Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0074)
DME Name	Sulfotransferase 2A1 (SULT2A1), Homo sapiens	DME Info
UniProt ID	ST2A1_HUMAN
EC Number	EC: 2.8.2.14 (Click to Show/Hide the Complete EC Tree) Transferase Sulfotransferase Sulfotransferase EC: 2.8.2.14
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification Healthy
ICD-11: Healthy		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
Splicing factor 1 (SF1)		Health		Activation
Uniprot ID	SF01_HUMAN
Interaction Name	SF1-SULT2A1 interaction				[1]
Studied Cell Lines	HEK 293T cell line
Description	Splicing factor 1 (SF1) is reported to activate the transcription of SULT2A1 gene, which leads to an increased expression of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between SF1 and SULT2A1 can activate the drug-metabolizing process of Sulfotransferase 2A1.
TF factor GATA-6 (GATA6)		Health		Activation
Uniprot ID	GATA6_HUMAN
Interaction Name	GATA6-SULT2A1 interaction				[1], [2]
Studied Cell Lines	HEK293 and H295R cell lines
Ensembl ID	ENSG00000141448
Description	TF factor GATA-6 (GATA6) is reported to activate the transcription of SULT2A1 gene, which leads to an increased expression of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between GATA6 and SULT2A1 can activate the drug-metabolizing process of Sulfotransferase 2A1.
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 5 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Brain neuroblastoma		Significant hypomethylation
Interaction Name	DNMT-SULT2A1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.36E-15; delta-beta: -5.17E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the SULT2A1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between DNMT and SULT2A1 can significantly affect the drug-metabolizing process of Sulfotransferase 2A1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Multilayered rosettes embryonal tumour		Significant hypomethylation
Interaction Name	DNMT-SULT2A1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.96E-25; delta-beta: -6.94E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the SULT2A1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between DNMT and SULT2A1 can significantly affect the drug-metabolizing process of Sulfotransferase 2A1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Diffuse midline glioma		Moderate hypomethylation
Interaction Name	DNMT-SULT2A1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 5.74E-19; delta-beta: -2.79E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT2A1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between DNMT and SULT2A1 can moderatly affect the drug-metabolizing process of Sulfotransferase 2A1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Third ventricle chordoid glioma		Moderate hypermethylation
Interaction Name	DNMT-SULT2A1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 3.19E-02; delta-beta: 2.79E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the SULT2A1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between DNMT and SULT2A1 can moderatly affect the drug-metabolizing process of Sulfotransferase 2A1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Peripheral neuroectodermal tumour		Significant hypomethylation
Interaction Name	DNMT-SULT2A1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.18E-05; delta-beta: -3.18E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the SULT2A1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between DNMT and SULT2A1 can significantly affect the drug-metabolizing process of Sulfotransferase 2A1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B5F Uterine carcinosarcoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Uterine carcinosarcoma		Significant hypomethylation
Interaction Name	DNMT-SULT2A1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 2.01E-03; delta-beta: -4.77E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the SULT2A1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between DNMT and SULT2A1 can significantly affect the drug-metabolizing process of Sulfotransferase 2A1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C25 Lung cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lung cancer		Moderate hypomethylation
Interaction Name	DNMT-SULT2A1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 5.83E-11; delta-beta: -2.02E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT2A1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between DNMT and SULT2A1 can moderatly affect the drug-metabolizing process of Sulfotransferase 2A1.
The Methylation Level of Disease Section Compare with the Other Disease Section	Moderate hypomethylation p-value: 4.90E-09; delta-beta: -2.99E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT2A1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between DNMT and SULT2A1 can moderatly affect the drug-metabolizing process of Sulfotransferase 2A1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C30 Melanoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Melanoma		Significant hypomethylation
Interaction Name	DNMT-SULT2A1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 2.92E-04; delta-beta: -3.17E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the SULT2A1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between DNMT and SULT2A1 can significantly affect the drug-metabolizing process of Sulfotransferase 2A1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C60 Breast cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Histone modification
Histone deacetylases (HDACs)		Breast cancer		Repression
Uniprot ID	HDAC1_HUMAN
Interaction Name	HDACs-SULT2A1 interaction				[3]
Studied Cell Lines	MCF-7 cell line
Description	Histone deacetylases (HDACs) are reported to deacetylate the SULT2A1 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between HDACs and SULT2A1 can inhibit the drug-metabolizing process of Sulfotransferase 2A1.
ICD-11: 2D11 Adrenocortical carcinoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Transcription-factor regulation
PPAR-binding protein (MED1)		Adrenocortical carcinoma		Activation
Uniprot ID	MED1_HUMAN
Interaction Name	MED1-SULT2A1 interaction				[2]
Studied Cell Lines	H295R cell line
Description	PPAR-binding protein (MED1) is reported to activate the transcription of SULT2A1 gene, which leads to an increased expression of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between MED1 and SULT2A1 can activate the drug-metabolizing process of Sulfotransferase 2A1.
ICD-11: 2D50 Brain cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Esthesioneuroblastoma		Significant hypomethylation
Interaction Name	DNMT-SULT2A1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 2.23E-06; delta-beta: -4.24E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the SULT2A1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between DNMT and SULT2A1 can significantly affect the drug-metabolizing process of Sulfotransferase 2A1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2F9A Endocrine gland cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Craniopharyngioma		Significant hypomethylation
Interaction Name	DNMT-SULT2A1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 2.11E-09; delta-beta: -4.05E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the SULT2A1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between DNMT and SULT2A1 can significantly affect the drug-metabolizing process of Sulfotransferase 2A1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases
ICD-11: 5B81 Obesity		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Obesity		Moderate hypomethylation
Interaction Name	DNMT-SULT2A1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 9.34E-12; delta-beta: -2.90E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT2A1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 2A1. As a result, the interaction between DNMT and SULT2A1 can moderatly affect the drug-metabolizing process of Sulfotransferase 2A1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal. Mol Endocrinol. 2005 Jan;19(1):184-97.
2	The mediator complex subunit 1 enhances transcription of genes needed for adrenal androgen production. Endocrinology. 2009 Sep;150(9):4145-53.
3	Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression. Breast Cancer Res Treat. 2010 Feb;120(1):35-45.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.