Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0033) | |||||
|---|---|---|---|---|---|
| DME Name | Cytochrome P450 2S1 (CYP2S1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.14.14.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification Healthy | |||||
| ICD-11: Healthy | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| Histone modification | |||||
| Histone deacetylases (HDACs) | Health | Repression | |||
| Uniprot ID | |||||
| Interaction Name | HDACs-CYP2S1 interaction | [1] | |||
| Studied Cell Lines | Human cell lines | ||||
| Description | Histone deacetylases (HDACs) are reported to deacetylate the CYP2S1 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Cytochrome P450 2S1. As a result, the interaction between HDACs and CYP2S1 can inhibit the drug-metabolizing process of Cytochrome P450 2S1. | ||||
| References | |||||
|---|---|---|---|---|---|
| 1 | CYP2S1 is negatively regulated by corticosteroids in human cell lines. Toxicol Lett. 2012 Feb 25;209(1):30-4. | ||||
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