Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0064)
DME Name	UDP-glucuronosyltransferase 1A8 (UGT1A8), Homo sapiens	DME Info
UniProt ID	UD18_HUMAN
EC Number	EC: 2.4.1.17 (Click to Show/Hide the Complete EC Tree) Transferase Glycosyltransferases Hexosyltransferase EC: 2.4.1.17
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Brain neuroblastoma		Significant hypomethylation
Interaction Name	DNMT-UGT1A8 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.32E-26; delta-beta: -6.05E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the UGT1A8 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A8. As a result, the interaction between DNMT and UGT1A8 can significantly affect the drug-metabolizing process of UDP-glucuronosyltransferase 1A8.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Cerebellar liponeurocytoma		Moderate hypomethylation
Interaction Name	DNMT-UGT1A8 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 2.29E-02; delta-beta: -2.48E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the UGT1A8 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A8. As a result, the interaction between DNMT and UGT1A8 can moderatly affect the drug-metabolizing process of UDP-glucuronosyltransferase 1A8.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B90 Colorectal cancer		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
Hepatocyte NF 1-alpha (HNF1A)		Colorectal cancer		Activation
Uniprot ID	HNF1A_HUMAN
Interaction Name	HNF1A-UGT1A8 interaction				[1]
Studied Cell Lines	Caco-2 cell line
Ensembl ID	ENSG00000135100
Description	Hepatocyte NF 1-alpha (HNF1A) is reported to activate the transcription of UGT1A8 gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A8. As a result, the interaction between HNF1A and UGT1A8 can activate the drug-metabolizing process of UDP-glucuronosyltransferase 1A8.
Homeobox protein CDX-2 (CDX2)		Colorectal cancer		Activation
Uniprot ID	CDX2_HUMAN
Interaction Name	CDX2-UGT1A8 interaction				[1]
Studied Cell Lines	Caco-2 cell line
Ensembl ID	ENSG00000165556
Description	Homeobox protein CDX-2 (CDX2) is reported to activate the transcription of UGT1A8 gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A8. As a result, the interaction between CDX2 and UGT1A8 can activate the drug-metabolizing process of UDP-glucuronosyltransferase 1A8.
ICD-11: 2C90 Renal cell carcinoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Renal cell carcinoma		Significant hypermethylation
Interaction Name	DNMT-UGT1A8 interaction
The Methylation Level of Disease Section Compare with the Other Disease Section	Significant hypermethylation p-value: 1.41E-02; delta-beta: 4.10E-02
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the UGT1A8 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A8. As a result, the interaction between DNMT and UGT1A8 can significantly affect the drug-metabolizing process of UDP-glucuronosyltransferase 1A8.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2D50 Brain cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Esthesioneuroblastoma		Significant hypomethylation
Interaction Name	DNMT-UGT1A8 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.38E-06; delta-beta: -3.06E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the UGT1A8 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A8. As a result, the interaction between DNMT and UGT1A8 can significantly affect the drug-metabolizing process of UDP-glucuronosyltransferase 1A8.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2F37 Endocrine gland cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Pituitary adenoma		Moderate hypomethylation
Interaction Name	DNMT-UGT1A8 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 8.38E-11; delta-beta: -2.78E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the UGT1A8 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A8. As a result, the interaction between DNMT and UGT1A8 can moderatly affect the drug-metabolizing process of UDP-glucuronosyltransferase 1A8.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	Coordinate regulation of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 genes by hepatocyte nuclear factor 1alpha and the caudal-related homeodomain protein 2. Mol Pharmacol. 2004 Apr;65(4):953-63.

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