General Information of Drug-Metabolizing Enzyme (DME ID: DME0079)
DME Name Alkaline phosphatase (ALPL), Homo sapiens DME Info
UniProt ID
PPBT_HUMAN
EC Number    EC: 3.1.3.1     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric monoester hydrolase
EC: 3.1.3.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        3 HOSPPI
                     Transcription-factor regulation
                            Transcription factor Sp3 (SP3) Health Activation
Uniprot ID
SP3_HUMAN
Interaction Name SP3-ALPL interaction [3]
Studied Cell Lines Drosophila Schneider cell line
Ensembl ID
ENSG00000172845
Description Transcription factor Sp3 (SP3) is reported to activate the transcription of ALPL gene, which leads to an increased expression of the drug-metabolizing enzyme Alkaline phosphatase. As a result, the interaction between SP3 and ALPL can activate the drug-metabolizing process of Alkaline phosphatase.
                     Non-coding RNA regulation
                            hsa-miR-204-5p Health Suppression
miRBase ID
MIMAT0000265
Interaction Name hsa-miR-204-5p--ALPL regulation [2]
Studied Cell Lines M-Osx cell line
Description hsa-miR-204-5p is reported to suppress ALPL mRNA translation by binding to the 3' untranslated region (3'UTR) of ALPL mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Alkaline phosphatase.
                     Histone modification
                            Histone methyltransferases (HMTs) Health Repression
Uniprot ID
EHMT1_HUMAN
Interaction Name HMTs-ALPL interaction [1]
Studied Cell Lines Human mesenchymal stem cells (hMSCs)
Description The Histone 3 lysine 9 trimethylation of ALPL gene is reported to repress the transcriptional activity of the drug-metabolizing enzyme Alkaline phosphatase. As a result, the interaction between Histone methyltransferases (HMTs) and ALPL can inhibit the drug-metabolizing process of Alkaline phosphatase.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2D50 Brain cancer metastasis Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Esthesioneuroblastoma Significant hypomethylation
Interaction Name DNMT-ALPL interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 5.45E-22; delta-beta: -5.78E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALPL gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alkaline phosphatase. As a result, the interaction between DNMT and ALPL can significantly affect the drug-metabolizing process of Alkaline phosphatase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2E06 Prostate cancer metastasis Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Prostate cancer metastasis Significant hypomethylation
Interaction Name DNMT-ALPL interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 3.37E-03; delta-beta: -5.21E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALPL gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alkaline phosphatase. As a result, the interaction between DNMT and ALPL can significantly affect the drug-metabolizing process of Alkaline phosphatase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2F9A Endocrine gland cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Craniopharyngioma Significant hypomethylation
Interaction Name DNMT-ALPL interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 1.68E-21; delta-beta: -5.95E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALPL gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alkaline phosphatase. As a result, the interaction between DNMT and ALPL can significantly affect the drug-metabolizing process of Alkaline phosphatase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
References
1 Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes. PLoS One. 2015 Jul 10;10(7):e0131998.
2 Identification and characterization of microRNAs controlled by the osteoblast-specific transcription factor Osterix. PLoS One. 2013;8(3):e58104.
3 Transcription factor Sp3 activates the liver/bone/kidney-type alkaline phosphatase promoter in hematopoietic cells. J Leukoc Biol. 2000 Nov;68(5):772-7.

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