Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0058)
DME Name Acetylcholinesterase (ACHE), Homo sapiens DME Info
UniProt ID
ACES_HUMAN
EC Number    EC: 3.1.1.7     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.7
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A11 Brain neuroblastoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Histone modification
                            Histone methyltransferases (HMTs) Neuroblastoma Repression
Uniprot ID
EHMT1_HUMAN
Interaction Name HMTs-ACHE interaction [1]
Studied Cell Lines Human neuroblastoma cells SH-SY5Y
Description The Histone 3 lysine 27 trimethylation of ACHE gene is reported to repress the transcriptional activity of the drug-metabolizing enzyme Acetylcholinesterase. As a result, the interaction between Histone methyltransferases (HMTs) and ACHE can inhibit the drug-metabolizing process of Acetylcholinesterase.
               ICD-11: 2C25 Lung cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-212-3p Lung cancer Suppression
miRBase ID
MIMAT0000269
Interaction Name hsa-miR-212-3p--ACHE regulation [2]
Studied Cell Lines NCI-H460 and NCI-H520 cell lines
Description hsa-miR-212-3p is reported to suppress ACHE mRNA translation by binding to the 3' untranslated region (3'UTR) of ACHE mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Acetylcholinesterase.
               ICD-11: 2C80 Testis cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            TF factor AP-2-alpha (TFAP2A) Teratocarcinoma Repression
Uniprot ID
AP2A_HUMAN
Interaction Name TFAP2A-ACHE interaction [3]
Studied Cell Lines Human NT2/D1 teratocarcinoma cell line
Ensembl ID
ENSG00000137203
Description TF factor AP-2-alpha (TFAP2A) is reported to repress the transcription of ACHE gene, which leads to a decreased expression of the drug-metabolizing enzyme Acetylcholinesterase. As a result, the interaction between TFAP2A and ACHE can repress the drug-metabolizing process of Acetylcholinesterase.
      ICD Disease Classification 13 Digestive system diseases
               ICD-11: DA96 Pediatric intestinal failure Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-124-5p Pediatric intestinal failure Suppression
miRBase ID
MIMAT0004591
Interaction Name hsa-miR-124-5p--ACHE regulation [4]
Studied Cell Lines Pediatric intestinal failure cells
Description hsa-miR-124-5p is reported to suppress ACHE mRNA translation by binding to the 3' untranslated region (3'UTR) of ACHE mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Acetylcholinesterase.
References
1 A novel understanding of postoperative complications: In vitro study of the impact of propofol on epigenetic modifications in cholinergic genes. PLoS One. 2019 May 29;14(5):e0217269.
2 Synaptic acetylcholinesterase targeted by microRNA-212 functions as a tumor suppressor in non-small cell lung cancer. Int J Biochem Cell Biol. 2013 Nov;45(11):2530-40.
3 Transcription factor repression and activation of the human acetylcholinesterase gene. J Biol Chem. 1995 Oct 6;270(40):23511-9.
4 Downregulated expression of microRNA-124 in pediatric intestinal failure patients modulates macrophages activation by inhibiting STAT3 and AChE. Cell Death Dis. 2016 Dec 15;7(12):e2521.

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