Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0027)
DME Name	Steroid 11-beta-hydroxylase (CYP11B1), Homo sapiens	DME Info
UniProt ID	C11B1_HUMAN
EC Number	EC: 1.14.15.4 (Click to Show/Hide the Complete EC Tree) Oxidoreductase Oxygen paired donor oxidoreductase Iron-sulfur protein donor oxidoreductase EC: 1.14.15.4
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification Healthy
ICD-11: Healthy		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Oligomerization
Progesterone receptor 1 (PGRMC1)		Health		Heterooligomer
Uniprot ID	PGRC1_HUMAN
Interaction Name	PGRMC1-CYP11B1 heterooligomerization				[1]
Studied Cell Lines	Monkey kidney fibroblast-like cell (COS)7
Affected Substrate(s):	Progesterone (Metabolic product: Progesterone 11-hydroxylase)
Description	Progesterone receptor 1 (PGRMC1) is reported to heterooligomerize with the CYP11B1 protein, which leads to a slight effect on the enzyme activity of Steroid 11-beta-hydroxylase. As a result, the interaction between PGRMC1 and CYP11B1 can slightly affect the drug-metabolizing process of Steroid 11-beta-hydroxylase.
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Multilayered rosettes embryonal tumour		Significant hypomethylation
Interaction Name	DNMT-CYP11B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 2.44E-39; delta-beta: -6.38E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP11B1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Steroid 11-beta-hydroxylase. As a result, the interaction between DNMT and CYP11B1 can significantly affect the drug-metabolizing process of Steroid 11-beta-hydroxylase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Cerebellar liponeurocytoma		Significant hypomethylation
Interaction Name	DNMT-CYP11B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 3.39E-05; delta-beta: -7.29E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP11B1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Steroid 11-beta-hydroxylase. As a result, the interaction between DNMT and CYP11B1 can significantly affect the drug-metabolizing process of Steroid 11-beta-hydroxylase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B5F Uterine carcinosarcoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Uterine carcinosarcoma		Significant hypomethylation
Interaction Name	DNMT-CYP11B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.74E-03; delta-beta: -3.26E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP11B1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Steroid 11-beta-hydroxylase. As a result, the interaction between DNMT and CYP11B1 can significantly affect the drug-metabolizing process of Steroid 11-beta-hydroxylase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B60 Squamous cell carcinoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Squamous cell carcinoma		Moderate hypomethylation
Interaction Name	DNMT-CYP11B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 6.82E-06; delta-beta: -2.16E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP11B1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Steroid 11-beta-hydroxylase. As a result, the interaction between DNMT and CYP11B1 can moderatly affect the drug-metabolizing process of Steroid 11-beta-hydroxylase.
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Moderate hypomethylation p-value: 7.26E-05; delta-beta: -2.01E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP11B1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Steroid 11-beta-hydroxylase. As a result, the interaction between DNMT and CYP11B1 can moderatly affect the drug-metabolizing process of Steroid 11-beta-hydroxylase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
ICD-11: 2B71 Gastric cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Gastric cancer		Significant hypermethylation
Interaction Name	DNMT-CYP11B1 interaction
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Significant hypermethylation p-value: 4.05E-02; delta-beta: 3.67E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CYP11B1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Steroid 11-beta-hydroxylase. As a result, the interaction between DNMT and CYP11B1 can significantly affect the drug-metabolizing process of Steroid 11-beta-hydroxylase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Liver cancer		Significant hypomethylation
Interaction Name	DNMT-CYP11B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.01E-07; delta-beta: -5.84E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP11B1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Steroid 11-beta-hydroxylase. As a result, the interaction between DNMT and CYP11B1 can significantly affect the drug-metabolizing process of Steroid 11-beta-hydroxylase.
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Significant hypomethylation p-value: 2.66E-29; delta-beta: -5.56E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP11B1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Steroid 11-beta-hydroxylase. As a result, the interaction between DNMT and CYP11B1 can significantly affect the drug-metabolizing process of Steroid 11-beta-hydroxylase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C30 Melanoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Melanoma		Moderate hypomethylation
Interaction Name	DNMT-CYP11B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 5.69E-03; delta-beta: -2.66E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP11B1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Steroid 11-beta-hydroxylase. As a result, the interaction between DNMT and CYP11B1 can moderatly affect the drug-metabolizing process of Steroid 11-beta-hydroxylase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2D11 Adrenocortical carcinoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Transcription-factor regulation
Nuclear receptor family 5 A2 (NR5A2)		Adrenocortical carcinoma		Activation
Uniprot ID	NR5A2_HUMAN
Interaction Name	NR5A2-CYP11B1 interaction				[2]
Studied Cell Lines	H295R cell line
Ensembl ID	ENSG00000116833
Description	Nuclear receptor family 5 A2 (NR5A2) is reported to activate the transcription of CYP11B1 gene, which leads to an increased expression of the drug-metabolizing enzyme Steroid 11-beta-hydroxylase. As a result, the interaction between NR5A2 and CYP11B1 can activate the drug-metabolizing process of Steroid 11-beta-hydroxylase.

References
1	Characterization of the adrenal-specific antigen IZA (inner zone antigen) and its role in the steroidogenesis. Mol Cell Endocrinol. 2004 Feb 27;215(1-2):143-8.
2	Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11 beta-hydroxylase. J Mol Endocrinol. 2001 Oct;27(2):255-8.

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