Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0090)
DME Name Catalase (CAT), Homo sapiens DME Info
UniProt ID
CATA_HUMAN
EC Number    EC: 1.11.1.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Peroxidase
Peroxidase
EC: 1.11.1.6
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        3 HOSPPI
                     Transcription-factor regulation
                            Early growth response 3 (EGR3) Health Activation
Uniprot ID
EGR3_HUMAN
Interaction Name EGR3-CAT interaction [1]
Studied Cell Lines Rodent and human fibroblasts and a monkey kidney epithelial cell line
Ensembl ID
ENSG00000179388
Description Early growth response 3 (EGR3) is reported to activate the transcription of CAT gene, which leads to an increased expression of the drug-metabolizing enzyme Catalase. As a result, the interaction between EGR3 and CAT can activate the drug-metabolizing process of Catalase.
                            PPA receptor delta (PPARD) Health Activation
Uniprot ID
PPARD_HUMAN
Interaction Name PPARD-CAT interaction [3]
Studied Cell Lines Human umbilical vein endothelial cell line
Ensembl ID
ENSG00000112033
Description PPA receptor delta (PPARD) is reported to activate the transcription of CAT gene, which leads to an increased expression of the drug-metabolizing enzyme Catalase. As a result, the interaction between PPARD and CAT can activate the drug-metabolizing process of Catalase.
                     Non-coding RNA regulation
                            hsa-miR-30b-5p Health Suppression
miRBase ID
MIMAT0000420
Interaction Name hsa-miR-30b-5p--CAT regulation [2]
Studied Cell Lines ARPE-19 cell line
Description hsa-miR-30b-5p is reported to suppress CAT mRNA translation by binding to the 3' untranslated region (3'UTR) of CAT mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Catalase.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C60 Breast cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            NFE2-related factor 2 (NFE2L2) Breast cancer Activation
Uniprot ID
NF2L2_HUMAN
Interaction Name NFE2L2-CAT interaction [4]
Studied Cell Lines MCF-7, T47D and HCC1937 cell lines
Ensembl ID
ENSG00000116044
Description NFE2-related factor 2 (NFE2L2) is reported to activate the transcription of CAT gene, which leads to an increased expression of the drug-metabolizing enzyme Catalase. As a result, the interaction between NFE2L2 and CAT can activate the drug-metabolizing process of Catalase.
References
1 EGR3, a novel member of the egr family of genes encoding immediate-early transcription factors. Oncogene. 1991 Jun;6(6):917-28.
2 MicroRNA-30b-mediated regulation of catalase expression in human ARPE-19 cells. PLoS One. 2012;7(8):e42542.
3 Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):315-21.
4 B-cell translocation gene 2 (BTG2) stimulates cellular antioxidant defenses through the antioxidant transcription factor NFE2L2 in human mammary epithelial cells. J Biol Chem. 2012 Sep 7;287(37):31503-14.

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