Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0044) | |||||
|---|---|---|---|---|---|
| DME Name | Monoamine oxidase type A (MAO-A), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.4.3.4 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-MAO-A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.12E-02; delta-beta: -3.88E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the MAO-A gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Monoamine oxidase type A. As a result, the interaction between DNMT and MAO-A can significantly affect the drug-metabolizing process of Monoamine oxidase type A. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Significant hypermethylation | |||
| Interaction Name | DNMT-MAO-A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.79E-02; delta-beta: 5.27E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MAO-A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Monoamine oxidase type A. As a result, the interaction between DNMT and MAO-A can significantly affect the drug-metabolizing process of Monoamine oxidase type A. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Spinal ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-MAO-A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.66E-02; delta-beta: -3.58E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the MAO-A gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Monoamine oxidase type A. As a result, the interaction between DNMT and MAO-A can significantly affect the drug-metabolizing process of Monoamine oxidase type A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Significant hypermethylation | |||
| Interaction Name | DNMT-MAO-A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.55E-33; delta-beta: 3.42E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MAO-A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Monoamine oxidase type A. As a result, the interaction between DNMT and MAO-A can significantly affect the drug-metabolizing process of Monoamine oxidase type A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A11 Brain neuroblastoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| Transcription-factor regulation | |||||
| Helix-loop-helix 2 (NHLH2) | Neuroblastoma | Activation | |||
| Uniprot ID | |||||
| Interaction Name | NHLH2-MAOA interaction | [1] | |||
| Studied Cell Lines | N2A cell line | ||||
| Ensembl ID | |||||
| Description | Helix-loop-helix 2 (NHLH2) is reported to activate the transcription of MAOA gene, which leads to an increased expression of the drug-metabolizing enzyme Monoamine oxidase type A. As a result, the interaction between NHLH2 and MAOA can activate the drug-metabolizing process of Monoamine oxidase type A. | ||||
| ICD-11: 2A60 Acute myeloid leukemia | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Acute myeloid leukemia | Significant hypermethylation | |||
| Interaction Name | DNMT-MAO-A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.24E-03; delta-beta: 4.72E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MAO-A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Monoamine oxidase type A. As a result, the interaction between DNMT and MAO-A can significantly affect the drug-metabolizing process of Monoamine oxidase type A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypermethylation | |||
| Interaction Name | DNMT-MAO-A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.00E-19; delta-beta: 6.58E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MAO-A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Monoamine oxidase type A. As a result, the interaction between DNMT and MAO-A can significantly affect the drug-metabolizing process of Monoamine oxidase type A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 06 Mental/behavioural/neurodevelopmental disorders | |||||
| ICD-11: 6B01 Panic disorder | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| Non-coding RNA regulation | |||||
| hsa-miR-22-3p | Panic disorder | Suppression | |||
| miRBase ID | |||||
| Interaction Name | hsa-miR-22-3p--MAOA regulation | [2] | |||
| Studied Cell Lines | Panic Disorder cells | ||||
| Description | hsa-miR-22-3p is reported to suppress MAOA mRNA translation by binding to the 3' untranslated region (3'UTR) of MAOA mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Monoamine oxidase type A. | ||||
| ICD Disease Classification 08 Nervous system diseases | |||||
| ICD-11: 8A20 Alzheimer disease | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Alzheimer disease | Significant hypermethylation | |||
| Interaction Name | DNMT-MAO-A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.50E-05; delta-beta: 5.14E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MAO-A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Monoamine oxidase type A. As a result, the interaction between DNMT and MAO-A can significantly affect the drug-metabolizing process of Monoamine oxidase type A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 8E49 Postviral fatigue syndrome | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Postviral fatigue syndrome | Significant hypermethylation | |||
| Interaction Name | DNMT-MAO-A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 6.62E-07; delta-beta: 5.71E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MAO-A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Monoamine oxidase type A. As a result, the interaction between DNMT and MAO-A can significantly affect the drug-metabolizing process of Monoamine oxidase type A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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