| General Information of Drug-Metabolizing Enzyme (DME ID: DME0047) |
| DME Name |
UDP-glucuronosyltransferase 2B4 (UGT2B4), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 2.4.1.17 (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.17
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C12 Liver cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Transcription-factor regulation |
| Bile acid receptor (NR1H4) |
Liver cancer |
Repression |
| Uniprot ID |
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| Interaction Name |
NR1H4-UGT2B4 interaction |
[1] |
| Studied Cell Lines |
HepG2 cell line |
| Ensembl ID |
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| Description |
Bile acid receptor (NR1H4) is reported to repress the transcription of UGT2B4 gene, which leads to a decreased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 2B4. As a result, the interaction between NR1H4 and UGT2B4 can repress the drug-metabolizing process of UDP-glucuronosyltransferase 2B4. |
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| References |
| 1 |
FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. Gastroenterology. 2003 Jun;124(7):1926-40.
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