Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0030) | |||||
|---|---|---|---|---|---|
| DME Name | Cytochrome P450 2A13 (CYP2A13), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.14.14.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2D42 Head and neck cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Head and neck cancer | Significant hypermethylation | |||
| Uniprot ID | |||||
| Interaction Name | DNMT-CYP2A13 interaction | [1] | |||
| Studied Cell Lines | Oral cavity tissue | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CYP2A13 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cytochrome P450 2A13. As a result, the interaction between DNMT and CYP2A13 can significantly affect the drug-metabolizing process of Cytochrome P450 2A13. | ||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Hypermethylation of carcinogen metabolism genes, CYP1A1, CYP2A13 and GSTM1 genes in head and neck cancer. Oral Dis. 2010 Oct;16(7):668-73. | ||||
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