| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2B90 Colorectal cancer |
Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
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| Transcription-factor regulation |
| Hepatocyte NF 1-alpha (HNF1A) |
Colorectal cancer |
Activation |
| Uniprot ID |
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| Interaction Name |
HNF1A-UGT1A10 interaction |
[1] |
| Studied Cell Lines |
Caco-2 cell line |
| Ensembl ID |
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| Description |
Hepatocyte NF 1-alpha (HNF1A) is reported to activate the transcription of UGT1A10 gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A10. As a result, the interaction between HNF1A and UGT1A10 can activate the drug-metabolizing process of UDP-glucuronosyltransferase 1A10. |
| Homeobox protein CDX-2 (CDX2) |
Colorectal cancer |
Activation |
| Uniprot ID |
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| Interaction Name |
CDX2-UGT1A10 interaction |
[1] |
| Studied Cell Lines |
Caco-2 cell line |
| Ensembl ID |
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| Description |
Homeobox protein CDX-2 (CDX2) is reported to activate the transcription of UGT1A10 gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucuronosyltransferase 1A10. As a result, the interaction between CDX2 and UGT1A10 can activate the drug-metabolizing process of UDP-glucuronosyltransferase 1A10. |
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