General Information of Drug-Metabolizing Enzyme (DME ID: DME0078)
DME Name Adenine phosphoribosyltransferase (APRT), Homo sapiens DME Info
UniProt ID
APT_HUMAN
EC Number    EC: 2.4.2.7     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Pentosyltransferase
EC: 2.4.2.7
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A00 Brain cancer Click to Show/Hide the Full List of HOSPPI:        6 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Brain neuroblastoma Significant hypomethylation
Interaction Name DNMT-APRT interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 6.59E-34; delta-beta: -6.22E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the APRT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can significantly affect the drug-metabolizing process of Adenine phosphoribosyltransferase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
                            DNA methyltransferase (DNMT) Brain neuroepithelial tumour Moderate hypomethylation
Interaction Name DNMT-APRT interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 1.57E-11; delta-beta: -2.02E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the APRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can moderatly affect the drug-metabolizing process of Adenine phosphoribosyltransferase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
                            DNA methyltransferase (DNMT) Cerebral hemispheric glioma Moderate hypomethylation
Interaction Name DNMT-APRT interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 3.13E-04; delta-beta: -2.02E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the APRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can moderatly affect the drug-metabolizing process of Adenine phosphoribosyltransferase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
                            DNA methyltransferase (DNMT) Melanocytoma Significant hypomethylation
Interaction Name DNMT-APRT interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 6.88E-09; delta-beta: -4.18E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the APRT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can significantly affect the drug-metabolizing process of Adenine phosphoribosyltransferase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
                            DNA methyltransferase (DNMT) Cerebellar liponeurocytoma Moderate hypomethylation
Interaction Name DNMT-APRT interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 5.26E-04; delta-beta: -2.45E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the APRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can moderatly affect the drug-metabolizing process of Adenine phosphoribosyltransferase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
                            DNA methyltransferase (DNMT) Atypical teratoid/rhabdoid tumour Moderate hypomethylation
Interaction Name DNMT-APRT interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 5.73E-13; delta-beta: -2.01E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the APRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can moderatly affect the drug-metabolizing process of Adenine phosphoribosyltransferase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2A60 Acute myeloid leukemia Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Acute myeloid leukemia Significant hypomethylation
Interaction Name DNMT-APRT interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 1.32E-11; delta-beta: -3.73E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the APRT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can significantly affect the drug-metabolizing process of Adenine phosphoribosyltransferase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2B5F Uterine carcinosarcoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Uterine carcinosarcoma Moderate hypomethylation
Interaction Name DNMT-APRT interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 8.53E-05; delta-beta: -2.08E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the APRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can moderatly affect the drug-metabolizing process of Adenine phosphoribosyltransferase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2C30 Melanoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Melanoma Significant hypomethylation
Interaction Name DNMT-APRT interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 2.69E-05; delta-beta: -3.13E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the APRT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can significantly affect the drug-metabolizing process of Adenine phosphoribosyltransferase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2D50 Brain cancer metastasis Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Posterior fossa ependymoma Moderate hypomethylation
Interaction Name DNMT-APRT interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 1.51E-83; delta-beta: -2.98E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the APRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Adenine phosphoribosyltransferase. As a result, the interaction between DNMT and APRT can moderatly affect the drug-metabolizing process of Adenine phosphoribosyltransferase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram

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