General Information of Drug-Metabolizing Enzyme (DME ID: DME0065)
DME Name UDP-glucuronosyltransferase 1A7 (UGT1A7), Homo sapiens DME Info
UniProt ID
UD17_HUMAN
EC Number    EC: 2.4.1.17     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.17
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Oligomerization
                            UDPGT 1-1 (UGT1A1) Health Heterodimer
Uniprot ID
UD11_HUMAN
Interaction Name UGT1A1-UGT1A7 heterodimerization [1]
Studied Cell Lines Monkey kidney fibroblast-like cell line (COS)
Affected Substrate(s): 2-Napthol
Description UDPGT 1-1 (UGT1A1) is reported to heterodimerize with the UGT1A7 protein, which leads to a slight effect on the enzyme activity of UDP-glucuronosyltransferase 1A7. As a result, the interaction between UGT1A1 and UGT1A7 can slightly affect the drug-metabolizing process of UDP-glucuronosyltransferase 1A7.
                            UDPGT 1-7 (UGT1A7) Health Homodimer
Uniprot ID
UD17_HUMAN
Interaction Name UGT1A7-UGT1A7 homodimerization [1]
Studied Cell Lines Monkey kidney fibroblast-like cell line (COS)
Affected Substrate(s): 2-Napthol
Description UDP-glucuronosyltransferase 1-7 (UGT1A7) is reported as a homodimer, which leads to a slight effect on the enzyme activity of drug-metabolizing enzyme UDP-glucuronosyltransferase 1A7. As a result, the UGT1A7 homodimerization can slightly affect the drug-metabolizing process of UDP-glucuronosyltransferase 1A7.
References
1 Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J Biol Chem. 2007 Feb 16;282(7):4821-9.

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