Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0080) | |||||
|---|---|---|---|---|---|
| DME Name | Cytidine aminohydrolase (CDA), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.5.4.5 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CDA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.31E-07; delta-beta: -2.52E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CDA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytidine aminohydrolase. As a result, the interaction between DNMT and CDA can moderatly affect the drug-metabolizing process of Cytidine aminohydrolase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-CDA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.60E-08; delta-beta: -2.56E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CDA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytidine aminohydrolase. As a result, the interaction between DNMT and CDA can moderatly affect the drug-metabolizing process of Cytidine aminohydrolase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-CDA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.35E-31; delta-beta: 2.40E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CDA gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cytidine aminohydrolase. As a result, the interaction between DNMT and CDA can moderatly affect the drug-metabolizing process of Cytidine aminohydrolase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A60 Acute myeloid leukemia | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| Transcription-factor regulation | |||||
| Erythroid TF factor (GATA1) | Acute myeloid leukemia | Activation | |||
| Uniprot ID | |||||
| Interaction Name | GATA1-CDA interaction | [1] | |||
| Studied Cell Lines | CMK cell line | ||||
| Ensembl ID | |||||
| Description | Erythroid TF factor (GATA1) is reported to activate the transcription of CDA gene, which leads to an increased expression of the drug-metabolizing enzyme Cytidine aminohydrolase. As a result, the interaction between GATA1 and CDA can activate the drug-metabolizing process of Cytidine aminohydrolase. | ||||
| ICD-11: 2B5F Uterine carcinosarcoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Uterine carcinosarcoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CDA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.11E-03; delta-beta: -2.21E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CDA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytidine aminohydrolase. As a result, the interaction between DNMT and CDA can moderatly affect the drug-metabolizing process of Cytidine aminohydrolase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-CDA interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypomethylation p-value: 2.59E-05; delta-beta: -2.20E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CDA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytidine aminohydrolase. As a result, the interaction between DNMT and CDA can moderatly affect the drug-metabolizing process of Cytidine aminohydrolase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Significant hypomethylation | |||
| Interaction Name | DNMT-CDA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.23E-03; delta-beta: -3.22E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CDA gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytidine aminohydrolase. As a result, the interaction between DNMT and CDA can significantly affect the drug-metabolizing process of Cytidine aminohydrolase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CDA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 6.15E-05; delta-beta: -2.36E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CDA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytidine aminohydrolase. As a result, the interaction between DNMT and CDA can moderatly affect the drug-metabolizing process of Cytidine aminohydrolase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F37 Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pituitary adenoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-CDA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.95E-10; delta-beta: 2.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CDA gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cytidine aminohydrolase. As a result, the interaction between DNMT and CDA can moderatly affect the drug-metabolizing process of Cytidine aminohydrolase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F9A Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Craniopharyngioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CDA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.34E-05; delta-beta: -2.30E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CDA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cytidine aminohydrolase. As a result, the interaction between DNMT and CDA can moderatly affect the drug-metabolizing process of Cytidine aminohydrolase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5A61 Pituitary gland hypofunction | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Chordoma | Significant hypomethylation | |||
| Interaction Name | DNMT-CDA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.00E-03; delta-beta: -3.30E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CDA gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytidine aminohydrolase. As a result, the interaction between DNMT and CDA can significantly affect the drug-metabolizing process of Cytidine aminohydrolase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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