Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0066)
DME Name UDP-glucuronosyltransferase 2B17 (UGT2B17), Homo sapiens DME Info
UniProt ID
UDB17_HUMAN
EC Number    EC: 2.4.1.17     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.17
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        3 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-376c-3p Health Suppression
miRBase ID
MIMAT0000720
Interaction Name hsa-miR-376c-3p--UGT2B17 regulation [1]
Studied Cell Lines HEK293 cell line
Description hsa-miR-376c-3p is reported to suppress UGT2B17 mRNA translation by binding to the 3' untranslated region (3'UTR) of UGT2B17 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 2B17.
                            hsa-miR-409-3p Health Suppression
miRBase ID
MIMAT0001639
Interaction Name hsa-miR-409-3p--UGT2B17 regulation [1]
Studied Cell Lines HEK293 cell line
Description hsa-miR-409-3p is reported to suppress UGT2B17 mRNA translation by binding to the 3' untranslated region (3'UTR) of UGT2B17 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 2B17.
                            hsa-miR-494-3p Health Suppression
miRBase ID
MIMAT0002816
Interaction Name hsa-miR-494-3p--UGT2B17 regulation [1]
Studied Cell Lines HEK293 cell line
Description hsa-miR-494-3p is reported to suppress UGT2B17 mRNA translation by binding to the 3' untranslated region (3'UTR) of UGT2B17 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 2B17.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2B90 Colorectal cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Oligomerization
                            Alcohol dehydrogenase 1B (ADH1B) Colorectal cancer Heterooligomer
Uniprot ID
ADH1B_HUMAN
Interaction Name ADH1B-UGT2B17 heterooligomerization [2]
Studied Cell Lines Colorectal adenocarcinomas cell line
Description Alcohol dehydrogenase 1B (ADH1B) is reported to heterooligomerize with the UGT2B17 protein, which leads to an increased activity of the drug-metabolizing enzyme UDP-glucuronosyltransferase 2B17. As a result, the interaction between ADH1B and UGT2B17 can facilitate the drug-metabolizing process of UDP-glucuronosyltransferase 2B17.
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Hepatocyte NF 1-alpha (HNF1A) Liver cancer Activation
Uniprot ID
HNF1A_HUMAN
Interaction Name HNF1A-UGT2B17 interaction [3]
Studied Cell Lines HepG2 cell line
Ensembl ID
ENSG00000135100
Description Hepatocyte NF 1-alpha (HNF1A) is reported to activate the transcription of UGT2B17 gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 2B17. As a result, the interaction between HNF1A and UGT2B17 can activate the drug-metabolizing process of UDP-glucuronosyltransferase 2B17.
               ICD-11: 2C82 Prostate cancer Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Transcription-factor regulation
                            Hepatocyte NF 1-alpha (HNF1A) Prostate cancer Activation
Uniprot ID
HNF1A_HUMAN
Interaction Name HNF1A-UGT2B17 interaction [3]
Studied Cell Lines LNCaP cell line
Ensembl ID
ENSG00000135100
Description Hepatocyte NF 1-alpha (HNF1A) is reported to activate the transcription of UGT2B17 gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 2B17. As a result, the interaction between HNF1A and UGT2B17 can activate the drug-metabolizing process of UDP-glucuronosyltransferase 2B17.
                            Hepatocyte NF 3-alpha (FOXA1) Prostate cancer Activation
Uniprot ID
FOXA1_HUMAN
Interaction Name FOXA1-UGT2B17 interaction [4]
Studied Cell Lines LNCaP cell line
Ensembl ID
ENSG00000129514
Description Hepatocyte NF 3-alpha (FOXA1) is reported to activate the transcription of UGT2B17 gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 2B17. As a result, the interaction between FOXA1 and UGT2B17 can activate the drug-metabolizing process of UDP-glucuronosyltransferase 2B17.
References
1 Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer. J Steroid Biochem Mol Biol. 2016 Jan;155(Pt A):85-93.
2 Identification of genes involved in the four stages of colorectal cancer: gene expression profiling. Mol Cell Probes. 2018 Feb;37:39-47.
3 Tissue specific differences in the regulation of the UDP glucuronosyltransferase 2B17 gene promoter. Pharmacogenetics. 2000 Dec;10(9):809-20.
4 A novel polymorphism in a forkhead box A1 (FOXA1) binding site of the human UDP glucuronosyltransferase 2B17 gene modulates promoter activity and is associated with altered levels of circulating androstane-3alpha,17beta-diol glucuronide. Mol Pharmacol. 2010 Oct;78(4):714-22.

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