Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0050)
DME Name N-acetyltransferase 1 (NAT1), Homo sapiens DME Info
UniProt ID
ARY1_HUMAN
EC Number    EC: 2.3.1.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Histone modification
                            Histone deacetylases (HDACs) Liver cancer Repression
Uniprot ID
HDAC1_HUMAN
Interaction Name HDACs-NAT1 interaction [1]
Studied Cell Lines HepG2 cell line
Description Histone deacetylases (HDACs) are reported to deacetylate the NAT1 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme N-acetyltransferase 1. As a result, the interaction between HDACs and NAT1 can inhibit the drug-metabolizing process of N-acetyltransferase 1.
               ICD-11: 2C60 Breast cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Androgen receptor (AR) Breast cancer Activation
Uniprot ID
ANDR_HUMAN
Interaction Name AR-NAT1 interaction [2]
Studied Cell Lines MCF10A and MCF7 cell lines
Ensembl ID
ENSG00000169083
Description Androgen receptor (AR) is reported to activate the transcription of NAT1 gene, which leads to an increased expression of the drug-metabolizing enzyme N-acetyltransferase 1. As a result, the interaction between AR and NAT1 can activate the drug-metabolizing process of N-acetyltransferase 1.
               ICD-11: 2C82 Prostate cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Heat shock factor 1 (HSF1) Prostate cancer Activation
Uniprot ID
HSF1_HUMAN
Interaction Name HSF1-NAT1 interaction [3]
Studied Cell Lines 22Rv1 cell line
Ensembl ID
ENSG00000185122
Description Heat shock factor 1 (HSF1) is reported to activate the transcription of NAT1 gene, which leads to an increased expression of the drug-metabolizing enzyme N-acetyltransferase 1. As a result, the interaction between HSF1 and NAT1 can activate the drug-metabolizing process of N-acetyltransferase 1.
References
1 Histone deacetylase inhibitors increase human arylamine N-acetyltransferase-1 expression in human tumor cells. Drug Metab Dispos. 2011 Jan;39(1):77-82.
2 Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells. Cancer Res. 2007 Jan 1;67(1):85-92.
3 Arylamine N-acetyltransferase 1 gene regulation by androgens requires a conserved heat shock element for heat shock factor-1. Carcinogenesis. 2010 May;31(5):820-6.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.