| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
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| Non-coding RNA regulation |
| hsa-miR-331-5p |
Health |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-331-5p--UGT2B15 regulation |
[1] |
| Studied Cell Lines |
HEK293 cell line |
| Description |
hsa-miR-331-5p is reported to suppress UGT2B15 mRNA translation by binding to the 3' untranslated region (3'UTR) of UGT2B15 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 2B15. |
| hsa-miR-376c-3p |
Health |
Suppression |
| miRBase ID |
|
| Interaction Name |
hsa-miR-376c-3p--UGT2B15 regulation |
[1] |
| Studied Cell Lines |
HEK293 cell line |
| Description |
hsa-miR-376c-3p is reported to suppress UGT2B15 mRNA translation by binding to the 3' untranslated region (3'UTR) of UGT2B15 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 2B15. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C60 Breast cancer |
Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI
|
| Transcription-factor regulation |
| Estrogen receptor (ESR1) |
Breast cancer |
Activation |
| Uniprot ID |
|
| Interaction Name |
ESR1-UGT2B15 interaction |
[2] |
| Studied Cell Lines |
MCF-7 cell line |
| Ensembl ID |
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| Description |
Estrogen receptor (ESR1) is reported to activate the transcription of UGT2B15 gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 2B15. As a result, the interaction between ESR1 and UGT2B15 can activate the drug-metabolizing process of UDP-glucuronosyltransferase 2B15. |
| Fos-related antigen 2 (FOSL2) |
Breast cancer |
Activation |
| Uniprot ID |
|
| Interaction Name |
FOSL2-UGT2B15 interaction |
[2] |
| Studied Cell Lines |
MCF-7 cell line |
| Ensembl ID |
|
| Description |
Fos-related antigen 2 (FOSL2) is reported to activate the transcription of UGT2B15 gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 2B15. As a result, the interaction between FOSL2 and UGT2B15 can activate the drug-metabolizing process of UDP-glucuronosyltransferase 2B15. |
| Transcription factor AP-1 (JUN) |
Breast cancer |
Activation |
| Uniprot ID |
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| Interaction Name |
JUN-UGT2B15 interaction |
[2] |
| Studied Cell Lines |
MCF-7 cell line |
| Ensembl ID |
|
| Description |
Transcription factor AP-1 (JUN) is reported to activate the transcription of UGT2B15 gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 2B15. As a result, the interaction between JUN and UGT2B15 can activate the drug-metabolizing process of UDP-glucuronosyltransferase 2B15. |
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