Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0079)
DME Name	Alkaline phosphatase (ALPL), Homo sapiens	DME Info
UniProt ID	PPBT_HUMAN
EC Number	EC: 3.1.3.1 (Click to Show/Hide the Complete EC Tree) Hydrolases Ester bond hydrolase Phosphoric monoester hydrolase EC: 3.1.3.1
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification Healthy
ICD-11: Healthy		Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI
Transcription-factor regulation
Transcription factor Sp3 (SP3)		Health		Activation
Uniprot ID	SP3_HUMAN
Interaction Name	SP3-ALPL interaction				[3]
Studied Cell Lines	Drosophila Schneider cell line
Ensembl ID	ENSG00000172845
Description	Transcription factor Sp3 (SP3) is reported to activate the transcription of ALPL gene, which leads to an increased expression of the drug-metabolizing enzyme Alkaline phosphatase. As a result, the interaction between SP3 and ALPL can activate the drug-metabolizing process of Alkaline phosphatase.
Non-coding RNA regulation
hsa-miR-204-5p		Health		Suppression
miRBase ID	MIMAT0000265
Interaction Name	hsa-miR-204-5p--ALPL regulation				[2]
Studied Cell Lines	M-Osx cell line
Description	hsa-miR-204-5p is reported to suppress ALPL mRNA translation by binding to the 3' untranslated region (3'UTR) of ALPL mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Alkaline phosphatase.
Histone modification
Histone methyltransferases (HMTs)		Health		Repression
Uniprot ID	EHMT1_HUMAN
Interaction Name	HMTs-ALPL interaction				[1]
Studied Cell Lines	Human mesenchymal stem cells (hMSCs)
Description	The Histone 3 lysine 9 trimethylation of ALPL gene is reported to repress the transcriptional activity of the drug-metabolizing enzyme Alkaline phosphatase. As a result, the interaction between Histone methyltransferases (HMTs) and ALPL can inhibit the drug-metabolizing process of Alkaline phosphatase.
ICD Disease Classification 02 Neoplasms
ICD-11: 2D50 Brain cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Esthesioneuroblastoma		Significant hypomethylation
Interaction Name	DNMT-ALPL interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 5.45E-22; delta-beta: -5.78E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALPL gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alkaline phosphatase. As a result, the interaction between DNMT and ALPL can significantly affect the drug-metabolizing process of Alkaline phosphatase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2E06 Prostate cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Prostate cancer metastasis		Significant hypomethylation
Interaction Name	DNMT-ALPL interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 3.37E-03; delta-beta: -5.21E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALPL gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alkaline phosphatase. As a result, the interaction between DNMT and ALPL can significantly affect the drug-metabolizing process of Alkaline phosphatase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2F9A Endocrine gland cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Craniopharyngioma		Significant hypomethylation
Interaction Name	DNMT-ALPL interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.68E-21; delta-beta: -5.95E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALPL gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alkaline phosphatase. As a result, the interaction between DNMT and ALPL can significantly affect the drug-metabolizing process of Alkaline phosphatase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes. PLoS One. 2015 Jul 10;10(7):e0131998.
2	Identification and characterization of microRNAs controlled by the osteoblast-specific transcription factor Osterix. PLoS One. 2013;8(3):e58104.
3	Transcription factor Sp3 activates the liver/bone/kidney-type alkaline phosphatase promoter in hematopoietic cells. J Leukoc Biol. 2000 Nov;68(5):772-7.

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