Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0022) | |||||
|---|---|---|---|---|---|
| DME Name | Cytochrome P450 3A43 (CYP3A43), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.14.14.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-CYP3A43 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.96E-41; delta-beta: -8.60E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP3A43 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 3A43. As a result, the interaction between DNMT and CYP3A43 can significantly affect the drug-metabolizing process of Cytochrome P450 3A43. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-CYP3A43 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 9.99E-23; delta-beta: -6.86E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP3A43 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 3A43. As a result, the interaction between DNMT and CYP3A43 can significantly affect the drug-metabolizing process of Cytochrome P450 3A43. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Significant hypomethylation | |||
| Interaction Name | DNMT-CYP3A43 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.51E-40; delta-beta: -3.90E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP3A43 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 3A43. As a result, the interaction between DNMT and CYP3A43 can significantly affect the drug-metabolizing process of Cytochrome P450 3A43. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.