Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0017) | |||||
|---|---|---|---|---|---|
| DME Name | Cytochrome P450 2C18 (CYP2C18), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.14.14.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-CYP2C18 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 9.03E-03; delta-beta: -4.30E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP2C18 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 2C18. As a result, the interaction between DNMT and CYP2C18 can significantly affect the drug-metabolizing process of Cytochrome P450 2C18. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2C25 Lung cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lung cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-CYP2C18 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 4.28E-25; delta-beta: -2.29E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP2C18 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 2C18. As a result, the interaction between DNMT and CYP2C18 can moderatly affect the drug-metabolizing process of Cytochrome P450 2C18. | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Moderate hypomethylation p-value: 5.63E-24; delta-beta: -2.40E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP2C18 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 2C18. As a result, the interaction between DNMT and CYP2C18 can moderatly affect the drug-metabolizing process of Cytochrome P450 2C18. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2C30 Melanoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanoma | Significant hypomethylation | |||
| Interaction Name | DNMT-CYP2C18 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.16E-04; delta-beta: -3.54E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP2C18 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 2C18. As a result, the interaction between DNMT and CYP2C18 can significantly affect the drug-metabolizing process of Cytochrome P450 2C18. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Moderate hypomethylation | |||
| Interaction Name | DNMT-CYP2C18 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 5.63E-10; delta-beta: -2.46E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP2C18 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytochrome P450 2C18. As a result, the interaction between DNMT and CYP2C18 can moderatly affect the drug-metabolizing process of Cytochrome P450 2C18. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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