| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Transcription-factor regulation |
| NFE2-related factor 2 (NFE2L2) |
Health |
Activation |
| Uniprot ID |
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| Interaction Name |
NFE2L2-MTHFR interaction |
[1] |
| Studied Cell Lines |
HEK 293T cell line |
| Ensembl ID |
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| Description |
NFE2-related factor 2 (NFE2L2) is reported to activate the transcription of MTHFR gene, which leads to an increased expression of the drug-metabolizing enzyme Methylenetetrahydrofolate reductase. As a result, the interaction between NFE2L2 and MTHFR can activate the drug-metabolizing process of Methylenetetrahydrofolate reductase. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C12 Liver cancer |
Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
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| Non-coding RNA regulation |
| hsa-miR-149-5p |
Liver cancer |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-149-5p--MTHFR regulation |
[2] |
| Studied Cell Lines |
QGY-7703 cell line |
| Description |
hsa-miR-149-5p is reported to suppress MTHFR mRNA translation by binding to the 3' untranslated region (3'UTR) of MTHFR mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Methylenetetrahydrofolate reductase. |
| hsa-miR-22-3p |
Liver cancer |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-22-3p--MTHFR regulation |
[2] |
| Studied Cell Lines |
QGY-7703 cell line |
| Description |
hsa-miR-22-3p is reported to suppress MTHFR mRNA translation by binding to the 3' untranslated region (3'UTR) of MTHFR mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Methylenetetrahydrofolate reductase. |
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