Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0069) | |||||
|---|---|---|---|---|---|
| DME Name | Butyrylcholine esterase (BCHE), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.1.1.8 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypomethylation | |||
| Interaction Name | DNMT-BCHE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 6.67E-14; delta-beta: -3.10E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the BCHE gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Butyrylcholine esterase. As a result, the interaction between DNMT and BCHE can significantly affect the drug-metabolizing process of Butyrylcholine esterase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 11 Circulatory system diseases | |||||
| ICD-11: BD51 Arterial aneurysm | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Arterial aneurysm | Moderate hypermethylation | |||
| Interaction Name | DNMT-BCHE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 7.32E-03; delta-beta: 2.28E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the BCHE gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Butyrylcholine esterase. As a result, the interaction between DNMT and BCHE can moderatly affect the drug-metabolizing process of Butyrylcholine esterase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A11 Brain neuroblastoma | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| Histone modification | |||||
| Histone deacetylases (HDACs) | Neuroblastoma | Repression | |||
| Uniprot ID | |||||
| Interaction Name | HDACs-BCHE interaction | [1] | |||
| Studied Cell Lines | SH-SY5Y cell line | ||||
| Description | Histone deacetylases (HDACs) are reported to deacetylate the BCHE gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Butyrylcholine esterase. As a result, the interaction between HDACs and BCHE can inhibit the drug-metabolizing process of Butyrylcholine esterase. | ||||
| Histone methyltransferases (HMTs) | Neuroblastoma | Repression | |||
| Uniprot ID | |||||
| Interaction Name | HMTs-BCHE interaction | [2] | |||
| Studied Cell Lines | Human neuroblastoma cells SH-SY5Y | ||||
| Description | The Histone 3 lysine 27 trimethylation of BCHE gene is reported to repress the transcriptional activity of the drug-metabolizing enzyme Butyrylcholine esterase. As a result, the interaction between Histone methyltransferases (HMTs) and BCHE can inhibit the drug-metabolizing process of Butyrylcholine esterase. | ||||
| ICD-11: 2A20 Chronic myelogenous leukaemia | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Chronic myelogenous leukaemia | Moderate hypomethylation | |||
| Interaction Name | DNMT-BCHE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 7.53E-03; delta-beta: -2.67E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the BCHE gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Butyrylcholine esterase. As a result, the interaction between DNMT and BCHE can moderatly affect the drug-metabolizing process of Butyrylcholine esterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypermethylation | |||
| Interaction Name | DNMT-BCHE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.53E-10; delta-beta: 3.18E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the BCHE gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Butyrylcholine esterase. As a result, the interaction between DNMT and BCHE can significantly affect the drug-metabolizing process of Butyrylcholine esterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-BCHE interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 9.11E-03; delta-beta: 3.13E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the BCHE gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Butyrylcholine esterase. As a result, the interaction between DNMT and BCHE can significantly affect the drug-metabolizing process of Butyrylcholine esterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B90 Colorectal cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Colorectal cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-BCHE interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypermethylation p-value: 8.43E-08; delta-beta: 2.09E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the BCHE gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Butyrylcholine esterase. As a result, the interaction between DNMT and BCHE can moderatly affect the drug-metabolizing process of Butyrylcholine esterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-BCHE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 6.13E-08; delta-beta: 2.26E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the BCHE gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Butyrylcholine esterase. As a result, the interaction between DNMT and BCHE can moderatly affect the drug-metabolizing process of Butyrylcholine esterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Moderate hypermethylation | |||
| Interaction Name | DNMT-BCHE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.00E-02; delta-beta: 2.59E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the BCHE gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Butyrylcholine esterase. As a result, the interaction between DNMT and BCHE can moderatly affect the drug-metabolizing process of Butyrylcholine esterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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