Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0039) | |||||
|---|---|---|---|---|---|
| DME Name | Dimethylaniline oxidase 3 (FMO3), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.14.13.8 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FMO3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 5.54E-20; delta-beta: -5.02E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FMO3 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 3. As a result, the interaction between DNMT and FMO3 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 3. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-FMO3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.04E-09; delta-beta: -4.77E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FMO3 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 3. As a result, the interaction between DNMT and FMO3 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 3. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C12 Liver cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Liver cancer | Significant hypomethylation | |||
| Interaction Name | DNMT-FMO3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.52E-17; delta-beta: -3.92E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FMO3 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 3. As a result, the interaction between DNMT and FMO3 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 3. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypomethylation p-value: 1.69E-10; delta-beta: -3.40E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FMO3 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 3. As a result, the interaction between DNMT and FMO3 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 3. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FMO3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 9.73E-11; delta-beta: -3.51E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FMO3 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 3. As a result, the interaction between DNMT and FMO3 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 3. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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