| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C12 Liver cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| DNA methylation |
| DNA methyltransferase (DNMT) |
Liver cancer |
Significant hypomethylation |
| Uniprot ID |
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| Interaction Name |
DNMT-CYP2J2 interaction |
[1] |
| Studied Cell Lines |
HCC clinical tumor tissues |
| Description |
DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP2J2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytochrome P450 2J2. As a result, the interaction between DNMT and CYP2J2 can significantly affect the drug-metabolizing process of Cytochrome P450 2J2. |
| ICD-11: 2C25 Lung cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Non-coding RNA regulation |
| hsa-let-7b-5p |
Lung cancer |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-let-7b-5p--CYP2J2 regulation |
[2] |
| Studied Cell Lines |
Lung cancer cells |
| Description |
hsa-let-7b-5p is reported to suppress CYP2J2 mRNA translation by binding to the 3' untranslated region (3'UTR) of CYP2J2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Cytochrome P450 2J2. |
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