Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0038)
DME Name Vitamin D(3) 24-hydroxylase (CYP24A1), Homo sapiens DME Info
UniProt ID
CP24A_HUMAN
EC Number    EC: 1.14.15.16     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.16
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Transcription-factor regulation
                            Nuclear receptor family 2 C2 (NR2C2) Health Repression
Uniprot ID
NR2C2_HUMAN
Interaction Name NR2C2-CYP24A1 interaction [1]
Studied Cell Lines Escherichia coli BL21(DE3) cell line
Description Nuclear receptor family 2 C2 (NR2C2) is reported to repress the transcription of CYP24A1 gene, which leads to a decreased expression of the drug-metabolizing enzyme Vitamin D(3) 24-hydroxylase. As a result, the interaction between NR2C2 and CYP24A1 can repress the drug-metabolizing process of Vitamin D(3) 24-hydroxylase.
                            Vitamin D3 receptor (VDR) Health Repression
Uniprot ID
VDR_HUMAN
Interaction Name VDR-CYP24A1 interaction [2]
Studied Cell Lines COS-1, CV-1 and 293-T cell lines
Ensembl ID
ENSG00000111424
Description Vitamin D3 receptor (VDR) is reported to repress the transcription of CYP24A1 gene, which leads to a decreased expression of the drug-metabolizing enzyme Vitamin D(3) 24-hydroxylase. As a result, the interaction between VDR and CYP24A1 can repress the drug-metabolizing process of Vitamin D(3) 24-hydroxylase.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2B90 Colorectal cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Vitamin D3 receptor (VDR) Colorectal cancer Activation
Uniprot ID
VDR_HUMAN
Interaction Name VDR-CYP24A1 interaction [3]
Studied Cell Lines Colorectal adenocarcinomas cell line
Ensembl ID
ENSG00000111424
Description Vitamin D3 receptor (VDR) is reported to activate the transcription of CYP24A1 gene, which leads to an increased expression of the drug-metabolizing enzyme Vitamin D(3) 24-hydroxylase. As a result, the interaction between VDR and CYP24A1 can activate the drug-metabolizing process of Vitamin D(3) 24-hydroxylase.
               ICD-11: 2C60 Breast cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-125b-5p Breast cancer Suppression
miRBase ID
MIMAT0000423
Interaction Name hsa-miR-125b-5p--CYP24A1 regulation [4]
Studied Cell Lines MCF-7 cell line
Description hsa-miR-125b-5p is reported to suppress CYP24A1 mRNA translation by binding to the 3' untranslated region (3'UTR) of CYP24A1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Vitamin D(3) 24-hydroxylase.
               ICD-11: 2C82 Prostate cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Histone modification
                            Histone deacetylases (HDACs) Prostate cancer Repression
Uniprot ID
HDAC1_HUMAN
Interaction Name HDACs-CYP24A1 interaction [5]
Studied Cell Lines Prostate cancer cells
Description Histone deacetylases (HDACs) are reported to deacetylate the CYP24A1 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Vitamin D(3 24-hydroxylase. As a result, the interaction between HDACs and CYP24A1 can inhibit the drug-metabolizing process of Vitamin D(3 24-hydroxylase.
               ICD-11: 2D50 Brain cancer metastasis Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Esthesioneuroblastoma Significant hypomethylation
Interaction Name DNMT-CYP24A1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 1.57E-04; delta-beta: -3.04E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP24A1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Vitamin D(3) 24-hydroxylase. As a result, the interaction between DNMT and CYP24A1 can significantly affect the drug-metabolizing process of Vitamin D(3) 24-hydroxylase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
References
1 Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor. J Biol Chem. 1999 Jun 4;274(23):16198-205.
2 Repression of basal transcription by vitamin D receptor: evidence for interaction of unliganded vitamin D receptor with two receptor interaction domains in RIP13delta1. J Mol Endocrinol. 1998 Jun;20(3):327-35.
3 Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer. Int J Cancer. 2013 Sep 15;133(6):1380-8.
4 Human CYP24 catalyzing the inactivation of calcitriol is post-transcriptionally regulated by miR-125b. Mol Pharmacol. 2009 Oct;76(4):702-9.
5 Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer. Cancer Res. 2010 Jul 15;70(14):5953-62.

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