Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0081)
DME Name	Glutathione S-transferase alpha-2 (GSTA2), Homo sapiens	DME Info
UniProt ID	GSTA2_HUMAN
EC Number	EC: 2.5.1.18 (Click to Show/Hide the Complete EC Tree) Transferase Alkyl/aryl transferase Alkyl/aryl transferase EC: 2.5.1.18
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 7 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Cerebral hemispheric glioma		Moderate hypomethylation
Interaction Name	DNMT-GSTA2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 6.27E-04; delta-beta: -2.21E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTA2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-2. As a result, the interaction between DNMT and GSTA2 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Vestibular melanotic schwannoma		Moderate hypomethylation
Interaction Name	DNMT-GSTA2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 2.43E-03; delta-beta: -2.20E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTA2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-2. As a result, the interaction between DNMT and GSTA2 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Multilayered rosettes embryonal tumour		Significant hypomethylation
Interaction Name	DNMT-GSTA2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.29E-24; delta-beta: -4.99E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GSTA2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-2. As a result, the interaction between DNMT and GSTA2 can significantly affect the drug-metabolizing process of Glutathione S-transferase alpha-2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Myxopapillary ependymoma		Moderate hypomethylation
Interaction Name	DNMT-GSTA2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 5.21E-03; delta-beta: -2.29E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTA2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-2. As a result, the interaction between DNMT and GSTA2 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Diffuse midline glioma		Moderate hypomethylation
Interaction Name	DNMT-GSTA2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 1.49E-23; delta-beta: -2.57E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTA2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-2. As a result, the interaction between DNMT and GSTA2 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Oligodendroglioma		Significant hypermethylation
Interaction Name	DNMT-GSTA2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 2.07E-20; delta-beta: 3.33E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the GSTA2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-2. As a result, the interaction between DNMT and GSTA2 can significantly affect the drug-metabolizing process of Glutathione S-transferase alpha-2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Atypical teratoid/rhabdoid tumour		Moderate hypermethylation
Interaction Name	DNMT-GSTA2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 2.06E-11; delta-beta: 2.90E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the GSTA2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-2. As a result, the interaction between DNMT and GSTA2 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Liver cancer		Moderate hypomethylation
Interaction Name	DNMT-GSTA2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 1.47E-12; delta-beta: -2.50E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTA2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-2. As a result, the interaction between DNMT and GSTA2 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C25 Lung cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lung cancer		Moderate hypomethylation
Interaction Name	DNMT-GSTA2 interaction
The Methylation Level of Disease Section Compare with the Other Disease Section	Moderate hypomethylation p-value: 5.04E-10; delta-beta: -2.30E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTA2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-2. As a result, the interaction between DNMT and GSTA2 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C82 Prostate cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Prostate cancer		Moderate hypermethylation
Interaction Name	DNMT-GSTA2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 1.49E-03; delta-beta: 2.46E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the GSTA2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-2. As a result, the interaction between DNMT and GSTA2 can moderatly affect the drug-metabolizing process of Glutathione S-transferase alpha-2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2F37 Endocrine gland cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Pituitary adenoma		Significant hypermethylation
Interaction Name	DNMT-GSTA2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 2.64E-07; delta-beta: 3.54E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the GSTA2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-2. As a result, the interaction between DNMT and GSTA2 can significantly affect the drug-metabolizing process of Glutathione S-transferase alpha-2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 12 Respiratory system diseases
ICD-11: CB03 Idiopathic pulmonary fibrosis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Idiopathic pulmonary fibrosis		Significant hypomethylation
Interaction Name	DNMT-GSTA2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.37E-02; delta-beta: -3.72E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GSTA2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Glutathione S-transferase alpha-2. As a result, the interaction between DNMT and GSTA2 can significantly affect the drug-metabolizing process of Glutathione S-transferase alpha-2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

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