Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0073) | |||||
|---|---|---|---|---|---|
| DME Name | Alcohol dehydrogenase class-V (ADH6), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.1.1.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-ADH6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 7.61E-10; delta-beta: -2.68E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ADH6 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Alcohol dehydrogenase class-V. As a result, the interaction between DNMT and ADH6 can moderatly affect the drug-metabolizing process of Alcohol dehydrogenase class-V. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-ADH6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.38E-07; delta-beta: -2.57E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ADH6 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Alcohol dehydrogenase class-V. As a result, the interaction between DNMT and ADH6 can moderatly affect the drug-metabolizing process of Alcohol dehydrogenase class-V. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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