Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0045)
DME Name	Monoamine oxidase type B (MAO-B), Homo sapiens	DME Info
UniProt ID	AOFB_HUMAN
EC Number	EC: 1.4.3.4 (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-NH2 donor oxidoreductase Oxygen acceptor oxidoreductase EC: 1.4.3.4
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 6 HOSPPI
Transcription-factor regulation
E2F phosphoprotein (EAPP)		Glioblastoma		Repression
Uniprot ID	EAPP_HUMAN
Interaction Name	EAPP-MAOB interaction				[1]
Studied Cell Lines	1242-MG cell line
Description	E2F phosphoprotein (EAPP) is reported to repress the transcription of MAOB gene, which leads to a decreased expression of the drug-metabolizing enzyme Monoamine oxidase type B. As a result, the interaction between EAPP and MAOB can repress the drug-metabolizing process of Monoamine oxidase type B.
Transcription factor RAM2 (CDCA7L)		Glioblastoma		Repression
Uniprot ID	CDA7L_HUMAN
Interaction Name	CDCA7L-MAOB interaction				[1]
Studied Cell Lines	1242-MG cell line
Description	Transcription factor RAM2 (CDCA7L) is reported to repress the transcription of MAOB gene, which leads to a decreased expression of the drug-metabolizing enzyme Monoamine oxidase type B. As a result, the interaction between CDCA7L and MAOB can repress the drug-metabolizing process of Monoamine oxidase type B.
Transcription factor Sp4 (SP4)		Glioblastoma		Activation
Uniprot ID	SP4_HUMAN
Interaction Name	SP4-MAOB interaction				[2]
Studied Cell Lines	1242-MG cell line
Ensembl ID	ENSG00000105866
Description	Transcription factor Sp4 (SP4) is reported to activate the transcription of MAOB gene, which leads to an increased expression of the drug-metabolizing enzyme Monoamine oxidase type B. As a result, the interaction between SP4 and MAOB can activate the drug-metabolizing process of Monoamine oxidase type B.
DNA methylation
DNA methyltransferase (DNMT)		Malignant astrocytoma		Moderate hypermethylation
Interaction Name	DNMT-MAOB interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 3.42E-22; delta-beta: 2.11E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the MAO-B gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Monoamine oxidase type B. As a result, the interaction between DNMT and MAO-B can moderatly affect the drug-metabolizing process of Monoamine oxidase type B.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Oligodendroglioma		Significant hypermethylation
Interaction Name	DNMT-MAOB interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 6.72E-29; delta-beta: 3.58E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MAO-B gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Monoamine oxidase type B. As a result, the interaction between DNMT and MAO-B can significantly affect the drug-metabolizing process of Monoamine oxidase type B.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Atypical teratoid/rhabdoid tumour		Moderate hypermethylation
Interaction Name	DNMT-MAOB interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 8.20E-14; delta-beta: 2.82E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the MAO-B gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Monoamine oxidase type B. As a result, the interaction between DNMT and MAO-B can moderatly affect the drug-metabolizing process of Monoamine oxidase type B.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2A60 Acute myeloid leukemia		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Acute myeloid leukemia		Moderate hypermethylation
Interaction Name	DNMT-MAOB interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 6.37E-03; delta-beta: 2.32E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the MAO-B gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Monoamine oxidase type B. As a result, the interaction between DNMT and MAO-B can moderatly affect the drug-metabolizing process of Monoamine oxidase type B.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B30 Lymphoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lymphoma		Significant hypermethylation
Interaction Name	DNMT-MAOB interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 1.18E-22; delta-beta: 5.08E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MAO-B gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Monoamine oxidase type B. As a result, the interaction between DNMT and MAO-B can significantly affect the drug-metabolizing process of Monoamine oxidase type B.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Transcription-factor regulation
Transcription factor Sp4 (SP4)		Liver cancer		Activation
Uniprot ID	SP4_HUMAN
Interaction Name	SP4-MAOB interaction				[2]
Studied Cell Lines	HepG2 cell line
Ensembl ID	ENSG00000105866
Description	Transcription factor Sp4 (SP4) is reported to activate the transcription of MAOB gene, which leads to an increased expression of the drug-metabolizing enzyme Monoamine oxidase type B. As a result, the interaction between SP4 and MAOB can activate the drug-metabolizing process of Monoamine oxidase type B.
ICD-11: 2C77 Cervical cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Transcription-factor regulation
Transcription factor Sp4 (SP4)		Cervical cancer		Activation
Uniprot ID	SP4_HUMAN
Interaction Name	SP4-MAOB interaction				[2]
Studied Cell Lines	HeLa cell line
Ensembl ID	ENSG00000105866
Description	Transcription factor Sp4 (SP4) is reported to activate the transcription of MAOB gene, which leads to an increased expression of the drug-metabolizing enzyme Monoamine oxidase type B. As a result, the interaction between SP4 and MAOB can activate the drug-metabolizing process of Monoamine oxidase type B.
ICD-11: 2E06 Prostate cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Prostate cancer metastasis		Significant hypermethylation
Interaction Name	DNMT-MAOB interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 2.31E-04; delta-beta: 7.51E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MAO-B gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Monoamine oxidase type B. As a result, the interaction between DNMT and MAO-B can significantly affect the drug-metabolizing process of Monoamine oxidase type B.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 08 Nervous system diseases
ICD-11: 8E49 Postviral fatigue syndrome		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Postviral fatigue syndrome		Moderate hypermethylation
Interaction Name	DNMT-MAOB interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 9.05E-10; delta-beta: 2.93E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the MAO-B gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Monoamine oxidase type B. As a result, the interaction between DNMT and MAO-B can moderatly affect the drug-metabolizing process of Monoamine oxidase type B.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	Transcription factor E2F-associated phosphoprotein (EAPP), RAM2/CDCA7L/JPO2 (R1), and simian virus 40 promoter factor 1 (Sp1) cooperatively regulate glucocorticoid activation of monoamine oxidase B. Mol Pharmacol. 2011 Feb;79(2):308-17.
2	Regulation of human monoamine oxidase B gene by Sp1 and Sp3. Mol Pharmacol. 2001 Apr;59(4):852-9.

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