| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 5 HOSPPI
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| Oligomerization |
| Bilirubin-specific UDPGT 2 (UGT1A4) |
Health |
Heterooligomer |
| Uniprot ID |
|
| Interaction Name |
UGT1A4-UGT1A9 heterooligomerization |
[1] |
| Studied Cell Lines |
Human embryonic kidney cell line (HEK293) |
| Affected Substrate(s): |
Propofol (Metabolic product: Propofol O-glucuronide)
|
| Activity |
Increasing Vmax |
| Description |
Bilirubin-specific UDPGT 2 (UGT1A4) is reported to heterooligomerize with the UGT1A9 protein, which leads to an increased activity of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A9. As a result, the interaction between UGT1A4 and UGT1A9 can facilitate the drug-metabolizing process of UDP-glucuronosyltransferase 1A9. |
| Phenol-metabolizing UDPGT (UGT1A6) |
Health |
Heterooligomer |
| Uniprot ID |
|
| Interaction Name |
UGT1A6-UGT1A9 heterooligomerization |
[1] |
| Studied Cell Lines |
Human embryonic kidney cell line (HEK293) |
| Affected Substrate(s): |
Propofol (Metabolic product: Propofol O-glucuronide)
|
| Activity |
Increasing Vmax |
| Description |
Phenol-metabolizing UDPGT (UGT1A6) is reported to heterooligomerize with the UGT1A9 protein, which leads to an increased activity of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A9. As a result, the interaction between UGT1A6 and UGT1A9 can facilitate the drug-metabolizing process of UDP-glucuronosyltransferase 1A9. |
| UDPGT 1-1 (UGT1A1) |
Health |
Heterooligomer |
| Uniprot ID |
|
| Interaction Name |
UGT1A1-UGT1A9 heterooligomerization |
[1] |
| Studied Cell Lines |
Human embryonic kidney cell line (HEK293) |
| Affected Substrate(s): |
Propofol (Metabolic product: Propofol O-glucuronide)
|
| Activity |
Increasing Km and decreasing the Vmax |
| Description |
UDPGT 1-1 (UGT1A1) is reported to heterooligomerize with the UGT1A9 protein, which leads to an increased activity of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A9. As a result, the interaction between UGT1A1 and UGT1A9 can facilitate the drug-metabolizing process of UDP-glucuronosyltransferase 1A9. |
| Transcription-factor regulation |
| PPA receptor alpha (PPARA) |
Health |
Activation |
| Uniprot ID |
|
| Interaction Name |
PPARA-UGT1A9 interaction |
[2] |
| Studied Cell Lines |
Peripheral blood mononuclear cell line |
| Ensembl ID |
|
| Description |
PPA receptor alpha (PPARA) is reported to activate the transcription of UGT1A9 gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A9. As a result, the interaction between PPARA and UGT1A9 can activate the drug-metabolizing process of UDP-glucuronosyltransferase 1A9. |
| PPA receptor gamma (PPARG) |
Health |
Activation |
| Uniprot ID |
|
| Interaction Name |
PPARG-UGT1A9 interaction |
[2] |
| Studied Cell Lines |
Peripheral blood mononuclear cell line |
| Ensembl ID |
|
| Description |
PPA receptor gamma (PPARG) is reported to activate the transcription of UGT1A9 gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A9. As a result, the interaction between PPARG and UGT1A9 can activate the drug-metabolizing process of UDP-glucuronosyltransferase 1A9. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2B90 Colorectal cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Transcription-factor regulation |
| Hepatocyte NF 1-alpha (HNF1A) |
Colorectal cancer |
Activation |
| Uniprot ID |
|
| Interaction Name |
HNF1A-UGT1A9 interaction |
[3] |
| Studied Cell Lines |
Caco-2 cell line |
| Ensembl ID |
|
| Description |
Hepatocyte NF 1-alpha (HNF1A) is reported to activate the transcription of UGT1A9 gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A9. As a result, the interaction between HNF1A and UGT1A9 can activate the drug-metabolizing process of UDP-glucuronosyltransferase 1A9. |
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