Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0071) | |||||
|---|---|---|---|---|---|
| DME Name | Cathepsin A (CTSA), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.4.16.5 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CTSA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.88E-20; delta-beta: -2.59E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CTSA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cathepsin A. As a result, the interaction between DNMT and CTSA can moderatly affect the drug-metabolizing process of Cathepsin A. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-CTSA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.49E-04; delta-beta: -3.18E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CTSA gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cathepsin A. As a result, the interaction between DNMT and CTSA can significantly affect the drug-metabolizing process of Cathepsin A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-CTSA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 6.62E-34; delta-beta: -2.48E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CTSA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cathepsin A. As a result, the interaction between DNMT and CTSA can moderatly affect the drug-metabolizing process of Cathepsin A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CTSA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 8.09E-07; delta-beta: -2.24E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CTSA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cathepsin A. As a result, the interaction between DNMT and CTSA can moderatly affect the drug-metabolizing process of Cathepsin A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-CTSA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 5.59E-82; delta-beta: -4.58E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CTSA gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cathepsin A. As a result, the interaction between DNMT and CTSA can significantly affect the drug-metabolizing process of Cathepsin A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F7C Connective tissue cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Hemangioblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CTSA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.46E-12; delta-beta: -2.65E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CTSA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cathepsin A. As a result, the interaction between DNMT and CTSA can moderatly affect the drug-metabolizing process of Cathepsin A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Moderate hypermethylation | |||
| Interaction Name | DNMT-CTSA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.55E-11; delta-beta: 2.51E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CTSA gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cathepsin A. As a result, the interaction between DNMT and CTSA can moderatly affect the drug-metabolizing process of Cathepsin A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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