Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0053)
DME Name	Dihydrothymine dehydrogenase (DPYD), Homo sapiens	DME Info
UniProt ID	DPYD_HUMAN
EC Number	EC: 1.3.1.2 (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-CH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.3.1.2
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 5 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Glioblastoma		Moderate hypomethylation
Interaction Name	DNMT-DPYD interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 4.33E-02; delta-beta: -2.13E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the DPYD gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Dihydrothymine dehydrogenase. As a result, the interaction between DNMT and DPYD can moderatly affect the drug-metabolizing process of Dihydrothymine dehydrogenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Brain neuroblastoma		Significant hypomethylation
Interaction Name	DNMT-DPYD interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 9.89E-15; delta-beta: -6.04E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the DPYD gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dihydrothymine dehydrogenase. As a result, the interaction between DNMT and DPYD can significantly affect the drug-metabolizing process of Dihydrothymine dehydrogenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Brain neuroepithelial tumour		Significant hypomethylation
Interaction Name	DNMT-DPYD interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 9.06E-16; delta-beta: -6.04E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the DPYD gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dihydrothymine dehydrogenase. As a result, the interaction between DNMT and DPYD can significantly affect the drug-metabolizing process of Dihydrothymine dehydrogenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Cerebellar liponeurocytoma		Significant hypomethylation
Interaction Name	DNMT-DPYD interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 2.61E-03; delta-beta: -6.95E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the DPYD gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dihydrothymine dehydrogenase. As a result, the interaction between DNMT and DPYD can significantly affect the drug-metabolizing process of Dihydrothymine dehydrogenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Diffuse midline glioma		Significant hypomethylation
Interaction Name	DNMT-DPYD interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.14E-30; delta-beta: -4.18E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the DPYD gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dihydrothymine dehydrogenase. As a result, the interaction between DNMT and DPYD can significantly affect the drug-metabolizing process of Dihydrothymine dehydrogenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B5F Uterine carcinosarcoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Uterine carcinosarcoma		Significant hypomethylation
Interaction Name	DNMT-DPYD interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.18E-17; delta-beta: -4.22E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the DPYD gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dihydrothymine dehydrogenase. As a result, the interaction between DNMT and DPYD can significantly affect the drug-metabolizing process of Dihydrothymine dehydrogenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B90 Colorectal cancer		Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI
Non-coding RNA regulation
hsa-miR-27a-3p		Colorectal cancer		Suppression
miRBase ID	MIMAT0000084
Interaction Name	hsa-miR-27a-3p--DPYD regulation				[1]
Studied Cell Lines	HCT116 cell line
Description	hsa-miR-27a-3p is reported to suppress DPYD mRNA translation by binding to the 3' untranslated region (3'UTR) of DPYD mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Dihydrothymine dehydrogenase.
hsa-miR-27b-3p		Colorectal cancer		Suppression
miRBase ID	MIMAT0000419
Interaction Name	hsa-miR-27b-3p--DPYD regulation				[1]
Studied Cell Lines	HCT116 cell line
Description	hsa-miR-27b-3p is reported to suppress DPYD mRNA translation by binding to the 3' untranslated region (3'UTR) of DPYD mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Dihydrothymine dehydrogenase.
hsa-miR-494-5p		Colorectal cancer		Suppression
miRBase ID	MIMAT0026607
Interaction Name	hsa-miR-494-5p--DPYD regulation				[2]
Studied Cell Lines	SW480 cell line
Description	hsa-miR-494-5p is reported to suppress DPYD mRNA translation by binding to the 3' untranslated region (3'UTR) of DPYD mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Dihydrothymine dehydrogenase.
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Non-coding RNA regulation
hsa-miR-302b-3p		Liver cancer		Suppression
miRBase ID	MIMAT0000715
Interaction Name	hsa-miR-302b-3p--DPYD regulation				[3]
Studied Cell Lines	HepG2 cell line
Description	hsa-miR-302b-3p is reported to suppress DPYD mRNA translation by binding to the 3' untranslated region (3'UTR) of DPYD mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Dihydrothymine dehydrogenase.
ICD-11: 2C82 Prostate cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Prostate cancer		Moderate hypermethylation
Interaction Name	DNMT-DPYD interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 1.62E-02; delta-beta: 2.99E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the DPYD gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Dihydrothymine dehydrogenase. As a result, the interaction between DNMT and DPYD can moderatly affect the drug-metabolizing process of Dihydrothymine dehydrogenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2D50 Brain cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Esthesioneuroblastoma		Moderate hypomethylation
Interaction Name	DNMT-DPYD interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 5.85E-03; delta-beta: -2.21E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the DPYD gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Dihydrothymine dehydrogenase. As a result, the interaction between DNMT and DPYD can moderatly affect the drug-metabolizing process of Dihydrothymine dehydrogenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2F7C Connective tissue cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Hemangioblastoma		Moderate hypermethylation
Interaction Name	DNMT-DPYD interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 1.18E-03; delta-beta: 2.17E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the DPYD gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Dihydrothymine dehydrogenase. As a result, the interaction between DNMT and DPYD can moderatly affect the drug-metabolizing process of Dihydrothymine dehydrogenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 11 Circulatory system diseases
ICD-11: BD51 Arterial aneurysm		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Arterial aneurysm		Moderate hypermethylation
Interaction Name	DNMT-DPYD interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 8.41E-03; delta-beta: 2.98E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the DPYD gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Dihydrothymine dehydrogenase. As a result, the interaction between DNMT and DPYD can moderatly affect the drug-metabolizing process of Dihydrothymine dehydrogenase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual

References
1	microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites. Mol Cancer Ther. 2014 Mar;13(3):742-51.
2	MicroRNA-494 sensitizes colon cancer cells to fluorouracil through regulation of DPYD. IUBMB Life. 2015 Mar;67(3):191-201.
3	MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD. Int J Mol Sci. 2015 Oct 6;16(10):23668-82.

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