Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0016) | |||||
|---|---|---|---|---|---|
| DME Name | Cytochrome P450 2F1 (CYP2F1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.14.14.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Medulloblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-CYP2F1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 0.00E+00; delta-beta: -5.02E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP2F1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 2F1. As a result, the interaction between DNMT and CYP2F1 can significantly affect the drug-metabolizing process of Cytochrome P450 2F1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CYP2F1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.16E-04; delta-beta: -2.12E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP2F1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 2F1. As a result, the interaction between DNMT and CYP2F1 can moderatly affect the drug-metabolizing process of Cytochrome P450 2F1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-CYP2F1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.21E-29; delta-beta: -8.08E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP2F1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 2F1. As a result, the interaction between DNMT and CYP2F1 can significantly affect the drug-metabolizing process of Cytochrome P450 2F1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-CYP2F1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 9.88E-03; delta-beta: 2.81E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CYP2F1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cytochrome P450 2F1. As a result, the interaction between DNMT and CYP2F1 can moderatly affect the drug-metabolizing process of Cytochrome P450 2F1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-CYP2F1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 1.80E-03; delta-beta: 3.29E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CYP2F1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cytochrome P450 2F1. As a result, the interaction between DNMT and CYP2F1 can significantly affect the drug-metabolizing process of Cytochrome P450 2F1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C25 Lung cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lung cancer | Significant hypomethylation | |||
| Interaction Name | DNMT-CYP2F1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.17E-31; delta-beta: -4.33E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP2F1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 2F1. As a result, the interaction between DNMT and CYP2F1 can significantly affect the drug-metabolizing process of Cytochrome P450 2F1. | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Significant hypomethylation p-value: 1.28E-20; delta-beta: -4.53E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP2F1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 2F1. As a result, the interaction between DNMT and CYP2F1 can significantly affect the drug-metabolizing process of Cytochrome P450 2F1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CYP2F1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.51E-40; delta-beta: -2.31E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP2F1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 2F1. As a result, the interaction between DNMT and CYP2F1 can moderatly affect the drug-metabolizing process of Cytochrome P450 2F1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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