Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0046)
DME Name	Calcidiol 1-monooxygenase (CYP27B1), Homo sapiens	DME Info
UniProt ID	CP27B_HUMAN
EC Number	EC: 1.14.15.18 (Click to Show/Hide the Complete EC Tree) Oxidoreductase Oxygen paired donor oxidoreductase Iron-sulfur protein donor oxidoreductase EC: 1.14.15.18
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 6 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Medulloblastoma		Significant hypomethylation
Interaction Name	DNMT-CYP27B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 6.48E-46; delta-beta: -3.44E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP27B1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between DNMT and CYP27B1 can significantly affect the drug-metabolizing process of Calcidiol 1-monooxygenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Oligodendroglial tumour		Moderate hypermethylation
Interaction Name	DNMT-CYP27B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 6.54E-03; delta-beta: 2.30E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CYP27B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between DNMT and CYP27B1 can moderatly affect the drug-metabolizing process of Calcidiol 1-monooxygenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Melanocytoma		Moderate hypermethylation
Interaction Name	DNMT-CYP27B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 2.59E-04; delta-beta: 2.73E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CYP27B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between DNMT and CYP27B1 can moderatly affect the drug-metabolizing process of Calcidiol 1-monooxygenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Multilayered rosettes embryonal tumour		Moderate hypermethylation
Interaction Name	DNMT-CYP27B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 1.95E-07; delta-beta: 2.60E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CYP27B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between DNMT and CYP27B1 can moderatly affect the drug-metabolizing process of Calcidiol 1-monooxygenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Oligodendroglioma		Significant hypermethylation
Interaction Name	DNMT-CYP27B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 2.65E-23; delta-beta: 4.50E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CYP27B1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between DNMT and CYP27B1 can significantly affect the drug-metabolizing process of Calcidiol 1-monooxygenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Atypical teratoid/rhabdoid tumour		Significant hypermethylation
Interaction Name	DNMT-CYP27B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 2.82E-07; delta-beta: 3.12E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CYP27B1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between DNMT and CYP27B1 can significantly affect the drug-metabolizing process of Calcidiol 1-monooxygenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B90 Colorectal cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Colorectal cancer		Moderate hypermethylation
Interaction Name	DNMT-CYP27B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 5.58E-10; delta-beta: 2.75E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CYP27B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between DNMT and CYP27B1 can moderatly affect the drug-metabolizing process of Calcidiol 1-monooxygenase.
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Moderate hypermethylation p-value: 7.53E-07; delta-beta: 2.53E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CYP27B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between DNMT and CYP27B1 can moderatly affect the drug-metabolizing process of Calcidiol 1-monooxygenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Liver cancer		Significant hypermethylation
Interaction Name	DNMT-CYP27B1 interaction
The Methylation Level of Disease Section Compare with the Other Disease Section	Significant hypermethylation p-value: 1.34E-02; delta-beta: 1.80E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CYP27B1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between DNMT and CYP27B1 can significantly affect the drug-metabolizing process of Calcidiol 1-monooxygenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C25 Lung cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lung cancer		Moderate hypomethylation
Interaction Name	DNMT-CYP27B1 interaction
The Methylation Level of Disease Section Compare with the Other Disease Section	Moderate hypomethylation p-value: 2.19E-05; delta-beta: -2.61E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CYP27B1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between DNMT and CYP27B1 can moderatly affect the drug-metabolizing process of Calcidiol 1-monooxygenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C30 Melanoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Melanoma		Significant hypermethylation
Interaction Name	DNMT-CYP27B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 3.33E-03; delta-beta: 3.44E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CYP27B1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between DNMT and CYP27B1 can significantly affect the drug-metabolizing process of Calcidiol 1-monooxygenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C60 Breast cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Histone modification
Histone deacetylases (HDACs)		Breast cancer		Repression
Uniprot ID	HDAC1_HUMAN
Interaction Name	HDACs-CYP27B1 interaction				[1]
Studied Cell Lines	MCF-7 cell line
Description	Histone deacetylases (HDACs) are reported to deacetylate the CYP27B1 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between HDACs and CYP27B1 can inhibit the drug-metabolizing process of Calcidiol 1-monooxygenase.
ICD-11: 2C82 Prostate cancer		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
Zinc finger Gfi-1 (GFI1)		Prostate cancer		Repression
Uniprot ID	GFI1_HUMAN
Interaction Name	GFI1-CYP27B1 interaction				[2], [3]
Studied Cell Lines	DU145, PC3 and LNCaP cell lines
Ensembl ID	ENSG00000162676
Description	Zinc finger Gfi-1 (GFI1) is reported to repress the transcription of CYP27B1 gene, which leads to a decreased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between GFI1 and CYP27B1 can repress the drug-metabolizing process of Calcidiol 1-monooxygenase.
DNA methylation
DNA methyltransferase (DNMT)		Prostate cancer		Significant hypermethylation
Interaction Name	DNMT-CYP27B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 2.31E-07; delta-beta: 3.84E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CYP27B1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between DNMT and CYP27B1 can significantly affect the drug-metabolizing process of Calcidiol 1-monooxygenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2E06 Prostate cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Prostate cancer metastasis		Moderate hypermethylation
Interaction Name	DNMT-CYP27B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 5.07E-03; delta-beta: 2.37E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CYP27B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between DNMT and CYP27B1 can moderatly affect the drug-metabolizing process of Calcidiol 1-monooxygenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2F37 Endocrine gland cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Pituitary adenoma		Moderate hypermethylation
Interaction Name	DNMT-CYP27B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 2.26E-06; delta-beta: 2.88E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CYP27B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between DNMT and CYP27B1 can moderatly affect the drug-metabolizing process of Calcidiol 1-monooxygenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases
ICD-11: 5B81 Obesity		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Obesity		Significant hypomethylation
Interaction Name	DNMT-CYP27B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 4.04E-21; delta-beta: -5.18E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP27B1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Calcidiol 1-monooxygenase. As a result, the interaction between DNMT and CYP27B1 can significantly affect the drug-metabolizing process of Calcidiol 1-monooxygenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	Histone deacetylase activity and vitamin D-dependent gene expressions in relation to sulforaphane in human breast cancer cells. J Food Biochem. 2020 Feb;44(2):e13114.
2	Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells. Endocr Relat Cancer. 2005 Jun;12(2):351-65.
3	Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):742-6.

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