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C90 Renal cell carcinoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Renal cell carcinoma		Significant hypermethylation
Interaction Name	DNMT-CYP2E1 interaction
The Methylation Level of Disease Section Compare with the Other Disease Section	Significant hypermethylation p-value: 1.55E-02; delta-beta: 1.76E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CYP2E1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between DNMT and CYP2E1 can significantly affect the drug-metabolizing process of Cytochrome P450 2E1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases
ICD-11: 5A61 Pituitary gland hypofunction		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Chordoma		Moderate hypermethylation
Interaction Name	DNMT-CYP2E1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 1.11E-02; delta-beta: 2.23E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CYP2E1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between DNMT and CYP2E1 can moderatly affect the drug-metabolizing process of Cytochrome P450 2E1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 5B81 Obesity		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Obesity		Moderate hypomethylation
Interaction Name	DNMT-CYP2E1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 1.72E-09; delta-beta: -2.35E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP2E1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 2E1. As a result, the interaction between DNMT and CYP2E1 can moderatly affect the drug-metabolizing process of Cytochrome P450 2E1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions. Arch Biochem Biophys. 1997 Jun 15;342(2):329-37.
2	Structural and functional effects of cytochrome b5 interactions with human cytochrome P450 enzymes. J Biol Chem. 2017 Dec 22;292(51):20818-20833.
3	Competitive interactions between cytochromes P450 2A6 and 2E1 for NADPH-cytochrome P450 oxidoreductase in the microsomal membranes produced by a baculovirus expression system. Arch Biochem Biophys. 1997 Jun 1;342(1):82-91.
4	Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions. Expert Opin Drug Metab Toxicol. 2011 May;7(5):543-58.
5	Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences. Biochem J. 2017 Oct 10;474(20):3523-3542.
6	Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequences. J Biol Chem. 2015 Feb 6;290(6):3850-64.
7	Fluorescence resonance energy transfer analysis of cytochromes P450 2C2 and 2E1 molecular interactions in living cells. J Biol Chem. 2003 Aug 15;278(33):31269-76.
8	Histone acetylation and arachidonic acid cytotoxicity in HepG2 cells overexpressing CYP2E1. Naunyn Schmiedebergs Arch Pharmacol. 2014 Mar;387(3):271-80.
9	IL-4-mediated transcriptional regulation of human CYP2E1 by two independent signaling pathways. Biochem Pharmacol. 2010 Nov 15;80(10):1592-600.
10	Progesterone receptor membrane component 1 modulates human cytochrome p450 activities in an isoform-dependent manner. Drug Metab Dispos. 2011 Nov;39(11):2057-65.

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