| General Information of Drug-Metabolizing Enzyme (DME ID: DME0072) |
| DME Name |
UDP-glucuronosyltransferase 1A6 (UGT1A6), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 2.4.1.17 (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.17
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Oligomerization |
| UDPGT 1-9 (UGT1A9) |
Health |
Heterooligomer |
| Uniprot ID |
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| Interaction Name |
UGT1A9-UGT1A6 heterooligomerization |
[1] |
| Studied Cell Lines |
Human embryonic kidney cell line (HEK293) |
| Affected Substrate(s): |
Serotonin (Metabolic product: Serotonin O-glucuronide)
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| Activity |
Decreasing Vmax |
| Description |
UDPGT 1-9 (UGT1A9) is reported to heterooligomerize with the UGT1A6 protein, which leads to a suppressed activity of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A6. As a result, the interaction between UGT1A9 and UGT1A6 can inhibit the drug-metabolizing process of UDP-glucuronosyltransferase 1A6. |
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| References |
| 1 |
Effects of coexpression of UGT1A9 on enzymatic activities of human UGT1A isoforms. Drug Metab Dispos. 2007 May;35(5):747-57.
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