Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0054) | |||||
|---|---|---|---|---|---|
| DME Name | Carboxylesterase 1 (CES1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.1.1.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Medulloblastoma | Significant hypermethylation | |||
| Interaction Name | DNMT-CES1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 6.77E-39; delta-beta: 3.29E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CES1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Carboxylesterase 1. As a result, the interaction between DNMT and CES1 can significantly affect the drug-metabolizing process of Carboxylesterase 1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Significant hypermethylation | |||
| Interaction Name | DNMT-CES1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 5.61E-07; delta-beta: 3.11E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CES1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Carboxylesterase 1. As a result, the interaction between DNMT and CES1 can significantly affect the drug-metabolizing process of Carboxylesterase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-CES1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.45E-15; delta-beta: -4.96E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CES1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Carboxylesterase 1. As a result, the interaction between DNMT and CES1 can significantly affect the drug-metabolizing process of Carboxylesterase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-CES1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.34E-02; delta-beta: 2.27E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CES1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Carboxylesterase 1. As a result, the interaction between DNMT and CES1 can moderatly affect the drug-metabolizing process of Carboxylesterase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-CES1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.73E-14; delta-beta: 2.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CES1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Carboxylesterase 1. As a result, the interaction between DNMT and CES1 can moderatly affect the drug-metabolizing process of Carboxylesterase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-CES1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 5.42E-14; delta-beta: -4.69E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CES1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Carboxylesterase 1. As a result, the interaction between DNMT and CES1 can significantly affect the drug-metabolizing process of Carboxylesterase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Significant hypomethylation | |||
| Interaction Name | DNMT-CES1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 7.24E-03; delta-beta: -3.93E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CES1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Carboxylesterase 1. As a result, the interaction between DNMT and CES1 can significantly affect the drug-metabolizing process of Carboxylesterase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F9A Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Craniopharyngioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CES1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 4.73E-05; delta-beta: -2.72E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CES1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Carboxylesterase 1. As a result, the interaction between DNMT and CES1 can moderatly affect the drug-metabolizing process of Carboxylesterase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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