| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2D11 Adrenocortical carcinoma |
Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
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| Transcription-factor regulation |
| Steroidogenic factor 1 (NR5A1) |
Adrenocortical carcinoma |
Repression |
| Uniprot ID |
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| Interaction Name |
NR5A1-CYP11B2 interaction |
[2] |
| Studied Cell Lines |
H295R cell line |
| Ensembl ID |
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| Description |
Steroidogenic factor 1 (NR5A1) is reported to repress the transcription of CYP11B2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Aldosterone synthase. As a result, the interaction between NR5A1 and CYP11B2 can repress the drug-metabolizing process of Aldosterone synthase. |
| Non-coding RNA regulation |
| hsa-miR-24-3p |
Adrenocortical carcinoma |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-24-3p--CYP11B2 regulation |
[1] |
| Studied Cell Lines |
H295R cell line |
| Description |
hsa-miR-24-3p is reported to suppress CYP11B2 mRNA translation by binding to the 3' untranslated region (3'UTR) of CYP11B2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Aldosterone synthase. |
| ICD Disease Classification 11 Circulatory system diseases |
| ICD-11: BA00 Hypertension |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Transcription-factor regulation |
| AP endonuclease 1 (APEX1) |
Hypertension |
Repression |
| Uniprot ID |
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| Interaction Name |
APEX1-CYP11B2 interaction |
[3] |
| Studied Cell Lines |
U3A cell line |
| Description |
AP endonuclease 1 (APEX1) is reported to repress the transcription of CYP11B2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Aldosterone synthase. As a result, the interaction between APEX1 and CYP11B2 can repress the drug-metabolizing process of Aldosterone synthase. |
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