Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0077)
DME Name Aldehyde dehydrogenase 2 (ALDH2), Homo sapiens DME Info
UniProt ID
ALDH2_HUMAN
EC Number    EC: 1.2.1.3     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Aldehyde/oxo donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.2.1.3
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Oligomerization
                            Mutated ALDH-E2 (mALDH2) Health Heterooligomer
Uniprot ID
ALDH2_HUMAN
Interaction Name mALDH2-ALDH2 heterooligomerization [1]
Studied Cell Lines Escherichia coli cell line
Affected Substrate(s): Acetaldehyde
Activity Km = 8.79 microM
Description Mutated ALDH-E2 (mALDH2) is reported to heterooligomerize with the ALDH2 protein, which leads to an increased activity of the drug-metabolizing enzyme Aldehyde dehydrogenase 2. As a result, the interaction between mALDH2 and ALDH2 can facilitate the drug-metabolizing process of Aldehyde dehydrogenase 2.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Histone modification
                            Histone deacetylases (HDACs) Liver cancer Repression
Uniprot ID
HDAC1_HUMAN
Interaction Name HDACs-ALDH2 interaction [2]
Studied Cell Lines HepG2 cell line
Description Histone deacetylases (HDACs) are reported to deacetylate the ALDH2 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Aldehyde dehydrogenase 2. As a result, the interaction between HDACs and ALDH2 can inhibit the drug-metabolizing process of Aldehyde dehydrogenase 2.
               ICD-11: 2C30 Melanoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Melanoma Significant hypermethylation
Interaction Name DNMT-ALDH2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypermethylation
p-value: 2.29E-06; delta-beta: 4.39E-01
Description DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ALDH2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Aldehyde dehydrogenase 2. As a result, the interaction between DNMT and ALDH2 can significantly affect the drug-metabolizing process of Aldehyde dehydrogenase 2.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
References
1 Chaperonin GroESL mediates the protein folding of human liver mitochondrial aldehyde dehydrogenase in Escherichia coli. Biochem Biophys Res Commun. 2002 Oct 25;298(2):216-24.
2 mTOR/HDAC1 Crosstalk Mediated Suppression of ADH1A and ALDH2 Links Alcohol Metabolism to Hepatocellular Carcinoma Onset and Progression in silico. Front Oncol. 2019 Oct 4;9:1000.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.