Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0078) | |||||
|---|---|---|---|---|---|
| DME Name | Adenine phosphoribosyltransferase (APRT), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.4.2.7 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 6 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-APRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 6.59E-34; delta-beta: -6.22E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the APRT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can significantly affect the drug-metabolizing process of Adenine phosphoribosyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-APRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.57E-11; delta-beta: -2.02E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the APRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can moderatly affect the drug-metabolizing process of Adenine phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebral hemispheric glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-APRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.13E-04; delta-beta: -2.02E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the APRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can moderatly affect the drug-metabolizing process of Adenine phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-APRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 6.88E-09; delta-beta: -4.18E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the APRT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can significantly affect the drug-metabolizing process of Adenine phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-APRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 5.26E-04; delta-beta: -2.45E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the APRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can moderatly affect the drug-metabolizing process of Adenine phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-APRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 5.73E-13; delta-beta: -2.01E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the APRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can moderatly affect the drug-metabolizing process of Adenine phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A60 Acute myeloid leukemia | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Acute myeloid leukemia | Significant hypomethylation | |||
| Interaction Name | DNMT-APRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.32E-11; delta-beta: -3.73E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the APRT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can significantly affect the drug-metabolizing process of Adenine phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B5F Uterine carcinosarcoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Uterine carcinosarcoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-APRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 8.53E-05; delta-beta: -2.08E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the APRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can moderatly affect the drug-metabolizing process of Adenine phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C30 Melanoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanoma | Significant hypomethylation | |||
| Interaction Name | DNMT-APRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.69E-05; delta-beta: -3.13E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the APRT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can significantly affect the drug-metabolizing process of Adenine phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-APRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.51E-83; delta-beta: -2.98E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the APRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can moderatly affect the drug-metabolizing process of Adenine phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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