| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Transcription-factor regulation |
| Transcription factor Sp1 (SP1) |
Health |
Activation |
| Uniprot ID |
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| Interaction Name |
SP1-POR interaction |
[1] |
| Studied Cell Lines |
Rat liver |
| Ensembl ID |
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| Description |
Transcription factor Sp1 (SP1) is reported to activate the transcription of CPR gene, which leads to an increased expression of the drug-metabolizing enzyme NADPH-cytochrome P450 reductase. As a result, the interaction between SP1 and CPR can activate the drug-metabolizing process of NADPH-cytochrome P450 reductase. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C12 Liver cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Non-coding RNA regulation |
| hsa-miR-214-3p |
Liver cancer |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-214-3p--POR regulation |
[2] |
| Studied Cell Lines |
Bel7402 cell line |
| Description |
hsa-miR-214-3p is reported to suppress POR mRNA translation by binding to the 3' untranslated region (3'UTR) of POR mRNA, which leads to a decreased expression of the drug-metabolizing enzyme NADPH-cytochrome P450 reductase. |
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