Details of Host Protein-DME Interaction (HOSPPI)
General Information of Drug-Metabolizing Enzyme (DME ID: DME0079) | |||||
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DME Name | Alkaline phosphatase (ALPL), Homo sapiens | DME Info | |||
UniProt ID | |||||
EC Number | EC: 3.1.3.1 (Click to Show/Hide the Complete EC Tree) | ||||
Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
Interactome |
Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
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ICD Disease Classification Healthy | |||||
ICD-11: Healthy | Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI | ||||
Transcription-factor regulation | |||||
Transcription factor Sp3 (SP3) | Health | Activation | |||
Uniprot ID | |||||
Interaction Name | SP3-ALPL interaction | [3] | |||
Studied Cell Lines | Drosophila Schneider cell line | ||||
Ensembl ID | |||||
Description | Transcription factor Sp3 (SP3) is reported to activate the transcription of ALPL gene, which leads to an increased expression of the drug-metabolizing enzyme Alkaline phosphatase. As a result, the interaction between SP3 and ALPL can activate the drug-metabolizing process of Alkaline phosphatase. | ||||
Non-coding RNA regulation | |||||
hsa-miR-204-5p | Health | Suppression | |||
miRBase ID | |||||
Interaction Name | hsa-miR-204-5p--ALPL regulation | [2] | |||
Studied Cell Lines | M-Osx cell line | ||||
Description | hsa-miR-204-5p is reported to suppress ALPL mRNA translation by binding to the 3' untranslated region (3'UTR) of ALPL mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Alkaline phosphatase. | ||||
Histone modification | |||||
Histone methyltransferases (HMTs) | Health | Repression | |||
Uniprot ID | |||||
Interaction Name | HMTs-ALPL interaction | [1] | |||
Studied Cell Lines | Human mesenchymal stem cells (hMSCs) | ||||
Description | The Histone 3 lysine 9 trimethylation of ALPL gene is reported to repress the transcriptional activity of the drug-metabolizing enzyme Alkaline phosphatase. As a result, the interaction between Histone methyltransferases (HMTs) and ALPL can inhibit the drug-metabolizing process of Alkaline phosphatase. | ||||
ICD Disease Classification 02 Neoplasms | |||||
ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
DNA methylation | |||||
DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Significant hypomethylation | |||
Interaction Name | DNMT-ALPL interaction | ||||
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 5.45E-22; delta-beta: -5.78E-01 | ||||
Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALPL gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alkaline phosphatase. As a result, the interaction between DNMT and ALPL can significantly affect the drug-metabolizing process of Alkaline phosphatase. | ||||
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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Violin Diagram of DME Disease-specific Methylation Level | Click to View the Clearer Original Diagram | ||||
ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
DNA methylation | |||||
DNA methyltransferase (DNMT) | Prostate cancer metastasis | Significant hypomethylation | |||
Interaction Name | DNMT-ALPL interaction | ||||
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.37E-03; delta-beta: -5.21E-01 | ||||
Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALPL gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alkaline phosphatase. As a result, the interaction between DNMT and ALPL can significantly affect the drug-metabolizing process of Alkaline phosphatase. | ||||
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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Violin Diagram of DME Disease-specific Methylation Level | Click to View the Clearer Original Diagram | ||||
ICD-11: 2F9A Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
DNA methylation | |||||
DNA methyltransferase (DNMT) | Craniopharyngioma | Significant hypomethylation | |||
Interaction Name | DNMT-ALPL interaction | ||||
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.68E-21; delta-beta: -5.95E-01 | ||||
Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALPL gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alkaline phosphatase. As a result, the interaction between DNMT and ALPL can significantly affect the drug-metabolizing process of Alkaline phosphatase. | ||||
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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Violin Diagram of DME Disease-specific Methylation Level | Click to View the Clearer Original Diagram | ||||
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