| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Non-coding RNA regulation |
| hsa-miR-199a-5p |
Health |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-199a-5p--SULT1E1 regulation |
[1] |
| Studied Cell Lines |
Human dermal microvascular endothelial cells |
| Description |
hsa-miR-199a-5p is reported to suppress SULT1E1 mRNA translation by binding to the 3' untranslated region (3'UTR) of SULT1E1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Sulfotransferase 1E1. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C60 Breast cancer |
Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
|
| Transcription-factor regulation |
| TF factor AP-2 gamma (TFAP2C) |
Breast cancer |
Activation |
| Uniprot ID |
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| Interaction Name |
TFAP2C-SULT1E1 interaction |
[2] |
| Studied Cell Lines |
MCF10A and MCF7 cell lines |
| Ensembl ID |
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| Description |
TF factor AP-2 gamma (TFAP2C) is reported to activate the transcription of SULT1E1 gene, which leads to an increased expression of the drug-metabolizing enzyme Sulfotransferase 1E1. As a result, the interaction between TFAP2C and SULT1E1 can activate the drug-metabolizing process of Sulfotransferase 1E1. |
| TF factor AP-2-alpha (TFAP2A) |
Breast cancer |
Activation |
| Uniprot ID |
|
| Interaction Name |
TFAP2A-SULT1E1 interaction |
[2] |
| Studied Cell Lines |
MCF10A and MCF7 cell lines |
| Ensembl ID |
|
| Description |
TF factor AP-2-alpha (TFAP2A) is reported to activate the transcription of SULT1E1 gene, which leads to an increased expression of the drug-metabolizing enzyme Sulfotransferase 1E1. As a result, the interaction between TFAP2A and SULT1E1 can activate the drug-metabolizing process of Sulfotransferase 1E1. |
| ICD Disease Classification 16 Genitourinary system diseases |
| ICD-11: GB22 Hypertrophy of breast |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Histone modification |
| Histone deacetylases (HDACs) |
Hypertrophy of breast |
Repression |
| Uniprot ID |
|
| Interaction Name |
HDACs-SULT1E1 interaction |
[3] |
| Studied Cell Lines |
MCF10A lineage cell line |
| Description |
Histone deacetylases (HDACs) are reported to deacetylate the SULT1E1 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Sulfotransferase 1E1. As a result, the interaction between HDACs and SULT1E1 can inhibit the drug-metabolizing process of Sulfotransferase 1E1. |
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