| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases |
| ICD-11: 5C56 Niemann-Pick disease type C |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Histone modification |
| Histone deacetylases (HDACs) |
Niemann-Pick disease type C |
Repression |
| Uniprot ID |
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| Interaction Name |
HDACs-CYP46A1 interaction |
[1] |
| Studied Cell Lines |
Niemman-Pick type C patients |
| Description |
Histone deacetylases (HDACs) are reported to deacetylate the CYP46A1 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Cholesterol 24-hydroxylase. As a result, the interaction between HDACs and CYP46A1 can inhibit the drug-metabolizing process of Cholesterol 24-hydroxylase. |
| ICD Disease Classification 08 Nervous system diseases |
| ICD-11: 8A20 Alzheimer disease |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| DNA methylation |
| DNA methyltransferase (DNMT) |
Alzheimer disease |
Significant hypermethylation |
| Uniprot ID |
|
| Interaction Name |
DNMT-CYP46A1 interaction |
[2] |
| Studied Cell Lines |
Brain CNS neurons |
| Description |
DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CYP46A1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cholesterol 24-hydroxylase. As a result, the interaction between DNMT and CYP46A1 can significantly affect the drug-metabolizing process of Cholesterol 24-hydroxylase. |
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