Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0043) | |||||
|---|---|---|---|---|---|
| DME Name | Catechol O-methyltransferase (COMT), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.1.1.6 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-COMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.78E-02; delta-beta: 5.59E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the COMT gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Catechol O-methyltransferase. As a result, the interaction between DNMT and COMT can significantly affect the drug-metabolizing process of Catechol O-methyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypomethylation | |||
| Interaction Name | DNMT-COMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.70E-07; delta-beta: -7.20E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the COMT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Catechol O-methyltransferase. As a result, the interaction between DNMT and COMT can significantly affect the drug-metabolizing process of Catechol O-methyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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