Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0048)
DME Name UDP-glucuronosyltransferase 1A4 (UGT1A4), Homo sapiens DME Info
UniProt ID
UD14_HUMAN
EC Number    EC: 2.4.1.17     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.17
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Oligomerization
                            UDPGT 1-9 (UGT1A9) Health Heterooligomer
Uniprot ID
UD19_HUMAN
Interaction Name UGT1A9-UGT1A4 heterooligomerization [1]
Studied Cell Lines Human embryonic kidney cell line (HEK293)
Affected Substrate(s): Imipramine (Metabolic product: Imipramine N-glucuronide)
Activity Increasing Vmax and Km
Description UDPGT 1-9 (UGT1A9) is reported to heterooligomerize with the UGT1A4 protein, which leads to an increased activity of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A4. As a result, the interaction between UGT1A9 and UGT1A4 can facilitate the drug-metabolizing process of UDP-glucuronosyltransferase 1A4.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Transcription-factor regulation
                            Estrogen receptor (ESR1) Liver cancer Activation
Uniprot ID
ESR1_HUMAN
Interaction Name ESR1-UGT1A4 interaction [2]
Studied Cell Lines HepG2 cell line
Ensembl ID
ENSG00000091831
Description Estrogen receptor (ESR1) is reported to activate the transcription of UGT1A4 gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A4. As a result, the interaction between ESR1 and UGT1A4 can activate the drug-metabolizing process of UDP-glucuronosyltransferase 1A4.
                            Transcription factor Sp1 (SP1) Liver cancer Activation
Uniprot ID
SP1_HUMAN
Interaction Name SP1-UGT1A4 interaction [2]
Studied Cell Lines HepG2 cell line
Ensembl ID
ENSG00000185591
Description Transcription factor Sp1 (SP1) is reported to activate the transcription of UGT1A4 gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A4. As a result, the interaction between SP1 and UGT1A4 can activate the drug-metabolizing process of UDP-glucuronosyltransferase 1A4.
References
1 Effects of coexpression of UGT1A9 on enzymatic activities of human UGT1A isoforms. Drug Metab Dispos. 2007 May;35(5):747-57.
2 Up-regulation of UDP-glucuronosyltransferase (UGT) 1A4 by 17beta-estradiol: a potential mechanism of increased lamotrigine elimination in pregnancy. Drug Metab Dispos. 2009 Sep;37(9):1841-7.

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