Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0087)
DME Name	Aldo-keto reductase 1B1 (AKR1B1), Homo sapiens	DME Info
UniProt ID	ALDR_HUMAN
EC Number	EC: 1.1.1.21 (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.21
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Liver cancer		Moderate hypermethylation
Interaction Name	DNMT-AKR1B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 2.63E-03; delta-beta: 2.84E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the AKR1B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Aldo-keto reductase 1B1. As a result, the interaction between DNMT and AKR1B1 can moderatly affect the drug-metabolizing process of Aldo-keto reductase 1B1.
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Moderate hypermethylation p-value: 1.15E-06; delta-beta: 2.62E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the AKR1B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Aldo-keto reductase 1B1. As a result, the interaction between DNMT and AKR1B1 can moderatly affect the drug-metabolizing process of Aldo-keto reductase 1B1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C82 Prostate cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Prostate cancer		Moderate hypermethylation
Interaction Name	DNMT-AKR1B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 1.04E-73; delta-beta: 2.16E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the AKR1B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Aldo-keto reductase 1B1. As a result, the interaction between DNMT and AKR1B1 can moderatly affect the drug-metabolizing process of Aldo-keto reductase 1B1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2E06 Prostate cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Prostate cancer metastasis		Significant hypermethylation
Interaction Name	DNMT-AKR1B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 2.90E-03; delta-beta: 3.92E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the AKR1B1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Aldo-keto reductase 1B1. As a result, the interaction between DNMT and AKR1B1 can significantly affect the drug-metabolizing process of Aldo-keto reductase 1B1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

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