| General Information of Drug-Metabolizing Enzyme (DME ID: DME0041) |
| DME Name |
UDP-glucuronosyltransferase 1A3 (UGT1A3), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 2.4.1.17 (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.17
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Oligomerization |
| UDPGT 1-3 (UGT1A3) |
Health |
Homodimer |
| Uniprot ID |
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| Interaction Name |
UGT1A3-UGT1A3 homodimerization |
[1] |
| Studied Cell Lines |
Monkey kidney fibroblast-like cell line (COS) |
| Affected Substrate(s): |
Octylgallate
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| Description |
UDP-glucuronosyltransferase 1-3 (UGT1A3) is reported as a homodimer, which leads to a slight effect on the enzyme activity of drug-metabolizing enzyme UDP-glucuronosyltransferase 1A3. As a result, the UGT1A3 homodimerization can slightly affect the drug-metabolizing process of UDP-glucuronosyltransferase 1A3. |
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| References |
| 1 |
Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J Biol Chem. 2007 Feb 16;282(7):4821-9.
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